Fetal therapy最新文献_第7页

Albumin transfusion in non-immune fetal hydrops: Doppler ultrasound evaluation of the acute effects on blood circulation in the fetal aorta and the umbilical arteries. 白蛋白输注在非免疫性胎儿水肿:多普勒超声评价对胎儿主动脉和脐动脉血液循环的急性影响。

Fetal therapy Pub Date : 1989-01-01 DOI: 10.1159/000263433

G Lingman, M Stangenberg, J Legarth, F Rahman

{"title":"Albumin transfusion in non-immune fetal hydrops: Doppler ultrasound evaluation of the acute effects on blood circulation in the fetal aorta and the umbilical arteries.","authors":"G Lingman, M Stangenberg, J Legarth, F Rahman","doi":"10.1159/000263433","DOIUrl":"https://doi.org/10.1159/000263433","url":null,"abstract":"A case of non-immune fetal hydrops, diagnosed as mucopolysaccharidosis VII with hypoalbuminemia, was treated in utero with albumin transfusions via cordocentesis on five occasions. Blood samples were taken for analysis of full blood count and blood gases before and after the transfusions. Pulsed Doppler ultrasound examinations of the arterial waveform were performed in the umbilical arteries and the descending fetal aorta and analyzed for the pulsatility index (PI). The hemoglobin concentration and the hematocrit decreased from 111 +/- 5 g/l and 0.335 +/- 0.008 to 95 +/- 5 g/l and 0.282 +/- 0.023 (mean +/- SD), respectively, after the transfusions. The calculated blood volume increased more than the given volume, indicating an autotransfusion causing additional plasma volume expansion. The blood gases were not significantly changed by transfusion. The PI decreased both in the umbilical arteries (p less than 0.05) and the descending fetal aorta, indicating peripheral vasodilatation. A positive correlation was found between the umbilical artery PI and the hematocrit before and after the albumin transfusion (r = 0.59; p less than 0.05). This relation could be due to covariation with other factors, e.g. peripheral vasodilatation secondary to the increased blood volume and the puncture of the umbilical vein itself. No improvement of the hydrops was seen after the albumin transfusions. The fetus died in utero during spontaneous labor after 30 gestational weeks.","PeriodicalId":77713,"journal":{"name":"Fetal therapy","volume":"4 2-3","pages":"120-5"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000263433","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13633889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

When to perform the next intra-uterine transfusion in patients with Rh allo-immunization: combined intravascular and intraperitoneal transfusion allows longer intervals. 同种异体Rh免疫患者何时进行下一次子宫内输血:血管内和腹腔内联合输血可延长间隔时间。

Fetal therapy Pub Date : 1989-01-01 DOI: 10.1159/000263385

U Nicolini, N K Kochenour, P Greco, E Letsky, C H Rodeck

{"title":"When to perform the next intra-uterine transfusion in patients with Rh allo-immunization: combined intravascular and intraperitoneal transfusion allows longer intervals.","authors":"U Nicolini, N K Kochenour, P Greco, E Letsky, C H Rodeck","doi":"10.1159/000263385","DOIUrl":"https://doi.org/10.1159/000263385","url":null,"abstract":"Data from 99 intra-uterine transfusions performed in 30 patients (31 fetuses) with Rh allo-immunization have been reviewed. Mean gestational age at the first transfusion was 23.6 weeks and mean fetal haematocrit 19.8%. The number of procedures was on average 3.2 per fetus. Survival rate was 84%. Fifty-nine intravascular transfusions were combined with intraperitoneal transfusions. Combined intravascular and intraperitoneal transfusions, when compared to intravascular transfusions alone, achieved a significantly longer interval between transfusions and also maintained a higher fetal haematocrit at the subsequent transfusion. Mean fall in fetal haematocrit was 0.98% per day with a wide range. There was a general tendency towards a less marked fall during the second interval between transfusions than in the first with the exception of those cases in which the percentage of fetal red cells at the start of the second transfusion was increased compared to that which was found at the end of the first, i.e., when fetal erythropoiesis was not suppressed.","PeriodicalId":77713,"journal":{"name":"Fetal therapy","volume":"4 1","pages":"14-20"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000263385","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13661710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 37

Reevaluation of nonstress test by umbilical venous blood profile using cordocentesis. 脐带穿刺法脐静脉血非应激试验的再评价。

