American Journal of Biomedical and Life Sciences最新文献

{"title":"Treating Open Fracture of Lower One Third of Tibia by Ilizarov Technique: A Study in a Tertiary Care Hospital of Bangladesh","authors":"Erfanul Huq Siddiqui, Sheikh Forhad, Shamsul Alam, Jannat Sultana, M. Shameem","doi":"10.11648/J.AJBLS.20210902.14","DOIUrl":"https://doi.org/10.11648/J.AJBLS.20210902.14","url":null,"abstract":"Introduction: Illizarov technique is a newer but popular method of treating open tibial fractures after debridement and open reduction. Illizarov method has many advantages and features. On the other hand, open fracture of lower one third of tibia is a common occurrence in the orthopedic treatment arena. Open fractures of tibia are classified into Type I, II, IIIA, IIIB and IIIC. Aim of the study: The aim of this study was to assess the Ilizarov technique in treating open fracture of lower one third of tibia. Methods: This observational prospective study was conducted at the Department of Orthopedics Surgery in Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh during the period from January 2017 to December 2017. Thirty six (36) patients with open fracture of lower one third of tibia were selected as the study population. Before starting the intervention the written consent of the participants was taken and this study was approved by the ethical committee of the mentioned hospital. A pre-designed questioner was used in collecting patient data. All data were processed, analyzed and disseminated by MS Office and SPSS version 20 as per need. Results: In this study we found highest 80.56% participants were from road accidents followed by 11.11% from sports injury and rest only 8.33% from general falls. The duration of treatment with the fixator was 12-23 weeks (average 16 weeks). The operation time ranged from 90 minutes to 120 minutes. According to the Karlstrom and Olerud criteria the highest 69.44% patient got ‘excellent’ result. Then 22.22%, 5.56% and 2.78% patients got ‘good’, ‘fair’ and ‘poor’ result respectively. Conclusion: The Ilizarov device is used worldwide for the treatment of several types of fractures. In our study, we found some good features of using Ilizarov induced method in the treatment of open fracture of lower one third of tibia. No case developed deep infection, non-union or unacceptable mal-union. We recommend for more use of Ilizarov technic.","PeriodicalId":7857,"journal":{"name":"American Journal of Biomedical and Life Sciences","volume":"357 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76509518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Parasites and Bacterial Contamination of Office Door Handles in Nnamdi Azikiwe University, Awka, Anambra State","authors":"P. Umeanaeto, U. Okafor, Miracle Chisom Unam, Chidiogo Chidimma Ilo, C. Okoli, S. C. Afulukwe, Nnamdi Enoch Nwakoby","doi":"10.11648/J.AJBLS.20210902.13","DOIUrl":"https://doi.org/10.11648/J.AJBLS.20210902.13","url":null,"abstract":"Microorganisms are present on all surfaces, to which they were carried by many direct and indirect methods of transmission. Bacteria and Parasites contaminating office door handles in Nnamdi Azikiwe University were assessed between June and November, 2019. The buildings and the door handles were randomly selected. Sterile swabs moistened in sterile normal saline were used to swab the door handles in a tri-directional manner. The swabs were cultured and subcultured onto nutrient, MacConkey and Salmonella-Shigella agar plates for bacterial growth. The specimens were then examined for parasites using Zinc Sulphate floatation and formol-ether sedimentation techniques. Of the 432 door handles examined, 136 (30.8%) were contaminated. The highest number of contaminated doors were found in Medical Centre 41 (30.1%) and the least in Faculty of Social Sciences Complex 10 (7.4%). E. histolytica 52 (38.2%) was the highest parasite encountered while E. vermicularis 2 (1.5%) was the least. The proportion of infected doors as well as the distribution of different species parasites in the door handles of different complexes examined was significant (P<0.05). Of 432 office door handles examined, 263 (60.9%) yielded bacterial growth. Female hostel 72 (27.4%) had more bacterial contamination while Faculty of Social Sciences 25 (9.5%) had the least. Staphylococcus spp 54 (20.5%) was the highest bacteria isolated, followed by Escherichia 53 (20.2%) while Klebsiella 53 (20.2%) was the least. The distribution of different species of bacteria in the door handles in different complexes was significant (P<0.05). Infectious diseases from microbial contaminated door handles are a potential threat to public health and safety therefore certain measures should be taken such as aggressive and frequent cleaning methods and good hand washing to reduce the incidence of bacterial and parasite transmission and contamination.","PeriodicalId":7857,"journal":{"name":"American Journal of Biomedical and Life