Animal Cells and Systems最新文献_第9页

Ginkgo biloba extract ameliorates skin fibrosis in a bleomycin-induced mouse model of systemic sclerosis 银杏叶提取物可改善博莱霉素诱导的系统性硬化症小鼠模型的皮肤纤维化状况

IF 2.9 2区生物学

Animal Cells and Systems Pub Date : 2024-04-18 DOI: 10.1080/19768354.2024.2337761

Beomgu Lee, Jong Seong Roh, Hoim Jeong, Yerin Kim, Jihyeon Lee, Changun Yun, Jiyoung Park, Da-sol Kim, Jungsoo Lee, Min Wook So, Aran Kim, Dong Hyun Sohn, Seung-Geun Lee

引用次数: 0

Effect of aerobic exercise and particulate matter exposure duration on the diversity of gut microbiota 有氧运动和颗粒物暴露时间对肠道微生物群多样性的影响

IF 2.9 2区生物学

Animal Cells and Systems Pub Date : 2024-04-08 DOI: 10.1080/19768354.2024.2338855

Saba Imdad, Jin-Hee Kim, Byunghun So, Junho Jang, Jinhan Park, Wonchung Lim, Yoon-Kwang Lee, Woo Shik Shin, Trae Hillyer, Chounghun Kang

引用次数: 0

Reprogramming of tumor-associated macrophages by metabolites generated from tumor microenvironment 肿瘤微环境产生的代谢物对肿瘤相关巨噬细胞的重编程作用

IF 2.9 2区生物学

Animal Cells and Systems Pub Date : 2024-04-03 DOI: 10.1080/19768354.2024.2336249

Seung Woo Kim, Chan Woo Kim, Young-Ah Moon, Hong Seok Kim

引用次数: 0

Tortoise-shell glue ameliorates male infertility through the hypothalamic-pituitary-gonadal axis in obese rats 龟甲胶通过下丘脑-垂体-性腺轴改善肥胖大鼠的雄性不育症

IF 2.9 2区生物学

Animal Cells and Systems Pub Date : 2024-03-15 DOI: 10.1080/19768354.2024.2329684

Wen Sheng, Yingqiu Li, Lumei Liu, Bonan Li, Tiansong Sun, Congxu Zhu, Qinghu He

引用次数: 0

The impact of MEIS1 TALE homeodomain transcription factor knockdown on glioma stem cell growth. MEIS1 TALE同源转录因子敲除对胶质瘤干细胞生长的影响

IF 2.9 2区生物学

Animal Cells and Systems Pub Date : 2024-03-13 eCollection Date: 2024-01-01 DOI: 10.1080/19768354.2024.2327340

Hyun-Jin Kim, Don Carlo Batara, Young-Jun Jeon, Seongsoo Lee, Samuel Beck, Sung-Hak Kim

{"title":"The impact of MEIS1 TALE homeodomain transcription factor knockdown on glioma stem cell growth.","authors":"Hyun-Jin Kim, Don Carlo Batara, Young-Jun Jeon, Seongsoo Lee, Samuel Beck, Sung-Hak Kim","doi":"10.1080/19768354.2024.2327340","DOIUrl":"10.1080/19768354.2024.2327340","url":null,"abstract":"Myeloid ecotropic virus insertion site 1 (MEIS1) is a HOX co-factor necessary for organ development and normal hematopoiesis. Recently, MEIS1 has been linked to the development and progression of various cancers. However, its role in gliomagenesis particularly on glioma stem cells (GSCs) remains unclear. Here, we demonstrate that MEIS1 is highly upregulated in GSCs compared to normal, and glioma cells and to its differentiated counterparts. Inhibition of MEIS1 expression by shRNA significantly reduced GSC growth in both in vitro and in vivo experiments. On the other hand, integrated transcriptomics analyses of glioma datasets revealed that MEIS1 expression is correlated to cell cycle-related genes. Clinical data analysis revealed that MEIS1 expression is elevated in high-grade gliomas, and patients with high MEIS1 levels have poorer overall survival outcomes. The findings suggest that MEIS1 is a prognostic biomarker for glioma patients and a possible target for developing novel therapeutic strategies against GBM.","PeriodicalId":7804,"journal":{"name":"Animal Cells and Systems","volume":"28 1","pages":"93-109"},"PeriodicalIF":2.9,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10939110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140130558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors affecting the cleavage efficiency of the CRISPR-Cas9 system. 影响 CRISPR-Cas9 系统切割效率的因素。

