{"title":"Official abstracts of papers o the XIII International Congress of Allergology and Clinical Immunology (ICACI). October 16-21, 1988, Montreux, Switzerland.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77755,"journal":{"name":"New England and regional allergy proceedings","volume":"9 4","pages":"249-521"},"PeriodicalIF":0.0,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14302722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Eastern pine sensitivity in New England.","authors":"J N Kalliel, G A Settipane","doi":"10.2500/108854188779023379","DOIUrl":"https://doi.org/10.2500/108854188779023379","url":null,"abstract":"<p><p>The purpose of this study is to assess the frequency of clinical sensitivity to Eastern White Pine Pollen, 100 consecutive patients with the seasonal (SAR) or perennial (PAR) allergic rhinitis seen in the allergy clinic were prick tested with pine pollen extract, 8-tree mixture, histamine and negative control. Positive skin test (ST) was defined as a wheal greater than 3 mm larger than control, plus flare. Patients with a positive ST were then asked to stop antihistamine and other related drug, for 48 hours and challenged in a double blind manner with increasing concentrations of intranasal pine extract, starting at 1/100,000 w/v, followed by 1/10,000, 1/1000 and 1/100 at 20 minute intervals. The dose given was 0.15 cc by metered dose spray; one nostril received pine extract diluted in saline, the other received plain saline,. Rhinometric measurements were obtained before and 20 minutes after each challenge. Positive challenges were defined as 1) subjective feeling of increased stuffiness or rhinorrhea and 2) greater than 25% decrease in nasal airflow. Six patients (6%) had a positive ST to pine pollen extract and two of four patients with positive pine skin test had a positive FAST. Four of these were challenged intranasally, 2 had a positive challenge. All six patients had a history of spring SAR and positive reaction to 8-tree mix. Out of the 100 patients skin tested, 61 had spring SAR; therefore, the incidence of positive ST to pine in patients with spring SAR was 6/61 (10%). We conclude that pine pollen can be a cause of spring SAR in the New England area.</p>","PeriodicalId":77755,"journal":{"name":"New England and regional allergy proceedings","volume":"9 3","pages":"233-5"},"PeriodicalIF":0.0,"publicationDate":"1988-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2500/108854188779023379","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14537588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exercise-induced asthma.","authors":"C W Bierman","doi":"10.2500/108854188779023414","DOIUrl":"https://doi.org/10.2500/108854188779023414","url":null,"abstract":"<p><p>Though exercise-induced asthma (EIA) has been recognized for centuries, its characteristics, standardized testing, and pharmacologic management have been clarified only in the last two decades. Controversy continues concerning etiology; whether or not cold air, hypertonic and hypotonic bronchial challenges involve the same mechanism(s); and the incidence and clinical significance of late phase reactions. Aerosolized adrenergic agents such as albuterol or terbutaline, when administered prior to exercise, are usually effective in preventing EIA. Theophylline varies in effectiveness from subject-to-subject as does cromolyn sodium. Other agents such as H-1 antihistamines, ipratropium bromide, calcium channel blockers and adrenocorticosteroids are less effective when used alone, but may be useful when used in association with the more potent drugs.</p>","PeriodicalId":77755,"journal":{"name":"New England and regional allergy proceedings","volume":"9 3","pages":"193-7"},"PeriodicalIF":0.0,"publicationDate":"1988-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2500/108854188779023414","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14178390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pathogenetic mechanisms of exercise-induced asthma and the refractory period.","authors":"N G Belcher, S O'Hickey, J P Arm, T H Lee","doi":"10.2500/108854188779023388","DOIUrl":"https://doi.org/10.2500/108854188779023388","url":null,"abstract":"<p><p>Exercise is a powerful stimulus to the development of asthma. In most asthmatic subjects the airways obstruction recovers spontaneously within 60 minutes, but in some subjects there is more prolonged airflow obstruction which requires bronchodilator treatment. Approximately 40-50% of subjects with EIA will show a refractory period of two to four hours after an initial exercise task, during which time an identical exercise task will evoke significantly less (less than 50%) bronchoconstriction. In some patients, particularly children, EIA will be followed three to nine hours later by a further episode of bronchospasm, termed the late asthmatic response. There remains considerable debate about the pathogenesis of EIA the refractory period and the late asthmatic response.