Sciences","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89048389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Hypoglycaemic, Antihyperlipidemic and Antioxidative Effects of Anacardium occidentale Methanolic Nut Extract in Streptozotocin-Induced Diabetic Rats","authors":"F. Ajao, M. Olamoyegun, M. O. Iyedupe","doi":"10.11648/J.AJBLS.20210903.11","DOIUrl":"https://doi.org/10.11648/J.AJBLS.20210903.11","url":null,"abstract":"This research work investigated the anti-diabetic, anti-hyperlipidemic, and anti-oxidative effects of Anacardium occidentale methanolic nut extract in Streptozotocin-induced diabetic Wistar rats. Forty (40) Wistar rats weighing 250±30g were randomly divided into five groups of 8rats each. Group1served as the control; Group2-5were induced with diabetes with a single dose of 50mg/kgbw of streptozotocin intraperitoneally. After diabetes induction, Group2 served as the streptozotocin only group, Group3and4 were administered 100mg/kgbw and 200mg/kgbwp.o of Anacardium occidentale nut extract, respectively, while Group5 was administered 2mg/kgbw of glimepiride as a reference drug for a period of 4weeks. Food and water intake were monitored daily, bodyweight, and blood glucose levels weekly throughout the experiment. On day29, the animals were sacrificed, and blood samples were collected through cardiac puncture for biochemical studies. Administration of Anacardium occidentale nut extract significantly decreased (p<0.05) the fasting blood glucose level, oral glucose tolerance test (OGTT), triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL) concentrations and significantly increase (p<0.05) the high-density lipoprotein (HDL) in diabetic treated rats. Superoxide dismutase (SOD), Glutathione peroxidase (GPx), Reduced glutathione (GSH), and Catalase (CAT) levels significantly (p<0.05) increases with a decrease Malondialdehyde (MDA) level in diabetic treated rats. Food intake and bodyweight of diabetic treated rats significantly increases (p<0.05). Markers of liver and kidney functions were also improved in diabetic treated rats. The results from this study suggest that Anacardium occidentale nut may be useful in the therapeutic management of diabetes and its related complications.","PeriodicalId":7857,"journal":{"name":"American Journal of Biomedical and Life Sciences","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90857149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective and Curative Potentials of Sida corymbosa Extract Against Antioxidant Depletion in Rats Administered Carbon Tetrachloride","authors":"C. Dike, F.C.Ezeonu, Chinenye E. Oguazu, E. Ezeokafor, H. Maduka, A. N. Okpogba, Akpoghene Eyeghre Onoriode, Sunday Jacob Asebioyo, Emilia Chika Nwankwo, Ebelechukwu Nwaoma Ihekwoaba, A. C. Nkechi","doi":"10.11648/J.AJBLS.20210902.11","DOIUrl":"https://doi.org/10.11648/J.AJBLS.20210902.11","url":null,"abstract":"Sida corymbosa plant is one of medicinal plants used in many parts of Africa, including Nigeria for the treatment of human diseases. The purpose of this work was to investigate the antioxidant effects of Sida corymbosa ethanolic leaf extract on rats administered carbon tetrachloride (CCl4). One hundred and sixty male-rats between 170-180 g were used. They were grouped into 8 major groups (groups A-H) and 4 subgroups (A1-H4) in each group making it 32 subgroups of 5 rats each. The major groups comprise A (positive control- normal rats giving feed and water only and left for 7-28 d), B (negative control-those administered CCl4 only at 0.4 ml/kgbw and left for 7-28 d), C-H (treatment groups-those administered extract before and after CCl4 administration at 5,000, 3,000 and 1,000 mg/kgbw for 7-28 d). Antioxidant assays were determined using UV-VIS spectrophotometer (model 752g, China). Results of serum antioxidant assays done revealed that levels of serum reduced glutathione (GSH), glutathione peroxidase (GPx), catalase (CAT), supraoxide dismutase (SOD) and total antioxidant capacity (TAC) increased significantly (P<0.05) in the treatment groups from 7-28 d, when compared with the negative control. Oxidative assay carried out showed that serum malondialdehyde (MDA) levels were significantly lower (P<0.05) in treatment groups than in negative control groups. These may be suggesting that the extract may have improved the antioxidant levels of the rats. Sida corymbosa ethanolic leaf extract may, therefore, have positive effects on antioxidant status of rats administered CCl4.","PeriodicalId":7857,"journal":{"name":"American Journal of Biomedical and Life Sciences","volume":"28 1","pages":"97"},"PeriodicalIF":0.0,"publicationDate":"2021-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81171402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Efficacy of Triple Regimen of Artemether, Lumefantrine and Hippocratea africana in the Treatment of Plasmodium berghei Infected Mice","authors":"A. Uwah, A. Bassey, Innocent Asukwo Edagha, Blessing Obinaju Effiong","doi":"10.11648/J.AJBLS.20210901.20","DOIUrl":"https://doi.org/10.11648/J.AJBLS.20210901.20","url":null,"abstract":"Combination