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Bulletin of the Osaka Medical College最新文献

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Acute curable pandysautonomia and chronic progressive pandysautonomia. 急性可治愈的自主神经症和慢性进行性自主神经症。
Bulletin of the Osaka Medical College Pub Date : 1989-11-01
K Hirayama
{"title":"Acute curable pandysautonomia and chronic progressive pandysautonomia.","authors":"K Hirayama","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77683,"journal":{"name":"Bulletin of the Osaka Medical College","volume":"35 1-2","pages":"113-7"},"PeriodicalIF":0.0,"publicationDate":"1989-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13630813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current aspects of trace element research in environmental health. 微量元素在环境卫生中的研究现状。
Bulletin of the Osaka Medical College Pub Date : 1989-11-01
K Kono, Y Yoshida
{"title":"Current aspects of trace element research in environmental health.","authors":"K Kono,&nbsp;Y Yoshida","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The field of research on trace element and its relationship to human health and disease is one of the most rapidly advancing fields among the health sciences. The methods of measuring elements in the body can be classified into two categories: i.e., destructive and non-destructive method. The latter analysis includes X-ray fluorescence (XRF) analysis, by which the authors determine fluorine (F) and elements in hair specimens among patients with chronic diseases and workers exposed to polluted elements. Some advantages offered by this method are a lack of necessity for the preliminary treatment of specimens and relative ease of operation. In this paper, the authors review the current aspect of trace element researches in the environmental health field, especially those in our laboratory.</p>","PeriodicalId":77683,"journal":{"name":"Bulletin of the Osaka Medical College","volume":"35 1-2","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"1989-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13631589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Variation of plasma fibronectin levels in leukemia patients. 白血病患者血浆纤维连接蛋白水平的变化。
Bulletin of the Osaka Medical College Pub Date : 1989-11-01
T Kageyama, H Ohyabu, S Ohshiba
{"title":"Variation of plasma fibronectin levels in leukemia patients.","authors":"T Kageyama,&nbsp;H Ohyabu,&nbsp;S Ohshiba","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In the present study plasma fibronectin levels were determined in patients with hematopoietic malignancy, particularly leukemias, in an effort to clarify their clinical implications. Among leukemia patients, those with AML, ALL, ATL or CLL had various plasma fibronectin levels that were higher in some cases, while lower in others, as compared to normal control values. An elevation of the fibronectin level was noted often in APL, while lower fibronectin values were observed in many instances of CML. In these types of leukemia, acute exacerbation as well as supervention of infection tended to be associated with lower than normal levels of fibronectin. An especially marked depression of fibronectin occurred, when leukemia was complicated by sepsis or DIC, in which a good parallel was noted between the progress of disease and the fibronectin level. In lymphoproliferative diseases, the fibronectin value varied widely, but low fibronectin levels were frequently associated with intercurrent infection or an extreme deterioration of the general physical conditions.</p>","PeriodicalId":77683,"journal":{"name":"Bulletin of the Osaka Medical College","volume":"35 1-2","pages":"71-6"},"PeriodicalIF":0.0,"publicationDate":"1989-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13630819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impaired regulation of skin temperature in patients with diabetes mellitus evaluated by the cold exposure test. 用冷暴露试验评价糖尿病患者皮肤温度调节功能受损。
Bulletin of the Osaka Medical College Pub Date : 1989-11-01
H Kitaoka, M Majima, A Kitazawa, S Sakane, K Takeda, J Takamatsu, N Ohsawa
