Radiation research. Supplement最新文献_第3页

Helium-ion radiation therapy at the Lawrence Berkeley Laboratory: recent results of a Northern California Oncology Group Clinical Trial. 劳伦斯伯克利实验室的氦离子放射治疗:北加州肿瘤小组临床试验的最新结果。

Radiation research. Supplement Pub Date : 1985-01-01 DOI: 10.2307/3576652

W. M. Saunders, J. Castro, George T. Y. Chen, J. Collier, S. Zink, S. Pitluck, T. Phillips, D. Char, P. Gutin, Grant E. Gauger, Cornelius A. Tobias, E. Alpen

引用次数: 35

Early production of radicals from charged particle tracks in water. 水中带电粒子轨道的早期自由基生成。

Radiation research. Supplement Pub Date : 1985-01-01 DOI: 10.2307/3576629

A. Mozumder

引用次数: 13

Current considerations in heavy charged-particle radiotherapy: a clinical research trial of the University of California Lawrence Berkeley Laboratory, Northern California Oncology Group, and Radiation Therapy Oncology Group. 重电荷粒子放射治疗的当前考虑:加州大学劳伦斯伯克利实验室，北加州肿瘤组和放射治疗肿瘤组的临床研究试验。

Radiation research. Supplement Pub Date : 1985-01-01 DOI: 10.2307/3576656

J. Castro, G. Chen, E. Blakely

引用次数: 42

Biomedical program for the converted 200-MeV synchrocyclotron at the Gustaf Werner Institute. 古斯塔夫·维尔纳研究所200兆电子伏特同步回旋加速器的生物医学项目。

Radiation research. Supplement Pub Date : 1985-01-01

B Larsson

引用次数: 0

Predictors of tumor response to radiotherapy. 肿瘤对放疗反应的预测因素。

Radiation research. Supplement Pub Date : 1985-01-01

W A Brock, M H Maor, L J Peters

引用次数: 0

Review of the SIN and Los Alamos Pion Trials. SIN和洛斯阿拉莫斯介子试验综述。

Radiation research. Supplement Pub Date : 1985-01-01

G Schmitt, C F von Essen, R Greiner, H Blattmann

{"title":"Review of the SIN and Los Alamos Pion Trials.","authors":"G Schmitt, C F von Essen, R Greiner, H Blattmann","doi":"","DOIUrl":"","url":null,"abstract":"Negative pi mesons (pions) were used to treat 227 patients at the Los Alamos Meson Production Facility (LAMPF) between 1974 and 1981. Persisting local control values for 129 patients treated with pions alone in the following tumor sites were recorded at a minimum post-treatment observation interval of 2.5 years in the following tumor sites: cerebral gliomas 3/29; head and neck, 8/31; lung, 1/7; pancreas, 0/17; large bowel, 3/13; cervix, 2/45; bladder, 3/4; prostate, 18/20; miscellaneous sites, 0/4. Late severe sequelae ranged from none to 30% for major sites. A dose-response relationship was seen for late severe sequelae with a high probability following dose levels of 4750 cGy (max) in approximately 38 fractions. RBE values for pions appeared to lie in the range of 1.4-1.6 for both acute normal tissue reactions and late sequelae. At the Swiss Institute for Nuclear Research (SIN), 126 patients were treated in Phase I-II protocol studies between 1982 and 1984 with a new technique of scanning with a focused spot of pions. With minimum observation intervals of only 6 months, the local complete response values in 67 evaluable patients treated with pions alone to selected sites are gliomas 1/15 (9 months); pancreas, 3/11; cervix, 4/8; bladder, 18/26 (at 1 year, 9/22); sarcomas, 4/5; biliary tract, 3/4. Late severe sequelae ranged from none to 50% for major sites. A steep dose-response relationship is seen for late severe sequelae with high probability following doses exceeding 3800 cGy (max) in 20 fractions and very low probability with doses below 3500 cGy (max).","PeriodicalId":77888,"journal":{"name":"Radiation research. Supplement","volume":"8 ","pages":"S272-8"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15051971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Some perspectives on cataractogenesis from heavy charged particles. 重带电粒子对白内障发生的一些看法。