therapy is fast replacing monotherapy in the treatment of infectious diseases and Plasmodium resistance to artemisinin–based combination therapies (ACTs) is an emerging challenge. Our study aimed to evaluate the therapeutic efficacy of combining Artemether-Lumefantrine with crude root bark extract of Hippocratea africana, on mice infected with Plasmodium berghei. Forty-five albino mice which weighed 30 - 38g were grouped into five with seven mice in each. The mice were inoculated intraperitoneally with Plasmodium berghei and kept for seven days for the parasitaemia to develop. A daily single dose of 200mg/Kg body weight of extract of H. africana was administered orally for ten days, while therapeutic dose of Artemether-lumefantrine was administered as daily single dose to the relevant groups on the last six days of treatment. A non-parasitized and parasitize untreated groups served as controls. The weights of the animals were recorded before and after treatment. The animals were sacrificed and blood obtained for determination of percentage parasitaemia and the erythrocytes count of the parasitized mice using standard methods. The results showed the mean body weight and percentage body weight changes of parasitized mice treated with combination of ACT plus H. africana not statistically different from those of non-parasitized untreated mice. Parasitized mice treated with ACT plus Extract had a significantly (p < 0.05) reduced percentage parasitaemia when compared with those treated with ACT only. Treatment with ACT plus Extract also showed a significant increase in parasite clearance (100%) when compared to mice treated with either ACT only (93.10%) or Extract only (82.15%). We concluded that combining artemether, lumefantrine and H. africana root bark extract exhibited a good therapeutic efficacy as demonstrated by body weight recovery, parasite clearance and reversion of clinical signs induced by Plasmodium berghei parasitaemia. The triple regimen was more efficacious than ACT alone, and therefore, may be a useful regimen in addressing the emerging problem of resistance of plasmodium species to standards ACTs.","PeriodicalId":7857,"journal":{"name":"American Journal of Biomedical and Life Sciences","volume":"365 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84909683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Potential Impact of Self-medication and Drug Misuse Practice Among Youth Population in Kinshasa, Democratic Republic of Congo","authors":"Kalonji Katengele, Fumwakwau Kiniati, Nkanga Isalomboto, D. K. Mana","doi":"10.11648/J.AJBLS.20210901.19","DOIUrl":"https://doi.org/10.11648/J.AJBLS.20210901.19","url":null,"abstract":"Self-medication refers to the act of medicating oneself with no guidance from a physician. There are sevral factors that promote self-medication along with drug misuse among the population. In the frame of developing countries, such as the Democratic Republic of Congo (DRC), these factors include lack of enforcement of laws governing the pharmaceutical sector, poor mindset of the population as well as easy access to drugs without official medical prescriptions. The purpose of this study was to evaluate the extent to which self-medication and drug misuse practices affect the youth Congolese population health in the DRC’s capital city, Kinshasa. Three sectors of Kinshasa were selected for a cross-sectional study conducted for five months (January to Mai 2020). Pharmacists or their auxiliairies were asked to draw up the list of ten drugs often purchased without medical prescriptions. In each of the selected pharmacies, 3 patients using self-medication were interviewed. A total of 120 phrarmacists or their auxiliairies and 360 patients (180 men and 180 women) were selected using systematic random sampling technique. Of the 120 questionnaires completed, a list of ten most used drugs in self-medication was established in the following dicreasing quantitative order: 106, 85, 83, 66, 66, 58, 51, 38, 29 and 23 pharmacists or their auxiliairies cited Amoxicillin capsule, Emergency Contraceptive Pill tablet, Paracetamol tablet, Dexamethasone tablet, Cyproheptadine tablet, Tetracyclin capsule, Levamisole tablet, Albendazole tablet, Quinine and Diclofenac injectables, respectively. Out of 360 questionnaires distributed, all medicines were administered by the route recommended by the physician except Dexamethasone tablet, Cyproheptadine tablet and Diclofenac injection where in 30.1%, 38.1% and 89.7% of self-medication cases the route of administration was other than the recommended route. From the recorded data, the age of most patients varied between 15-24 years old. Girls were more in self-medication than boys. Sometimes, the disease for which the drug was used, as well as the dosing, were found to be different from the instructions in patients’ leaflet. And lastly, for most patients, the main source of information was family and/or friends. This study demonstrated that the practice of self-medication is very widespread in