Fetal therapy Pub Date : 1989-01-01 DOI: 10.1159/000263437

K Okamura, H Endoh, T Watanabe, S Tanigawara, M Iwamoto, J Murotsuki, A Yajima

{"title":"Reevaluation of nonstress test by umbilical venous blood profile using cordocentesis.","authors":"K Okamura, H Endoh, T Watanabe, S Tanigawara, M Iwamoto, J Murotsuki, A Yajima","doi":"10.1159/000263437","DOIUrl":"https://doi.org/10.1159/000263437","url":null,"abstract":"Fetal blood sampling by cordocentesis was performed in 85 cases of fetuses with either nonimmune hydrops fetalis, anomalies, intrauterine growth retardation, maternal immunological disorders, Rh incompatibility, hydronephrosis, polyhydramnios, maternal preeclampsia or fetal tumor. Fetal heart rate monitoring was also recorded before cordocentesis. We evaluated the usefulness of the nonstress test (NST) with regard to fetal hematologic gas profiles including pH, pO2 and pCO2. When the acceleration was classified into reactive and nonreactive group, pH and pO2 were significantly higher in the reactive group than in the nonreactive group. pCO2 was significantly lower in the former than the latter. However, the sensitivity and specificity of the reactive NST predicting fetal umbilical venous pO2 over 20 mm Hg was 79.7 and 68.7%, respectively. The false-positive rate of nonreactive NST predicting hypoxemia below 20 mm Hg pO2 was 44%. As a consequence, we cannot always rely on the NST, and should perform fetal blood sampling to assess fetal condition for further management.","PeriodicalId":77713,"journal":{"name":"Fetal therapy","volume":"4 2-3","pages":"146-51"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000263437","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13662902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

First trimester maternal serum lysosomal enzymes: implications for carrier testing and prenatal diagnosis. 孕早期母体血清溶酶体酶:携带者检测和产前诊断的意义。

Fetal therapy Pub Date : 1989-01-01 DOI: 10.1159/000263445

R A Kaufmann, A Drugan, M I Evans, D Mitchell, Y Ben-Yoseph, K S Moghissi

{"title":"First trimester maternal serum lysosomal enzymes: implications for carrier testing and prenatal diagnosis.","authors":"R A Kaufmann, A Drugan, M I Evans, D Mitchell, Y Ben-Yoseph, K S Moghissi","doi":"10.1159/000263445","DOIUrl":"https://doi.org/10.1159/000263445","url":null,"abstract":"Carrier detection for lysosomal storage diseases is sometimes possible by evaluating maternal serum levels of specific enzymes. However, lysosomal enzymes (LE) can be modified by maternal hormonal changes in pregnancy or embryonic contributions. Maternal serum was obtained prospectively in the follicular phase and at 2-5 and 7-11 weeks after conception from 13 infertility patients with precisely known ovulation dates. Eleven enzyme activities were determined fluorimetrically using 4-methylumbelliferyl substrates. Using repeated measures ANOVA, alpha-N-acetyl-glucosaminidase (p less than 0.05), hexosaminidase A (p less than 0.005) and hexosaminidase A and B (p less than 0.005) increased during the first trimester, and 8 enzymes did not change significantly. Our data show differing patterns of LE in the first trimester. These may be explained by: (1) variability of maternal reaction to hormonal changes of pregnancy, or (2) variable embryonic contributions suggesting differential ontogeny and placental transfer of these enzymes. The increase in levels of the 3 specific LE in maternal serum may interfere with the accuracy of carrier testing in early pregnancy, but pregnancy should not interfere with the other 8.","PeriodicalId":77713,"journal":{"name":"Fetal therapy","volume":"4 4","pages":"161-5"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000263445","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13662748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amniotic fluid alpha-fetoprotein levels in the differential diagnosis of cystic hygroma. 羊水甲胎蛋白水平在囊性水肿鉴别诊断中的应用。