Radiation research. Supplement Pub Date : 1985-01-01 DOI: 10.2307/3576648

J. Lett, A. Cox, A. C. Lee

{"title":"Some perspectives on cataractogenesis from heavy charged particles.","authors":"J. Lett, A. Cox, A. C. Lee","doi":"10.2307/3576648","DOIUrl":"https://doi.org/10.2307/3576648","url":null,"abstract":"Two sets of observations on cataractogenesis in the New Zealand white (NZW) rabbit (Oryctolagus cuniculus) following localized exposure of optic and proximate tissues to heavy ions are reported. The experiments involved measurements of lenticular opacification in young (ca. 9 weeks old) rabbits caused by graded doses (0.5-5.0 Gy) of 460 MeV/u (incident energy) 56Fe ions and the effects of animal age (9 +/- 0.3 week, 1 +/- 0.5 year, and 4.5 +/- 1.3 year) on lenticular opacifications caused by 9 Gy of 400 MeV/u (incident energy) 20Ne ions. In substantiation of earlier results from NZW rabbits exposed to other low- and high-LET radiations, there was a dose-dependent onset of cataractogenesis following 56Fe-ion irradiation, with the highest doses causing the earliest appearance of cataracts. The level of stationary cataracts was also dependent on dose, and preliminary estimates of RBE yield values comparable to those found at similar doses (0.5-5.0 Gy) by others with populations of cultured cells. With increasing age at the time of exposure to 20Ne ions, the onset of lenticular opacification was delayed progressively and the level of stationary cataracts was reduced, but the onset and progression of late cataractogenesis was most rapid in the oldest group of animals. A discussion of the use of cataract measurements in risk assessment is included in this article.","PeriodicalId":77888,"journal":{"name":"Radiation research. Supplement","volume":"507 1","pages":"S201-7"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77837207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Progress in low-LET heavy particle therapy: intracranial and paracranial tumors and uveal melanomas. 低let重粒子治疗的进展:颅内和颅旁肿瘤和葡萄膜黑色素瘤。

Radiation research. Supplement Pub Date : 1985-01-01

M Austin-Seymour, J E Munzenrider, M Goitein, R Gentry, E Gragoudas, A M Koehler, P McNulty, E Osborne, D K Ryugo, J Seddon

{"title":"Progress in low-LET heavy particle therapy: intracranial and paracranial tumors and uveal melanomas.","authors":"M Austin-Seymour, J E Munzenrider, M Goitein, R Gentry, E Gragoudas, A M Koehler, P McNulty, E Osborne, D K Ryugo, J Seddon","doi":"","DOIUrl":"","url":null,"abstract":"The Harvard Cyclotron Laboratory in collaboration with the Department of Radiation Medicine of the Massachusetts General Hospital and the Retina Service of the Massachusetts Eye and Ear Infirmary provides low-LET heavy particle therapy with 160 MeV protons. The improved dose distribution of protons results from their physical characteristics. A total of 965 patients have been treated as of December 31, 1984. Dose is expressed in units of cobalt gray equivalent (CGE) which is the dose in Gy multiplied by the RBE (1.1) for modulated protons relative to 60Co radiation. Sixty-seven patients with chordomas or low-grade chondrosarcomas of the base of skull or cervical spine have received proton treatment. Forty-three of these patients have been followed for at least 8 months with a median follow-up of 27 months. The median dose is 69 CGE. The 3-year actuarial local control rate is 89%. Seven patients with gliomas, eight with craniopharyngiomas, and six with meningiomas have also received proton radiation treatments. A total of 615 patients with uveal melanomas have received a median dose of 70 CGE in five fractions. Tumor regression has been seen in 94% with 66% having vision of 20/100 or better.","PeriodicalId":77888,"journal":{"name":"Radiation research. Supplement","volume":"8 ","pages":"S219-26"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14137024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Helium-ion radiation therapy at the Lawrence Berkeley Laboratory: recent results of a Northern California Oncology Group Clinical Trial. 劳伦斯伯克利实验室的氦离子放射治疗:北加州肿瘤小组临床试验的最新结果。

Radiation research. Supplement Pub Date : 1985-01-01

W Saunders, J R Castro, G T Chen, J M Collier, S R Zink, S Pitluck, T L Phillips, D Char, P Gutin, G Gauger

引用次数: 0

Early production of radicals from charged particle tracks in water. 水中带电粒子轨道的早期自由基生成。

Radiation research. Supplement Pub Date : 1985-01-01

A Mozumder

引用次数: 0