Iraqi Dental Journal最新文献

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Evaluation of some trace elements levels in sera of patients with Angina Pectoris in Erbil city 埃尔比勒市心绞痛患者血清中微量元素含量测定
Iraqi Dental Journal Pub Date : 2014-09-15 DOI: 10.26477/IDJ.V36I3.21
P. Ismail, A. Yousif, N. A. Ismail
{"title":"Evaluation of some trace elements levels in sera of patients with Angina Pectoris in Erbil city","authors":"P. Ismail, A. Yousif, N. A. Ismail","doi":"10.26477/IDJ.V36I3.21","DOIUrl":"https://doi.org/10.26477/IDJ.V36I3.21","url":null,"abstract":"Background: Angina pectoris(AP) is one of the most prevalent diseases in developed countries and is becoming an area of increasing concern in other parts of the world. Among the several causes of the disease alteration in the levels of trace elements are also important. Objectives : This study was undertaken in order to investigate the serum trace elements level in patients with Angina pectoris compared to healthy individuals, and to find whether there is any relationship between serum trace elements levels and patients with Angina pectoris.. Methods: The study involved 50 patients with Angina pectoris(AP) for evaluation of these trace elements level ( Se Cu, Zn ,Fe& Cr ) as well as TG, TC and LDL-C and HDL as compared with 50 control subjects . Results The results indicate that patients exhibited significant decrease in the serum of selinum(Se),zinc(Zn), copper(Cu), chromium(Cr) and iron(Fe) level (p<0.001) as compared to the healthy controls. TG, TC and LDL-C were elevated in patients and HDL-C was lower in our patients, Conclusions. Deficiency or suboptimal levels of micronutriants( Se ,Cu, Zn ,Fe& Cr ) may play a role in the development of Angina pectoris(AP). Measurement of serum trace elements level l might provide additional and useful laboratory test for the assessment of the patients with Angina pectoris and oral trace elements may have a role in therapy.","PeriodicalId":78326,"journal":{"name":"Iraqi Dental Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90970879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunohistochemical Evaluation of Epidermal Growth Factor Receptor (EGFR), MMP-2 and Heparanase in Pleomorphic Adenoma of Salivary Glands 涎腺多形性腺瘤中表皮生长因子受体(EGFR)、MMP-2和肝素酶的免疫组化评价
Iraqi Dental Journal Pub Date : 2014-09-15 DOI: 10.26477/idj.v36i3.23
B. Hamid, S. Sarkis, M. Merza
{"title":"Immunohistochemical Evaluation of Epidermal Growth Factor Receptor (EGFR), MMP-2 and Heparanase in Pleomorphic Adenoma of Salivary Glands","authors":"B. Hamid, S. Sarkis, M. Merza","doi":"10.26477/idj.v36i3.23","DOIUrl":"https://doi.org/10.26477/idj.v36i3.23","url":null,"abstract":"Background: Salivary gland tumors are morphologically and clinically diverse group of neoplasms .The most common benign tumor is the pleomorphic adenoma, it contains the epithelial, myoepithelial and mesenchymal component, with variable morphological patterns. Epidermal growth factor receptor (EGFR) is a 170 KD glycoprotein which has a tyrosine kinase activity. It is found at abnormally high levels on the surface of many types of cells, so these cells may divide excessively in the presence of epidermal growth factor.MMP-2 is a widely studied matrix metalloproteinase which participates in extracellular matrix (ECM) degradation, having a wide range of substrates and able to degrade type I, IV, V, VII and X collagens, laminin, elastin, fibronectin and proteoglycans. Heparanase (HPA) is an endo-β-D-glucuronidase that has the activity of cleaving heparan sulfate (HS) side chains of heparan sulfate proteoglycans (HSPGs), the major proteoglycans of the extracellular matrix (ECM) and basement membrane (BM) which play a key role in preventing tumor cells invasion and metastasis. Aims of the study: This study aimed to evaluate the expression of EGFR, MMP-2 and heparanase in pleomorphic adenoma of salivary glands and to correlate the expression of the aforementioned biomarkers with the clinical parameters, histological subtypes and components, and with each other as well. Materials and methods: Twenty five paraffin blocks of pleomorphic adenoma were included in this study. Sections immunohistochemically stained with anti EGFR, anti MMP-2 and anti heparanase monoclonal antibodies (Mabs). Results: Positive EGFR, MMP-2 and hepranase immunohistochemical expression was found in 22 (88%), 14(56%) and 21 (84%) of the studied cases respectively. Statistically non- significant correlation was found among the aforementioned markers with each