IF 2.9 2区生物学

Animal Cells and Systems Pub Date : 2024-03-03 eCollection Date: 2024-01-01 DOI: 10.1080/19768354.2024.2322054

Won Jun Jung, Soo-Ji Park, Seongkwang Cha, Kyoungmi Kim

{"title":"Factors affecting the cleavage efficiency of the CRISPR-Cas9 system.","authors":"Won Jun Jung, Soo-Ji Park, Seongkwang Cha, Kyoungmi Kim","doi":"10.1080/19768354.2024.2322054","DOIUrl":"10.1080/19768354.2024.2322054","url":null,"abstract":"The CRISPR-Cas system stands out as a promising genome editing tool due to its cost-effectiveness and time efficiency compared to other methods. This system has tremendous potential for treating various diseases, including genetic disorders and cancer, and promotes therapeutic research for a wide range of genetic diseases. Additionally, the CRISPR-Cas system simplifies the generation of animal models, offering a more accessible alternative to traditional methods. The CRISPR-Cas9 system can be used to cleave target DNA strands that need to be corrected, causing double-strand breaks (DSBs). DNA with DSBs can then be recovered by the DNA repair pathway that the CRISPR-Cas9 system uses to edit target gene sequences. High cleavage efficiency of the CRISPR-Cas9 system is thus imperative for effective gene editing. Herein, we explore several factors affecting the cleavage efficiency of the CRISPR-Cas9 system. These factors include the GC content of the protospacer-adjacent motif (PAM) proximal and distal regions, single-guide RNA (sgRNA) properties, and chromatin state. These considerations contribute to the efficiency of genome editing.","PeriodicalId":7804,"journal":{"name":"Animal Cells and Systems","volume":"28 1","pages":"75-83"},"PeriodicalIF":2.9,"publicationDate":"2024-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10911232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140027187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inducing aortic aneurysm/dissection in zebrafish: evaluating the efficacy of β-Aminopropionic Nitrile as a model 诱发斑马鱼主动脉瘤/夹层：评估β-氨基丙腈作为模型的功效

IF 2.9 2区生物学

Animal Cells and Systems Pub Date : 2024-03-01 DOI: 10.1080/19768354.2024.2322055

Jiarui Zhang, Yaowen Liang, Weiyue Zeng, Xiaoyan Gao, Dingchen Wang, Cong Mai, Zhuoheng Lin, Haishan Zhao, Xin Li

引用次数: 0

Transcriptional corepressor activity of CtBP1 is regulated by ISG15 modification CtBP1 的转录核心抑制因子活性受 ISG15 修饰调节

IF 2.9 2区生物学

Animal Cells and Systems Pub Date : 2024-02-22 DOI: 10.1080/19768354.2024.2321354

Yun Hwan Lim, Yoon Jin Park, Jieun Lee, Jung Hwa Kim

引用次数: 0

Scoparone attenuates PD-L1 expression in human breast cancer cells by MKP-3 upregulation. 莨菪通过上调 MKP-3 减轻人乳腺癌细胞中 PD-L1 的表达。

IF 2.9 2区生物学

Animal Cells and Systems Pub Date : 2024-02-09 eCollection Date: 2024-01-01 DOI: 10.1080/19768354.2024.2315950

