Bulletin of the Osaka Medical College最新文献

Bulletin of the Osaka Medical College Pub Date : 1990-11-01

H Isozaki, K Okajima, S Morita, Y Takeda, T Ishibashi, M Tanimura, H Hara, M Niki, H Akimoto, M Kobayashi

{"title":"Review of pancreatic cancer.","authors":"H Isozaki, K Okajima, S Morita, Y Takeda, T Ishibashi, M Tanimura, H Hara, M Niki, H Akimoto, M Kobayashi","doi":"","DOIUrl":"","url":null,"abstract":"In 83 cases of pancreatic cancer (25 resected and 58 non-resected cases) which underwent laparotomy in the Department of General and Gastroenterological Surgery, Osaka Medical College Hospital over the past 11 years, we analyzed symptoms at diagnosis, duration of illness, tumor markers, surgical procedures, and long-term results. In many cases, jaundice was the premonitory symptom of pancreatic cancer. There was no relationship between duration of illness and tumor resectability. In analysis of tumor markers, abnormal CA19-9 levels were noted in 71% of resected cases and 89% of non-resected cases, and abnormal CEA, elastase and amylase levels were found in 38, 46 and 47% of resected cases and 76, 58 and 27% of non-resected cases, respectively. Operative mortality was higher for non-resected cases (22%) than that for resected cases (8%). Long-term results were significantly better in resected cases than non-resected cases. However, 1-, 2- and 3-year survival rates after macroscopic curative resection were 45, 19 and 9%, respectively. Prognosis of patients after absolute non-curative resection was poor, indicating no efficacy of the resection. To improve these very poor surgical results for pancreatic cancer, the early cancer detection and multi-disciplinary therapy seem to be necessary.","PeriodicalId":77683,"journal":{"name":"Bulletin of the Osaka Medical College","volume":"36 1-2","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"1990-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13289386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathohistological study on changes observed in the temporomandibular joint after experimental mutilation and shortening of the mandibular process with special reference to the changes under abnormal mandibular movement. 实验性下颌突截短后颞下颌关节变化的病理组织学研究，特别参考了下颌异常运动下的变化。

Bulletin of the Osaka Medical College Pub Date : 1990-11-01

M Shimahara, K Ono, N Hashiguchi

{"title":"Pathohistological study on changes observed in the temporomandibular joint after experimental mutilation and shortening of the mandibular process with special reference to the changes under abnormal mandibular movement.","authors":"M Shimahara, K Ono, N Hashiguchi","doi":"","DOIUrl":"","url":null,"abstract":"Abnormal mandibular movement continues to occur when fracture of the mandibular process has resulted in abnormal occlusion or abnormal mandibular movement. However, what changes might occur in the temporomandibular joint have not yet been fully clarified. In the present study, a fracture of the condylar process was experimentally induced in rats, and the resulting bone ends were wired in place. That is to say, the resulting displacement was fixed permanently. Histological studies were made on the changes of the temporomandibular joint at the postoperative third month in those rats which demonstrated abnormal occlusion and abnormal mandibular movement. Lack of uniformity of the fibrous layer and a shallowing of the mandibular fossa; proliferation of the fibrous connective tissue and reduction in size of the superior and inferior articular cavity; tylosis and irregularity in the articular disc; deformation and tylosis of the fibrous layer of the articular cartilage, tendency of the layer structure in the articular cartilage to disappear, and some effect on cartilaginous ossification in the condyle; flattening of the condyle and thinning of the layer structure in the condylar articular cartilage in the unaffected side of the mandibular joint. These changes were observed to be more marked as the displacement and occlusal abnormality of the mandible intensified, showing no morphological adaptation of the temporomandibular joint.","PeriodicalId":77683,"journal":{"name":"Bulletin of the Osaka Medical College","volume":"36 1-2","pages":"79-92"},"PeriodicalIF":0.0,"publicationDate":"1990-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13289912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pupillary dynamics in patients with primary open angle glaucoma. 原发性开角型青光眼患者的瞳孔动力学。

Bulletin of the Osaka Medical College Pub Date : 1990-11-01

E Hashimoto-Takahashi

引用次数: 0

The role of MHC compatibility in recurrence of autoimmune type I diabetes mellitus: comparison of the immune response of BB/W rats to pancreatic islet and heart allografts. MHC相容性在自身免疫性I型糖尿病复发中的作用:BB/W大鼠对胰岛和心脏同种异体移植的免疫反应比较