Kinshasa, unfortunately even antibiotics are misused, exposing the population to high risk of antimicrobial resistance development. The present findings encourage further investigations at national level to better advise the dicision makers to take appropriate measures to substantially mitigate self-medication and drug misuse practices.","PeriodicalId":7857,"journal":{"name":"American Journal of Biomedical and Life Sciences","volume":"16 1","pages":"69"},"PeriodicalIF":0.0,"publicationDate":"2021-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87188680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary Evaluation of an Autologous Dendritic Cell Vaccine Using Nanoparticle Technology for the Treatment of Canine Malignant Melanoma","authors":"M. Eren, Julianne K. Hwang, J. Fidel, R. Sellon, C. Souza","doi":"10.11648/J.AJBLS.20210901.21","DOIUrl":"https://doi.org/10.11648/J.AJBLS.20210901.21","url":null,"abstract":"Canine malignant melanoma is an aggressive neoplasm that carries a poor prognosis due to its minimal responsiveness to traditional therapy protocols, particularly if the oral cavity, mucocutaneous junctions, or subungual sites are involved. This proof-of-concept study evaluated a prototype autologous dendritic cell vaccine using poly-lactic-co-glycolic (PLGA) nanoparticles containing antigens from patient-derived whole tumor lysate and the adjuvant monophosphoryl lipid A in five canines with stages III-IV malignant melanoma. Nanoparticle constructs biochemical characterization; encapsulation efficiency and kinetic release studies were determined. Our results showed that tumor antigens were successfully incorporated in the PLGA/monophosphoryl lipid A nanoparticle constructs. Additional in vitro experiments showed that the PLGA/monophosphoryl lipid A nanoparticle constructs effectively activated autologous dendritic cells, and generated a greater than twofold increase in the release of the pro-immune cytokine IFN-γ. No significant adverse effects were observed in any of the patients following intradermal vaccination, and flow cytometry of whole blood revealed increased CD4:CD8 T lymphocyte ratios by the completion of the study. These results suggest that a dendritic cell vaccine utilizing PLGA/monophosphoryl lipid A nanoparticle technology could potentially initiate an adaptive immune response and is safe to administer to canine patients. Further in vivo studies with a larger cohort of patients are warranted.","PeriodicalId":7857,"journal":{"name":"American Journal of Biomedical and Life Sciences","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80715848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival Advantage of Non-hispanic White Patients with Pancreatic Head Carcinoma: A Population-based Study","authors":"H. Yu, Chengzhuo Li, Qi-heng Wu, Jukun Su, An-Nuo Liu, Qi-qi Ke, Qiaohong Yang","doi":"10.11648/J.AJBLS.20210901.18","DOIUrl":"https://doi.org/10.11648/J.AJBLS.20210901.18","url":null,"abstract":"Numerous studies have shown that racial health disparities in gastroenterology and hepatology, but little is known about its effect on pancreatic head carcinoma (PHC). The aim of the present study was to determine whether racial disparities in the overall survival (OS) and cancer-specific survival (CSS) rates exist among US patients with PHC. The SEER database was searched for US residents who had been diagnosed with PHC from 2007 to 2015. The outcomes for 9724 Hispanic white (HW) patients and their non-Hispanic white (NHW) counterparts were compared using Kaplan-Meier survival and Cox regression analyses. We found that race affected both OS and CSS. The 5-year OS rate was worse for HW patients (45.9%) than for NHW patients (49.6%, P<0.001), as was the 5-year CSS rate (39.8% versus 44.0%, P=0.002). Race appeared to be an independent prognostic factor for PHC in the multivariate analysis, with NHW patients showing superior OS (P=0.007) and CSS (P=0.037) compared with HW patients. Subgroup analysis showed that race influenced survival among patients who received surgery, enjoyed Medicaid, and those at American Joint Committee on Cancer (AJCC) tumor-node-metastasis (TNM) stage II, but not of patients at AJCC TNM stage I, III, or IV and those who did not receive surgery or had no insurance. In short, the survival outcomes for PHC are better for NHW than HW patients. The survival advantage is more skewed towards NHW patients than HW patients with PHC, so culturally appropriate interventions, strengthened preventive services, and additional financial support should focus more on HWs.","PeriodicalId":7857,"journal":{"name":"American Journal of Biomedical and Life Sciences","volume":"17 1","pages":"58"},"PeriodicalIF":0.0,"publicationDate":"2021-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84231210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional Outcome of Surgical Management of Tibial Plateau Fractures: A Study in a Tertiary Care Hospital","authors":"Md. Nazibullah, M. Islam, Tapas kumer Talukder, Amanul