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Biulleten' Vsesoiuznogo kardiologicheskogo nauchnogo tsentra AMN SSSR最新文献

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[An immunoenzyme method of diagnosing familial hypercholesterolemia]. [一种诊断家族性高胆固醇血症的免疫酶方法]。
Biulleten' Vsesoiuznogo kardiologicheskogo nauchnogo tsentra AMN SSSR Pub Date : 1988-01-01
I V Fuki, S N Preobrazhenskiĭ, Kh A Kurdanov, V S Repin, Kh A Khashimov
{"title":"[An immunoenzyme method of diagnosing familial hypercholesterolemia].","authors":"I V Fuki,&nbsp;S N Preobrazhenskiĭ,&nbsp;Kh A Kurdanov,&nbsp;V S Repin,&nbsp;Kh A Khashimov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A new modification of enzyme immunoassay: enzyme-linked-immunoreceptor assay (ELIRA)--was used to study the activity of LDL-receptors on cultured fibroblasts from 10 patients with elevated plasma cholesterol levels, IHD, accelerated atherosclerosis and xanthomatosis. Four patients were found to have heterozygous form of familial hypercholesterolemia. We have also shown that the results of ELIRA were quantitatively similar to the data obtained by traditional radioisotopic method. This indicates that simple, rapid, inexpensive ELIRA can be used for diagnosis of FH.</p>","PeriodicalId":77680,"journal":{"name":"Biulleten' Vsesoiuznogo kardiologicheskogo nauchnogo tsentra AMN SSSR","volume":"11 1","pages":"107-9"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14174457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Comparison of methods for computer and visual assessment of stenosing lesions of the coronary arteries. 1]. 冠状动脉狭窄病变的计算机与视觉评估方法比较。1]。
Biulleten' Vsesoiuznogo kardiologicheskogo nauchnogo tsentra AMN SSSR Pub Date : 1988-01-01
E V Pomerantsev, M L Blank, A A Smirnov, S A Abugov, A P Savchenko
{"title":"[Comparison of methods for computer and visual assessment of stenosing lesions of the coronary arteries. 1].","authors":"E V Pomerantsev,&nbsp;M L Blank,&nbsp;A A Smirnov,&nbsp;S A Abugov,&nbsp;A P Savchenko","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A system of computer analysis of coronary arteries stenotic lesions developed in the USSR Cardiology Research Centre, Academy of Medical Sciences of the USSR, is described. Reliability of the computer analysis data was assessed, and computer and visual methods were compared on the basis of phantom study. The study was performed in 5 models of stenotic coronary arteries, the main parameters of which were measured mechanically as well as by computer and visual analysis of their images. Both methods proved to give highly reproducible intraobserver and interobserver results. Comparison to mechanically obtained data showed that the results of computer analysis are highly significant while visual evaluation allows no accurate evaluation of the stenosis degree (it is overestimated).</p>","PeriodicalId":77680,"journal":{"name":"Biulleten' Vsesoiuznogo kardiologicheskogo nauchnogo tsentra AMN SSSR","volume":"11 2","pages":"62-7"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14201157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Calcium metabolism of the thrombocytes in ischemic heart disease]. 缺血性心脏病中血栓细胞的钙代谢
Biulleten' Vsesoiuznogo kardiologicheskogo nauchnogo tsentra AMN SSSR Pub Date : 1988-01-01
V G Kiktev, M Iu Men'shikov, E M Bugriĭ, A V Kuz'min, Iu A Karpov
{"title":"[Calcium metabolism of the thrombocytes in ischemic heart disease].","authors":"V G Kiktev,&nbsp;M Iu Men'shikov,&nbsp;E M Bugriĭ,&nbsp;A V Kuz'min,&nbsp;Iu A Karpov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Changes in Ca++ concentration were studied in platelets of patients with acute myocardial infarction, unstable or stable angina pectoris and those of healthy donors by means of fluorescent probe Quin-2 AM. Influence of aggregation inductors on the process of Ca++ level increase in these cells was also investigated. Intracellular Ca++ concentration increased in patients with acute myocardial infarction in the presence of PAF 2.10(-7) M (1337 +/- 255 nM) and in the presence of ADP 10(-5) M (1767 +/- 296 nM). A certain increase in calcium responses to stimulators was observed also in patients with unstable or stable angina pectoris. Dynamic follow up of patients with acute myocardial infarction starting from the 14th day demonstrated significant fall in intracellular Ca++ concentration (from 1767 +/- 296 nM to 834 +/- 186 nM, p less than 0.01). Platelet sensitivity to inductors during the course of therapy did not change significantly in patients with stable angina pectoris and tended to decrease in those with unstable angina pectoris (from 707 +/- 274 nM to 410 +/- 95 nM, p greater than 0.05). Increase in platelet aggregability and in calcium responses to stimulators in patients with IHD is an evidence of calcium metabolism disturbances which play an important role in the pathogenesis of the disease.</p>","PeriodicalId":77680,"journal":{"name":"Biulleten' Vsesoiuznogo kardiologicheskogo nauchnogo tsentra AMN SSSR","volume":"11 2","pages":"58-61"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14362511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Myocardial ultrastructure, energetics and function in chronic adriamycin-induced lesions]. [慢性阿霉素诱导病变的心肌超微结构、能量学和功能]。