Seung-Woo Kim, Chan Woo Kim, Hong Seok Kim

{"title":"Scoparone attenuates PD-L1 expression in human breast cancer cells by MKP-3 upregulation.","authors":"Seung-Woo Kim, Chan Woo Kim, Hong Seok Kim","doi":"10.1080/19768354.2024.2315950","DOIUrl":"10.1080/19768354.2024.2315950","url":null,"abstract":"Breast cancer is a frequently occurring malignant tumor that is one of the leading causes of cancer-related deaths in women worldwide. Monoclonal antibodies that block programed cell death 1 (PD-1)/programed cell death ligand 1 (PD-L1) - a typical immune checkpoint - are currently the recommended standard therapies for many advanced and metastatic tumors such as triple-negative breast cancer. However, some patients develop drug resistance, leading to unfavorable treatment outcomes. Therefore, other approaches are required for anticancer treatments, such as downregulation of PD-L1 expression and promotion of degradation of PD-L1. Scoparone (SCO) is a bioactive compound isolated from Artemisia capillaris that exhibits antitumor activity. However, the effect of SCO on PD-L1 expression in cancer has not been confirmed yet. This study aimed to evaluate the role of SCO in PD-L1 expression in breast cancer cells in vitro. Our results show that SCO downregulated PD-L1 expression in a dose-dependent manner, via AKT inhibition. Interestingly, SCO treatment did not alter PTEN expression, but increased the expression of mitogen-activated protein kinase phosphatase-3 (MKP-3). In addition, the SCO-induced decrease in PD-L1 expression was reversed by siRNA-mediated MKP-3 knockdown. Collectively, these findings suggest that SCO inhibited the expression of PD-L1 in breast cancer cells by upregulating MKP-3 expression. Therefore, SCO may serve as an innovative combinatorial agent for cancer immunotherapy.","PeriodicalId":7804,"journal":{"name":"Animal Cells and Systems","volume":"28 1","pages":"55-65"},"PeriodicalIF":2.9,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10860470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139721246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The nasal lymphatic route of CSF outflow: implications for neurodegenerative disease diagnosis and monitoring. CSF 流出的鼻腔淋巴途径：对神经退行性疾病诊断和监测的影响。

IF 2.5 2区生物学

Animal Cells and Systems Pub Date : 2024-01-29 eCollection Date: 2024-01-01 DOI: 10.1080/19768354.2024.2307559

Jiwon Chae, Mina Choi, Juyoung Choi, Seung-Jun Yoo

{"title":"The nasal lymphatic route of CSF outflow: implications for neurodegenerative disease diagnosis and monitoring.","authors":"Jiwon Chae, Mina Choi, Juyoung Choi, Seung-Jun Yoo","doi":"10.1080/19768354.2024.2307559","DOIUrl":"10.1080/19768354.2024.2307559","url":null,"abstract":"Cerebrospinal fluid (CSF) plays a crucial role in the brain's lymphatics as it traverses the central nervous system (CNS). Its primary function is to facilitate the outward transport of waste. Among the various CSF outflow pathways, the route through the cribriform plate along the olfactory nerves stands out as the most predominant. This review describes the outflow pathway of CSF into the nasal lymphatics. Additionally, we examine existing studies to describe mutual influences observed between the brain and extracranial regions due to this outflow pathway. Notably, pathological conditions in the CNS often influence CSF outflow, leading to observable changes in extracranial regions. The established connection between the brain and the nose is significant, and our review underscores its potential relevance in monitoring CNS ailments, including neurodegenerative diseases. Considering that aging - the most significant risk factor for the onset of neurodegeneration - is also a principal factor in CSF turnover alterations, we suggest a novel approach to studying neurodegenerative diseases in therapeutic terms.","PeriodicalId":7804,"journal":{"name":"Animal Cells and Systems","volume":"28 1","pages":"45-54"},"PeriodicalIF":2.5,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10826790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139641501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0