American Journal of Physical Medicine & Rehabilitation最新文献

{"title":"Outcomes of Proprioceptive Training on Recovery After Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-analysis.","authors":"Lei Huang, Guixuan You, Minghui Li, Zhangrong Xia, Siyi Yang, Xin Zhou, Houyin Shi, Dingxuan Wang, Lei Zhang","doi":"10.1097/PHM.0000000000002639","DOIUrl":"10.1097/PHM.0000000000002639","url":null,"abstract":"<p><strong>Objective: </strong>The study was designed to explore the effect of proprioceptive training in contrast to conventional training among individuals after anterior cruciate ligament reconstruction. It includes joint position sense, subjective functional outcomes (Cincinnati, Knee injury Osteoarthritis Outcome Score, International Knee Documentation Committee knee form), muscle strength, pain, and kinesthesia.</p><p><strong>Methods: </strong>PubMed, Embase, The Cochrane Library, and Web of Science databases were searched. Quality assessment was performed through the Cochrane Risk of Bias tool and GRADE system. The standardized mean deviation was selected as the effect size.</p><p><strong>Results: </strong>Fifteen studies and 537 participants were included. Compared with conventional training, proprioceptive training may significantly enhance passive joint position sense (standardized mean deviation = -1.87 [95% CI = -2.39 to -1.34]) and single-leg hop function test performance (standardized mean deviation = 0.29 [95% CI = 0.04 to 0.54]). Data also indicated that proprioceptive training can moderately improve subjective functional outcomes (standardized mean deviation = 0.61 [95% CI = 0.23 to 0.99]). However, there were no significant effects on active joint position sense, muscle strength, and visual analogue scale.</p><p><strong>Conclusions: </strong>Proprioceptive training has the potential to yield beneficial effects on knee passive joint position sense, hop functional test, and subjective functional outcomes in patients after anterior cruciate ligament reconstruction. However, its impact on enhancing knee active joint position sense and kinesthesia may not be statistically significant.</p>","PeriodicalId":7850,"journal":{"name":"American Journal of Physical Medicine & Rehabilitation","volume":" ","pages":"436-444"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PM&R Connections: A Pilot Study Evaluating the Adoptability and Impact of a Serious Educational Game on Trainees at a Physical Medicine and Rehabilitation Program.","authors":"Shane N Stone, Steven Kirshblum","doi":"10.1097/PHM.0000000000002620","DOIUrl":"10.1097/PHM.0000000000002620","url":null,"abstract":"<p><strong>Abstract: </strong>To enhance engagement and educational outcomes, game-based learning has been introduced into undergraduate and graduate medical education programs. Using a free website, \"PM&R Connections,\" a serious game, was created to provide trainees with an alternative method of reviewing content to identify knowledge gaps to direct studying. The game was used by 19/33 trainees and 92.3% of users required ≤10 mins to complete a puzzle. 76.9% of users found the tool helpful, 69.2% recommended the game, and 92.3% desired more puzzles to be developed. Confusion on how to play and intimidation were the most reported barriers to play, and only 46% of users changed their study habits. The positive feedback and desire for more puzzles to be developed provide a foundation to further develop the game.</p>","PeriodicalId":7850,"journal":{"name":"American Journal of Physical Medicine & Rehabilitation","volume":" ","pages":"e78-e81"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound-Guided Perineural Hydrodissection for the Treatment of Lacertus Fibrosus Syndrome in a Baseball Player: A Case Report.","authors":"Hirotaka F Nakagawa, Kevin Zheng, Kyungje Sung, Walter I Sussman","doi":"10.1097/PHM.0000000000002597","DOIUrl":"10.1097/PHM.0000000000002597","url":null,"abstract":"<p><strong>Abstract: </strong>Lacertus fibrosus syndrome is a rare cause of persistent medial elbow pain in baseball players, often not considered in the initial diagnostic considerations. This case report details a 19-yr-old collegiate baseball player who presented with insidious left anterior medial elbow pain, initially diagnosed as biceps tendonitis. The patient did not experience pain relief after 6 mos of conservative management. Sonopalpation