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Biological research in pregnancy and perinatology最新文献

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Alterations of immunologic parameters in pregnancies complicated by EPH-gestosis. 妊娠合并epf妊娠的免疫参数改变。
Biological research in pregnancy and perinatology Pub Date : 1985-01-01
W Bartl, G Bernaschek, G Wagner, K Liszka
{"title":"Alterations of immunologic parameters in pregnancies complicated by EPH-gestosis.","authors":"W Bartl,&nbsp;G Bernaschek,&nbsp;G Wagner,&nbsp;K Liszka","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>To characterize the cellular and humoral immune situation in pregnancies with EPH-gestosis (n = 44), percentages of peripheral T-lymphocytes, ratio of helper and suppressor T-lymphocytes further circulating immuncomplexes (CIC), beta 2-Microglobulin (beta 2-MG) and lysozyme (Lz) were determined. 50 pregnant women without EPH-gestosis were examined as controls. The mean counts of total lymphocytes decreased with increasing gestosis index in contrast to T-lymphocyte percentages. The mean T-helper/T-suppressorcell ratio indicated a severe imbalance in a few cases with severe gestosis. CIC were present in all serum samples of patients with moderate and severe gestosis. Lz was found to be elevated in EPH-gestosis in correlation to severity of disease. beta 2-MG levels in serum were only increased in women with reduced renal function. This parameter was not strictly correlated to the severity of EPH-gestosis but only to the degree of kidney dysfunctioning. EPH-gestosis represents a heterogeneous group with uniform symptomatology. Only in severe gestosis an imbalance of T-lymphocyte subpopulations as well as CIC and elevated Lz levels were detected. In mild gestosis no alterations of the used parameters were found.</p>","PeriodicalId":77679,"journal":{"name":"Biological research in pregnancy and perinatology","volume":"6 2","pages":"73-8"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15009120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lithium in pregnancy--avoidance of toxicity. A case report. 孕期使用锂——避免中毒。一份病例报告。
Biological research in pregnancy and perinatology Pub Date : 1985-01-01
K R Kaufman, B L Okeya
{"title":"Lithium in pregnancy--avoidance of toxicity. A case report.","authors":"K R Kaufman,&nbsp;B L Okeya","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The authors present a case in which lithium toxicity in a pregnant patient was avoided. If salt restriction and/or diuretics are necessary during lithium therapy in pregnancy, the authors recommend the careful monitoring of lithium side effects, dosage, and serum levels. Further, lithium therapy should be discontinued twenty-four hours prior to delivery and only restarted after post-delivery levels have been carefully reevaluated.</p>","PeriodicalId":77679,"journal":{"name":"Biological research in pregnancy and perinatology","volume":"6 2","pages":"55-8"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15039802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of bromocriptine on plasma prolactin, human placental lactogen, beta-HCG and steroid hormones in early human pregnancy. 溴隐亭对妊娠早期血浆催乳素、胎盘乳原、β - hcg及类固醇激素的影响。
Biological research in pregnancy and perinatology Pub Date : 1985-01-01
A Tolino, A Tedeschi, U Montemagno
{"title":"Influence of bromocriptine on plasma prolactin, human placental lactogen, beta-HCG and steroid hormones in early human pregnancy.","authors":"A Tolino,&nbsp;A Tedeschi,&nbsp;U Montemagno","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>To study the role of prolactin in the regulation of the production of 17 beta-oestradiol, HPL, beta-HCG, progesterone, testosterone, delta 4-androstenedione and 5 alpha-dihydrotestosterone, 20 healthy women were given 5 mg of bromocriptine daily for two weeks between 7-9 weeks of normal pregnancy. Plasma HPRL, HPL, HCG, oestradiol, progesterone, testosterone, delta 4-androstenedione and 5 alpha-dihydrotestosterone levels were measured before and one and two weeks after the start of bromocriptine-application, and they were compared with those examined in control groups (18 women). Bromocriptine induced a significant HPRL depression at one week and two weeks. Other hormones, except progesterone, showed no significant differences between two groups. These data suggest that neither maternal hypoprolactinemia nor bromocriptine during normal early human pregnancy interfere with the normal synthesis of sex steroids.</p>","PeriodicalId":77679,"journal":{"name":"Biological research in pregnancy and perinatology","volume":"6 2","pages":"70-2"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15127861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The outcome of pregnancy after chemotherapy for gestational trophoblastic disease. 妊娠滋养细胞疾病化疗后妊娠结局。
