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Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology最新文献

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Enterochromaffin (Argentaffin) cells of the rat gastrointestinal tract. An ultrastructural study. 大鼠胃肠道肠色素细胞。超微结构研究。
Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology Pub Date : 1984-03-01
G M Portela-Gomes, L Grimelius, R Bergström
{"title":"Enterochromaffin (Argentaffin) cells of the rat gastrointestinal tract. An ultrastructural study.","authors":"G M Portela-Gomes,&nbsp;L Grimelius,&nbsp;R Bergström","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Argentaffin cells from different parts of the gastro-intestinal tract were examined electron microscopically by the semi-thin/ultra-thin sectioning technique. All these cells contained round or pleomorphic secretory granules, which were mainly concentrated in the infranuclear zone, except in the antrum, where they occurred with a similar frequency in all the peri-nuclear areas. The highest frequency of granules was found in the colon. The largest granules were seen in the duodenum and the smallest in the large intestine. Argentaffin cells with processes oriented towards the glandular and villous surface were most frequent in the small intestine. No secretory granules were seen in the most apical part of these processes, where in an earlier study serotonin immunoreactivity was observed. This may indicate that serotonin can be stores in a non-granular form. No close topographic relationship was found between the argentaffin cells and other endocrine cell types or the nervous system.</p>","PeriodicalId":77652,"journal":{"name":"Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology","volume":"92 2","pages":"83-9"},"PeriodicalIF":0.0,"publicationDate":"1984-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17383729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Benign solitary neurilemoma (Schwannoma). A correlative cytological and histological study of 28 cases. 良性孤立神经鞘瘤(神经鞘瘤)。28例相关细胞学和组织学研究。
Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology Pub Date : 1984-03-01
I Dahl, B Hagmar, I Idvall
{"title":"Benign solitary neurilemoma (Schwannoma). A correlative cytological and histological study of 28 cases.","authors":"I Dahl,&nbsp;B Hagmar,&nbsp;I Idvall","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A correlative histological and cytological study of 28 cases of solitary neurilemoma is presented. The typical histological mixture of Antoni type A and B tissue correlated well with the cytological findings. In the smears, the Antoni type A tissue was represented by tissue fragments with a fibrillar ground substance and slender, spindle-shaped cells forming obvious Verocay bodies in 24 cases, and the Antoni type B tissue by loose, microcystic fragments with single, elongated nuclei sometimes looking like fish-hooks and with indistinct, slender, cytoplasmic processes. The ancient neurilemomas, a variant of the ordinary neurilemomas, in this series were characterised both histologically and cytologically by nuclear hyperchromasia and polymorphism, which it is important to be aware of in order to avoid an erroneous diagnosis of sarcoma or probable sarcoma. The differential diagnosis is discussed and it is concluded that diagnosis of neurilemoma by fine-needle aspiration biopsy is possible, particularly when Verocay bodies and/or a fibrillar ground substance are present in the smears. It is stressed that fine-needle aspiration biopsy is an important aid to pre-operative diagnosis of neurilemoma, and thus to planning of the operative treatment.</p>","PeriodicalId":77652,"journal":{"name":"Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology","volume":"92 2","pages":"91-101"},"PeriodicalIF":0.0,"publicationDate":"1984-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17755916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nasal polyps with atypical stroma cells: a pseudosarcomatous lesion. A light and electron-microscopic and immunohistochemical investigation with implications on the type and nature of the mesenchymal cells. 伴有非典型间质细胞的鼻息肉:一种假肉瘤病变。光镜、电镜和免疫组化检查对间充质细胞的类型和性质的影响。
Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology Pub Date : 1984-01-01
L G Kindblom, L Angervall