Bulletin of the Osaka Medical College Pub Date : 1990-11-01

K Tezuka

{"title":"The role of MHC compatibility in recurrence of autoimmune type I diabetes mellitus: comparison of the immune response of BB/W rats to pancreatic islet and heart allografts.","authors":"K Tezuka","doi":"","DOIUrl":"","url":null,"abstract":"Human type I diabetes mellitus has been shown to be an autoimmune disease. The BioBreeding/Worcester (BB/W) rat is an excellent model of insulin dependent diabetes mellitus (IDDM). Using the spontaneous diabetic BB/W rats, autoimmune recurrence of diabetes mellitus was evaluated. To prevent allorejection of islets, a combination of ultraviolet B (UVB) donor islet pretreatment and brief peritransplant host immunosuppression with cyclosporine was utilized. Such combination led frequently to indefinite survival of MHC mismatched islets in the chronically diabetic BB/W recipients more than 15 days after onset of hyperglycemia, while MHC matched islets survived only briefly. The most likely reason for the relatively rapid loss of graft function of MHC matched islets is the autoimmune destruction by previously primed cells. The result of this study, together with the previous report of CHABOT et al that both MHC matched and MHC mismatched islets are destroyed in acutely diabetic BB/W rats (less than 15 days after onset) despite the use of UVB irradiation and cyclosporine, demonstrates that the initiation of autoimmune response toward islets is most likely MHC restricted. These results led to the conclusion that MHC matching may be contraindicated in future human pancreatic islet transplantation to avoid reactivation of the original autoimmune disease.","PeriodicalId":77683,"journal":{"name":"Bulletin of the Osaka Medical College","volume":"36 1-2","pages":"57-69"},"PeriodicalIF":0.0,"publicationDate":"1990-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13289910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alteration of natural killer cell subsets (two color analysis) and their activity in peripheral blood in inflammatory bowel disease. 炎性肠病患者外周血自然杀伤细胞亚群(双色分析)及其活性的改变

Bulletin of the Osaka Medical College Pub Date : 1990-11-01

I Hirata, K Hayashi, S Asada, H Miyoshi, K Iwakoshi, S Ohshiba

引用次数: 0

Effects of H+ and HCO3- secretion on mucus gel pH in isolated antral mucosa of bullfrog stomach. H+和HCO3-分泌对牛蛙离体胃窦黏膜粘液凝胶pH的影响。

Bulletin of the Osaka Medical College Pub Date : 1990-11-01

F Nagano, H Masaki, M Fujimoto, K Kotera, T Yonehara, S Ohshiba

{"title":"Effects of H+ and HCO3- secretion on mucus gel pH in isolated antral mucosa of bullfrog stomach.","authors":"F Nagano, H Masaki, M Fujimoto, K Kotera, T Yonehara, S Ohshiba","doi":"","DOIUrl":"","url":null,"abstract":"To study the mechanism of self-protection of the gastric surface epithelium, we measured the pH gradient of the mucus gel layer in the isolated bullfrog antral mucosa with pH-sensitive microelectrodes in the Ussing chamber preparation. Under the control condition of 15mM HCO3- and 1.5% CO2 serosal perfusion, the pH on the interface between luminal solution and mucus gel layer (pHLMI) was 6.04 +/- 0.12 (n = 7), and the pH on the interface between the mucus gel layer and epithelial cell (pHMEI) was 5.69 +/- 0.13 (n = 7). When gastric acid secretion was stimulated by histamine (10(-4) M), the pHLMI became 5.43 +/- 0.12 (n = 4) and the pHMEI 4.40 +/- 0.18 (n = 4). Inhibition of acid secretion by cimetidine (10(-4) M) raised the pHLMI to 6.51 +/- 0.07 (n = 7) and the pHMEI to 6.23 +/- 0.08 (n = 7). Omeprazole (10(-4) M) also raised the pHLMI and the pHMEI to 6.78 +/- 0.13 (n = 7) and 6.56 +/- 0.13 (n = 7), respectively. These data suggested that the H+ ions secreted from the oxyntic cells were able to diffuse to the lateral side within the mucus gel layer, affecting the local pH just above the surface epithelial cells. Under high serosal HCO3- condition (45mM HCO3- and 1.5% CO2 in serosal side), the pHLMI and the pHMEI were elevated to 7.22 +/- 0.10 (n = 7) and 6.92 +/- 0.10 (n = 7), respectively. This result suggested that HCO3- secretion, which was served to neutralize the invading acid, depended upon the supply of HCO3- from the serosal medium. Thus, the serosal HCO3- would be working not only in the acid-protection, but also in the maintenance of pH gradient across the mucus gel layer.","PeriodicalId":77683,"journal":{"name":"Bulletin of the Osaka Medical College","volume":"36 1-2","pages":"13-25"},"PeriodicalIF":0.0,"publicationDate":"1990-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13289387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum and urinary N-acetyl-beta-D-glucosaminidase activity among the inhabitants of a rural area in Japan--the effect of age and hypertension. 日本农村地区居民血清和尿液n-乙酰- β - d -氨基葡萄糖酶活性——年龄和高血压的影响