{"title":"Impaired regulation of skin temperature in patients with diabetes mellitus evaluated by the cold exposure test.","authors":"H Kitaoka,&nbsp;M Majima,&nbsp;A Kitazawa,&nbsp;S Sakane,&nbsp;K Takeda,&nbsp;J Takamatsu,&nbsp;N Ohsawa","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This study aimed at evaluating vasomotor response of the hand in patients with diabetes mellitus. A skin temperature of the hand was measured before and after exposure to ice water, and the recovery rates of the skin temperature were determined at 3, 5, and 10 min after the cold exposure. Ninety-two diabetics ranging in age from 25 to 59 years and 43 normal subjects ranging from 23 to 69 years old participated in this study. Since the recovery rate was delayed in normal subjects over the age of 60, comparison was made between the diabetics and the normals under 60 years old. The skin temperature was significantly lower in 26 diabetics with severe peripheral neuropathy (PN) than 40 diabetics without PN. The recovery rate were markedly delayed in the patients with PN, and also delayed in diabetics with severe retinopathy. The recovery rate was not different between the patients with and without ischemic changes in electrocardiogram. The delayed recovery rate was most prominent in the diabetics who had both abnormal heart rate variation (HRV) and orthostatic hypotension, followed by those with abnormal HRV but without orthostatic hypotension. Recovery rates in the diabetics with abnormal HRV alone were within the normal range. Our data suggest that the dysfunction of the regulation of skin temperature in the patients with diabetes mellitus was due to peripheral sympathetic nerve abnormality. The cold exposure test would be useful in the estimation of the sympathetic nerve activity of the diabetics.</p>","PeriodicalId":77683,"journal":{"name":"Bulletin of the Osaka Medical College","volume":"35 1-2","pages":"99-105"},"PeriodicalIF":0.0,"publicationDate":"1989-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13630663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intracellular pH of gastric surface epithelial cells exposed to HCl and ethanol. 暴露于盐酸和乙醇的胃表面上皮细胞胞内pH值。
Bulletin of the Osaka Medical College Pub Date : 1989-11-01
F Nagano, H Masaki, T Yonehara, S Ohshiba, M Fujimoto
{"title":"Intracellular pH of gastric surface epithelial cells exposed to HCl and ethanol.","authors":"F Nagano,&nbsp;H Masaki,&nbsp;T Yonehara,&nbsp;S Ohshiba,&nbsp;M Fujimoto","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Ultramicro-pH electrodes were used to determine intracellular pH changes induced by luminal perfusion of acid and alcohol in the gastric mucosa. In preparations of the bullfrog antral mucosa mounted on a horizontal type Ussing chamber, we determined intracellular pH (pHi) in situ of the surface epithelial cells exposed to HCl in the presence or absence of 10% ethanol in the luminal side. The pHi and apical membrane potential (LEM) of the surface epithelial cells were measured with double-barreled liquid ion-exchanger pH microelectrodes. In normal control conditions, the mucosal pHi was 7.43 +/- 0.01 and LEM was 29.5 +/- 0.7 mV (SE, n = 54). Acidification of luminal perfusate to pH 3.5 had no influence on pHi. Exposure to luminal 1 mM HCl (luminal pH: pHL = 3.1) lowered pHi to 7.31 +/- 0.01 (n = 6). Addition of 10% ethanol (EtOH) to luminal perfusate at pH 4.2 (0.1 mM HCl) led to immediate and progressive acidification of pHi (delta pHi = 0.12 +/- 0.02, n = 6). Hyperpolarization of LEM (by several mV) was also observed under such conditions, indicating an altered ion permeability of the apical membrane. These results suggest that even a low concentration of alcohol added to the gastric lumen causes a significant change in the surface epithelial cells, and this change becomes manifest when the luminal fluid is acidified to pH lower than 4.</p>","PeriodicalId":77683,"journal":{"name":"Bulletin of the Osaka Medical College","volume":"35 1-2","pages":"21-8"},"PeriodicalIF":0.0,"publicationDate":"1989-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13630814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antihypertensive mechanism of an angiotensin converting enzyme inhibitor, SA446, in dogs. 血管紧张素转换酶抑制剂SA446在狗体内的降压机制。
