Effects of parenterally administered ciprofloxacin in a murine model of pulmonary Pseudomonas aeruginosa infection mimicking ventilator-associated pneumonia.

Biometrische Zeitschrift Pub Date : 2001-12-01 DOI:10.1159/000048553

Y Kaneko, K Yanagihara, M Kuroki, H Ohi, H Kakeya, Y Miyazaki, Y Higashiyama, Y Hirakata, K Tomono, J I Kadota, S Kohno

{"title":"Effects of parenterally administered ciprofloxacin in a murine model of pulmonary Pseudomonas aeruginosa infection mimicking ventilator-associated pneumonia.","authors":"Y Kaneko, K Yanagihara, M Kuroki, H Ohi, H Kakeya, Y Miyazaki, Y Higashiyama, Y Hirakata, K Tomono, J I Kadota, S Kohno","doi":"10.1159/000048553","DOIUrl":null,"url":null,"abstract":"Background and methods: We compared the bacteriological, pharmacological and histopathological effects of parenterally administered ciprofloxacin (CPFX) to those of imipenem/cilastatin (IMP/CS) and cefozopran (CZOP) in a murine model of mucoid Pseudomonas aeruginosa pneumonia mimicking ventilator-associated pneumonia.Results: The minimum inhibitory concentrations (MICs) of CPFX, IMP and CZOP were 1.0, 1.0 and 4.0 mg/l, respectively. Treatment with CPFX resulted in a significant decrease in the number of viable bacteria [control, IMP/CS, CZOP and CPFX (mean +/- SEM): 5.02 +/- 0.20, 4.96 +/- 0.38, 5.44 +/- 0.13 and 3.27 +/- 0.02 log(10) colony-forming units lung, respectively]. Histopathological examination revealed that inflammatory changes in the CPFX-treated group were less marked than in other groups. Of the drugs analyzed, the pharmacokinetic parameters of area under the time-concentration curve (AUC)/MIC, AUC exceeding MIC and the time that lung concentrations of drug remained above the MIC were highest for CPFX.Conclusion: Our results suggest that parenterally administered ciprofloxacin is effective in ventilator-associated P. aeruginosa pneumonia.","PeriodicalId":78882,"journal":{"name":"Biometrische Zeitschrift","volume":"2 1","pages":"421-9"},"PeriodicalIF":0.0000,"publicationDate":"2001-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000048553","citationCount":"10","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biometrische Zeitschrift","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000048553","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 10

Abstract

Background and methods: We compared the bacteriological, pharmacological and histopathological effects of parenterally administered ciprofloxacin (CPFX) to those of imipenem/cilastatin (IMP/CS) and cefozopran (CZOP) in a murine model of mucoid Pseudomonas aeruginosa pneumonia mimicking ventilator-associated pneumonia.

Results: The minimum inhibitory concentrations (MICs) of CPFX, IMP and CZOP were 1.0, 1.0 and 4.0 mg/l, respectively. Treatment with CPFX resulted in a significant decrease in the number of viable bacteria [control, IMP/CS, CZOP and CPFX (mean +/- SEM): 5.02 +/- 0.20, 4.96 +/- 0.38, 5.44 +/- 0.13 and 3.27 +/- 0.02 log(10) colony-forming units lung, respectively]. Histopathological examination revealed that inflammatory changes in the CPFX-treated group were less marked than in other groups. Of the drugs analyzed, the pharmacokinetic parameters of area under the time-concentration curve (AUC)/MIC, AUC exceeding MIC and the time that lung concentrations of drug remained above the MIC were highest for CPFX.

Conclusion: Our results suggest that parenterally administered ciprofloxacin is effective in ventilator-associated P. aeruginosa pneumonia.

查看原文本刊更多论文

肠外给药环丙沙星对模仿呼吸机相关肺炎的肺绿脓杆菌感染小鼠模型的影响

背景和方法:在模拟呼吸机相关性肺炎的小鼠黏液性铜绿假单胞菌肺炎模型中，我们比较了肠外注射环丙沙星(CPFX)与亚胺培南/西司他汀(IMP/CS)和头孢唑普兰(CZOP)的细菌学、药理学和组织病理学效果。结果:CPFX、IMP和CZOP的最低抑菌浓度(mic)分别为1.0、1.0和4.0 mg/l。CPFX处理导致活菌数量显著减少[对照组，IMP/CS, CZOP和CPFX(平均+/- SEM)分别为5.02 +/- 0.20,4.96 +/- 0.38,5.44 +/- 0.13和3.27 +/- 0.02 log(10)个菌落形成单位肺]。组织病理学检查显示，与其他组相比，cpfx治疗组炎症变化不明显。在所分析的药物中，CPFX的药代动力学参数时间-浓度曲线下面积(AUC)/MIC、AUC超过MIC以及药物的肺浓度保持在MIC以上的时间最高。结论:本研究结果提示环丙沙星是治疗呼吸机相关性铜绿假单胞菌肺炎的有效药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Biometrische Zeitschrift

自引率

0.00%

发文量