Biulleten' Vsesoiuznogo kardiologicheskogo nauchnogo tsentra AMN SSSR Pub Date : 1988-01-01
V I Kapel'ko, M I Popovich, V G Sharov, S I Kostin, M A Golikov
{"title":"[Myocardial ultrastructure, energetics and function in chronic adriamycin-induced lesions].","authors":"V I Kapel'ko,&nbsp;M I Popovich,&nbsp;V G Sharov,&nbsp;S I Kostin,&nbsp;M A Golikov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The ultrastructural study of the myocardium of rats received adriamycin for 8-10 weeks revealed the picture of mosaic lesions of cardiomyocytes. Cells with little changes were coincided with apparently changed cardiomyocytes in which hypercontracted or atrophied sarcomeres with distended Z-lines, glycogen disappearance and swollen or hypertrophied mitochondria were seen. Myocardial content of ATP did not change but that of phosphocreatine was decreased by 45 percent. The pump function of the isolated heart was moderately lower that was associated with almost twofold increase in left ventricular diastolic stiffness suggesting a deterioration of its filling. A rise in Ca++ concentration in the perfusate exerted similar positive inotropic effect on hearts of both groups which was associated with a prominent fall of diastolic stiffness. Results suggest that increased diastolic stiffness in adriamycin-treated hearts may be due to both local ATP deficiency in myofibrils or incomplete Ca++ removal from them.</p>","PeriodicalId":77680,"journal":{"name":"Biulleten' Vsesoiuznogo kardiologicheskogo nauchnogo tsentra AMN SSSR","volume":"11 2","pages":"22-7"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14363404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Comparative pharmacological characteristics of peptides of the atrial natriuretic factor family]. 【心房利钠因子家族多肽的比较药理学特征】。
Biulleten' Vsesoiuznogo kardiologicheskogo nauchnogo tsentra AMN SSSR Pub Date : 1988-01-01
Zh D Bespalova, V A Vinogradov, S V Zhukovskiĭ, M I Kaĭkov, N V Korobov
{"title":"[Comparative pharmacological characteristics of peptides of the atrial natriuretic factor family].","authors":"Zh D Bespalova,&nbsp;V A Vinogradov,&nbsp;S V Zhukovskiĭ,&nbsp;M I Kaĭkov,&nbsp;N V Korobov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Comparative antihypertensive and natriuretic activities of atrial natriuretic factor (ANF) and its nearest shortened analogues--atriopeptines (AP) were studied in vivo on narcotized rats; and their peripheral vasodilating activities were studied in vitro on isolated rings of rat's thoracic aorta. The results obtained in vivo allow a following series of comparative antihypertensive and vasodilating activity: alpha rANF greater than APII greater than AP7-27. alpha rANF, APIII and APII did not differ significantly in vasodilating activity on isolated vessels; analogue 7-27 was less active. Thus further search of highly active shortened atriopeptin analogues is necessary for developing new drugs on their basis.</p>","PeriodicalId":77680,"journal":{"name":"Biulleten' Vsesoiuznogo kardiologicheskogo nauchnogo tsentra AMN SSSR","volume":"11 1","pages":"86-9"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14105275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The genetics of noncoronarogenic lesions of the heart muscle]. [心肌非冠状病变的遗传学]。
Biulleten' Vsesoiuznogo kardiologicheskogo nauchnogo tsentra AMN SSSR Pub Date : 1988-01-01
V A Koshechkin
{"title":"[The genetics of noncoronarogenic lesions of the heart muscle].","authors":"V A Koshechkin","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77680,"journal":{"name":"Biulleten' Vsesoiuznogo kardiologicheskogo nauchnogo tsentra AMN SSSR","volume":"11 2","pages":"106-14"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14277983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Indirect signs of coronary reperfusion in patients with myocardial infarction]. 【心肌梗死患者冠脉再灌注的间接征象】。