Bulletin of the Osaka Medical College Pub Date : 1989-11-01
K Nishimura, H Okunishi, M Miyazaki
{"title":"Antihypertensive mechanism of an angiotensin converting enzyme inhibitor, SA446, in dogs.","authors":"K Nishimura,&nbsp;H Okunishi,&nbsp;M Miyazaki","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Antihypertensive mechanisms of SA446, an angiotensin converting enzyme (ACE) inhibitor, were examined in dogs. In isolated dog pulmonary artery, SA446 inhibited the contractile response to angiotensin (Ang) I, but did not affect the response to Ang II. In conscious dogs, SA446 (1 mg/kg po) remarkably inhibited the pressor response to Ang I between 1 and 6 hr after the administration. In normotensive dogs, SA446 (30 mg/kg po) significantly lowered the arterial pressure 3 hr after administration, which recovered at 24 hr, while plasma ACE activity was apparently inhibited even at 24 hr. The antihypertensive effect of SA446 (5 mg/kg po) was more potent in 2-kidney, 1-clip renal hypertensive dogs than in normotensive dogs. SA446 (10(-9) - 10(-7) M) inhibited the ACE activities in arteries isolated from dogs in concentration-dependent fashion. These results suggest that the antihypertensive effect of SA446 is related, at least partially, to inhibition of ACE in the vascular wall.</p>","PeriodicalId":77683,"journal":{"name":"Bulletin of the Osaka Medical College","volume":"35 1-2","pages":"29-37"},"PeriodicalIF":0.0,"publicationDate":"1989-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13630815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Zinc protoporphyrin in the red blood cell. Analytical method and screening level for environmental lead exposure. 红细胞中的原卟啉锌。环境铅暴露的分析方法和筛选水平。
Bulletin of the Osaka Medical College Pub Date : 1989-11-01
S Inoue
{"title":"Zinc protoporphyrin in the red blood cell. Analytical method and screening level for environmental lead exposure.","authors":"S Inoue","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>An appropriate method of measurement was established for zinc protoporphyrin (ZnP) in the red blood cell (RBC) and applied to Japanese rural and urban inhabitants as well as the workers exposed to lead (Pb). ZnP was sufficiently extracted by an acetone extraction method by spinning the blood sample at more than 10,000 rpm. The author set the upper fiducial limit of ZnP concentration at 70 micrograms/dl RBC for adult males and 90 micrograms/dl RBC for adult females for the persons who were not occupationally exposed to Pb. ZnP concentration in RBC was well correlated to blood Pb level among the workers exposed to relatively high level of Pb. The author's procedure for the measurement of ZnP level is useful for the control of occupational health in Pb exposure.</p>","PeriodicalId":77683,"journal":{"name":"Bulletin of the Osaka Medical College","volume":"35 1-2","pages":"49-60"},"PeriodicalIF":0.0,"publicationDate":"1989-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13630817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary structure of a lambda Bence Jones protein (Os). Bence Jones蛋白(o)的一级结构。
Bulletin of the Osaka Medical College Pub Date : 1989-11-01
S Ito, H Matsumoto
{"title":"Primary structure of a lambda Bence Jones protein (Os).","authors":"S Ito,&nbsp;H Matsumoto","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The primary structure of a human lambda type Bence-Jones protein Os was determined by analyzing amino acid sequence of the completely reduced and aminoethylated protein. Nineteen tryptic peptides covering 213 residues were isolated and 10 of these were completely sequenced. For the remaining peptides, only partial sequences or the amino acid composition were determined. All the tryptic peptides could be arranged in order on the basis of the above results and homology with other lambda chains of known sequences. The sequence of the variable region, which contains 109 residues, is homologous with those of proteins of subgroup V lambda I. The sequence of the constant region indicates that protein Os has Mcg(+), Kern(+) and Oz(-) as isotypic markers, in spite of having a unique residue at position 164.</p>","PeriodicalId":77683,"journal":{"name":"Bulletin of the Osaka Medical College","volume":"35 1-2","pages":"61-70"},"PeriodicalIF":0.0,"publicationDate":"1989-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13630818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A surgical case of giant mediastinal tumor in a child associated with rib deformity. 儿童巨大纵隔肿瘤伴肋骨畸形一例。
