Radiation research. Supplement最新文献

Potential for low-LET charged-particle radiation therapy in cancer. 低let带电粒子放射治疗癌症的潜力。

Radiation research. Supplement Pub Date : 1985-11-01 DOI: 10.2307/3576661

M. Goitein, H. Suit, E. Gragoudas, A. Koehler, R. Wilson

引用次数: 9

Predictors of tumor response to radiotherapy. 肿瘤对放疗反应的预测因素。

Radiation research. Supplement Pub Date : 1985-11-01 DOI: 10.2307/3576660

W. Brock, M. Maor, L. Peters

引用次数: 32

Progress in low-LET heavy particle therapy: intracranial and paracranial tumors and uveal melanomas. 低let重粒子治疗的进展:颅内和颅旁肿瘤和葡萄膜黑色素瘤。

Radiation research. Supplement Pub Date : 1985-11-01 DOI: 10.2307/3576651

Mary Austin-Seymour, J. Munzenrider, M. Goitein, R. Gentry, E. Gragoudas, Andreas Koehler, P. Mcnulty, Estelle Osborne, D. Ryugo, Joanna Seddon, M. Urie, Lynn Verhey, H. Suit

{"title":"Progress in low-LET heavy particle therapy: intracranial and paracranial tumors and uveal melanomas.","authors":"Mary Austin-Seymour, J. Munzenrider, M. Goitein, R. Gentry, E. Gragoudas, Andreas Koehler, P. Mcnulty, Estelle Osborne, D. Ryugo, Joanna Seddon, M. Urie, Lynn Verhey, H. Suit","doi":"10.2307/3576651","DOIUrl":"https://doi.org/10.2307/3576651","url":null,"abstract":"The Harvard Cyclotron Laboratory in collaboration with the Department of Radiation Medicine of the Massachusetts General Hospital and the Retina Service of the Massachusetts Eye and Ear Infirmary provides low-LET heavy particle therapy with 160 MeV protons. The improved dose distribution of protons results from their physical characteristics. A total of 965 patients have been treated as of December 31, 1984. Dose is expressed in units of cobalt gray equivalent (CGE) which is the dose in Gy multiplied by the RBE (1.1) for modulated protons relative to 60Co radiation. Sixty-seven patients with chordomas or low-grade chondrosarcomas of the base of skull or cervical spine have received proton treatment. Forty-three of these patients have been followed for at least 8 months with a median follow-up of 27 months. The median dose is 69 CGE. The 3-year actuarial local control rate is 89%. Seven patients with gliomas, eight with craniopharyngiomas, and six with meningiomas have also received proton radiation treatments. A total of 615 patients with uveal melanomas have received a median dose of 70 CGE in five fractions. Tumor regression has been seen in 94% with 66% having vision of 20/100 or better.","PeriodicalId":77888,"journal":{"name":"Radiation research. Supplement","volume":"220 1","pages":"S219-26"},"PeriodicalIF":0.0,"publicationDate":"1985-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81254149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 81

Cellular fast-mixing techniques: possible applications with particle beams. 细胞快速混合技术:粒子束的可能应用。

Radiation research. Supplement Pub Date : 1985-11-01 DOI: 10.2307/3576630

G. E. Adams

引用次数: 5

Heavy charged-particle Bragg peak radiosurgery for intracranial vascular disorders. 重电荷粒子Bragg峰放射治疗颅内血管疾病。

Radiation research. Supplement Pub Date : 1985-01-01

J I Fabrikant, J T Lyman, K A Frankel

{"title":"Heavy charged-particle Bragg peak radiosurgery for intracranial vascular disorders.","authors":"J I Fabrikant, J T Lyman, K A Frankel","doi":"","DOIUrl":"","url":null,"abstract":"The program at Donner Pavilion has applied nuclear medicine research to the diagnosis and radiosurgical treatment of life-threatening intracranial vascular disorders that affect approximately one million Americans. Stereotactic heavy-ion Bragg peak radiosurgery, using narrow beams of heavy ions (helium), demonstrates superior biological and physical characteristics in brain over X and gamma rays and protons, viz., improved dose distribution in the Bragg peak, sharp lateral and distal borders, and less multiple scattering and range straggling for the same residual range in CNS tissue. Examination of CNS tissue response and alteration of cerebral blood-flow dynamics related to heavy-ion Bragg peak radiosurgery is being undertaken using three-dimensional treatment planning and quantitative imaging utilizing cerebral angiography, computerized tomography (CT), magnetic resonance imaging (MRI), cine-CT, xenon X-ray CT, and positron emission tomography (PET). Also under examination are the physical properties of narrow heavy-ion beams for improving methods of dose delivery and dose distribution and for establishing clinical RBE/LET and dose-response relationships for human CNS tissues. Based on the evaluation and treatment with stereotactically directed narrow beams of heavy ions of over 130 patients, with cerebral angiography and CT scanning, and with MRI and radioisotope scanning of selected patients, plus extensive clinical and neuroradiological follow-up, it appears that heavy-ion radiosurgery obliterates intracranial arteriovenous malformations or protects against rebleeding with reduced morbidity and mortality.","PeriodicalId":77888,"journal":{"name":"Radiation research. Supplement","volume":"8 ","pages":"S244-58"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15051969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential for low-LET charged-particle radiation therapy in cancer. 低let带电粒子放射治疗癌症的潜力。

