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Biological research in pregnancy and perinatology最新文献

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RDS prophylaxis in preterm labor: corticosteroids and beta-mimetics association-indications and limits. 早产的RDS预防:皮质类固醇和β -模拟物相关的适应症和限制。
Biological research in pregnancy and perinatology Pub Date : 1984-01-01
F E Mansani, M Caltabiano, F Gazza
{"title":"RDS prophylaxis in preterm labor: corticosteroids and beta-mimetics association-indications and limits.","authors":"F E Mansani,&nbsp;M Caltabiano,&nbsp;F Gazza","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This study relates an incidence of maternal and feto-neonatal side effects at the Institute of Obstetrics and Gynecology of the University of Parma. Neonatal morbidity and mortality upon administration of corticosteroids and beta-mimetic drugs were observed. Remarkable was the low rate of maternal side effects and that their seriousness was quite inferior to that found by other authors. The fetal and neonatal side effects or symptoms were very few and it was impossible to ascertain whether they were due to the therapy, a consequence of maternal pathological events, the kind of delivery, gestational age or some other unknown factor. Finally, this study points out that the maternal, fetal and neonatal side effects can not be considered serious enough to judge the associated tocolytic and corticosteroid treatment unacceptable.</p>","PeriodicalId":77679,"journal":{"name":"Biological research in pregnancy and perinatology","volume":"5 4","pages":"153-6"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17581966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HLA typing in couples with repetitive abortion. 反复流产夫妇的HLA分型。
Biological research in pregnancy and perinatology Pub Date : 1984-01-01
P F Bolis, M M Bianchi, V Soro, M Belvedere
{"title":"HLA typing in couples with repetitive abortion.","authors":"P F Bolis,&nbsp;M M Bianchi,&nbsp;V Soro,&nbsp;M Belvedere","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Highly inbred strains of mice have a reduced reproductive capacity. In contrast, an increased capacity is associated with an immune response to placental antigens. In humans, repeated miscarriages seem to be associated to a higher frequency of HLA allele BW35. Twenty couples with repetitive spontaneous abortions of unknown etiology and 20 control couples with normal fertility were HLA typed. The sera of wives of infertile couples were tested against the husbands lymphocytes in complement dependent lympholysis test in order to detect anti-paternal HLA antibodies. The data show an HLA significant compatibility between the husbands and the wives with a history of repetitive spontaneous abortions. The best probability of evaluating different loci is that of HLA-A (p less than 0.01). The frequency of HLA-BW35 in women with repeated miscarriages is higher than in control women or than in the general Italian population. In infertile couples, all the sera collected from the wife were negative against the husband lymphocytes.</p>","PeriodicalId":77679,"journal":{"name":"Biological research in pregnancy and perinatology","volume":"5 3","pages":"135-7"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17648305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human amniotic membrane and prostaglandin biosynthesis. 人羊膜与前列腺素的生物合成。
Biological research in pregnancy and perinatology Pub Date : 1984-01-01
K Kinoshita, K Satoh, S Sakamoto
{"title":"Human amniotic membrane and prostaglandin biosynthesis.","authors":"K Kinoshita,&nbsp;K Satoh,&nbsp;S Sakamoto","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The human amnion has become a significant tissue for metabolism of chemical substances with biologic activities, such as steroid hormones and prostaglandins. In this paper our studies on the biosynthesis of prostaglandins in human amnion focused on the role of prostaglandins in initiating and maintaining labor. First of all, the source of prostaglandins released in amniotic fluid was investigated. The amnion was demonstrated to possess the highest activity of generating prostaglandins among amnion, chorion laeve, and decidua vera, obtained after normal vaginal delivery. Subsequently, the bioconversion of arachidonic acid into prostaglandins and related compounds using the homogenate of human amnion was carried out without the addition of cofactors in the incubation mixture to show the natural spectrum of various types of PGs formed. PGE2 was revealed to be a main product of the amnion; its conversion rate was 5% of incubated radioactivity. Other compounds catalyzed by cyclooxygenase were PGF2 alpha (0.2%), TXB2 (0.3%), and HHT (1-2%), whereas 15-HETE (2-3%) and a mixture of 9, 11, 12-HETE (1-2%) were formed by lipoxygenase in the amnion. And third, the activity to produce PGE2 in the amnion obtained at normal vaginal delivery was greater than that obtained at cesarean section prior to the onset of labor. Thus, these results suggested that the amnion played a significant role in prostaglandin biosynthesis in uterine tissues. To provide a better understanding of the metabolism of arachidonic acid in the amnion as regards initiation and maintenance of labor, we discuss prostaglandin biosynthesis in the amnion and the mechanism of arachidonic acid release.</p>","PeriodicalId":77679,"journal":{"name":"Biological research in pregnancy and perinatology","volume":"5 2","pages":"61-7"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17797271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Simple assay of estrogen in urine during pregnancy by means of latex agglutination inhibition reaction. 用乳胶凝集抑制反应的方法测定妊娠期尿中雌激素。