other, and between the markers and any of the clinical parameters and histological classifications, except a statistically highly significant negative correlation revealed regarding EGFR expression with the squamous cells of epithelial component (p =0.001) and a highly significant positive correlation found regarding MMP-2 expression with the chondroid stromal component (0.003). Conclusions: Histological variation of pleomorphic adenoma has no influence on its biological behavior concerning EGFR, MMP-2 and heparanase expression. The immunoscores reorded in this study are expected to contribute to a better understanding of the biological behavior of PA.","PeriodicalId":78326,"journal":{"name":"Iraqi Dental Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81308639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of Addition of Titanium Oxide Nanofillers on The Water Sorption and Solubility of Resin Based Composite (An In Vitro Study) 纳米二氧化钛填料的加入对树脂基复合材料吸水性和溶解度的影响(体外研究)
Iraqi Dental Journal Pub Date : 2014-09-15 DOI: 10.26477/IDJ.V36I3.28
S. Saleem, D. Bakr, Dara H. Saeed
{"title":"The Effect of Addition of Titanium Oxide Nanofillers on The Water Sorption and Solubility of Resin Based Composite (An In Vitro Study)","authors":"S. Saleem, D. Bakr, Dara H. Saeed","doi":"10.26477/IDJ.V36I3.28","DOIUrl":"https://doi.org/10.26477/IDJ.V36I3.28","url":null,"abstract":"Background and Objectives: The aim of this study was to measure the water sorption (Wsp) and water solubility (Wsl) of modified microhybrid composite resins by adding Titanium oxide nanofillers in four concentration 0.5% , 1%, 3% and 5% and comparing them to unmodified microhybrid composite resins and to nanofilled composite resin. Methods: For water sorption (Wsp) and solubility (Wsl), ten disk-shaped specimens of each resin composite were made for each group and stored in desiccators until constant mass was achieved. Specimens were then stored in water for 7 days, and the mass of each specimen was measured. The specimens were dried again and weighed. The Wsp and Wsl were calculated from these measurements. Data analyzed by one-way ANOVA. Results: The results showed there were significant differences among the groups in the Wsp mean values which ranged from 20.2120 to 28.4680 μg/ mm³, while the Wsl mean values were ranged from 1.1060 to 5.6800 μg/ mm³. Conclusion: The addition of TiO2 nanofillers to microhybrid composite increased the Wsp and Wsl values compared to the control group but still lower than the value established by the ISO 4049 standard","PeriodicalId":78326,"journal":{"name":"Iraqi Dental Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87882112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of Iraqi White Mustard Seed Extracts on Periodontal Disease 伊拉克白芥菜籽提取物对牙周病的影响
Iraqi Dental Journal Pub Date : 2014-09-15 DOI: 10.26477/IDJ.V36I3.24
A. Ali
{"title":"The Effect of Iraqi White Mustard Seed Extracts on Periodontal Disease","authors":"A. Ali","doi":"10.26477/IDJ.V36I3.24","DOIUrl":"https://doi.org/10.26477/IDJ.V36I3.24","url":null,"abstract":"","PeriodicalId":78326,"journal":{"name":"Iraqi Dental Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86159517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Determination of Acrylic Denture Resin Surface Roughness by Different Processing Techniques 不同加工工艺对丙烯酸义齿树脂表面粗糙度的测定
Iraqi Dental Journal Pub Date : 2014-09-15 DOI: 10.26477/IDJ.V36I3.26
Akhlas Zeid Abood
{"title":"Determination of Acrylic Denture Resin Surface Roughness by Different Processing Techniques","authors":"Akhlas Zeid Abood","doi":"10.26477/IDJ.V36I3.26","DOIUrl":"https://doi.org/10.26477/IDJ.V36I3.26","url":null,"abstract":"Background: Poly (methyl methacrylate) (PMMA) seems to be the most commonly used material in the construction of denture base due to its advantages. However, it is still far from being ideal in fulfilling the physical and mechanical properties. Therefore, attempts to improve the properties of PMMA were taken by the researcher through many ways The purpose of this study was to estimate the effect of different processing techniques on surface roughness of acrylic base denture resin. Materials and Methods: A total sample of (50) specimens were prepared; these specimens were divided into 3 main processing techniques, and 5 experimental sub-groups (n=10): Group (A), acrylic denture base material processed by conventional water bath technique (74C for 1 and half hours then boiled for 30 min; Group (B), acrylic resins processed by microwave