Radiation research. Supplement Pub Date : 1985-01-01

M Goitein, H D Suit, E Gragoudas, A M Koehler, R Wilson

引用次数: 0

Preparatory clinical studies of Pi-mesons at TRIUMF. π介子在TRIUMF的预备临床研究。

Radiation research. Supplement Pub Date : 1985-01-01 DOI: 10.2307/3583538

G. Goodman, P. Dixon, G. Lam, R. Harrison, R. Kornelsen, C. Ludgate, A. Flores

{"title":"Preparatory clinical studies of Pi-mesons at TRIUMF.","authors":"G. Goodman, P. Dixon, G. Lam, R. Harrison, R. Kornelsen, C. Ludgate, A. Flores","doi":"10.2307/3583538","DOIUrl":"https://doi.org/10.2307/3583538","url":null,"abstract":"Eighty patients have been treated with Pi-mesons (pions) at TRIUMF between 1979-1984. The patients had tumors rarely curable by standard methods and had no prior radiotherapy. The distribution by site included skin, metastatic nodules (13), brain, glioblastoma multiforme (32), pelvis, rectosigmoid (15), prostate (12), bladder (7), and ovary (1). The studies involve serial escalations of pion dose until maximum tissue tolerance is reached, monitoring the response at each dose increment. Sites were chosen for study where lack of local control is a significant cause of treatment failure with conventional radiation therapy. The low dose rate and the available beam access at TRIUMF limit the number of patients treated and the volume treatable. A 3-D treatment planning program is in use, and a 3-D display of the dose distribution delivered in brain tumor treatments has been developed using the PET scanner. In practice, new methods introduced for measurement of tissue response include tumor growth delay curves, fine-needle biopsy mapping, and PET scanning of brain tumors. The use of endoscopic assessment of the rectosigmoid region is emphasized. Treatment results of glioblastoma multiforme show that the median survival for patients treated to 125 pion cGy/fx is in the range of 187-198 days; for patients receiving 170 cGy per dose/fraction (fx) the range is 290-315 days, and for those receiving 200-220 cGy/fx the median survival is in excess of 290 days. For pelvic malignancies the local control obtained with doses of 2500 cGy or less was 50% in 12 assessable patients; it was 75% in 20 patients who had 3000 cGy or more.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":77888,"journal":{"name":"Radiation research. Supplement","volume":"40 1","pages":"S279-84"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77470098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

High-LET radiation carcinogenesis. 高let辐射致癌作用。

Radiation research. Supplement Pub Date : 1985-01-01 DOI: 10.2307/3576646

R. Fry, P. Powers-Risius, E. Alpen, E. J. Ainsworth

引用次数: 129

In vitro and in vivo studies of the TRIUMF pion therapy beam. TRIUMF介子治疗束的体外和体内研究。

Radiation research. Supplement Pub Date : 1985-01-01 DOI: 10.2307/3583520

L. Skarsgard, B. Douglas, J. Denekamp, D. Chaplin, G. Lam, R. Harrison, R. Kornelsen, B. Palcic

{"title":"In vitro and in vivo studies of the TRIUMF pion therapy beam.","authors":"L. Skarsgard, B. Douglas, J. Denekamp, D. Chaplin, G. Lam, R. Harrison, R. Kornelsen, B. Palcic","doi":"10.2307/3583520","DOIUrl":"https://doi.org/10.2307/3583520","url":null,"abstract":"Patient treatments at TRIUMF (Tri-University Meson Facility, Vancouver, B. C.) use a moving spot raster scan technique where the pion range is modulated in depth for each position of the moving spot. The spot scans in a stepwise fashion and can produce any desired field shape. This approach provides very good dose uniformity across the treatment field and allows maximum flexibility in shaping the treatment volume. Survival of cultured cells has been used as a biological dosimeter to test the isoeffectiveness of the pion dose distributions, which must be shaped in depth to compensate for the depth-dependent LET distribution. Isoeffectiveness across the treatment field has also been verified using this system, which involves irradiating cells supported in a gelatin matrix. The response of pig skin to pion irradiation at TRIUMF has provided a check on the in vivo RBE for acute effects derived from our earlier studies with mouse foot. In addition, the pig skin reactions have been followed for several months to assess the later dermal response. The RBE of our pion beam relative to 270 kVp X rays is approximately 1.5 for both the acute epidermal and the later dermal responses.","PeriodicalId":77888,"journal":{"name":"Radiation research. Supplement","volume":"74 1","pages":"S135-44"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80643547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Calculation of heavy-ion tracks in liquid water. 液态水重离子径迹的计算。

Radiation research. Supplement Pub Date : 1985-01-01

R N Hamm, J E Turner, R H Ritchie, H A Wright

{"title":"Calculation of heavy-ion tracks in liquid water.","authors":"R N Hamm, J E Turner, R H Ritchie, H A Wright","doi":"","DOIUrl":"","url":null,"abstract":"Detailed Monte Carlo calculations are presented of proton and alpha-particle tracks in liquid water. The computations treat the interactions of the primary particle and all secondary electrons on a statistical, event-by-event basis to simulate the initial physical changes that accompany the passage of an ion through water. Our methods for obtaining the cross sections needed for such calculations are described. Inelastic scattering probabilities (inverse mean free paths) are derived from a complex dielectric response function constructed for liquid water, based on experimental and theoretical data. Examples of partial cross sections for ionization and excitation by protons are shown. The computation of electron transport and energy loss includes exchange, elastic scattering, and a scheme for the delocalization of energy shared collectively by a large number of electrons in the condensed medium. Several examples of calculated proton and alpha-particle tracks are presented and discussed. The meaning and significance of the concept of a track core are briefly addressed in the light of this work. The present paper treats only the initial, physical changes produced by radiation in water (in approximately 10(-15) s in local regions of a track). The work described here is used in calculations that we have reported in other publications on the later chemical development of charged-particle tracks.","PeriodicalId":77888,"journal":{"name":"Radiation research. Supplement","volume":"8 ","pages":"S20-6"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14137023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0