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Transmission of adult T-cell leukemia virus (HTLV-I) through blood transfusion and its prevention. 成人t细胞白血病病毒(HTLV-I)经输血传播及其预防。
AIDS research Pub Date : 1986-12-01
K Okochi, H Sato
{"title":"Transmission of adult T-cell leukemia virus (HTLV-I) through blood transfusion and its prevention.","authors":"K Okochi,&nbsp;H Sato","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cell-associated transmission of adult T-cell leukemia virus (ATLV/HTLV-I) suggested early in a follow-up study on recipients of blood has been supported with the latest results of an extended follow-up. Approximately 10(8) lymphocytes of blood donors carrying the antibodies against ATLV seemed to be necessary for the infection through blood transfusion. The infection transmitted by transfusion is now almost completely prevented by eliminating blood units that have been derived from blood donors having antibodies to ATLV/HTLV-I.</p>","PeriodicalId":77660,"journal":{"name":"AIDS research","volume":"2 Suppl 1 ","pages":"S157-61"},"PeriodicalIF":0.0,"publicationDate":"1986-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14018625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genes encoding the alpha, beta, and gamma chains of the human T-cell antigen receptor. 编码人类t细胞抗原受体的α、β和γ链的基因。
AIDS research Pub Date : 1986-12-01
T W Mak, N Caccia, M Reis, P Ohashi, R Sangster, N Kimura, B Toyonaga
{"title":"Genes encoding the alpha, beta, and gamma chains of the human T-cell antigen receptor.","authors":"T W Mak,&nbsp;N Caccia,&nbsp;M Reis,&nbsp;P Ohashi,&nbsp;R Sangster,&nbsp;N Kimura,&nbsp;B Toyonaga","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77660,"journal":{"name":"AIDS research","volume":"2 Suppl 1 ","pages":"S95-102"},"PeriodicalIF":0.0,"publicationDate":"1986-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14085216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The global epidemic of AIDS. 全球流行的艾滋病。
AIDS research Pub Date : 1986-12-01
P Ebbesen
{"title":"The global epidemic of AIDS.","authors":"P Ebbesen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Recent changes in sexual habits have likely contributed to the emergence of a new sexually transmissible agent, acquired immune deficiency syndrome (AIDS) virus. This virus may have been present in central Africa as early as 1959; however, frequent infection did not produce an epidemic until the late 1970's. Migration of Africans from rural to urban areas may have contributed to the transmission of AIDS virus. An estimated 1.7 million Americans and 5,000,000 Africans are infected. An incubation period of five years +/- 36 months to onset of disease is estimated. Development of AIDS during a three-year period after detection of AIDS virus antibodies has occurred in 30% of homosexual males in Manhattan and 10% of infected men in Denmark. Conservatively, in excess of 20% of seropositive will likely develop AIDS. Although modification of sexual behavior is recommended, those who will develop AIDS in the near future are already infected. Public health workers ought to be preparing for additional pandemics of infectious diseases which may arise from changing cultural habits.</p>","PeriodicalId":77660,"journal":{"name":"AIDS research","volume":"2 Suppl 1 ","pages":"S23-8"},"PeriodicalIF":0.0,"publicationDate":"1986-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14671596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epstein-Barr virus-enhancing plant promoters in east Africa. Epstein-Barr病毒增强植物启动子在东非。
AIDS research Pub Date : 1986-12-01
F Mizuno, T Osato, S Imai, S Koizumi, T Aya, T Kinoshita, N Hirai, M Hirota, H Ohigashi, K Koshimizu
{"title":"Epstein-Barr virus-enhancing plant promoters in east Africa.","authors":"F Mizuno,&nbsp;T Osato,&nbsp;S Imai,&nbsp;S Koizumi,&nbsp;T Aya,&nbsp;T Kinoshita,&nbsp;N Hirai,&nbsp;M Hirota,&nbsp;H Ohigashi,&nbsp;K Koshimizu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The extracts of a certain African plant species, Euphorbia tirucalli, were found to have markedly enhancing effects on the activation of latent Epstein-Barr virus (EBV) genomes in the EBV carrying lymphoblastoid cells and also on EBV-induced transformation of human lymphocytes. The Euphorbia tirucalli was especially noticeable in highly endemic areas of Burkitt's lymphoma (BL), an EBV-associated malignancy, in Kenya and Tanzania. The activation of the latent EBV genome and the EBV-induced transformation enhancement were also observed with the soil and drinking water taken around the plants, strongly indicating that the people living in BL endemic areas are frequently exposed to such an EBV-enhancing plant promoter substance.</p>","PeriodicalId":77660,"journal":{"name":"AIDS research","volume":"2 Suppl 1 ","pages":"S151-5"},"PeriodicalIF":0.0,"publicationDate":"1986-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14163477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epstein-Barr virus-specific cytoskeletal early antigen in EBV-transformed cell lines. eb病毒转化细胞系中eb病毒特异性细胞骨架早期抗原的研究。