{"title":"Nasal polyps with atypical stroma cells: a pseudosarcomatous lesion. A light and electron-microscopic and immunohistochemical investigation with implications on the type and nature of the mesenchymal cells.","authors":"L G Kindblom,&nbsp;L Angervall","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A case of nasal polyposis with stroma cell atypia in a 33-year-old man is reported. The light microscopic appearance made a rhabdomyosarcoma strongly suspected because of the presence of polymorphous, acidophilic, rhabdomyoblast-like cells. The clinical course was that of an ordinary recurring inflammatory nasal polyp. The ultrastructural and immunohistochemical analysis showed the fibroblastic and histiocytic nature of the atypical cells as being of a probably reactive nature. The reported case illustrates the value of electron microscopy and immunohistochemistry in the evaluation of the true type and nature of atypical mesenchymal cells in pseudosarcomatous lesions.</p>","PeriodicalId":77652,"journal":{"name":"Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology","volume":"92 1","pages":"65-72"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17664491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The elimination of i. v.-injected tumor cells. Studies with 125IUDR labelled cells in 4 syngeneic murine tumor systems. 消除静脉注射的肿瘤细胞。125IUDR标记细胞在4种同基因小鼠肿瘤系统中的研究。
Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology Pub Date : 1984-01-01
W Ryd, B Hagmar
{"title":"The elimination of i. v.-injected tumor cells. Studies with 125IUDR labelled cells in 4 syngeneic murine tumor systems.","authors":"W Ryd,&nbsp;B Hagmar","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We have studied the elimination of radiolabelled (125IUDR) i.v. injected tumor cells. We have used four different murine tumors with different abilities to metastasize and with different metastasis patterns. The elimination of the tumor cells was determined by gamma-countings from different organs. The results were compared with the elimination of heat killed and x-ray sterilized tumor cells. We found a poor correlation between on the one hand the clearance of tumor cells from the blood and distribution of radiolabelled cells and on the other hand the ability of the tumors to metastasize and the metastasis distribution upon i.v. injection. The radioactivity outside the first capillary bed seemed mainly to come from dead cells.</p>","PeriodicalId":77652,"journal":{"name":"Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology","volume":"92 1","pages":"23-30"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17756824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fatal atherosclerosis developed in less than 4 years in an aortocoronary vein graft in a hyperlipidemic patient. 致死性动脉粥样硬化在不到4年的时间内发生在一个高脂血症患者的冠状动脉血管移植。
Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology Pub Date : 1984-01-01
E Falk
{"title":"Fatal atherosclerosis developed in less than 4 years in an aortocoronary vein graft in a hyperlipidemic patient.","authors":"E Falk","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>It is generally believed that it takes decades to develop a complicated atherosclerotic plaque. This view is challenged by the present case describing a hyperlipidemic patient who died of vein graft atherosclerosis less than 4 years after otherwise successful coronary bypass surgery. Although the atherogenesis may be accelerated in autogenous coronary vein grafts compared with native coronary arteries, the present case illustrates that complicated atherosclerosis may develop in the course of only a few years if appropriate conditions prevail.</p>","PeriodicalId":77652,"journal":{"name":"Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology","volume":"92 1","pages":"73-5"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17664492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
D-penicillamine-induced angiopathy in rats. The effect of high dose D-penicillamine treatment on aortic permeability to albumin and on the ultrastructure of the vessel. d -青霉胺致大鼠血管病变。大剂量d -青霉胺治疗对主动脉对白蛋白通透性及血管超微结构的影响。
Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology Pub Date : 1983-11-01
B A Jensen, J Chemnitz, B C Christensen, P Junker, I Lorenzen
{"title":"D-penicillamine-induced angiopathy in rats. The effect of high dose D-penicillamine treatment on aortic permeability to albumin and on the ultrastructure of the vessel.","authors":"B A Jensen,&nbsp;J Chemnitz,&nbsp;B C Christensen,&nbsp;P Junker,&nbsp;I Lorenzen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Male Sprague-Dawley rats were treated with D-penicillamine (D-pen) 500 mg/kg/day for 10 or 42 days. Pair fed rats served as controls. Changes in aortic morphology were examined by light- and transmission-electron microscopy (TEM). In addition, the endothelial permeability and the penetration through the aortic wall of albumin were studied 10 minutes, 24 and 48 hours after i. v. injection of human serum 131I-albumin (131I-HSA). TEM revealed extensive elastolysis in the arterial wall of D-pen-treated