Ancient Science of Life最新文献

{"title":"Long-term administration of Ziziphus jujuba extract attenuates cardiovascular responses in hypertensive rats induced by angiotensinii","authors":"R. Mohebbati, M. Rahimi, Kosar Bavarsad, M. Shafei","doi":"10.4103/asl.ASL_122_17","DOIUrl":"https://doi.org/10.4103/asl.ASL_122_17","url":null,"abstract":"Objective: The fruit of Ziziphus jujuba (ZJ) traditionally has been used for the treatment of hypertension in Iran. The mechanism of this effect of ZJ is unknown but may be mediated via an effect on the renin-angiotensin system (RAS). This study evaluates the effect of hydroalcoholic ZJ extract on acute hypertension induced by angiotensinII (AngII), a main product of RAS. Materials and Methods: Animals were divided into six groups; 1) saline, 2) AngII that received (50 ng/kg) intravenously (i. v.), 3) Losartan (Los, 10 mg/kg) +AngII group that received Los (i.v.) before AngII and 4-6) three groups of ZJ (100, 200 and 400 mg/kg) that were treated four weeks by gavage and on 28th day of experiment received AngII (i. v.). Cardiovascular responses were recorded by cannulation of the femoral artery and drug injection done via the tail vein. Systolic blood pressure (SBP), Mean arterial pressure (MAP) and heart rate (HR) were recorded continuously by power lab system. Maximal changes (Δ) of SBP,MAP and HR were calculated and compared with those of control and AngII groups. Statistical analysis was performed by one-way ANOVA. Results: In AngII group maximal Δ SBP, ΔMAP significantly increased than in control but ΔHR was not significant. Pretreatment of two lower doses (100 and 200 mg/kg) of ZJ significantly attenuate increased ΔSBP and ΔMAP induced by AngII. In contrast pretreatment with a higher dose (400 mg/kg) significantly increased the ΔSBP and ΔMAP compared to AngII group. The ΔHR only in dose 200 mg/kg was significantly lower than AngII group. Conclusion: Consistent with the traditional view, the results indicate that ZJ extract has an antihypertensive effect, and effect of its lower doses partly mediated by an inhibitory effect on RAS.","PeriodicalId":7805,"journal":{"name":"Ancient Science of Life","volume":"37 1","pages":"68 - 73"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70684525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical screening and high-performance thin-layer chromatography fingerprint profile of three species of leucas (Lamiaceae)","authors":"K. Geethika, P. Sunojkumar","doi":"10.4103/asl.ASL_63_18","DOIUrl":"https://doi.org/10.4103/asl.ASL_63_18","url":null,"abstract":"Background: The members of genus Leucas possess high economic potential. As medicinal herbs these were well known as 'Droṇapuhṣpī' in Ayurveda literature. The present study aims to carry out the phytochemical screening as well as the HPTLC fingerprint profiling of three species of Leucas. Materials and Methods: Aqueous, methanol, ethanol and chloroform extracts of each plant were subjected to qualitative phytochemical screening. The total phenols, flavonoids and tannins were quantified in the methanolic extract by standard spectrophotometric methods. HPTLC method for the separation of the active constituents in extracts has been developed and TLC of the methanolic extracts on silica gel pre-coated aluminum plates of Merck by automatic TLC applicator and using solvent system Toluene: ethyl acetate:7:3 was performed. Results: Preliminary phytochemical screening of different extracts showed the presence of different phytoconstituents such as flavonoids, terpenes, tannins, carbohydrates, glycosides, phenolic compounds, proteins and amino acids. Among all the three extracts studied, L. ciliata had the highest concentration of phenolics (34.5 ± 0.35), flavonoids (48.25 ± 1.06) and tannins (6.45 ± 0.5). A HPTLC fingerprint scanned at 550 nm for methanol leaf extracts revealed 12 peaks for L. stelligera, 15 peaks for L. eriostoma and 13 peaks for L. ciliata with Rf values in the range of 0.06 to 0.98.","PeriodicalId":7805,"journal":{"name":"Ancient Science of Life","volume":"37 1","pages":"102 - 107"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70684780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study the efficacy of herbal formulation Niśāmalakī in animal model of polycystic ovarian disease syndrome","authors":"J. Dawane, V. Pandit, K. Khade, Sonali P. Suryawanshi, A. Wele, M. Pawar, S. Bhalerao","doi":"10.4103/asl.ASL_51_18","DOIUrl":"https://doi.org/10.4103/asl.ASL_51_18","url":null,"abstract":"Polycystic