Impact of Śodhana (Ayurvedic purification process) on thrombolytic effect of Semecarpus anacardium Linn. f. Nut

Aims and Objectives: In vitro evaluation and comparison of thrombolytic activity of raw and purified bhallātaka (Semecarpus anacardium Linn.f.) nuts by means of % of clot lysis. Materials and Methods: An in vitro thrombolytic model was used to check the clot lysis effect of two aqueous preparations of herbal extracts viz. raw and purified bhallātaka nuts along with Streptokinase as a positive control and distilled water as a negative control. Results: Among the drugs studied both raw and purified bhallātaka nuts showed significant percentage of clot lysis viz. 59.82% and 66.59% respectively with reference to Streptokinase whose percentage was 87.31%. Clot lysis percentage of purified bhallātaka was highest as compared to raw bhallātaka and was comparable to positive control, i.e. streptokinase. Conclusion: Extremely significant difference (P < 0.0001) between mean clot lysis percentage of tested drug samples was found as compared to positive control streptokinase and negative control distilled water. Both raw and purified bhallātaka nuts showed extremely significant mean clot lysis percentage as compared to negative control distilled water (P < 0.001).