性别与食管鳞状细胞癌患者的总生存率相关:一项基于人群的研究

Yaoxiang Li, Na Wang, Z. Zhao, Jiale Wang, Jun Lyu, Qinyang Wu, Qi-qi Ke, Qiaohong Yang
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引用次数: 0

摘要

食管癌是严重威胁全世界患者生命健康的癌症之一。鳞状细胞癌在食管癌病例中所占比例较高。同时,食管鳞状细胞癌(ESCC)患者数量也有逐年增加的趋势。因此,明确ESCC的预后因素对改善患者的生存和预后具有重要意义。性别作为一个重要的社会人口学因素,对某些疾病的发生、发展和预后有重要影响。然而,现有研究尚不清楚性别是否会影响ESCC患者的预后。本研究的目的是确定性别对ESCC患者总生存率(OS)的影响。方法:本研究分析了2007年至2015年在SEER(监测、流行病学和最终结果)数据库中发现的6890例ESCC患者。采用Kaplan-Meier法和Cox比例风险模型进行生存分析和回归分析,评价性别与OS的相关性。结果:我们发现ESCC患者的OS存在性别差异,女性的5年OS率(19.2%)高于男性(12.9%)。Cox多因素分析显示,性别是ESCC的独立预后因素,女性患者的OS明显优于男性患者(P<0.001)。亚组分析显示,性别影响美国癌症联合委员会肿瘤、淋巴结和转移期I (P=0.013)、II (P<0.001)、III (P=0.014)和IV (P<0.001)患者的生存率。结论:我们的研究结果表明,女性ESCC患者的OS明显优于男性。因此,应重视男性ESCC患者的预后,采用前瞻性干预措施和健康教育,以改善其生存结局。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Sex Is Related to Overall Survival in Patients with Esophageal Squamous Cell Carcinoma: A Population-Based Study
Esophageal cancer is one of the cancers that seriously threaten the lives and health of patients around the world. Squamous cell carcinoma accounts for a higher proportion of esophageal cancer cases. At the same time, the number of esophageal squamous cell carcinoma (ESCC) patients also has an increasing trend year by year. Therefore, it is important to identify the prognostic factors of ESCC to improve the survival and prognosis of patients. As an important sociodemographic factor, gender has an important influence on the occurrence, development and prognosis of certain diseases. However, it has not been clear from existing studies whether gender affects the prognosis of ESCC patients. The aim of this study was to determine the effect of sex on overall survival (OS) in patients with ESCC. Methods: This study analyzed 6890 patients with ESCC diagnosed from 2007 to 2015 who were identified in the SEER (Surveillance, Epidemiology, and End Results) database. Kaplan-Meier method and Cox Proportional Hazards model were used to conduct survival analysis and regression analysis to evaluate the association between gender and OS. Results: We found that the OS differed with sex in patients with ESCC, with the 5-year OS rate being higher in females (19.2%) than in males (12.9%). A Cox multivariate analysis showed that sex was an independent prognostic factor for ESCC, with the OS being significantly better in female patients than in male patients (P<0.001). Subgroup analyses showed that sex affected the survival rate of patients with American Joint Committee on Cancer tumor, node, and metastasis stages I (P=0.013), II (P<0.001), III (P=0.014), and IV (P<0.001). Conclusion: Our results suggest that the OS of patients with ESCC is significantly better in females than males. Therefore, more attention should be paid to the prognosis of male patients with ESCC, with prospective interventions and health education applied in order to improve their survival outcomes.
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