</p>","PeriodicalId":77755,"journal":{"name":"New England and regional allergy proceedings","volume":"9 3","pages":"199-201"},"PeriodicalIF":0.0,"publicationDate":"1988-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2500/108854188779023388","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14178394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y Iikura, H Inui, T Obata, T Nagakura, H Sugimoto, T H Lee, A B Kay
{"title":"Drug effects on exercise-induced late asthmatic responses.","authors":"Y Iikura, H Inui, T Obata, T Nagakura, H Sugimoto, T H Lee, A B Kay","doi":"10.2500/108854188779023423","DOIUrl":"https://doi.org/10.2500/108854188779023423","url":null,"abstract":"<p><p>Disodium cromoglycate, prednisolone, beclomethasone and salbutamol were administered prior to the cycle ergometer exercise task separately to different groups of children with exercise-induced dual asthmatic reaction. Pre-treatment with disodium cromoglycate of ten asthmatics totally inhibited the dual reaction. Prednisolone treatment of eleven asthmatics and beclomethasone treatment of five asthmatics did not inhibit the early response but only the late response. Salbutamol treatment of ten asthmatics mainly inhibited the early phase reaction. Changes in neutrophil chemotactic activity correlated with airflow limitation in the disodium cromoglycate and prednisolone study, however, there were some discrepancies between the changes in FEV1 and neutrophil chemotactic activity in the beclomethasone and salbutamol studies. These findings suggest that exercise-induced dual asthmatic reaction are modified by disodium cromoglycate, prednisolone, beclomethasone or salbutamol in a mechanism which may be different in each drug and that there are similarities in the inflammatory responses in antigen- and exercise-induced dual asthmatic responses.</p>","PeriodicalId":77755,"journal":{"name":"New England and regional allergy proceedings","volume":"9 3","pages":"203-7"},"PeriodicalIF":0.0,"publicationDate":"1988-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2500/108854188779023423","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14267407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mountain cedar pollinosis: can it occur in non-atopics?","authors":"M J Reid, L A Schwietz, B A Whisman, R B Moss","doi":"10.2500/108854188779023450","DOIUrl":"https://doi.org/10.2500/108854188779023450","url":null,"abstract":"<p><p>In 1984 Ramirez postulated the existance of two subgroups of patients with Mountain Cedar (MC) pollinosis. One subgroup had a single positive skin test (SPST) to MC only, lacked other atopic diseases, and required prolonged MC exposure to develop the disease. The second subgroup had multiple positive skin tests (MPST) in addition to MC, had other atopic diseases, and developed clinical symptoms after a shorter period of MC exposure. To validate these findings, and to explore the clinical and immunologic differences between these two subgroups, 13 SPST and nine MPST patients underwent immunotherapy with MC pollen extract. Six SPST and ten non-allergic controls did not receive immunotherapy. MC specific IgE (sIgE), MC sIgG, and MC sIgG subclasses were measured by ELISA pre and intra season. Symptom Medication Score (SMS) were measured during the MC season. SPST patients had a significantly lower baseline sIgE than MPST patients, 2.1 IU/ml versus 22.3 IU/ml, p = 0.023, and were also older than MPST patients, 52.4 versus 32.2 years, p less than 0.001. Baseline MC sIgG and MC sIgG subclass antibody levels were similar in both patient groups. SMS were lower in treated SPST patients compared to treated MPST patients, p less than 0.01, but in vitro responses to immunotherapy were not significantly different between the two groups. MC sIgE, MC sIgG, MC sIgG1 and MC sIgG4 rose in both treated groups. MC sIgG1 (but not MC sIgG4) rose during the MC season in both non-immunotherapy groups.(ABSTRACT TRUNCATED AT 250 WORDS)</p>","PeriodicalId":77755,"journal":{"name":"New England and regional allergy proceedings","volume":"9 3","pages":"225-32"},"PeriodicalIF":0.0,"publicationDate":"1988-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2500/108854188779023450","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14536477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M B Boxer, M S Dykewicz, R Patterson, P A Greenberger, J F Kelly
