Fetal therapy最新文献_第8页

Prenatal diagnosis of congenital uropathies. 先天性泌尿系统疾病的产前诊断。

Fetal therapy Pub Date : 1989-01-01 DOI: 10.1159/000263465

G Noia, L Masini, A Caruso, L Perrelli, A Calisti, E Salvaggio, S Mancuso

引用次数: 10

Tryptophan availability and fetal behavioral states. 色氨酸可用性与胎儿行为状态。

Fetal therapy Pub Date : 1989-01-01 DOI: 10.1159/000263468

C Romanini, H Valensise, G Ciotti, D Arduini, P Giorgi

引用次数: 6

Neural tube defects: considerations on the pathogenesis and correlation with myelodysplasia in man. II. An experimental model. 神经管缺损:对男性骨髓发育异常的发病机制及相关性的思考。2实验模型。

Fetal therapy Pub Date : 1989-01-01 DOI: 10.1159/000263473

C Di Rocco, M Rende

引用次数: 5

Ethical issues in prenatal diagnosis and fetal therapy: a Catholic perspective. 产前诊断和胎儿治疗中的伦理问题:天主教的观点。

Fetal therapy Pub Date : 1989-01-01 DOI: 10.1159/000263463

E. Sgreccia

引用次数: 8

Effect of prednisone and heparin treatment in 14 patients with poor reproductive efficiency related to lupus anticoagulant. 强的松联合肝素治疗狼疮抗凝相关生殖功能低下患者14例疗效观察。

Fetal therapy Pub Date : 1989-01-01 DOI: 10.1159/000263469

A E Semprini, A Vucetich, S Garbo, G Agostoni, G Pardi

{"title":"Effect of prednisone and heparin treatment in 14 patients with poor reproductive efficiency related to lupus anticoagulant.","authors":"A E Semprini, A Vucetich, S Garbo, G Agostoni, G Pardi","doi":"10.1159/000263469","DOIUrl":"https://doi.org/10.1159/000263469","url":null,"abstract":"In women with a previous intrauterine fetal death related to lupus anticoagulant (LAC), we studied the effect of prednisone and calcieparine treatment to enable longer intrauterine life, increased fetal growth and increased survival rate. LAC was determined by the kaolin clotting time and was associated with elevated levels of antinuclear and anticardiolipin antibody in 42% and 21% of the cases, respectively. 14 women entered the study; they had a past history of 27 pregnancies, with only 1 small-for-gestational age (SGA) liveborn. The mean gestational age at the time of fetal death was 30 +/- 4 weeks. During index pregnancies, we observed 2 miscarriage, 9 liveborns (6 of appropriated gestational weight, 3 SGA) and a mean gestational age of 35 +/- 3 weeks. The mean decrease in fetal weight from the 50th percentile in previous pregnancies was 44%, and with treatment this was reduced to 12%. All these differences were statistically significant. We conclude that prednisone and heparin treatment can improve reproductive prognosis in fertile patients with LAC.","PeriodicalId":77713,"journal":{"name":"Fetal therapy","volume":"4 Suppl 1 ","pages":"73-6"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000263469","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13663140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Fetal blood values by percutaneous umbilical blood sampling. 经皮脐血取样胎儿血液值。

Fetal therapy Pub Date : 1989-01-01 DOI: 10.1159/000263438

K Takagi, H Tanaka, S Nishijima, N Masaoka, Y Miyake, H Sakata, K Satoh

引用次数: 14

Seasonal variation in conception does not appear to influence the rate of prenatal diagnosis of nondisjunction. 季节变化的概念似乎不影响产前诊断率不分离。

Fetal therapy Pub Date : 1989-01-01 DOI: 10.1159/000263451

A Drugan, S F Bottoms, M P Johnson, M I Evans

{"title":"Seasonal variation in conception does not appear to influence the rate of prenatal diagnosis of nondisjunction.","authors":"A Drugan, S F Bottoms, M P Johnson, M I Evans","doi":"10.1159/000263451","DOIUrl":"https://doi.org/10.1159/000263451","url":null,"abstract":"A seasonal effect on ovulation patterns and conception rates is well documented in animal studies. The etiology of reported variation in human fertility is, however, uncertain. Abnormal ovulation has been implicated in the etiology of aneuploid conceptions, many of which abort spontaneously. To investigate the possibility that the frequency of aneuploidy reflects seasonal variation in ovulation patterns, we analyzed 5,292 consecutive prenatal karyotypes obtained from 1985 to 1987. Karyotypes were logged according to month and year of conception. Results were evaluated for cyclicity using frequency spectrum and time series analysis. Variation in the number of prenatal diagnostic procedures corresponded to known peaks in conception and delivery rates. No significant monthly or quarterly trend in the total rate of trisomies or in the rate of trisomy 21 was demonstrated. Although the sample size in this study may not be adequate to detect minor effects, seasonal variation does not appear to be a major determinant of nondisjunction rates in the population referred for prenatal diagnosis.","PeriodicalId":77713,"journal":{"name":"Fetal therapy","volume":"4 4","pages":"195-9"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000263451","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13633333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Prevention and treatment of fetal lung immaturity. 胎儿肺不成熟的预防与治疗。

Fetal therapy Pub Date : 1989-01-01 DOI: 10.1159/000263466

E V Cosmi, G C Di Renzo

{"title":"Prevention and treatment of fetal lung immaturity.","authors":"E V Cosmi, G C Di Renzo","doi":"10.1159/000263466","DOIUrl":"https://doi.org/10.1159/000263466","url":null,"abstract":"In the last 10 years the strategy for the prevention of neonatal respiratory distress syndrome (RDS) has been directed towards the acceleration of fetal lung maturity in utero by means of drugs administered to the mother, the most thoroughly investigated being glucocorticoids (GC), and to the development of surfactant substitutes for the treatment of surfactant deficiency at birth or following the development of RDS. GC decreases the incidence of RDS in the neonate delivered between 28 and 32 weeks and weighing less than 1,500 g. The type of GC and the drug-delivery interval are critical. Harmful potential side effects of GC have led to the testing of other drugs capable of accelerating fetal lung maturity, among which are ambroxol and aminophylline. Ambroxol has been shown to significantly reduce RDS compared to placebo without causing important adverse effects in either mother or baby. Our experimental studies on aminophylline have shown that the drug exerts only minor beneficial effects on fetal lung maturation and surfactant production. We have evaluated the association of GC with inositol. The sugar alcohol administered to the mother dramatically affected fetal lung mechanics, reducing GC adverse effects such as the decrease of lung protein content. More recently supplementary surfactant instilled into the trachea has been shown to improve oxygenation of premature babies and to reduce the severity of RDS.","PeriodicalId":77713,"journal":{"name":"Fetal therapy","volume":"4 Suppl 1 ","pages":"52-62"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000263466","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13720827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Genetic correction of hereditary disease. 遗传性疾病的基因校正。

Fetal therapy Pub Date : 1989-01-01 DOI: 10.1159/000263464

M P Johnson, A Drugan, O J Miller, M I Evans

引用次数: 7

Comparison of four types of intrauterine transfusion: effect on fetal hematocrit. 四种宫内输血方式对胎儿红细胞压积的影响。

Fetal therapy Pub Date : 1989-01-01 DOI: 10.1159/000263434

K J Moise, R J Carpenter, B Kirshon, R L Deter, J D Sala, L E Cano

引用次数: 40