oven at (500 Watts) for 3 min; Group (C) samples processed by autoclave device with 3 different timing set up : (C1) for l0 min, (C2) for 20 min and (C3) for 30 min. This is done to make a comparison of different autoclave polymerization conditions on the surface roughness of denture base resin. Results: Statistically, there was no significant difference between the traditional water bath group technique and an autoclave system when the specimen processed at (121C/210Kpa) for 30 min. However, there was a statistically significant difference compared to other experimental groups. Conclusion: The autoclave processing technique could be the new alternative system to process the acrylic resin base material alongside the conventional methods. The experimental group prepared by autoclave system at (121C/21Kpa) for 30 min showed an improvement in the surface roughness compared to microwave and water bath techniques.","PeriodicalId":78326,"journal":{"name":"Iraqi Dental Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80747806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of panoramic image quality in three images system. 三图像系统中全景图像质量的评价。
Iraqi Dental Journal Pub Date : 2014-09-15 DOI: 10.26477/idj.v36i3.22
Amaal kadhim ALSaadi
{"title":"Evaluation of panoramic image quality in three images system.","authors":"Amaal kadhim ALSaadi","doi":"10.26477/idj.v36i3.22","DOIUrl":"https://doi.org/10.26477/idj.v36i3.22","url":null,"abstract":"In vitro study to evaluate the diagnostic image quality of dental panoramic radiography by comparing between conventional and digital systems. Aim of the Study: The aim of this study was to compare and evaluate the image quality of panoramic radiograph. Material and Method: Study comparing the image quality of dental Panoramic between conventional and digital in three dental institutions diagnostic imaging department. Forty five panoramic image were collected and divided in to three groups consisting of conventional images obtained with STRATO 2000, CE by VILLA SISTEMI MEDICALI–ITALY (screen based film) Dimax3digital system pan/ceph, PLANMECA, Helsinki, Finland, and Kodak 8000 carestream health, France (CCD X–ray image sensor). Image quality was assessed by rating the visibility of three evaluation aspect commonly found on panoramic radiographs for each image Depending on three evaluation aspect which is include the anatomy coverage, contrast and density of the teeth and anatomical structure, high score representing better image quality and the lower score indicating poor image quality. Results: the data collected from the evaluation of digital and film based image by two examiner were analyzed by chi square and the difference was statistically significant. Conclusion: The highest quality scores were obtained with carestream health digital system whereas images from Dimax3 digital system and conventional panoramic image type by VILLA SISTEMI were ranked significantly lower.","PeriodicalId":78326,"journal":{"name":"Iraqi Dental Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86267187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Antiviral Activity of κ-carrageenan Gel on Herpes Simplex Type І, a Human Study: An Open-Label Clinical Trial κ-卡拉胶凝胶对单纯疱疹І型的抗病毒活性研究:一项开放标签临床试验
Iraqi Dental Journal Pub Date : 2014-06-08 DOI: 10.26477/IDJ.V36I2.17
H. Abdulla, M. Al-Nimer, Aseel J. Ali
{"title":"Antiviral Activity of κ-carrageenan Gel on Herpes Simplex Type І, a Human Study: An Open-Label Clinical Trial","authors":"H. Abdulla, M. Al-Nimer, Aseel J. Ali","doi":"10.26477/IDJ.V36I2.17","DOIUrl":"https://doi.org/10.26477/IDJ.V36I2.17","url":null,"abstract":"Aim of study This study aimed to study the possible application of carrageenan on the illnesses related to the oral cavity by studying its effects in Viral infection presented with herpes simplex in human.(an-open label study) Subjects,materials and methods In this study patients presented with oral herpes simplex lesions were treated with carrageenan gel (0.9%)that was prepared .The gel was applied twice daily and the end-points of the study are the complete healing in absence of any discomfort within a short period of treatment. Results The results showed that two applications of κ-carrageenan per day accelerated the healing process within a short period (1-2 days) without complications or disfigurement in all patients. Conclusion κ –carrageenan besides ι-ond λ- carrageenan is useful in management of viral infection. κ –carrageenan is effective against herpes simplex labialis .","PeriodicalId":78326,"journal":{"name":"Iraqi Dental Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74218707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of SBS between Artificial Teeth and Denture Base after Different Surface Treatment 不同表面处理对义齿与义齿基托间SBS的影响