during diagnostic ultrasound localized the source of pain to the median nerve at the level of the lacertus fibrosus, and the decision was made to perform ultrasound-guided hydrodissection of the median nerve at this level. The procedure resulted in rapid and sustained symptom relief without the scarring that has been associated with traditional surgical techniques. To date, there has been no study investigating the use of ultrasound-guided hydrodissection targeting lacertus fibrosus. This report highlights the importance of considering lacertus fibrosus syndrome in throwing athletes with persistent elbow pain and advocates for considering ultrasound-guided hydrodissection as a management option for patients with clinical suspicion of LFS.</p>","PeriodicalId":7850,"journal":{"name":"American Journal of Physical Medicine & Rehabilitation","volume":" ","pages":"e75-e77"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141854469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does Early Continuous Passive Motion Improves Effectiveness of Physical Therapy After Arthroscopic Release of Elbow Contracture: A Prospective Randomized Trial.","authors":"Lihua Huang, Yanmao Wang, Yanhong Ma, Jian Ding, Shengdi Lu","doi":"10.1097/PHM.0000000000002646","DOIUrl":"10.1097/PHM.0000000000002646","url":null,"abstract":"<p><strong>Objective: </strong>The aim of the study is to investigate the effectiveness of early continuous passive motion combined with physical therapy compared to physical therapy alone as the rehabilitation protocol after the release of elbow contracture.</p><p><strong>Design: </strong>In this randomized controlled trial, 61 patients were randomly assigned to two groups (31 in the early continuous passive motion with physical therapy group vs. 30 in the physical therapy group). The patients received rehabilitation with or without early continuous passive motion for 4 wks and were followed up for 6 mos. The outcome measures were the range of motion and Mayo Elbow Performance Score.</p><p><strong>Results: </strong>The early continuous passive motion with physical therapy group demonstrated statistically significant improvements in range of motion and the Mayo Elbow Performance Score compared with the physical therapy group at 6 wks, 3 mos, and 6 mos postoperatively. These differences were not observed in the stability subscale of the Mayo Elbow Performance Score at any of the assessed time points, nor in its pain subscale at 6 mos.</p><p><strong>Conclusions: </strong>Compared with physical therapy alone, early continuous passive motion combined with physical therapy enabled a quicker recovery of functional elbow motion and early pain control within the 6-mo follow-up after arthroscopic release of elbow contracture.</p>","PeriodicalId":7850,"journal":{"name":"American Journal of Physical Medicine & Rehabilitation","volume":" ","pages":"445-451"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142456279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Rehabilitation After Surgical Repair of Hip Fracture Has Been Associated With Handgrip Strength But Not With Orthostatic Hypotension in Patients 65 Yrs of Age and Above.","authors":"Abdu El Karim Hilali, David Shacham, Reut Frenkel, Ahmed Abu-Ajaj, Evgeniya Zikrin, Tamar Freud, Yan Press","doi":"10.1097/PHM.0000000000002618","DOIUrl":"10.1097/PHM.0000000000002618","url":null,"abstract":"<p><strong>Objective: </strong>The identification of factors associated with successful rehabilitation after hip fractures enables more successful planning of the rehabilitation process and discharge from the hospital. Orthostatic hypotension and handgrip strength have been evaluated in previous studies as potential predictors of rehabilitation outcomes, with inconsistent results.</p><p><strong>Design: </strong>A retrospective study of patients 65 yrs of age and above who underwent rehabilitation after surgical repair of hip fracture in the geriatric department between July 2020 and October 2023. Handgrip strength was measured during the first 3 days of hospitalization using a digital dynamometer. Orthostatic hypotension was measured a week after admission to the ward by the tilt table test. Successful rehabilitation was defined as a Montebello Rehabilitation Factor Score Revised above 50%.