Fetal therapy Pub Date : 1989-01-01 DOI: 10.1159/000263448

Y Sorokin, M P Johnson, A Drugan, F C Koppitch, M I Evans

{"title":"Amniotic fluid alpha-fetoprotein levels in the differential diagnosis of cystic hygroma.","authors":"Y Sorokin, M P Johnson, A Drugan, F C Koppitch, M I Evans","doi":"10.1159/000263448","DOIUrl":"https://doi.org/10.1159/000263448","url":null,"abstract":"In 7 second trimester pregnancies ultrasound (US) demonstrated cystic hygroma colli (CHC); amniocentesis was performed in 6 patients. In the 7th patient, because of oligohydramnios, the fluid for karyotype was aspirated from the CHC. Five pregnancies had been referred secondary to abnormalities on US and 2 others because of low maternal serum alpha-fetoprotein (MSAFP). Four karyotypes were abnormal (45,X;47,XX+21; 47,XY+21; 46,XX/45,X), and 3 had normal karyotypes. Amniotic fluid alpha-fetoprotein (AFAFP) was normal in 4 pregnancies and low in 2 (0.09 MOM, 0.41 MOM). Of 2 pregnancies with trisomy 21 one had been referred for low MSAFP. In 2 pregnancies with normal karyotypes, US findings at early gestational age (14-17 weeks) of small, nonseptated, bilateral CHC disappeared during pregnancy; these women delivered normal, term babies. Most prenatally diagnosed CHC are not in fetuses with Turner syndrome. With a normal karyotype and CHC as the only finding on early US in utero, normal neonatal survival is possible. AFAFP is not elevated in pregnancies with CHC. If AFAFP is elevated with a positive acetylcholinesterase, such results may suggest that the CHC was inadvertently aspirated.","PeriodicalId":77713,"journal":{"name":"Fetal therapy","volume":"4 4","pages":"178-84"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000263448","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13631384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Placenta previa and congenital cardiac anomalies. 前置胎盘和先天性心脏异常。

Fetal therapy Pub Date : 1989-01-01 DOI: 10.1159/000263435

A Neri, Y Manor, A Matityahu, L Blieden

引用次数: 4

Fetal goitrous hypothyroidism. A new diagnostic and therapeutic approach. 胎儿甲状腺功能减退。一种新的诊断和治疗方法。

Fetal therapy Pub Date : 1989-01-01

R L Johnson, H J Finberg, A H Perelman, W H Clewell

引用次数: 0

Early third trimester selective feticide of a compromising twin. 妊娠晚期早期选择性堕胎的妥协双胞胎。

Fetal therapy Pub Date : 1989-01-01 DOI: 10.1159/000263428

K Still, T Kolatat, T Corbett, P Byrne

引用次数: 3

Aneuploidy with neural tube defects: another reason for complete evaluation in patients with suspected ultrasound anomalies or elevated maternal serum alpha-fetoprotein. 非整倍体伴神经管缺陷:怀疑超声异常或母体血清甲胎蛋白升高的患者需要完全评估的另一个原因。

Fetal therapy Pub Date : 1989-01-01 DOI: 10.1159/000263429

A Drugan, M P Johnson, E Dvorin, J Moody, E L Krivchenia, D Schwartz, M I Evans

引用次数: 27

Compensatory adrenal hypertrophy following unilateral adrenalectomy of fetuses of rats given alcohol throughout gestation. 妊娠期间给予酒精的大鼠胎儿单侧肾上腺切除术后代偿性肾上腺肥大。

Fetal therapy Pub Date : 1989-01-01 DOI: 10.1159/000263447

K Arishima, M Lee, M Yamamoto, Y Eguchi

{"title":"Compensatory adrenal hypertrophy following unilateral adrenalectomy of fetuses of rats given alcohol throughout gestation.","authors":"K Arishima, M Lee, M Yamamoto, Y Eguchi","doi":"10.1159/000263447","DOIUrl":"https://doi.org/10.1159/000263447","url":null,"abstract":"The effect of maternal alcohol consumption on fetal compensatory adrenal hypertrophy following unilateral adrenalectomy was studied in rats. Females were given 20% alcohol in tap water for 4 weeks prior to mating and 30% alcohol in tap water throughout gestation (alcohol), or were pair-fed to the alcohol group (pair-fed) or were fed ad libitum (control). On day 20, fetuses were unilaterally left-adrenalectomized or sham operated. Mothers were sacrificed on day 22 of gestation and right adrenals of adrenalectomized, sham-operated, and unoperated fetuses were removed and weighed. Some adrenals were fixed, sectioned, and stained for histological examination. Adrenalectomized fetuses of all three dietary treatment groups demonstrated compensatory hypertrophy. Adrenals of alcohol-exposed fetuses weighed less than those of pair-fed or control fetuses, and the ratio of adrenal weight/body weight was greater, regardless of surgical procedure. Histological sections of right adrenals of left-adrenalectomized fetuses showed larger cells and widened sinusoids, compared to unoperated fetuses in the corresponding dietary treatment groups. These results are consistent with a retardation in adrenal growth and development as a result of alcohol exposure, but show that alcohol consumption throughout gestation does not affect the ability of the adrenals to undergo compensatory hypertrophy following unilateral adrenalectomy.","PeriodicalId":77713,"journal":{"name":"Fetal therapy","volume":"4 4","pages":"171-7"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000263447","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13633331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1