{"title":"Seeing Is Believing? Scientific Misconduct and the Detection of Problematic Images.","authors":"Elisabeth M Bik","doi":"10.1213/ane.0000000000008033","DOIUrl":"https://doi.org/10.1213/ane.0000000000008033","url":null,"abstract":"","PeriodicalId":7799,"journal":{"name":"Anesthesia & Analgesia","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147495160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elise V Butler,Jacqueline L Robson,Stephanie Ponsonby,Avik Majumdar,Simone I Strasser,Sanchia Smith,Ken Liu,Andrew D J Watts
{"title":"Hepatocellular Cancer Recurrence After Liver Transplantation With and Without the Use of Intraoperative Blood Salvage and Autotransfusion: A Retrospective Study.","authors":"Elise V Butler,Jacqueline L Robson,Stephanie Ponsonby,Avik Majumdar,Simone I Strasser,Sanchia Smith,Ken Liu,Andrew D J Watts","doi":"10.1213/ane.0000000000007998","DOIUrl":"https://doi.org/10.1213/ane.0000000000007998","url":null,"abstract":"BACKGROUNDIntraoperative blood salvage (IBS) and autotransfusion have been widely implemented to minimize allogenic blood transfusion in major surgery. Despite published literature, controversy exists around its use in liver transplantation (LT) for patients with hepatocellular carcinoma (HCC) due to concern for oncological recurrence.METHODSWe retrospectively studied adults with HCC who underwent deceased donor LT at a single LT center in Australia (August 2007-July 2020), comparing those who received IBS and autotransfusion with those who did not. Leukodepletion filters were not used. The primary outcome was time to HCC recurrence. The secondary outcomes were HCC recurrence-free survival and overall survival post-LT.RESULTSA total of 245 patients having concurrent LT and HCC were analyzed. Of these, 167 received IBS and 78 did not. HCC recurrence occurred in 22/245 (9.0%) after a median of 20 months (IQR 13.5-24.5). For the primary outcome, IBS and autotransfusion was not associated with a decrease in time to HCC recurrence on unadjusted analysis (hazard ratio [HR] 0.80, 95% confidence interval [CI] 0.34-1.92; P = .62). Independent predictors of time to HCC recurrence were: hepatitis C (adjusted HR [aHR] 3.57, 95% CI, 1.03-12.4, P = .04), number of HCCs (aHR 1.17 per lesion increase, 95% CI, 1.06-1.30, P < .01), higher alpha-fetal protein levels (aHR 1.002 per kIU/L increase, 95% CI, 1.0003-1.003, P = .01), and microvascular invasion (aHR 3.27, 95% CI, 1.26-8.50, P = .01). After adjusting for these confounders, there remained no relationship between IBS and autotransfusion and time to HCC recurrence (aHR 0.57, 95% CI, 0.23-1.44, P = .24). For the secondary outcomes, IBS and autotransfusion was not a predictor of HCC recurrence-free survival (aHR 0.75, 95% CI, 0.39-1.42, P = .38) or overall survival (aHR 0.68, 95% CI, 0.35-1.33, P = .26) on multivariable analysis.CONCLUSIONSIn this single-center study, IBS and autotransfusion during LT in patients with concurrent HCC was not associated with an increased risk of recurrence. No unexpected risk factors for HCC recurrence after LT were identified. This study provides further evidence to confirm the safety of IBS in LT for HCC without the use of leukodepletion filters.","PeriodicalId":7799,"journal":{"name":"Anesthesia & Analgesia","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147483691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adam J Milam,Jose Rios-Monterrosa,Travis L Reece-Nguyen,Jaideep J Pandit