ovarian syndrome (PCOS) is a complex endocrine disorder characterized by insulin resistance which in turn leads to elevated levels of androgens, anovulation, amenorrhea or oligomenorrhea, obesity and polycystic ovaries. Objectives: To evaluate efficacy of herbal formulations-Nishamalaki and Kanchanar Guggulu in animal model of PCOS. Material and Methods: Six female rats of Group I served as control (No Letrozole, no treatment), Letrozole was given 1mg/kg /day for 28 days to induce PCOS in remaining female wistar rats which were then divided into 6 groups of 6 animals each Group II- PCOS disease control, Group III – Clomiphene citrate, Group IV- Nishamalaki, Group V- Metformin, Group VI- Nishamalaki & Metformin and Group VII- Kanchanar Guggulu. Animals were treated orally according to groups for 56 days. Body weight, food intake, Insulin, blood glucose levels and lipid profile checked before and after treatment. Vaginal smear was done daily to study estrous changes. Results: Along with dyslipidaemia, Rats with PCOS showed increase in body weight and insulin levels. Significant reduction in body weight, lipid profile, Blood sugar and insulin was seen in Nishamalaki treated animals but not in Kanchanar Guggulu group. Kanchanar Guggulu and Nishamalaki regularized the cycles in 1st and 3rd weeks respectively. Conclusion: Nishamalaki effectively corrected all changes in PCOS whereas Kanchanar Guggulu only regularized the estrous cycles.","PeriodicalId":7805,"journal":{"name":"Ancient Science of Life","volume":"37 1","pages":"86 - 93"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70685109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Śodhana (Ayurvedic purification process) on thrombolytic effect of Semecarpus anacardium Linn. f. Nut","authors":"D. Sarvade, K. Bhingardive, M. Jaiswal","doi":"10.4103/asl.ASL_117_17","DOIUrl":"https://doi.org/10.4103/asl.ASL_117_17","url":null,"abstract":"Aims and Objectives: In vitro evaluation and comparison of thrombolytic activity of raw and purified bhallātaka (Semecarpus anacardium Linn.f.) nuts by means of % of clot lysis. Materials and Methods: An in vitro thrombolytic model was used to check the clot lysis effect of two aqueous preparations of herbal extracts viz. raw and purified bhallātaka nuts along with Streptokinase as a positive control and distilled water as a negative control. Results: Among the drugs studied both raw and purified bhallātaka nuts showed significant percentage of clot lysis viz. 59.82% and 66.59% respectively with reference to Streptokinase whose percentage was 87.31%. Clot lysis percentage of purified bhallātaka was highest as compared to raw bhallātaka and was comparable to positive control, i.e. streptokinase. Conclusion: Extremely significant difference (P < 0.0001) between mean clot lysis percentage of tested drug samples was found as compared to positive control streptokinase and negative control distilled water. Both raw and purified bhallātaka nuts showed extremely significant mean clot lysis percentage as compared to negative control distilled water (P < 0.001).","PeriodicalId":7805,"journal":{"name":"Ancient Science of Life","volume":"37 1","pages":"63 - 67"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70684467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kāma kautūhalam - A monograph on aphrodite care","authors":"Arhanth A Jain, Shreevathsa Manjunath","doi":"10.4103/asl.ASL_36_18","DOIUrl":"https://doi.org/10.4103/asl.ASL_36_18","url":null,"abstract":"Kāma Kautūhalam is an unfamiliar monograph on Aphrodite care authored by Śrī Mehanātha. It encompasses 75 verses spanning four chapters dealing with various aspects of Aphrodite care. Employing lucid Sanskrit versification is the connected advantage of the text. Śrī Śāligrāmaji Vaiśya has written a Hindi commentary named Napuṃsakasanjīvinī. Mehanātha restricts the subject only to understanding and managing strategies for sexual disorders in the monograph. Nowhere in the monograph have sexual acts or related instructions been described. The first chapter introduces the subject. The second narrates aetiology, pathogenesis and treatment principles for sexual ailments and related issues. The third and fourth chapter contains 70 distinct formulations. In this connection an attempt has been made to probe, analyse and familiarize the monograph to the Ayurveda community.","PeriodicalId":7805,"journal":{"name":"Ancient Science of Life","volume":"37 1","pages":"111 - 