Biological research in pregnancy and perinatology Pub Date : 1984-01-01
R Tahara, K Ogawa, T Kosaki, K Matsuhashi, T Yanaihara, T Nakayama
{"title":"Simple assay of estrogen in urine during pregnancy by means of latex agglutination inhibition reaction.","authors":"R Tahara,&nbsp;K Ogawa,&nbsp;T Kosaki,&nbsp;K Matsuhashi,&nbsp;T Yanaihara,&nbsp;T Nakayama","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A simple and rapid method, latex agglutination inhibition reaction (LAIR), using anti-estriol-16-glucuronide coupled with BSA for estimating estrogen in urine has been developed. Agglutination of the latex reagent by the antiserum occurs within 3 min. The agglutination, however, was completely inhibited by 100 ng/ml or more of estriol. There was a good correlation in results obtained by LAIR and by colorimetry, RIA and GLC. Urine samples (3329) obtained at various gestational weeks were assayed. The samples from 94% of the normal pregnant patients in the third trimester revealed 10 micrograms/ml or more of estrogens. Although the assay is semiquantitative, it may be useful in screening for fetal well-being in high-risk pregnancies.</p>","PeriodicalId":77679,"journal":{"name":"Biological research in pregnancy and perinatology","volume":"5 2","pages":"74-7"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17797273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of cadmium on the placental uptake and transport to the fetus of nutrients. 镉对胎盘吸收和向胎儿输送营养物质的影响。
Biological research in pregnancy and perinatology Pub Date : 1984-01-01
B R Danielsson, L Dencker
{"title":"Effects of cadmium on the placental uptake and transport to the fetus of nutrients.","authors":"B R Danielsson,&nbsp;L Dencker","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cadmium (Cd) is known to produce malformations, growth inhibition of the fetus, and placental necrosis in rodents at higher doses (3-4 mg/kg body wt). We studied the influence of Cd in various doses (0.5-4 mg/kg body wt) and at different survival intervals on the placental uptake and transfer to the fetus of vitamin B12 (vit. B12), zinc (Zn), alpha-aminobutyric acid (AIB), and deoxyglucose (DOX). These were chosen to represent various mechanisms of membrane transport. We show that vit. B12, which is accumulated in the placenta by a presumed receptor-mediated mechanism, is most easily disturbed by Cd. Thus, a significant decrease in transfer to the fetus was seen already 1 h after a high dose (4 mg/kg body wt) of Cd, and also at longer intervals (24 h) after low doses (0.5 mg/kg body wt). The transport of Zn (chemically similar to Cd) was also disturbed, but its inhibition was probably due in part to a decreased maternal serum concentration. The transport of AIB and DOX was largely unaffected. We conclude that inhibition of nutrient transfer to the fetus may be the underlying mechanism of growth retardation and possibly of the malformations produced by Cd. Vitamin B12 may be a sensitive indicator of early and subtle disturbances of placental function, not only for Cd but also for other chemicals suspected of causing placental disturbances.</p>","PeriodicalId":77679,"journal":{"name":"Biological research in pregnancy and perinatology","volume":"5 3","pages":"93-101"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17535998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dynamic fetoplacental unit function test with dehydroepiandrosterone sulfate. 硫酸脱氢表雄酮动态胎胎盘单位功能试验。
Biological research in pregnancy and perinatology Pub Date : 1984-01-01
G Zucconi, P Borri, P Ciardetti, C Cozzi, P Buzzoni
{"title":"Dynamic fetoplacental unit function test with dehydroepiandrosterone sulfate.","authors":"G Zucconi,&nbsp;P Borri,&nbsp;P Ciardetti,&nbsp;C Cozzi,&nbsp;P Buzzoni","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The authors present their experience with the dynamic fetoplacental unit function test using a commercial product containing dehydroepiandrosterone sulfate. The recent literature is cited and the results are discussed. Emphasis is placed on the practicability and applicability of the method in connection with a continuous, reliable evaluation of \"at risk\" pregnancy.</p>","PeriodicalId":77679,"journal":{"name":"Biological research in pregnancy and perinatology","volume":"5 2","pages":"90-2"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17297936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phototherapy in bile duct-ligated Gunn rats. 胆管结扎大鼠的光疗。
Biological research in pregnancy and perinatology Pub Date : 1984-01-01
L Ballowitz, W H Müller, G Wiese
