Transfer of piperacillin to various uterine tissues. Piperacillin study group for application in the field of obstetrics and gynecology.

Z Takase
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Abstract

As part of our series of fundamental studies on the application of piperacillin (PIPC) in the gynecologic field, we studied the transfer of PIPC to the uterine tissues. During our pharmacokinetic study of PIPC, a two-compartment model was used for blood levels: C1 = Ae-beta t + Be-alpha t. A three-compartment model was applied for the levels in the various uterine tissues and the retroperitoneum; C3 = A'e-beta t + B'e-alpha t + Ce-K31t. PIPC showed rapid transfer to the various uterine tissues and its disappearance rate developed parallel to decreases in blood concentrations. Although its transfer to the retroperitoneum was relatively rapid, since there was a clear delay in time required for the drug concentration to reach its peak (C max), the existence of a third compartment was conjectured. From the correlation between the MIC80 and the drug concentrations in the various uterine tissues and the retroperitoneum, it was found that effective doses were maintained in the uterine tissues for 3-5 h and in the retroperitoneum for 8-19 h. Thus, adequate clinical efficacy could be anticipated during administration of PIPC.

哌拉西林转移到各种子宫组织。研究小组探讨哌拉西林在妇产科领域的应用。
作为我们在妇科领域应用哌拉西林(PIPC)的一系列基础研究的一部分,我们研究了PIPC向子宫组织的转移。在我们的PIPC药代动力学研究中,血药浓度采用双室模型:C1 = ae - β t + be - α t。子宫各组织和腹膜后的浓度采用三室模型;C3 = A' t + B' t + Ce-K31t。PIPC迅速转移到子宫各组织,其消失速度与血药浓度下降平行。虽然其转移到腹膜后的速度相对较快,但由于药物浓度达到峰值(cmax)需要明显的时间延迟,因此推测存在第三间室。从MIC80与子宫各组织及腹膜后药物浓度的相关性可以看出,子宫组织和腹膜后药物浓度分别维持3 ~ 5 h和8 ~ 19 h的有效剂量。因此,在给药过程中可以预期PIPC有足够的临床疗效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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