Bulletin of the Osaka Medical College Pub Date : 1990-11-01

K Kono, Y Yoshida, M Watanabe, H Watanabe, S Inoue, Y Tanioka, T Dote, Y Orita, K Umebayashi, Y Tanimura

{"title":"Serum and urinary N-acetyl-beta-D-glucosaminidase activity among the inhabitants of a rural area in Japan--the effect of age and hypertension.","authors":"K Kono, Y Yoshida, M Watanabe, H Watanabe, S Inoue, Y Tanioka, T Dote, Y Orita, K Umebayashi, Y Tanimura","doi":"","DOIUrl":"","url":null,"abstract":"In this paper, the normal values, distribution, and variations in serum and urinary activities of the lysosomal enzyme, N-acetyl-beta-D-glucosaminidase (NAG), were estimated in a rural area of Japan. The frequency distribution of NAG activities both in the serum and urine of 1,152 males and females (aged 35 to 87), living in a rural area of Gifu Prefecture in Japan, showed an approximately log-normal distribution. Geometric mean values (with S.D. ranges) in healthy subjects (876 males and females) were 12.61 U/l (9.56-16.63) for serum NAG and 8.05 U/l (4.03-16.07) for urinary NAG. There was no significant difference between those of males and females. Serum and urinary NAG activities increased with advancing ages, and these NAG activities in hypertensive subjects were higher than those in normotensives. Since the serum and urinary levels of several commonly measured cytosolic chemicals were within normal limits, the above results could not be ascribed to tissue necrosis. Thus, the estimation of serum and urinary NAG could be a useful indicator discriminating the essential hypertensive patients from the normal subjects.","PeriodicalId":77683,"journal":{"name":"Bulletin of the Osaka Medical College","volume":"36 1-2","pages":"27-34"},"PeriodicalIF":0.0,"publicationDate":"1990-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13289388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An experimental study on the healing process after excision of the articular disc of the mandible--effect of short-term intermaxillary fixation. 下颌骨关节盘切除后愈合过程的实验研究——短期颌间固定的效果。

Bulletin of the Osaka Medical College Pub Date : 1990-11-01

M Shimahara, K Ono, N Hashiguchi, J Senda, T Shimamura, T Honke, S Higashisawa

{"title":"An experimental study on the healing process after excision of the articular disc of the mandible--effect of short-term intermaxillary fixation.","authors":"M Shimahara, K Ono, N Hashiguchi, J Senda, T Shimamura, T Honke, S Higashisawa","doi":"","DOIUrl":"","url":null,"abstract":"In the present study, intermaxillary fixation for a period of 1 or 2 weeks after excision of the articular disc was administered to maturing rats. After removal of the fixation, the animals were allowed unrestricted mandibular movement. Histological observations were made at the postoperative 3rd month in those rats which demonstrated normal occlusion. As a result, it was found that the normal articular disc did not regenerate. However, in the articular cavity, both connective tissue and articular disc-like structures were found. The major changes in the mandibular fossa were tylosis of the outer fibrous layer of the fossa and an accompanying shallowing tendency. The major changes in the condyle were tylosis and morphological deformation of the fibrous layer of the parietal region. The deformation was mainly manifested by a fan-shaped hypertrophy. In the cases in which neither connective tissue nor articular disc-like structures were present in the articular cavity, changes in the mandibular fossa and condyle were remarkable. The appearance of the articular disc-like structure was more frequent in cases with 2-week intermaxillary fixation than in those with 1-week fixation.","PeriodicalId":77683,"journal":{"name":"Bulletin of the Osaka Medical College","volume":"36 1-2","pages":"93-102"},"PeriodicalIF":0.0,"publicationDate":"1990-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13289913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnosis of familial dysalbuminemic hyperthyroxinemia and investigation of the nature of the variant albumin. 家族性白蛋白异常血症性高甲状腺素血症的诊断及变异白蛋白性质的研究。

Bulletin of the Osaka Medical College Pub Date : 1990-11-01

J Takamatsu, N Ohsawa

引用次数: 0

Studies on the treatment of hydrofluoric acid burn. 氢氟酸烧伤的治疗研究。

Bulletin of the Osaka Medical College Pub Date : 1989-11-01

M Murao

引用次数: 0