{"title":"Phototherapy in bile duct-ligated Gunn rats.","authors":"L Ballowitz,&nbsp;W H Müller,&nbsp;G Wiese","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Davis and co-workers reported on the failure of phototherapy to reduce plasma bilirubin levels in the bile duct-ligated Gunn rat. We cannot confirm this conclusion. We found that the effect was reduced by a factor of 4-5. With higher effective irradiances distinct decreases of the serum bilirubin concentration can be achieved and the excretion of bilirubin photoproducts in the urine markedly will rise.</p>","PeriodicalId":77679,"journal":{"name":"Biological research in pregnancy and perinatology","volume":"5 1","pages":"36-41"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17758302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Blood sampling from the ovarian vein in the unstressed pregnant guinea pig. 从没有压力的怀孕豚鼠的卵巢静脉抽血。
Biological research in pregnancy and perinatology Pub Date : 1984-01-01
L L Peeters, H C Wallenburg
{"title":"Blood sampling from the ovarian vein in the unstressed pregnant guinea pig.","authors":"L L Peeters,&nbsp;H C Wallenburg","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A new technique is described which allows sampling of blood from the ovarian vein in the pregnant guinea pig, after recovery from surgery and anesthesia. The technique involves retrograde insertion of a double catheter into the thoracic inferior vena cava from the right jugular vein. The outer catheter serves as a guide for the inner catheter which is advanced into either ovarian vein. The overall rate of success was 45% in 40 animals near term. Sampling of blood from the ovarian vein in the conscious animal remained possible for up to 17 days after surgery. Since in the pregnant guinea pig the ovarian veins drain most of the uteroplacental blood, the technique of retrograde cannulation of the ovarian vein allows study of uteroplacental metabolism in the conscious pregnant animal during prolonged periods.</p>","PeriodicalId":77679,"journal":{"name":"Biological research in pregnancy and perinatology","volume":"5 3","pages":"118-20"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17535996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of prostacyclin on fetal platelet function. 前列环素对胎儿血小板功能的影响。
Biological research in pregnancy and perinatology Pub Date : 1984-01-01
T Matsumoto, M Kihira, M Ito, Y Sugiyama
{"title":"Effects of prostacyclin on fetal platelet function.","authors":"T Matsumoto,&nbsp;M Kihira,&nbsp;M Ito,&nbsp;Y Sugiyama","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Prostacyclin (PGI2), the major active metabolite of arachidonic acid in the vascular endothelium, is characterized by antiaggregatory and vasodilator properties. In this report the significance of PGI2 on fetal platelets was studied. Platelet aggregation induced by ADP, collagen, and adrenaline was found to be augmented in maternal blood but suppressed in umbilical cord blood. The plasma beta-thromboglobulin levels were higher in maternal and umbilical cord blood compared with that of a control group. Plasma 6-keto-PGF1 alpha, TxB2, cyclic AMP, and cyclic GMP values were significantly higher in umbilical cord blood than in maternal blood. A much larger amount of PGI2-like substance was released from the umbilical vessels than from the placental vascular tissues. The generation of this substance was reduced in the umbilical vessels in patients with severe pre-eclampsia associated with intrauterine fetal growth retardation. These results indicate that various factors, such as PGI2, TxA2, and cyclic nucleotides, may co-exist at high levels in the fetus. A balance is needed to maintain physical interaction between platelets and the vascular wall in the fetal blood vessels. Especially PGI2 may play an important role in this balance and in the regulation of the placental-fetal circulation.</p>","PeriodicalId":77679,"journal":{"name":"Biological research in pregnancy and perinatology","volume":"5 1","pages":"11-5"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17383908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Caffeine, theophylline and theobromine in pregnancy. 孕期咖啡因，茶碱和可可碱。
Biological research in pregnancy and perinatology Pub Date : 1984-01-01
I H Tebbutt, A J Teare, J H Meek, K A Mallett, D F Hawkins
{"title":"Caffeine, theophylline and theobromine in pregnancy.","authors":"I H Tebbutt,&nbsp;A J Teare,&nbsp;J H Meek,&nbsp;K A Mallett,&nbsp;D F Hawkins","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Dietary surveys estimated the caffeine intake of pregnant women in London to average 1.4 mmol (270 mg) with a range of 0 to 6.0 mmol (0-1160 mg)/day. The average plasma caffeine was 6.5 (SD 2.8-14.8), plasma theophylline 2.9 (SD 1.3-6.7), plasma theobromine 2.1 (SD 0.9-4.9) mumol/l. The results of the dietary surveys showed a fair correlation (r = 0.59; p less than 0.01) with plasma caffeine levels, but the surveys are best regarded as a basis for counseling rather than an accurate estimate of intake.</p>","PeriodicalId":77679,"journal":{"name":"Biological research in pregnancy and perinatology","volume":"5 4","pages":"174-6"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17581967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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