{"title":"Words Matter: Setting Standards for Culturally Sensitive and Inclusive Words for Perioperative Medicine Research.","authors":"Adam J Milam,Jose Rios-Monterrosa,Travis L Reece-Nguyen,Jaideep J Pandit","doi":"10.1213/ane.0000000000008027","DOIUrl":"https://doi.org/10.1213/ane.0000000000008027","url":null,"abstract":"","PeriodicalId":7799,"journal":{"name":"Anesthesia & Analgesia","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147483693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Anaphylaxis Induced by Rocuronium, Sugammadex, or Rocuronium-Sugammadex Complex: Summary of Published Cases.","authors":"Bin Gao,Yang Liu,Yun-Tai Yao","doi":"10.1213/ane.0000000000008024","DOIUrl":"https://doi.org/10.1213/ane.0000000000008024","url":null,"abstract":"","PeriodicalId":7799,"journal":{"name":"Anesthesia & Analgesia","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147483696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Martin Soehle,Jan Menzenbach,Katharina Riedel,Mark Coburn,Marcus Thudium
{"title":"The Value of the Aperiodic Exponent of the Intraoperative Electroencephalogram for Predicting Postoperative Delirium in Elderly Patients.","authors":"Martin Soehle,Jan Menzenbach,Katharina Riedel,Mark Coburn,Marcus Thudium","doi":"10.1213/ane.0000000000008013","DOIUrl":"https://doi.org/10.1213/ane.0000000000008013","url":null,"abstract":"BACKGROUNDPostoperative delirium (POD) is a frequent and serious complication after surgery. Parameters of the electroencephalogram (EEG), such as the Bispectral Index and the occurrence of burst suppression, have been associated with POD. We analyzed the predictive properties of periodic and aperiodic parameters of the EEG power spectrum.METHODSIn a secondary post-hoc analysis of a prospective observational study, patients with an age of at least 60 years undergoing major cardiac or non-cardiac surgery were analyzed. The frontal intraoperative raw EEG was recorded by a BIS monitor and offline analyzed with the FOOOF toolbox, revealing the periodic and aperiodic parameters of the power spectrum. Patients were screened for POD and divided in a 2:1 ratio into a training and a validation cohort. Predictors of POD were identified by uni- and multivariable logistic regression.RESULTSThirty-two out of the 120 training group patients developed POD. These showed a significantly longer median duration of surgery (286 [interquartile range {IQR} 236-391] vs 223 [127-331] min, P = .005), lower median BIS (40.4 [IQR 38.1-43.4] vs 42.7 [39.5-46.0], P = .038), and a higher mean aperiodic exponent (2.09 ± 0.19 vs 1.99 ± 0.17, P = .017). Duration of surgery (odds ratio [OR] = 1.01; 95% confidence interval [CI], 1.00-1.01, P = .005), peak center frequency (OR = 0.79; CI, 0.62-0.97, P = .039) and aperiodic exponent (OR = 23.2; CI, 2.1-318.2, P = .013) were predictors of POD according to univariable logistic regression. At a cutoff of 1.967, the aperiodic exponent had a sensitivity of 0.813 and a specificity of 0.478 for the prediction of POD. A low duration of time spent in burst suppression was observed in both patients with POD (67 [6-363] s) and without POD (173 [4-641] s, P = .30), and cumulative burst suppression time was not a predictor of POD. In a stepwise regression model, age, duration of surgery, peak power, and the aperiodic exponent were associated with POD (AUROC = 0.80 (CI, 0.71-0.89, P < .001). The predictive model was confirmed in the validation group (n = 60) with an AUROC = 0.77 (CI, 0.65-0.90, P = .001).CONCLUSIONSA higher aperiodic exponent, for example, a less complex EEG signal, is associated with a greater POD risk, especially in combination with known POD predictors such as age and duration of surgery.","PeriodicalId":7799,"journal":{"name":"Anesthesia & Analgesia","volume":"192 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147495162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"GLP-1 Agonists: More Answers, More Questions.","authors":"","doi":"10.1213/ane.0000000000007994","DOIUrl":"https://doi.org/10.1213/ane.0000000000007994","url":null,"abstract":"","PeriodicalId":7799,"journal":{"name":"Anesthesia & Analgesia","volume":"33 1","pages":"639"},"PeriodicalIF":0.0,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147446992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}