Islam","doi":"10.11648/J.AJBLS.20210901.17","DOIUrl":"https://doi.org/10.11648/J.AJBLS.20210901.17","url":null,"abstract":"Background: Tibial plateau fractures are serious injuries resulting frequently in functional impairment. Low and high-energy tibial plateau fractures usually result from axial loading in combination with valgus stress forces, present a variety of soft tissue and bony injuries that can produce permanent disabilities. Since there are various modalities for fixation of these fractures with satisfactory results, but there is no general consensus as to which modality is the best in terms of functional outcome and proving the superiority of one over the other. Aim of the study: The aim of this study was to evaluate the functional outcome of surgical management of tibial plateau fractures. Methods: It was a prospective observational study and it was conducted in the Department of Orthopaedics & Traumatology, TMSS Medical College, Bogura, Bangladesh during the period from January 2018 to December 2018. The total of cases included in the study was 56 in number. More than 20 years old patients of both sexes with tibial plateau fractures attended to the mentioned hospital during the first six months of the study were selected as the study population. All simple or Gustilo Anderson Grade I fractures of tibial plateau presenting in patients requiring open or closed reduction and internal fixation to restore the articular anatomy were finalized for this study. Result: In this study among total 56 participants 37 were male which was 66.07% and 19 were female which was 33.93%. On the other hand in this study we found satisfactory outcome in 50 patients which was 89.29% and not satisfactory in 6 patients which was 10.71% among all the participants. Final end result as per Rasmussen’s criteria was excellent in 34 (60.71%), good in 9 (16.07%), fair in 7 (12.50%) and poor in 6 (10.71%) patients. Conclusion: In this study we found satisfactory outcome in 50 patients which was 89.29% and not satisfactory in 6 patients which was 10.71% among all the participants. These findings may be helpful for the future researchers for any further research in the same issue.","PeriodicalId":7857,"journal":{"name":"American Journal of Biomedical and Life Sciences","volume":"55 1","pages":"53"},"PeriodicalIF":0.0,"publicationDate":"2021-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74808441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex Is Related to Overall Survival in Patients with Esophageal Squamous Cell Carcinoma: A Population-Based Study","authors":"Yaoxiang Li, Na Wang, Z. Zhao, Jiale Wang, Jun Lyu, Qinyang Wu, Qi-qi Ke, Qiaohong Yang","doi":"10.11648/J.AJBLS.20210901.16","DOIUrl":"https://doi.org/10.11648/J.AJBLS.20210901.16","url":null,"abstract":"Esophageal cancer is one of the cancers that seriously threaten the lives and health of patients around the world. Squamous cell carcinoma accounts for a higher proportion of esophageal cancer cases. At the same time, the number of esophageal squamous cell carcinoma (ESCC) patients also has an increasing trend year by year. Therefore, it is important to identify the prognostic factors of ESCC to improve the survival and prognosis of patients. As an important sociodemographic factor, gender has an important influence on the occurrence, development and prognosis of certain diseases. However, it has not been clear from existing studies whether gender affects the prognosis of ESCC patients. The aim of this study was to determine the effect of sex on overall survival (OS) in patients with ESCC. Methods: This study analyzed 6890 patients with ESCC diagnosed from 2007 to 2015 who were identified in the SEER (Surveillance, Epidemiology, and End Results) database. Kaplan-Meier method and Cox Proportional Hazards model were used to conduct survival analysis and regression analysis to evaluate the association between gender and OS. Results: We found that the OS differed with sex in patients with ESCC, with the 5-year OS rate being higher in females (19.2%) than in males (12.9%). A Cox multivariate analysis showed that sex was an independent prognostic factor for ESCC, with the OS being significantly better in female patients than in male patients (P<0.001). Subgroup analyses showed that sex affected the survival rate of patients with American Joint Committee on Cancer tumor, node, and metastasis stages I (P=0.013), II (P<0.001), III (P=0.014), and IV (P<0.001). Conclusion: Our results suggest that the OS of patients with ESCC is significantly better in females than males. Therefore, more attention should be paid to the prognosis of male patients with ESCC, with prospective interventions and health education applied in order to improve their survival outcomes.","PeriodicalId":7857,"journal":{"name":"American Journal of Biomedical and Life Sciences","volume":"27 1","pages":"43"},"PeriodicalIF":0.0,"publicationDate":"2021-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83138742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}