</p><p><strong>Results: </strong>Data were collected for 253 patients. The mean age was 80.5 ± 7.7 and 32.4% were males. The mean handgrip strength was 17.2 ± 6.6 kg. Orthostatic hypotension was diagnosed in 32.8%. One hundred ninety-three patients (76.3%) reached the goal of Montebello Rehabilitation Factor Score Revised ≥ 50 at the end of the rehabilitation. In a logistic regression analysis, handgrip strength, cognitive state, and sex were associated with successful rehabilitation.</p><p><strong>Conclusions: </strong>Measuring handgrip strength, but not orthostatic hypotension, can predict successful rehabilitation.</p>","PeriodicalId":7850,"journal":{"name":"American Journal of Physical Medicine & Rehabilitation","volume":" ","pages":"407-414"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142139054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Knee Strengthening Exercises and Lifestyle Modifications Through Mobile Phone Support in People Suffering From Knee Osteoarthritis.","authors":"Nikhil Garg, Nikhil Gupta, Kavin Khatri, Abhinav Kanwal, Zeeshan Hussain, Jimmy Sachdeva","doi":"10.1097/PHM.0000000000002624","DOIUrl":"10.1097/PHM.0000000000002624","url":null,"abstract":"<p><strong>Objective: </strong>The study aimed to evaluate the effectiveness of mobile phone-based support in improving exercise adherence and outcomes in knee osteoarthritis.</p><p><strong>Designs: </strong>A prospective comparative cohort study was conducted with a follow-up at 3, 6, and 12 wks, involving 210 participants allocated into intervention and control groups. The intervention group received knee exercise flyers and mobile phone-based adherence support, while the control group received only standard instructions after physiotherapy. Outcome measures included Western Ontario and McMaster Universities Arthritis Index scores, numeric rating scale pain scores, and quality of life assessments at baseline and follow-ups at 3, 6, and 12 wks.</p><p><strong>Results: </strong>The intervention group exhibited significant reductions in Western Ontario and McMaster Universities Arthritis Index scores, pain scores, and improvement in quality of life over the 12-wk follow-up compared to baseline. The intervention group exhibited significantly greater improvements in the outcomes as compared to control group.</p><p><strong>Conclusions: </strong>A combined intervention of knee exercises leaflets and SMS/phone call adherence support led to significant improvements in pain, functional outcomes, and quality of life among individuals with knee osteoarthritis. These findings underscore the potential of mobile phone-based interventions as effective adjuncts to traditional therapies for knee osteoarthritis.</p>","PeriodicalId":7850,"journal":{"name":"American Journal of Physical Medicine & Rehabilitation","volume":" ","pages":"422-429"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social Media Adoption and Utilization by Physical Medicine and Rehabilitation Residency Programs and Implications for Remote Resident Recruitment.","authors":"Christopher W Lewis, Alethea J Appavu, Tiffany Holland, Oksana Witt, Katrina Ngo, Hannah Uhlig-Reche, Toqa Afifi, Michael Galibov, Alexandra Fry, Monica Verduzco-Gutierrez","doi":"10.1097/PHM.0000000000002644","DOIUrl":"10.1097/PHM.0000000000002644","url":null,"abstract":"<p><strong>Abstract: </strong>We aim to investigate the association of Instagram and Twitter (rebranded X) adoption by physical medicine and rehabilitation residencies with the number of National Resident Matching Program applications received in the 2020-2021 application cycle. Among 88 physical medicine and rehabilitation residency programs, 67 (77%) had Instagram accounts, 45 (51%) had Twitter accounts, and 41 (47%) had both. Forty (60%) Instagram accounts and 19 (42%) Twitter accounts were opened during the 2020-2021 application cycle, correlating with the introduction of virtual interviews and the COVID-19 pandemic. Residency programs with active Instagram or Twitter accounts had more National Resident Matching Program applications (F(2,85) = 7.49, P = 0.001). Simple main effects analysis showed that programs with an Instagram account ( P = 0.03) or a Twitter account ( P = 0.03) received more residency applications. In multivariate linear regression analysis including presence of an Instagram account, program size, program setting, and program region, the presence of a Twitter account (coefficient 37.3, P = 0.04, 95% confidence interval 1.71-72.96) and ≥16 residents in the residency program (coefficient 77.9, P < 0.001, 95% confidence interval 44.43-111.31) were positively correlated with the number of residency applications. In conclusion, residency programs that were larger and adopted Twitter had more applicants in 2020-2021. Future research is needed to determine how social media activity impacts residency applicant decision making.