115"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70684743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful treatment of common warts with alum","authors":"E. Saburi, Asma Behdari","doi":"10.4103/asl.asl_79_18","DOIUrl":"https://doi.org/10.4103/asl.asl_79_18","url":null,"abstract":"Verruca vulgaris (Vv) as named common wart is an epidermal proliferation caused by the Human Papilloma Virus. Due to specialists and equipment requirements as well as high cost, the most effective treatment for wart such as cryosurgery and electrocautery are not most popular, availability and minimally invasiveness of topical agents turned them into the most appropriate and preferred method especially in children and citizens with low incomes. The purpose of this study was evaluating the efficacy of Alum in the treatment of Vv in two cases. Warts have been disappeared and recurrences were not seen for more than one-year follow-up. For years, Alum used as a powerful adjuvant in many types of vaccines based on its role in immune system activation as adjuvant to activation of cytotoxic T-cells.","PeriodicalId":7805,"journal":{"name":"Ancient Science of Life","volume":"37 1","pages":"214 - 216"},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47100359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review on the elucidation of fundamentals of Ayurveda in rasavaiśeṣika through the concept of Prakṛti","authors":"J. Remya, K. Sundaran, R. Jishnu, S. Athri","doi":"10.4103/asl.asl_138_20","DOIUrl":"https://doi.org/10.4103/asl.asl_138_20","url":null,"abstract":"Background: rasavaiśeṣika stands distinct from the different literature works in Ayurveda available today. Although categorized as more significant in pharmacology and pharmacodynamics, the insight it throws on the fundamentals of Ayurveda is remarkable. Rasavaiśeṣika in sūtra form presents subjects in brevity and the necessity of bhāṣyakāra becomes mandatory to comprehend the idea. Aim: To decode the debate on prakṛti in rasavaiśeṣika to illuminate its intelligible way of presentation as well as the novel contributions to the fundamentals of Ayurveda. Materials and Methods: Data is collected from the different editions of rasavaiśeṣika which is analyzed and discussed here. Results: The debate on prakṛti is presented by showcasing the proposition as well as opposition sides. The author disapproves taddoṣavattaprakṛtipakṣa as well as guṇavimiśraprakṛtipakṣa and establishes bāhulyapakṣa. Even though prakṛti remains intact throughout one's life from birth to death, its mental and physical expressions change as life advances. Also we have to take the notion of 'birth to until the person exhibits riṣṭa'. The prakṛti is not contingent on the doṣa predominance of śukra and śoṇita but also on the food and regimen of pregnant woman highlighting pre and post conceptional care in preventing hereditary diseases. Conclusion: The adept representation of prakṛti, bala etc., and the multiple ripples of thoughts Nagarjuna and Narasimha bring to our minds through rasavaiśeṣika makes it an exemplary pathfinder for the practitioners. It is the need of the hour to recognize the huge significance of rasavaiśeṣika and introduce it in to our academic curriculum.","PeriodicalId":7805,"journal":{"name":"Ancient Science of Life","volume":"37 1","pages":"175 - 179"},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41890407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seminar training for sensitization of final year undergraduate ayurveda students about knowledge, attitude, and aptitude of research","authors":"Amit Nakanekar, M. Kothekar, Swapnil Bhowte, Kiran A. Tawalare, Snehavibha Mishra","doi":"10.4103/asl.asl_58_19","DOIUrl":"https://doi.org/10.4103/asl.asl_58_19","url":null,"abstract":"Background: Knowledge and training in research skills and knowledge of research in early career have been related with continued professional growth and helps to produce good future researchers in society. Central Council of Indian Medicine has recently introduced research methodology as a subject in the final year of the Bachelor of Ayurveda Medicine and Surgery (BAMS) curriculum. Hence, we designed a seminar training program for final year BAMS students to assess Knowledge, Attitude, and Aptitude toward Research Methodology and Medical Statistics among final year BAMS students and to evaluate the impact of 2-day seminar of this subject. Methodology: An interventional study has been carried out for 2 days 9th and 10th August 2016. Out of 77 enrolled participants, 