Iraqi Dental Journal Pub Date : 2014-06-08 DOI: 10.26477/IDJ.V36I2.18
M. A. Abduljabbar, Nihad Hasan Mohammed, Yasameen Ibrahim Mahbas
{"title":"Evaluation of SBS between Artificial Teeth and Denture Base after Different Surface Treatment","authors":"M. A. Abduljabbar, Nihad Hasan Mohammed, Yasameen Ibrahim Mahbas","doi":"10.26477/IDJ.V36I2.18","DOIUrl":"https://doi.org/10.26477/IDJ.V36I2.18","url":null,"abstract":"Background : Fracture or detachment(debond) of artificial plastic teeth from the denture base is a common clinical problem phenomenon.This fracture or detachment could be a result of many variable causes. This study was conducted to compare and evaluate the shear bond strength between artificial denture teeth and denture base material that was cured by conventional method using water path device after application of different surface treatment and to the best of our knowledge no study has been reported using dental cement resin and chemically cure composite as surface treatment. Materials and method: 45 cylindrical sticks of acrylic resin with denture teeth were prepared. Various treatments were done upon the acrylic resin teeth surfaces. The samples were divided into three groups, containing 15 samples for each. Over all the treated surfaces of all groups the first group included, surface treatment with monomer of self-cure acrylic resin that acted as a control group. The second group included the surface treatment with chemically cured composite resin .The third group included the surface treatment with dental cement resin. All surface treatments took time about 180 seconds on the denture teeth surfaces. The shear strengths were measured in a Universal Testing Machine using a knife-edge shear test. Results : The results showed that all surface treatments application improved the shear bond strength (SBS) significantly level at (Pvalue < 0.05) , while the third group (cement resin) showed the highest SBS than other groups.The surface treatments technique in this study influenced the shear bond strength of the tooth to the base . Conclusion : It was concluded that the cement resin surface treatment may be recommended to be applied on the denture teeth lab prior to the denture base processing .This result is of significant importance to improve the solution of fractured or detached artificial teeth from denture base material.","PeriodicalId":78326,"journal":{"name":"Iraqi Dental Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84875345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Estradiol, Progesterone and Testosterone on Oral Health Status and Gender Identification of Fetus in Women During Pregnancy 雌二醇、孕酮和睾酮对孕期妇女口腔健康状况和胎儿性别识别的影响
Iraqi Dental Journal Pub Date : 2014-06-08 DOI: 10.26477/idj.v36i2.15
H. Abdulla, Zeena R Helmi, Zena Kamel Kadhem
{"title":"Effects of Estradiol, Progesterone and Testosterone on Oral Health Status and Gender Identification of Fetus in Women During Pregnancy","authors":"H. Abdulla, Zeena R Helmi, Zena Kamel Kadhem","doi":"10.26477/idj.v36i2.15","DOIUrl":"https://doi.org/10.26477/idj.v36i2.15","url":null,"abstract":"Background: The metabolism and immunology of the body are modified by hormones like progesterone, estrogen and testosterone as well as other local factors as dental plaque and calculus. The hormonal changes occurring during pregnancy may be associated with pregnancy gingivitis, gingival bleeding, and pregnancy tumor in the presence of local factors that may accentuate the gingival response. Aims of the study: 1.Find out the association between the oral health status and endogenous sex steroid salivary hormones level. 