AIDS research Pub Date : 1986-12-01
T Sairenji, Q V Nguyen, B Woda, R E Humphreys
{"title":"Epstein-Barr virus-specific cytoskeletal early antigen in EBV-transformed cell lines.","authors":"T Sairenji,&nbsp;Q V Nguyen,&nbsp;B Woda,&nbsp;R E Humphreys","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>An Epstein-Barr virus (EBV)-specific determinant of early antigen (EA) character was found to be associated with intermediate filaments of EBV genome-activated cells. This determinant was defined with a murine monoclonal antibody (MAb) and with human MAb derived from lymphoblastoid cell lines of patients with acute infectious mononucleosis (IM). Such patients' antibodies either recognized intermediate filament determinants in general, or were restricted to the intermediate filament determinant of EBV genome-activated cells, as also recognized with the 1B6 murine MAb. The 1B6 determinant was a component of EA as defined by phosphonoacetate-resistance, methanol-sensitivity, and various co-staining and antibody-blocking experiments. While anti-intermediate filament antibodies have been reported after various viral illnesses, the 1B6 and some patients' antibodies recognize an EBV-specific determinant which might function in the lytic cycle of these cells.</p>","PeriodicalId":77660,"journal":{"name":"AIDS research","volume":"2 Suppl 1 ","pages":"S57-60"},"PeriodicalIF":0.0,"publicationDate":"1986-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14163481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unusual lymphoproliferation associated with chronic active Epstein-Barr virus infection. 与慢性活动性eb病毒感染相关的异常淋巴增生。
AIDS research Pub Date : 1986-12-01
M Okano, Y Sakiyama, S Matsumoto, F Mizuno, T Osato
{"title":"Unusual lymphoproliferation associated with chronic active Epstein-Barr virus infection.","authors":"M Okano,&nbsp;Y Sakiyama,&nbsp;S Matsumoto,&nbsp;F Mizuno,&nbsp;T Osato","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A chronic active Epstein-Barr virus (EBV) infection with no significant underlying diseases was evidenced in 7 Japanese children and adolescents. In these patients, massive EBV-positive polyclonal lymphoproliferation occurred with extremely high EBV antibody titers.</p>","PeriodicalId":77660,"journal":{"name":"AIDS research","volume":"2 Suppl 1 ","pages":"S121-3"},"PeriodicalIF":0.0,"publicationDate":"1986-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14162963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Substances affecting the infection and replication of human immunodeficiency virus (HIV). 影响人类免疫缺陷病毒(HIV)感染和复制的物质。
AIDS research Pub Date : 1986-12-01
N Yamamoto, S Harada, H Nakashima
{"title":"Substances affecting the infection and replication of human immunodeficiency virus (HIV).","authors":"N Yamamoto,&nbsp;S Harada,&nbsp;H Nakashima","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effects of various compounds were studied quantitatively on the growth of human immunodeficiency virus (HIV). For this we used a human T-cell leukemia virus type I carrying cell line, MT-4 which is most permissive for HIV infection. The results are summarized as follows: 1) Prostaglandin E2 and 12-0-tetradecanoylphorbol-13-acetate enhanced the production of HIV significantly in MT-4 cells as well as a continuous HIV producer Molt-4/HTLV-III cells. 2) Interferon gamma, retinoic acid and 3'-azido-3'-deoxythymidine inhibited the replication of HIV at the concentrations which were not cytotoxic. Mechanism of action of these compounds and its clinical implications are discussed.</p>","PeriodicalId":77660,"journal":{"name":"AIDS research","volume":"2 Suppl 1 ","pages":"S183-9"},"PeriodicalIF":0.0,"publicationDate":"1986-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14163479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence and transmission of human immunodeficiency virus in Japan. 人类免疫缺陷病毒在日本的流行和传播。