Biulleten' Vsesoiuznogo kardiologicheskogo nauchnogo tsentra AMN SSSR Pub Date : 1988-01-01
A A Smirnov
{"title":"[Indirect signs of coronary reperfusion in patients with myocardial infarction].","authors":"A A Smirnov","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77680,"journal":{"name":"Biulleten' Vsesoiuznogo kardiologicheskogo nauchnogo tsentra AMN SSSR","volume":"11 1","pages":"112-3"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14525165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Calcium metabolism in arterial hypertension. II. Changes in thrombocyte sensitivity to verapamil]. 动脉性高血压的钙代谢。2血小板对维拉帕米敏感性的变化[j]。
Biulleten' Vsesoiuznogo kardiologicheskogo nauchnogo tsentra AMN SSSR Pub Date : 1988-01-01
Sh E Atakhanov, E B Tkhostova, A P Iurenev, M Iu Men'shikov, A V Mazaev
{"title":"[Calcium metabolism in arterial hypertension. II. Changes in thrombocyte sensitivity to verapamil].","authors":"Sh E Atakhanov,&nbsp;E B Tkhostova,&nbsp;A P Iurenev,&nbsp;M Iu Men'shikov,&nbsp;A V Mazaev","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Verapamil produced dose-dependent inhibition of ADP- and TAF-induced increase in thrombocyte calcium concentration in hypertensive patients. Sensitivity to verapamil tested by EC50-half-maximal inhibition of responses to hormones can be weakened in vitro by adrenalin and strengthened by papaverin. Thrombocytes of hypertensive patients were individually sensitive to combination of papaverin and verapamil. The cellular sensitivity to verapamil disappeared when clonidine was substituted for verapamil and was restored when papaverin was added to verapamil.</p>","PeriodicalId":77680,"journal":{"name":"Biulleten' Vsesoiuznogo kardiologicheskogo nauchnogo tsentra AMN SSSR","volume":"11 1","pages":"28-32"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14525166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Use of computerized tomography in the study of the etiology of various forms of symptomatic arterial hypertension]. [利用计算机断层扫描研究各种形式的症状性动脉高血压的病因]。
Biulleten' Vsesoiuznogo kardiologicheskogo nauchnogo tsentra AMN SSSR Pub Date : 1988-01-01
L S Shapkina, G N Pogrebnaia, F I Tolua
{"title":"[Use of computerized tomography in the study of the etiology of various forms of symptomatic arterial hypertension].","authors":"L S Shapkina,&nbsp;G N Pogrebnaia,&nbsp;F I Tolua","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In 181 patients with arterial hypertension of various genesis clinical-laboratory data were compared with those obtained by computed tomography of kidneys and adrenal glands for etiology verification. Computer tomography is proved to be a valuable noninvasive method for elucidation of retroperitoneal space organs pathology which can cause arterial hypertension. Hormonal-active tumors are better identified when patients are purposely selected according to the catecholamine and VMA levels as well as the state of renin-angiotensin-aldosterone system. Computer tomography allowed determination of alterations in kidneys including those not identifiable by other methods (small cysts in kidneys, tumors, concrements).</p>","PeriodicalId":77680,"journal":{"name":"Biulleten' Vsesoiuznogo kardiologicheskogo nauchnogo tsentra AMN SSSR","volume":"11 1","pages":"41-3"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14525169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Activities of plasma proteinases and their acid-stable urinary inhibitors in patients with arterial hypertension]. [高血压患者血浆蛋白酶及其酸稳定尿抑制剂的活性]。
Biulleten' Vsesoiuznogo kardiologicheskogo nauchnogo tsentra AMN SSSR Pub Date : 1988-01-01
G A Parfenkova, O G Orloblina, V K Sitina
{"title":"[Activities of plasma proteinases and their acid-stable urinary inhibitors in patients with arterial hypertension].","authors":"G A Parfenkova,&nbsp;O G Orloblina,&nbsp;V K Sitina","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The data obtained allow to consider urine acid-stable proteinase inhibitor (ASPI) activity as an early and informative index of renal parenchyma damage in patients with renal symptomatic arterial hypertensions without significant urine changes. Urine ASPI activities seems to be useful in differentiation of patients with chronic glomerulonephritis without significant urine changes and patients with hypertensions.</p>","PeriodicalId":77680,"journal":{"name":"Biulleten' Vsesoiuznogo kardiologicheskogo nauchnogo tsentra AMN SSSR","volume":"11 1","pages":"43-6"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14527528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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