Carcinogenesis; a comprehensive survey最新文献_第3页

Mechanisms of multistage chemical carcinogenesis and their relevance to respiratory tract cancer. 多阶段化学致癌机制及其与呼吸道肿瘤的关系。

Carcinogenesis; a comprehensive survey Pub Date : 1985-01-01

I B Weinstein, J Arcoleo, M Lambert, W Hsiao, S Gattoni-Celli, A M Jeffrey, P Kirschmeier

{"title":"Mechanisms of multistage chemical carcinogenesis and their relevance to respiratory tract cancer.","authors":"I B Weinstein, J Arcoleo, M Lambert, W Hsiao, S Gattoni-Celli, A M Jeffrey, P Kirschmeier","doi":"","DOIUrl":"","url":null,"abstract":"The evolution of a fully malignant tumor is a multistep process resulting from the action of multiple factors, both environmental and endogenous, and involves alterations in the function of multiple cellular genes. Chemical carcinogens that initiate this process appear to do so by damaging cellular DNA. In addition to producing simple point mutations, this damage appears to induce the synthesis of a transacting factor that can induce asynchronous DNA replication. This response may result in gene amplification and/or gene rearrangement. This phenomenon may also play a role in synergistic interactions between chemicals and viruses in the causation of certain cancers. The primary target of the tumor promoters TPA, teleocidin, and aplysiatoxin appears to be cell membranes. All three of these agents act, at least in part by, enhancing the activity of the phospholipid-dependent enzyme PKC. We have proposed a stereochemical model to explain the interaction of these amphiphilic compounds with the PKC system. We have found that TPA and teleocidin markedly enhance the transformation of C3H10T1/2 mouse fibroblasts when these cells are transfected with the cloned H-ras human bladder cancer oncogene. Thus, tumor promoters can act synergistically with an activated oncogene to enhance cell transformation. Furthermore, carcinogen-transformed rodent cells display aberrations in the expression of various endogenous retrovirus-related sequences. Activation of some of these sequences may lead to insertion mutations and further aberrations in gene expression. These findings are discussed in terms of a multistep model that involves progressive changes in cellular oncogenes and aberrations in the function of DNA transcription enhancer sequences. It will be of interest to determine to what extent these concepts apply to the etiology of cancers of the respiratory tract.","PeriodicalId":77688,"journal":{"name":"Carcinogenesis; a comprehensive survey","volume":"8 ","pages":"395-409"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14288647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Initiation and promotion in cultures of C3H10T1/2 mouse embryo fibroblasts. C3H10T1/2小鼠胚胎成纤维细胞的起始和促进。

Carcinogenesis; a comprehensive survey Pub Date : 1985-01-01

C J Boreiko

{"title":"Initiation and promotion in cultures of C3H10T1/2 mouse embryo fibroblasts.","authors":"C J Boreiko","doi":"","DOIUrl":"","url":null,"abstract":"Studies conducted in numerous laboratories have demonstrated that the transformation of C3H10T1/2 cells can proceed through discrete stages of initiation and promotion. Indeed, multiple operational aspects of initiation and promotion in this system closely mimic the essential characteristics of initiation and promotion on mouse skin. The sensitivity of this system to the effects of different tumor promoters also appears to parallel that of mouse skin, and there is evidence to suggest that the C3H10T1/2 system is most sensitive to agents acting as stage II tumor promoters on mouse skin. Sensitivity to compounds active at other tissue sites in rodents and perhaps man has also been observed. At this time it is difficult to assess the relevance of the C3H10T1/2 system for the study of agents capable of modulating respiratory carcinogenesis. The process of promotion can possess extreme tissue and species specificity and effects observed in murine fibroblasts of embryonic origin may have little practical bearing upon effects to be anticipated in the tracheal epithelium of the rat or the bronchial epithelium of man. This is not to say that the C3H10T1/2 system is irrelevant to respiratory carcinogenesis. However, due recognition must be taken of the probable natural limitations of this system for the study of promoters of respiratory carcinogenesis. As the data base for the use of this system is expanded, the relationship between promotion in C3H10T1/2 cells and the respiratory tract of man and rodents will become better defined. Until such time as this relationship is firmly established, it is perhaps best to regard the C3H10T1/2 system as an interesting model with which results obtained using respiratory tissue can be compared or contrasted.","PeriodicalId":77688,"journal":{"name":"Carcinogenesis; a comprehensive survey","volume":"8 ","pages":"329-40"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15100374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tumor promotion and tumor progression. 肿瘤促进和肿瘤进展。

Carcinogenesis; a comprehensive survey Pub Date : 1985-01-01

J C Barrett

引用次数: 0

Mammalian cell transformation. Mechanisms of carcinogenesis and assays for carcinogens. 哺乳动物细胞转化。致癌机制及致癌物的测定。

Carcinogenesis; a comprehensive survey Pub Date : 1985-01-01

引用次数: 0

Role of chemically induced mutagenic events in neoplastic transformation of Syrian hamster embryo cells. 化学诱导诱变事件在叙利亚仓鼠胚胎细胞肿瘤转化中的作用。

Carcinogenesis; a comprehensive survey Pub Date : 1985-01-01

J C Barrett, T W Hesterberg, M Oshimura, T Tsutsui

引用次数: 0

Role of intercellular communication in BALB/c 3T3 cell transformation. 细胞间通讯在BALB/c 3T3细胞转化中的作用。

Carcinogenesis; a comprehensive survey Pub Date : 1985-01-01

H Yamasaki, T Enomoto

引用次数: 0

In vitro transformation of rat tracheal epithelial cells: a model for the study of multistage carcinogenesis. 大鼠气管上皮细胞体外转化:研究多阶段癌变的模型。

Carcinogenesis; a comprehensive survey Pub Date : 1985-01-01

P Nettesheim, J C Barrett

引用次数: 0

Cellular and molecular mechanisms in malignant transformation of diploid rodent and human cells by radiation. 二倍体鼠类和人细胞辐射恶性转化的细胞和分子机制。

Carcinogenesis; a comprehensive survey Pub Date : 1985-01-01

C Borek

引用次数: 0

Cell culture studies on the mechanism of action of chemical carcinogens and tumor promoters. 化学致癌物和肿瘤促进剂作用机制的细胞培养研究。

Carcinogenesis; a comprehensive survey Pub Date : 1985-01-01

I B Weinstein

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引用次数: 0

Mechanisms of chemically induced multistep neoplastic transformation in C3H 10T 1/2 cells. 化学诱导c3h10t1 /2细胞多步骤肿瘤转化的机制。

Carcinogenesis; a comprehensive survey Pub Date : 1985-01-01

J R Landolph

引用次数: 0