rats, consistent with an inhibitory effect on crosslink formation. In experimental animals excess deposition of collagen and glycoaminoglycans was observed in the subendothelial and medial layer of the aortic wall, together with prominent basal membrane substance around aortic smooth muscle cells. The aorta/serum-ratio and the radioactive build-up 24 and 48 hours after injection of 131I-HSA was reduced in animals treated with D-pen for 42 days, indicating an impeded transmural transport of tracer which may be caused by a steric exclusion effect of abundant hyaluronate. The endothelial ultrastructure was unaffected by D-pen, and no differences in aortic 131I-HSA radioactivity or aorta/serum-ratio were recorded between experimental and control groups 10 minutes after tracer injection, indicating that the permeability of the endothelial barrier to albumin remained unaffected by D-pen treatment. These observations support the hypothesis that treatment with high doses of D-pen may induce a fibroproliferative response in rat aorta, possibly by an inhibitory effect on the cross-linking of collagen and elastin.</p>","PeriodicalId":77652,"journal":{"name":"Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology","volume":"91 6","pages":"403-11"},"PeriodicalIF":0.0,"publicationDate":"1983-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17721575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Skin carcinogenesis in rats by 3-methylcholanthrene and 7,12-dimethylbenz(alpha)anthracene. Influence of dose and frequency on tumour response and its histological type. 3-甲基胆蒽和7,12-二甲基苯(α)蒽在大鼠皮肤癌变中的作用。剂量和频率对肿瘤反应及其组织学类型的影响。
Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology Pub Date : 1983-11-01
K S Rasmussen, A Glenthøj, E Arffmann
{"title":"Skin carcinogenesis in rats by 3-methylcholanthrene and 7,12-dimethylbenz(alpha)anthracene. Influence of dose and frequency on tumour response and its histological type.","authors":"K S Rasmussen,&nbsp;A Glenthøj,&nbsp;E Arffmann","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Skin tumours were induced in male inbred rats of the Lister and Wistar strains and in (WixBN) F1 hybrids by topical application of 3-methylcholanthrene (MCA) and 7,12-dimethylbenz(alpha)anthracene (DMBA). Several schedules of application were compared. At a weight basis DMBA was more potent than MCA and the tumour response to DMBA was most clearly related to total dose applied, while the frequency of application was very important for the tumour crop on MCA-treated rats. DMBA led to a marked predominance of squamous celled tumours (SQCT) when treatment was potent, while basal celled and adnexal tumours (BCAT) prevailed after any dosage of MCA. The carcinogenic effect of DMBA in a low total dose approached that of the most potent dosage of MCA. At this level of activity DMBA induced more BCAT than SQCT in both strains and in the hybrids, while MCA induced an increased number of SQCT. Strain differences did not interfere with these main results.</p>","PeriodicalId":77652,"journal":{"name":"Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology","volume":"91 6","pages":"445-55"},"PeriodicalIF":0.0,"publicationDate":"1983-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17479777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Repair in arterial tissue. An ultrastructural demonstration of proteoglycans in low temperature embedded normal and healing arterial tissue. 动脉组织修复。低温下正常和愈合动脉组织中蛋白聚糖的超微结构展示。
Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology Pub Date : 1983-11-01
J Chemnitz, B C Christensen
{"title":"Repair in arterial tissue. An ultrastructural demonstration of proteoglycans in low temperature embedded normal and healing arterial tissue.","authors":"J Chemnitz,&nbsp;B C Christensen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Low temperature embedded normal and healing arterial tissues were studied by transmission electron microscopy. The most conspicuous observation was the ultrastructurally well-preserved extracellular matrix of the arterial tissue. The proteoglycans were visible as rod-like structures (20-50 nm in width and about 200 nm in length) and radiating filaments connecting the granules to each other. The rod-like structures were removed after testicular hyaluronidase digestion. Chondroitinase ABC digestion removed most of the rod-like structures. Re-endothelialized neointima revealed a high content of rod-like structures forming a three-dimensional muralium joining together basal membrane microfibrils, collagen microfibrils and the microfibrillar component of elastin, whereas non-re-endothelialized neointima showed a reduced content of proteoglycans. The cylindrical granules may represent the proteoglycan monomer with condensed glycosaminoglycan chains.</p>","PeriodicalId":77652,"journal":{"name":"Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology","volume":"91 6","pages":"477-82"},"PeriodicalIF":0.0,"publicationDate":"1983-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17721375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thanatophoric dysplasia. A report of three cases. Thanatophoric发育不良。三个病例的报告。
Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology Pub Date : 1983-09-01
L Sundkvist
{"title":"Thanatophoric dysplasia. A report of three cases.","authors":"L Sundkvist","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Thanatophoric dysplasia is an osteochondrodysplasia always lethal already in the neonatal period. Three cases, showing the characteristic X-ray picture of the disease, are described. Histopathologically, an abnormality in the endochondral ossification process was observed. In sections from tubular bones the growth zone was found to be irregular with deficient chondrocyte maturation, absence of orderly chondrocyte columns, and the development of coarse bone trabeculae. Moreover, prominent subperiostal bone formation could be demonstrated. A constant finding was also a fibrous band, continuous with the periosteum/perichondrium, and extending into the growth zone. From this fibrous tissue membranous bone formation, directed towards the metaphysis and appearing to add to bone length, was observed. It seems as if direct bone formation predominates in thanatophoric dysplasia.</p>","PeriodicalId":77652,"journal":{"name":"Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology","volume":"91 5","pages":"335-41"},"PeriodicalIF":0.0,"publicationDate":"1983-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17471669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidermal changes in heat and electrically injured pig skin. A light microscopic study of the influence of heat energy intensity and electrical current frequency. 热和电损伤猪皮肤的表皮变化。对热能强度和电流频率影响的光显微研究。
Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology Pub Date : 1983-09-01
H K Thomsen, L Danielsen, O Nielsen, O Aalund, K G Nielsen, T Karlsmark, I K Genefke, P Christoffersen
{"title":"Epidermal changes in heat and electrically injured pig skin. A light microscopic study of the influence of heat energy intensity and electrical current frequency.","authors":"H K Thomsen,&nbsp;L Danielsen,&nbsp;O Nielsen,&nbsp;O Aalund,&nbsp;K G Nielsen,&nbsp;T Karlsmark,&nbsp;I K Genefke,&nbsp;P Christoffersen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Pigs were exposed to heat of low and high temperature and electricity of various frequences. Comparable amounts of energy were transferred in all experiments. In lesions induced by heat of low temperature granularity and/or fibrillarity of the cytoplasm were present in the epidermal cells. Lesions induced by heat of high temperature had a similar appearance, but occasionally \"white necrosis\", defects in the epithelium and light yellow material in stratum corneum were present. Lesions induced by 100.000 hz alternating current were segmental but otherwise microscopically often indistinguishable from lesions produced via transfer of heat of low temperature. Lesions induced by 8000 hz and 59 hz alternating current were segmental. Vesicular nuclei, \"white necrosis\" and yellow, clumped keratin were present in most lesions. Anode areas in direct current induced lesions showed a shrunken epidermis. The cytoplasm of the epidermal cells were often eosinophilic and homogeneous, and the nuclei were small with condensed chromatin. Occasionally, \"empty\" nuclei were noted. Yellow, clumped keratin was presented in all lesions. In cathode areas epidermis was of varying thickness and \"white necrosis\" and vesicular nuclei were present. The pathogenesis of the individual morphological features is discussed based upon theoretical concepts and the difference in morphology of the various lesions encountered in the present study as well as in other studies in this series of experiments. It is concluded that except for lesions produced via transfer of high frequency alternating current the morphology of electrical lesions is specific. Further, an alleged torture instrument was able to produce lesions similar to those observed in the experimental studies.</p>","PeriodicalId":77652,"journal":{"name":"Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology","volume":"91 5","pages":"297-306"},"PeriodicalIF":0.0,"publicationDate":"1983-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17258363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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