</p>","PeriodicalId":7850,"journal":{"name":"American Journal of Physical Medicine & Rehabilitation","volume":" ","pages":"478-484"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142493148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic Review and Meta-analysis of Radiofrequency Ablation for Morton's Neuroma: Outcomes and Predictors of Success.","authors":"Rafael Llombart-Blanco, Gonzalo Mariscal, María Benlloch, Carlos Barrios, Rafael Llombart-Ais","doi":"10.1097/PHM.0000000000002668","DOIUrl":"10.1097/PHM.0000000000002668","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;Morton's neuroma presents a challenge in terms of pain management. This study aimed to evaluate the available evidence on the efficacy and safety of radiofrequency ablation for Morton's neuroma.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Design: &lt;/strong&gt;The Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines were followed. Prospective clinical trials, cohort studies, and case series were also included. Data analysis was performed using Review Manager 5.4. Meta-analysis applied fixed- or random-effects models depending on the heterogeneity. Sensitivity analyses were performed to assess the effects of temperature, radiofrequency cycles, and imaging guidance.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Eight studies ( N = 237) were included. Significant pain reduction was observed at the final follow-up (mean difference = 5.74; 95% confidence interval = 5.58, 5.90). At the final follow-up, 47.57% (95% confidence interval = 25.13%-70.00%) experienced complete pain relief, while 16.40% (95% confidence interval = 11.86%-20.94%) reported no benefit at final follow-up. Sensitivity analyses found higher-temperature settings (≥85°C) conferred greater relief on visual analog scale (mean difference = -6.97; 95% confidence interval = -6.75 to -7.18) compared to temperatures &lt;85°C (mean difference = -3.94; 95% confidence interval = -3.68 to -4.19). Fewer radiofrequency cycles (≤3) also demonstrated significantly greater visual analog scale improvement (mean difference = -6.97; 95% confidence interval = -6.75 to -7.18) versus &gt;three cycles (mean difference = -4.79; 95% confidence interval = -3.02 to -6.57). Complications were minimal (2.1%), and most resolved without significant interventions.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Radiofrequency ablation, particularly at specific temperatures and cycle thresholds, is effective and safe for the management of Morton's neuroma.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;To claim cme credits: &lt;/strong&gt;Complete the self-assessment activity and evaluation online at http://www.physiatry.org/JournalCME.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Cme objectives: &lt;/strong&gt;Upon completion of this article, the reader should be able to: 1): Determine the effect of knee extensor muscle strength changes on the medial and lateral meniscus, tibia, and medial and lateral femoral cartilage over 2 yrs in mild to moderate knee osteoarthritis patients; 2): Describe the correlation of knee extensor strength with the medial and lateral meniscus, tibia, and medial and lateral femoral cartilage at different WOMAC-pain levels; and 3): Discuss the relationship between changes in muscle strength and changes in meniscus and cartilage volume and WOMAC pain scores over 2 yrs in mild to moderate knee osteoarthritis patients.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Level: &lt;/strong&gt;Advanced.