AIDS research Pub Date : 1986-12-01
T Kurimura, T Kawatani, N Hattori, H Tsuchie
{"title":"Prevalence and transmission of human immunodeficiency virus in Japan.","authors":"T Kurimura,&nbsp;T Kawatani,&nbsp;N Hattori,&nbsp;H Tsuchie","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The routes of transmission of human immunodeficiency virus (HIV) can be divided into two categories, 1. sexual transmission (male-to-male, male-to-female and female-to-male) and 2. parenteral transmission by blood or blood products. Among 488 Japanese hemophiliacs, 165 (33.8%) were seropositive and were infected by the injection of factor VIII or factor IX manufactured from American sources. The rates of infection among hemophiliacs were 21.8% (19/87) and 36.8% (43/117), respectively for 1984 and 1985. Sera of 10,272 volunteer blood donors were all negative for anti-HIV. There have been 16 confirmed AIDS cases in Japan consisting of 8 male homosexuals and 8 hemophiliacs, so it can be concluded HIV infections have exclusively occurred among male homosexuals and hemophiliacs. But there are chances to transmit HIV by blood transfusion if the screening of whole blood units is not implemented in the near future.</p>","PeriodicalId":77660,"journal":{"name":"AIDS research","volume":"2 Suppl 1 ","pages":"S163-6"},"PeriodicalIF":0.0,"publicationDate":"1986-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14235935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epstein-Barr virus infection and oncogenesis in primary immunodeficiency. 原发性免疫缺陷的eb病毒感染和肿瘤发生。
AIDS research Pub Date : 1986-12-01
M Okano, T Osato, S Koizumi, S Imai, T Aya, S Fujiwara, F Mizuno, Y Sakiyama, S Matsumoto, O Sugawara
{"title":"Epstein-Barr virus infection and oncogenesis in primary immunodeficiency.","authors":"M Okano,&nbsp;T Osato,&nbsp;S Koizumi,&nbsp;S Imai,&nbsp;T Aya,&nbsp;S Fujiwara,&nbsp;F Mizuno,&nbsp;Y Sakiyama,&nbsp;S Matsumoto,&nbsp;O Sugawara","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Lymphomas occurred in 3 of 16 Japanese patients with ataxia telangiectasia (AT) and Wiskott-Aldrich syndrome (WAS). The patients had a persistently reactivated Epstein-Barr virus (EBV) infection with a remarkable decrease in virus-specific cellular immunity. In these patients, the B lymphocytes were more sensitive to EBV-induced events and to cellular proto-oncogene activation than seen in the healthy counterparts. This immunologic and genetic background was considered to explain the massive lymphoproliferation in these primary immunodeficiency disorders.</p>","PeriodicalId":77660,"journal":{"name":"AIDS research","volume":"2 Suppl 1 ","pages":"S115-9"},"PeriodicalIF":0.0,"publicationDate":"1986-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14162962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impairment of T-cell control of Epstein-Barr virus infected B-cells in patients with adult T-cell leukemia. 成人t细胞白血病患者eb病毒感染b细胞对t细胞控制的损害
AIDS research Pub Date : 1986-12-01
T Katsuki, K Yamaguchi, Y Matsuoka, Y Hinuma
{"title":"Impairment of T-cell control of Epstein-Barr virus infected B-cells in patients with adult T-cell leukemia.","authors":"T Katsuki,&nbsp;K Yamaguchi,&nbsp;Y Matsuoka,&nbsp;Y Hinuma","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The abilities of peripheral blood lymphocytes from 9 patients with adult T-cell leukemia (ATL) and 14 healthy control adults to cause regression of proliferating B-cell foci induced by Epstein-Barr virus (EBV) were examined. Marked regression of EBV-transformed B-cell foci was observed in lymphocytes from all 10 EBV-seropositive donors but with none of those of the 4 EBV-seronegative donors in the control group. The lymphocyte of all 9 patients with ATL, who were EBV-seropositive, caused little or no regression of B-cell foci like those of EBV-negative healthy donors. These results suggest that the absence of regression of EBV-induced B-cell proliferation observed in ATL patients is due to impairment of EBV-specific killer T-cell activities.</p>","PeriodicalId":77660,"journal":{"name":"AIDS research","volume":"2 Suppl 1 ","pages":"S125-30"},"PeriodicalIF":0.0,"publicationDate":"1986-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14162964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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