Biological research in pregnancy and perinatology Pub Date : 1985-01-01
F J Hsieh, T C Chen, Y T Cheng, S C Huang, C Y Hsieh, P C Ouyang
{"title":"The outcome of pregnancy after chemotherapy for gestational trophoblastic disease.","authors":"F J Hsieh,&nbsp;T C Chen,&nbsp;Y T Cheng,&nbsp;S C Huang,&nbsp;C Y Hsieh,&nbsp;P C Ouyang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Thirteen pregnancies in 11 women previously treated with cytotoxic chemotherapy for GTD were studied. There were 11 live full-term babies (84.6%), 2 blighted ova (15.4%), 1 placenta accreta (7.7%) and 1 fetal anomaly (7.7%). Unlike other series, 69% of the pregnancies occurred within 1 year after the termination of chemotherapy. The rate of successful pregnancy was not different from that reported by others. Prenatal elimination of abnormal embryos after conception rather than wastage of damaged oocyte before conception might explain this observed low incidence of abnormal birth in GTD patients treated with cytotoxic chemotherapy.</p>","PeriodicalId":77679,"journal":{"name":"Biological research in pregnancy and perinatology","volume":"6 4","pages":"177-80"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14132251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hyperprolactinemia and its effect on female sterility. 高催乳素血症及其对女性不育的影响。
Biological research in pregnancy and perinatology Pub Date : 1985-01-01
T Atasü, D Kösebay, M Arvas
{"title":"Hyperprolactinemia and its effect on female sterility.","authors":"T Atasü,&nbsp;D Kösebay,&nbsp;M Arvas","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Starting with the isolation and purification of human prolactin, several studies have been conducted in order to understand prolactin (PRL) physiology and pathology in the human. Results of research effected since then have shown that high levels of PRL could cause sterility either through its effects on ovulation at the hypothalamic, hypophyseal or gonadal level or through the inhibition of steroid synthesis in the ovaries which leads to amenorrhea. In parallel with these findings, bromocriptine, a dopamin agonist inhibiting PRL secretion has been used in the clinic for the treatment of hyperprolactinemic states and the positive results obtained confirmed the role of PRL in human reproduction. The aim of our study is to investigate the causative mechanisms of sterility in hyperprolactinemic patients. For this purpose, in hyperprolactinemic cases with sterility a possible correlation between the PRL values and endometrial changes is investigated. Our findings indicate that effects of PRL on the receptors of distal organs show individual variations and depend on the degree of receptor sensitivity. It is believed that the effects of PRL through receptor mediation deserve further investigation.</p>","PeriodicalId":77679,"journal":{"name":"Biological research in pregnancy and perinatology","volume":"6 3","pages":"133-6"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14951459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of pregnancy on the natural course of preexistent glomerular disease. 妊娠对既往肾小球疾病自然病程的影响。
Biological research in pregnancy and perinatology Pub Date : 1985-01-01
D Grekas, S Vasiliou, H Kalekou, A Tourkantonis
{"title":"Effect of pregnancy on the natural course of preexistent glomerular disease.","authors":"D Grekas,&nbsp;S Vasiliou,&nbsp;H Kalekou,&nbsp;A Tourkantonis","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The clinical course of pregnancies in 3 patients with well defined glomerular diseases is described. Two women who had moderate renal insufficiency (serum creatinine greater than or equal to 1.6 mg/dl) at conception had also a dramatic progress to end-stage renal disease during pregnancy which in one case resulted in fetal loss. Glomerular diseases were focal glomerular sclerosis and poststreptococcal glomerulonephritis respectively. One patient with membranoproliferative glomerulonephritis was not affected. It is concluded that pregnancy can change the natural course of preexistent glomerular disease in patients with impaired renal function.</p>","PeriodicalId":77679,"journal":{"name":"Biological research in pregnancy and perinatology","volume":"6 4","pages":"184-6"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15175396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The fetal distribution of some aliphatic chlorinated hydrocarbons in the rat after vapor phase exposure. 气相暴露后大鼠体内某些脂肪族氯代烃的胎儿分布。
Biological research in pregnancy and perinatology Pub Date : 1985-01-01
J R Withey, K Karpinski
