Radiation research. Supplement最新文献_第4页

The repair-misrepair model in radiobiology: comparison to other models. 放射生物学中的修复-误修复模型:与其他模型的比较。

Radiation research. Supplement Pub Date : 1985-01-01 DOI: 10.2307/3576635

C. Tobias

引用次数: 183

Comparison of transformation, chromosome aberrations, and reproductive death induced in cultured mammalian cells by neutrons of different energies. 不同能量中子诱导哺乳动物细胞转化、染色体畸变和生殖死亡的比较。

Radiation research. Supplement Pub Date : 1985-01-01 DOI: 10.2307/3576642

G. Barendsen

{"title":"Comparison of transformation, chromosome aberrations, and reproductive death induced in cultured mammalian cells by neutrons of different energies.","authors":"G. Barendsen","doi":"10.2307/3576642","DOIUrl":"https://doi.org/10.2307/3576642","url":null,"abstract":"Dose-effect relations for cell transformation and reproductive death induced in C3H/10T1/2 cells, NBCH-3 cells, and WAGR-2 cells by 300 kV X rays and monoenergetic fast neutrons of 0.5, 4.2, and 15 MeV energy have been analyzed on the basis of the relations F(D) = t1D + t2D2 and S(D)/S(0) = exp - (a1D + a2D2), respectively. Values of a1 are a factor of about 10(3) larger than corresponding values of t1, while the dependence on neutron energy is similar for both effects. RBE values and relations between the a1 and t1 values are compared with characteristics, derived from corresponding parameters for chromosome aberrations and reproductive death, induced in other cell lines after irradiation with the same neutron beams. A hypothesis is developed assuming that nonrandom structural changes at a restricted number of sites on one or more chromosomes are the primary causes of transformation of cultured mammalian cells by ionizing radiations, whereas similar but randomly distributed chromosomal changes, which are induced at many sites on all chromosomes, cause observable aberrations and reproductive death. Flow cytometry of chromosome suspensions has been used to demonstrate nonrandom changes of chromosomes in selected clones of transformed cells and of random changes of chromosomes in cells inactivated by X rays and neutrons.","PeriodicalId":77888,"journal":{"name":"Radiation research. Supplement","volume":"66 1","pages":"S158-64"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76285519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Comparison of transformation, chromosome aberrations, and reproductive death induced in cultured mammalian cells by neutrons of different energies. 不同能量中子诱导哺乳动物细胞转化、染色体畸变和生殖死亡的比较。

Radiation research. Supplement Pub Date : 1985-01-01

G W Barendsen

{"title":"Comparison of transformation, chromosome aberrations, and reproductive death induced in cultured mammalian cells by neutrons of different energies.","authors":"G W Barendsen","doi":"","DOIUrl":"","url":null,"abstract":"Dose-effect relations for cell transformation and reproductive death induced in C3H/10T1/2 cells, NBCH-3 cells, and WAGR-2 cells by 300 kV X rays and monoenergetic fast neutrons of 0.5, 4.2, and 15 MeV energy have been analyzed on the basis of the relations F(D) = t1D + t2D2 and S(D)/S(0) = exp - (a1D + a2D2), respectively. Values of a1 are a factor of about 10(3) larger than corresponding values of t1, while the dependence on neutron energy is similar for both effects. RBE values and relations between the a1 and t1 values are compared with characteristics, derived from corresponding parameters for chromosome aberrations and reproductive death, induced in other cell lines after irradiation with the same neutron beams. A hypothesis is developed assuming that nonrandom structural changes at a restricted number of sites on one or more chromosomes are the primary causes of transformation of cultured mammalian cells by ionizing radiations, whereas similar but randomly distributed chromosomal changes, which are induced at many sites on all chromosomes, cause observable aberrations and reproductive death. Flow cytometry of chromosome suspensions has been used to demonstrate nonrandom changes of chromosomes in selected clones of transformed cells and of random changes of chromosomes in cells inactivated by X rays and neutrons.","PeriodicalId":77888,"journal":{"name":"Radiation research. Supplement","volume":"8 ","pages":"S158-64"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14984026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic effects of neutrons and charged particles on spinal cord, lung, and rectum. 中子和带电粒子对脊髓、肺和直肠的慢性影响。