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Accreditation: &lt;/strong&gt;The Association of Academic Physiatrists is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.The Association","PeriodicalId":7850,"journal":{"name":"American Journal of Physical Medicine & Rehabilitation","volume":" ","pages":"465-472"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142789473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factor Prediction and Categorization for Glenohumeral Osteoarthritis: A Classification and Regression Tree Analysis.","authors":"Elyse N McNamara-Pittler, Ravi Prakash, Folefac D Atem, Rashmi Pathak, Wenting Liu, Michael Khazzam, Nitin B Jain","doi":"10.1097/PHM.0000000000002616","DOIUrl":"10.1097/PHM.0000000000002616","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to apply classification and regression tree analysis to determine factors associated with glenohumeral osteoarthritis and establish specific cutoff points for risk factors based on this methodology.</p><p><strong>Design: </strong>The cross-sectional study included 3383 participants with shoulder pain. Cases were selected for glenohumeral osteoarthritis. Patients with other shoulder pathologies were included as controls. Thirty-three potential risk factors were assessed. The classification and regression tree analysis was used to determine the highest-ranked risk factors associated with glenohumeral osteoarthritis. Multivariable logistic regression analysis was then performed using the cutoff points obtained from the classification and regression tree analysis.</p><p><strong>Results: </strong>The classification and regression tree analysis showed that age and body mass index were the two most significant risk factors for glenohumeral osteoarthritis. Multivariable logistic regression revealed that age categories ≥31 to < 58 yrs (odds ratio = 8.92), ≥58 to < 64 yrs (odds ratio = 20.20), and ≥64 yrs (odds ratio = 42.20), and body mass index categories ≥25-30 kg/m 2 (odds ratio = 1.47) and ≥30 kg/m 2 (odds ratio = 1.71) had higher odds of developing glenohumeral osteoarthritis compared with age <31 yrs and body mass index <25 kg/m 2 .</p><p><strong>Conclusions: </strong>This was the first study to use classification and regression tree analysis to evaluate significant risk factors for glenohumeral osteoarthritis and establish cutoff points for increased risk. The findings present age categories that are distinct from the arbitrary age groups used in previous studies.</p>","PeriodicalId":7850,"journal":{"name":"American Journal of Physical Medicine & Rehabilitation","volume":" ","pages":"401-406"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142131659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of the ACTN3 R577X Polymorphism on Serum Creatine Kinase and Interleukin-6 Levels After Maximal Eccentric Exercise.","authors":"Minoru Deguchi, Hiroki Homma, Kathleen Y de Almeida, Ayumu Kozuma, Mika Saito, Yosuke Tsuchiya, Karina Kouzaki, Eisuke Ochi, Takanobu Okamoto, Koichi Nakazato, Naoki Kikuchi","doi":"10.1097/PHM.0000000000002623","DOIUrl":"10.1097/PHM.0000000000002623","url":null,"abstract":"<p><strong>Objective: </strong>This study explored the interaction among ACTN3 R577X polymorphism, muscle damage, and postexercise inflammatory response by assessing changes over time in serum creatine kinase and interleukin-6 levels.</p><p><strong>Design: </strong>Ninety-five active Japanese participants (50 men and 45 women: 22.2 ± 2.3 yrs) who did not perform daily upper limb strength exercises were enrolled. Participants executed five sets of six maximal eccentric elbow flexion exercises. The exercise duration was 9 mins, including rest between sets (90 secs). Maximum voluntary isometric contraction, range of motion, muscle soreness, and serum creatine kinase and interleukin-6 levels were assessed pre and post and 1, 2, 3, and 5 days after exercise. Genotype groups were classified as RR + RX and XX based on the absence of ACTN3 expression.</p><p><strong>Results: </strong>A significant time and group interaction ( P = 0.045) on creatine kinase levels was observed between the groups, indicating that the absence of ACTN3 significantly affects creatine kinase changes. Conversely, no significant interaction on change in interleukin-6, maximum voluntary isometric contraction, range of motion, and muscle soreness was observed between groups.</p><p><strong>Conclusions: </strong>The results highlight an interaction on creatine kinase activity after exercise by ACTN3 R577X polymorphism, with elevated activity in the XX genotype.</p>","PeriodicalId":7850,"journal":{"name":"American Journal of Physical Medicine & Rehabilitation","volume":" ","pages":"415-421"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}