64 were assessed by predefined, tested, and validated questionnaires for knowledge attitude and aptitude before and after seminar training. Feedback of students about their outlooks and problems was also taken in focused group discussion. Results: Out of 77 enrolled participants, 11 participants were absent and 66 were present. Out of 66 who attended 2 dropouts, and 64 participants successfully completed. Out of 66 who attended 10 were males and 56 were females. Significant impact of the seminar was found to sensitize in all three domains. Nonparametric correlation was also presented between knowledge attitude and aptitude (ŕ = 0.4757 and ŕ = 0.2614). Many of Ayurveda students also talked about the unavailability of teachers and books for this subject. They also demanded interpathy mixed trainers for such training. Conclusion: Such type of seminar training is beneficial for the students. Compulsory training of 2–3 days for undergraduate students at the university level would definitely be a positive step to develop interest for this newly included subject at the undergraduate level.","PeriodicalId":7805,"journal":{"name":"Ancient Science of Life","volume":"37 1","pages":"226 - 230"},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43947195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"”Vīrasiṃhāvalokaḥ:” Āyurvedic classic with applied Jyotiṣyaśāstra and Dharmaśāstra","authors":"Santhosh Avangapur","doi":"10.4103/asl.asl_83_20","DOIUrl":"https://doi.org/10.4103/asl.asl_83_20","url":null,"abstract":"","PeriodicalId":7805,"journal":{"name":"Ancient Science of Life","volume":"37 1","pages":"231 - 234"},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42257805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-inflammatory profile of different plant parts of Agnimantha: A comparative evaluation of two entities enumerated in ayurvedic literature","authors":"N. Brindavanam, G. Kimothi, P. Reddanna, Rajaram Azad","doi":"10.4103/asl.asl_62_19","DOIUrl":"https://doi.org/10.4103/asl.asl_62_19","url":null,"abstract":"Background: Agnimantha is a constituent of the bṛhatpañcamūla (the roots drugs of 5 tree species) which in turn is a part of daśamūla used in Ayurvedic pharmaceutical practices. Traditionally, the concept of bṛhatpañcamūla envisages the usage of root/ root bark of these tree species. By and large, use of stem bark came into vogue many decades ago for this sub-group of daśamūla. Going by descriptions in Ayurvedic lexicon of medicinal plants- two species are considered as Agnimantha viz. Clerodendrum phlomidis L.f. (Fam.: Lamiaceae) and Premna integrifolia L. (Syn. Premna serratifolia L) (Fam.: Lamiaceae). Objective: With an objective to address sustainability concerns associated with use of root or stem bark a comprehensive study was carried out on bṛhatpañcamūla group. This study kept the anti-inflammatory profile of candidate extracts in the centre-stage. As a part of this study, comparative assessment of two species used as Agnimantha was also carried out. Study Methodology: Different plant parts (Root bark, Stem bark, Leaves and Young roots) of C. phlomidis and P. integrifolia were collected from different parts of India. Each sample was extracted successively into four solvents. These extracts were evaluated for their anti-inflammatory profile using a battery of in-vitro assays, involving inhibition of regulatory enzymes like 5-lipoxygenase (5-LOX), cyclooxygenase 1&2 (COX-1 & COX-2) and analysis of the expression of pro- and anti-inflammatory cytokines in LPS-stimulated RAW 264.7 cells.Result and Conclusions: Both the species were observed to exhibit anti-inflammatory activity of varied degrees in this study. However, the sample of 12 months old roots of P. integrifolia was found to possess profound effect on all markers of inflammation. This sample was followed by 36 months old roots of C. phlomidis in terms of anti-inflammatory profile. Basing on these observations, the study suggests the use of 12 months roots of P. integrifolia (often referred to as Bṛhat-agnimantha) as part of daśamūla. Since the harvesting cycle is of 12 months, it is possible to produce the roots using High-Density Short-Term plantation protocols to address the sustainability concerns associated with use of root or stem bark.","PeriodicalId":7805,"journal":{"name":"Ancient Science of Life","volume":"37 1","pages":"200 - 207"},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45987731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}