2.The assessment of fetus gender and compare the clinical and biochemical variables of pregnant with gingivitis who are carrying male fetuses and with those who are carrying female fetuses. Patients and methods: This study was done in Obstetrics and Gynecology Department at Al-Yarmouk Teaching Hospital, from February 2013 to July 2013. Clinical examination had been done for (53) study pregnant women with gingivitis and/or pregnancy tumor at the gestational age range (20-33) and (25) pregnant women with healthy gingiva at gestational age range (22-31), age matched control subjects for check number of gestational age and fetus gender with the consultation of specialist by sonography and confirm the gender in postpartum follow up visits. Oral clinical examination including an assessment of gingival inflammation (GI), plaque amount (PLI), gingival bleeding by (GBI), presence of pregnancy tumor, dental status (DMFT), and salivary flow rate (SFR) had also been done. Samples of whole unstimulated (resting) saliva were collected from all participants then investigated for sex steroids salivary hormonal levels of Estradiol, Progesterone and Testosterone. Results: Gingivitis pregnant and pregnant controls were matched in age. Oral health measurements including: GI, PI and GBI were significantly higher in study compared to controls, while SFR were less in study compared to controls and DMFT showed no significant difference between study and controls. Sex steroids salivary hormonal levels of Estradiol, Progesterone and Testosterone in study pregnant women were higher than that of controls. Prevalence of gingivitis among samples population of present study is 67.9% and the percentage of the presence of pregnancy tumor is 3.8%. PLI significantly correlated with elevated salivary hormones level of Testosterone and Estradiol and non-significantly correlated with salivary hormone level of progesterone.GI significantly correlated with elevated salivary hormones level of Estradiol, Progesterone and Testosterone. GBI significantly correlated with elevated salivary Estradiol hormone level and non-significantly correlated with salivary hormones level of Testosterone and Progesterone. Pregnancy tumor significantly correlated with elevated salivary hormones level of Estradiol, Progesterone and Testosterone. Pregnant women with gingivitis who were carrying females’ fetuses showed significant elevated salivary hormone level of Estradiol and significant elevat","PeriodicalId":78326,"journal":{"name":"Iraqi Dental Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82959029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Early Effect of Simvastatin Gel on Bone Formation of Orthopaedically Expanded Sagittal Suture of Rabbits 辛伐他汀凝胶对兔矫形扩张矢状缝骨形成的早期影响
Iraqi Dental Journal Pub Date : 2014-06-08 DOI: 10.26477/IDJ.V36I2.14
A. Mahmood, Khudhair Adday Salman Al-Jumaili, H. I. Al-Sadi
{"title":"Early Effect of Simvastatin Gel on Bone Formation of Orthopaedically Expanded Sagittal Suture of Rabbits","authors":"A. Mahmood, Khudhair Adday Salman Al-Jumaili, H. I. Al-Sadi","doi":"10.26477/IDJ.V36I2.14","DOIUrl":"https://doi.org/10.26477/IDJ.V36I2.14","url":null,"abstract":"OBJECTIVES: To evaluate early bone-healing effects of local simvastatin application to orthopaedically expanded sagittal suture of rabbits. MATERIALS AND METHODS: A total of 30 male Rabbits of an average weight of 0 .75-1.0 kg and aged 2-3 months were used in this study. The animals were divided into three groups of ten animals each: simvastatin (group I), active control (group II), and passive control (group III). The sagittal suture was expanded with an expansion spring for one week, after that, the expander was removed and replaced with wire retainer for two weeks .At the time of wire retainer placement: Group I received an injection of 0.5mg simvastatin /0.5ml methylcellulose gel over the suture; group II received 0.5 ml of methylcellulose gel subcutaneously over the expanded suture; group III received no treatment. Half of the animals (five animals in each group) were sacrificed after two weeks of retention, and the sutures were prepared for radiological and histological assessment of regenerated bone. In the other half, the wire retainer was removed after two weeks of retention and the relapsed ratio of the expanded suture was calculated one week later. RESULTS: Local application of simvastatin has been found to have a positive influence on bone regeneration of orthopaedically expanded sagittal suture in comparison to control group. The density of the suture in the simvastatin group was significantly higher than control group. The relapse ratio in simvastatin gel treated group was nearly half that of methyl cellulose carrier gel and control groups, the difference was highly significant. CONCLUSION: 0.5 mg simvastatin greatly promote early bone formation of orthopaedically expanded sagittal suture.","PeriodicalId":78326,"journal":{"name":"Iraqi Dental Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79748478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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