Bulletin of the Osaka Medical College Pub Date : 1989-11-01
H Horimoto, M Sasaki, K Kuroda
{"title":"A surgical case of giant mediastinal tumor in a child associated with rib deformity.","authors":"H Horimoto,&nbsp;M Sasaki,&nbsp;K Kuroda","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A five-year-old boy was admitted, complaining of a persistent cough. Chest film showed a smooth round mass in right mediastinal region and deformity of 6th rib. CT studies revealed the presence of a well-defined mass with low density. Pulmonary arteriography demonstrated hypovascularity in right pulmonary field. Preoperative diagnosis was a benign neurogenic tumor originated from intercostal nerve located at the posterior mediastinum. At operation, a large round smooth mass was found adhered to chest wall and, in part, parietal pleura, and it was removed completely. The sixth rib with deformity was also resected partly. The specimen measured 9.5 x 5.0 x 4.0 cm and weighed 175 g. Histopathological findings demonstrated that the tumor proved to be ganglioneuroma.</p>","PeriodicalId":77683,"journal":{"name":"Bulletin of the Osaka Medical College","volume":"35 1-2","pages":"107-11"},"PeriodicalIF":0.0,"publicationDate":"1989-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13631590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of norepinephrine on the proximal tubular cells in perfused bullfrog kidney. 去甲肾上腺素对灌注牛蛙肾近端小管细胞的影响。
Bulletin of the Osaka Medical College Pub Date : 1989-11-01
T Kubota, N Hagiwara, M Kubokawa, M Fujimoto
{"title":"Effects of norepinephrine on the proximal tubular cells in perfused bullfrog kidney.","authors":"T Kubota,&nbsp;N Hagiwara,&nbsp;M Kubokawa,&nbsp;M Fujimoto","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Unlabelled: </strong>To study effects of norepinephrine (NE) on sodium and hydrogen ion transport, we used H(+)-, Ca2(+)-, or Na(+)-selective microelectrode and split-oil droplet techniques in doubly-perfused bullfrog proximal tubules. Peritubular membrane potential difference (EM), intracellular activities of Na+ ((Na)i) and Ca2+ ((Ca)i), and pH of the cytosol (pHi) and the lumen (pHTF) were monitored continuously during peritubular administration of NE (10(-6)-10(-7) M), phenylephrine (PHE, 10(-7) M), or dibutyryl cyclic AMP (db-cAMP, 10(-4) M).</p><p><strong>Results: </strong>(1) The peritubular application of NE produced: a) an enhancement of proximal fluid reabsorption, b) a transient fall of pHTF by about 0.2, c) a gradual hyperpolarization of EM and a slight decrease of (Na)i with oscillation, d) a mild cell acidification by about 0.05 pH, and e) an increase of (Ca)i. (2) The peritubular perfusion of PHE (alpha 1-agonist) caused: a) a transient fall of pHTF by about 0.3, b) a transient depolarization of EM and an increase of (Na)i, followed by sustained hyperpolarization of EM and a decrease of (Na)i, c) cytosolic acidification by about 0.1 pH, and d) a slight decrease of (Ca)i, followed by a sustained increase of (Ca)i. (3) The peritubular application of db-cAMP produced: a) a reduction of proximal fluid reabsorption, b) a transient elevation of pHTF by about 0.15, c) a hyperpolarization of EM with a gradual decrease of (Na)i, d) cytosolic alkalinization by about 0.15 pH, and e) biphasic change of (Ca)i: i.e., a slight increase of (Ca)i followed by a sustained decrease of (Ca)i.(ABSTRACT TRUNCATED AT 250 WORDS)</p>","PeriodicalId":77683,"journal":{"name":"Bulletin of the Osaka Medical College","volume":"35 1-2","pages":"11-9"},"PeriodicalIF":0.0,"publicationDate":"1989-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13631591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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