Radiation research. Supplement Pub Date : 1985-01-01

A J van der Kogel

引用次数: 0

Proton therapy in Japan. 质子治疗在日本。

Radiation research. Supplement Pub Date : 1985-01-01 DOI: 10.2307/3576653

H. Tsunemoto, S. Morita, T. Ishikawa, S. Furukawa, K. Kawachi, T. Kanai, H. Ohara, T. Kitagawa, T. Inada

{"title":"Proton therapy in Japan.","authors":"H. Tsunemoto, S. Morita, T. Ishikawa, S. Furukawa, K. Kawachi, T. Kanai, H. Ohara, T. Kitagawa, T. Inada","doi":"10.2307/3576653","DOIUrl":"https://doi.org/10.2307/3576653","url":null,"abstract":"There are two facilities for clinical trials with protons in Japan: the National Institute of Radiological Sciences (NIRS), Chiba, and the Particle Radiation Medical Science Center (PARMS), University of Tsukuba. At the National Institute of Radiological Sciences, patient treatment with the 70 MeV proton beam began in November 1979, and 29 patients were treated through December 1984. Of 11 patients who received protons only, 9 have had local control of the tumor. Two of the 9 patients, suffering from recurrent tumor after radical photon beam irradiation, developed complications after proton treatment. In the patients treated with photons or neutrons followed by proton boost, tumors were controlled in 12 of 18 patients (66.6%), and no complications were observed in this series. Malignant melanoma could not be controlled with the proton beam. A spot-beam-scanning system for protons has been effectively used in the clinical trials to minimize the dose to the normal tissues and to concentrate the dose in the target volume. At the Particle Radiation Medical Science Center, University of Tsukuba, treatment with a vertical 250 MeV proton beam was begun in April 1983, and 22 patients were treated through February 1984. Local control of the tumor was observed in 14 of 22 patients (63.6%), whereas there was no local control in the treatment of glioblastoma multiforme. There have been no severe complications in patients treated at PARMS. The results suggest that local control of tumors will be better with proton beams than with photon beams, whereas additional modalities are required to manage radioresistant tumors.","PeriodicalId":77888,"journal":{"name":"Radiation research. Supplement","volume":"39 1","pages":"S235-43"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80597097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

Possible damage of repair systems by Pi-mesons of different LET spectra. 不同LET谱的π介子对修复系统可能造成的损伤。

Radiation research. Supplement Pub Date : 1985-01-01 DOI: 10.2307/3576643

H. Fritz-Niggli, C. Buechi, K. Schaeppi

引用次数: 4

Complication probability as assessed from dose-volume histograms. 从剂量-体积直方图评估并发症概率。

Radiation research. Supplement Pub Date : 1985-01-01 DOI: 10.2307/3583506

J. Lyman

引用次数: 661

Heavy charged particles in research and medicine. Proceedings of a symposium. Berkeley, California, May 1-3, 1985. 研究和医学中的重带电粒子。研讨会记录。加州伯克利，1985年5月1日至3日。

Radiation research. Supplement Pub Date : 1985-01-01

引用次数: 0

Some perspectives on cataractogenesis from heavy charged particles. 重带电粒子对白内障发生的一些看法。

Radiation research. Supplement Pub Date : 1985-01-01

J T Lett, A B Cox, A C Lee

{"title":"Some perspectives on cataractogenesis from heavy charged particles.","authors":"J T Lett, A B Cox, A C Lee","doi":"","DOIUrl":"","url":null,"abstract":"Two sets of observations on cataractogenesis in the New Zealand white (NZW) rabbit (Oryctolagus cuniculus) following localized exposure of optic and proximate tissues to heavy ions are reported. The experiments involved measurements of lenticular opacification in young (ca. 9 weeks old) rabbits caused by graded doses (0.5-5.0 Gy) of 460 MeV/u (incident energy) 56Fe ions and the effects of animal age (9 +/- 0.3 week, 1 +/- 0.5 year, and 4.5 +/- 1.3 year) on lenticular opacifications caused by 9 Gy of 400 MeV/u (incident energy) 20Ne ions. In substantiation of earlier results from NZW rabbits exposed to other low- and high-LET radiations, there was a dose-dependent onset of cataractogenesis following 56Fe-ion irradiation, with the highest doses causing the earliest appearance of cataracts. The level of stationary cataracts was also dependent on dose, and preliminary estimates of RBE yield values comparable to those found at similar doses (0.5-5.0 Gy) by others with populations of cultured cells. With increasing age at the time of exposure to 20Ne ions, the onset of lenticular opacification was delayed progressively and the level of stationary cataracts was reduced, but the onset and progression of late cataractogenesis was most rapid in the oldest group of animals. A discussion of the use of cataract measurements in risk assessment is included in this article.","PeriodicalId":77888,"journal":{"name":"Radiation research. Supplement","volume":"8 ","pages":"S201-7"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14984029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual radiation action and the initial slope of survival curves. 双重辐射作用与生存曲线的初始斜率。

Radiation research. Supplement Pub Date : 1985-01-01

M Zaider, H H Rossi

引用次数: 0