{"title":"The management of patients with sulfonamide allergy.","authors":"M B Boxer, M S Dykewicz, R Patterson, P A Greenberger, J F Kelly","doi":"10.2500/108854188779023432","DOIUrl":"https://doi.org/10.2500/108854188779023432","url":null,"abstract":"<p><p>To illustrate the variety of clinical strategies that may be used in treatment of patients allergic to sulfa medications, we report the management of eight sulfa allergic patients, seven of whom required readministration of the sulfa drug. Slow oral readministration of a sulfonamide over the course of four weeks was successful in two patients who had a history of cutaneous reactions to sulfa use and did not require sulfa urgently. Rapid oral or intravenous readministration of a sulfonamide was attempted unsuccessfully in three patients, each of whom urgently needed continuation of a sulfa drug. Occasionally a sulfa drug must be continued despite the presence of a cutaneous drug eruption secondary to that drug. In four patients, including two of the patients in whom rapid test dosing of a sulfonamide had been unsuccessful, treatment of the sulfa reaction with corticosteroids and antihistamines permitted continued sulfa administration. Readministration of a sulfonamide should not be attempted in patients who previously have had reactions such as Stevens-Johnson syndrome unless essential for survival of a patient.</p>","PeriodicalId":77755,"journal":{"name":"New England and regional allergy proceedings","volume":"9 3","pages":"219-23"},"PeriodicalIF":0.0,"publicationDate":"1988-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2500/108854188779023432","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14537586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exercise-induced anaphylaxis.","authors":"A L Sheffer","doi":"10.2500/108854188779023441","DOIUrl":"https://doi.org/10.2500/108854188779023441","url":null,"abstract":"<p><p>Anaphylaxis, the most emergent manifestation of allergy, is best described by its clinical pathologic alterations. Sites of involvement include skin (urticaria), upper respiratory tract (laryngeal edema), lower respiratory tract (bronchospasm), and the cardiovascular system (severe hypotension). Ultrastructural analysis of skin biopsies obtained from individuals experiencing exercise-induced anaphylaxis prior to and immediately after exercise revealed changes indistinguishable from those observed following immunologic challenge of pulmonary mast cells. These alterations included enlargement of the mast cell granules, solubilization (discharge) of mast cell granule contents, merger of the granule membranes with adjacent granule membranes, as well as the mast cell membrane. The successful reversal of anaphylaxis requires the prompt recognition of symptoms and early institution of therapy for anaphylaxis. Patients suffering from exercise-induced anaphylaxis should avoid any foods, drinks, or pharmaceutical agents, particularly acetyl salicylic acid for four and preferably six hours prior to exercise.</p>","PeriodicalId":77755,"journal":{"name":"New England and regional allergy proceedings","volume":"9 3","pages":"215-7"},"PeriodicalIF":0.0,"publicationDate":"1988-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2500/108854188779023441","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14536474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exercise-induced bronchospasm in the XXIII summer Olympic games.","authors":"W E Pierson, R O Voy","doi":"10.2500/108854188779023405","DOIUrl":"https://doi.org/10.2500/108854188779023405","url":null,"abstract":"<p><p>The U.S. Olympic Team demonstrated a significant prevalence of Exercise-Induced Bronchospasm (EIB) among world-class athletes (11.2). Nearly all sports were involved but endurance events seemed to have the highest prevalence of team members with EIB. Resting pulmonary function studies were poor discriminators of athletes affected with EIB. The 67 athletes of the 597 member team were responsible for winning 41 Olympic medals including 15 golds and 21 silvers, clearly demonstrating their ability to compete and succeed in world-class competitive events. These results should send a strong message to young people that they can strive to excel in sports with proper medication and management.</p>","PeriodicalId":77755,"journal":{"name":"New England and regional allergy proceedings","volume":"9 3","pages":"209-13"},"PeriodicalIF":0.0,"publicationDate":"1988-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2500/108854188779023405","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14389915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}