{"title":"The fetal distribution of some aliphatic chlorinated hydrocarbons in the rat after vapor phase exposure.","authors":"J R Withey,&nbsp;K Karpinski","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Rats, on the 17th day of pregnancy, were exposed for five h to several different concentrations, ranging from about 100 to 3,000 ppm, of methylene chloride, 1,2-dichloroethane, chloroform and trichloroethylene. Immediately following exposure, the concentrations of these compounds were determined in each fetus and in the maternal blood and characterized as a function of the administered dose. Fetal weights and fetal concentrations were related to their position on the two horns of the uterus. Fetal weight distribution conformed with observations previously reported [Withey and Karpinski 1983, Barr et al. 1969]. Fetuses at either end of each branch of the uterine horns had the lowest concentration of trichloroethylene. The data for methylene chloride and dichloroethane revealed a linear decrease in fetal concentration with the location of the fetus from the ovarian to the cervical end of the uterine horns. These relationships were consistent across doses. Fetal chloroform concentrations did not appear to be related to fetal position. Good linear relationships between the mean fetal concentrations and the maternal blood concentrations with exposure level were observed for the four compounds used in this study.</p>","PeriodicalId":77679,"journal":{"name":"Biological research in pregnancy and perinatology","volume":"6 2","pages":"79-88"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15127862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Embryotoxic drugs. Embryotoxic药物。
Biological research in pregnancy and perinatology Pub Date : 1985-01-01
K Brendel, R C Duhamel, T H Shepard
{"title":"Embryotoxic drugs.","authors":"K Brendel,&nbsp;R C Duhamel,&nbsp;T H Shepard","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77679,"journal":{"name":"Biological research in pregnancy and perinatology","volume":"6 1","pages":"1-54"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13721946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fetal distribution of styrene in rats after vapor phase exposures. 气相暴露后苯乙烯在大鼠体内的胎儿分布。
Biological research in pregnancy and perinatology Pub Date : 1985-01-01
J R Withey, K Karpinski
{"title":"Fetal distribution of styrene in rats after vapor phase exposures.","authors":"J R Withey,&nbsp;K Karpinski","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Pregnant rats were subjected to a 5-hour exposure of either 2,000 or 1,000 ppm atmospheres of styrene. Concentrations of styrene in the maternal blood and in each fetus were measured. The fetal concentrations in the 2,000 ppm exposure group were significantly more than double that in the 1,000 ppm group. Fetal weight and distribution of styrene appear to be related to the fetal position on the uterine horn. Those at the ovarian and cervical ends of the uterine horn were of lowest weight and those at the ovarian end had the highest concentration of styrene. Concentrations of styrene appeared to be much lower in the fetuses than in maternal organs and tissues after similar exposures.</p>","PeriodicalId":77679,"journal":{"name":"Biological research in pregnancy and perinatology","volume":"6 2","pages":"59-64"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15127860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The enzyme immunosorbent assay (ELISA) for serologic diagnosis of toxoplasmosis in pregnancy. 酶免疫吸附试验(ELISA)在妊娠弓形虫病血清学诊断中的应用。
Biological research in pregnancy and perinatology Pub Date : 1984-01-01
M Luerti, C Corticelli, A Santini, G Privitera, G Nardi
{"title":"The enzyme immunosorbent assay (ELISA) for serologic diagnosis of toxoplasmosis in pregnancy.","authors":"M Luerti,&nbsp;C Corticelli,&nbsp;A Santini,&nbsp;G Privitera,&nbsp;G Nardi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The enzyme-linked immunosorbent assay (ELISA) is simple, quick, and inexpensive, characteristics that make it particularly suitable for large screening programs. We compared the results obtained by ELISA with those obtained by immunofluorescent antibody test (IFAT), indirect hemoagglutination test (IHAT), and Sabin Feldman Dye test in a group of 105 pregnant women in the course of a screening for toxoplasmosis. Prevalence of IgG antibody titers were not significantly different. ELISA results were particularly close to those of the reference tests (IFAT and Dye test).</p>","PeriodicalId":77679,"journal":{"name":"Biological research in pregnancy and perinatology","volume":"5 1","pages":"20-2"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17427291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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