Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology最新文献_第2页

Epidemiology of soft-tissue sarcoma in the locomotor system. A retrospective population-based study of the inter-relationships between clinical and morphologic variables. 运动系统软组织肉瘤的流行病学。临床和形态学变量之间相互关系的回顾性人群研究。

Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology Pub Date : 2009-08-17 DOI: 10.1111/J.1699-0463.1984.TB04416.X

A. Rydholm, N. Berg, B. Gullberg, K. Thorngren, B. Persson

{"title":"Epidemiology of soft-tissue sarcoma in the locomotor system. A retrospective population-based study of the inter-relationships between clinical and morphologic variables.","authors":"A. Rydholm, N. Berg, B. Gullberg, K. Thorngren, B. Persson","doi":"10.1111/J.1699-0463.1984.TB04416.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1984.TB04416.X","url":null,"abstract":"From all soft-tissue malignancies reported to the Swedish National Cancer Registry in Southern Sweden (1.3 mill. inhabitants) from 1964 through 1978, 278 cases were accepted as sarcomas after histologic re-examination. All these were malignancy-graded on a four-grade scale, without knowledge of the clinical course. A number of clinical and morphological variables were recorded and subjected to uni-, bi- and multi-variate analysis. Follow-up was available in all patients. The annual incidence rate over all ages was 1.4/100,000. The mean age was 58 years and males dominated (1.3/1). Malignant fibrous histiocytoma, liposarcoma and leiomyosarcoma were the most common histologic groups. Three-fourths of the tumors were high-grade malignant (Grade III-IV). Sixty per cent were deep-seated, having a median size of 8 cm compared to 4 cm for the superficial tumors. One third of all tumors were located in the thigh. The histologic groups were characterized by age, tumor depth and size, the occurrence of pain, malignancy grade and five-year survival; it was seen that each group, with respect to at least one of the variables, differed significantly from all the other groups. Thus histologic classification seems to identify different tumor entities. Out of several pair-wise associations the strongest were as follows: histologic groups versus depth, size, malignancy grade and age; depth versus size; and size versus malignancy grade (Grade IV tumors being larger). The proportion of superficial and small tumors in this series is high, compared to several reported series, probably owing to \"referral selection\" in the previous studies. The inter-relationships found between several variables and conclusions based on selected series may explain, in part, the differing opinions which can be found in the literature regarding prognostic variables in soft-tissue sarcoma.","PeriodicalId":77652,"journal":{"name":"Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology","volume":"178 1","pages":"363-74"},"PeriodicalIF":0.0,"publicationDate":"2009-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76880625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 64

Intestinal lymphangiectasia in the Lundehund. Scanning electron microscopy of intestinal mucosa. 伦德猎犬肠淋巴管扩张。肠黏膜扫描电镜。

Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology Pub Date : 2009-08-17 DOI: 10.1111/J.1699-0463.1984.TB04415.X

T. Landsverk, H. Gamlem

引用次数: 16

The ultrastructure of alveolar and embryonal rhabdomyosarcoma. A correlative light and electron microscopic study of 17 cases. 肺泡型和胚胎型横纹肌肉瘤的超微结构。17例的相关光镜和电镜研究。

Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology Pub Date : 2009-08-17 DOI: 10.1111/J.1699-0463.1984.TB04400.X

T. Seidal, L. Kindblom

引用次数: 29

Benign solitary neurilemoma (Schwannoma). A correlative cytological and histological study of 28 cases. 良性孤立神经鞘瘤(神经鞘瘤)。28例相关细胞学和组织学研究。

Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology Pub Date : 2009-08-17 DOI: 10.1111/J.1699-0463.1984.TB04383.X

I. Dahl, B. Hagmar, I. Idvall

{"title":"Benign solitary neurilemoma (Schwannoma). A correlative cytological and histological study of 28 cases.","authors":"I. Dahl, B. Hagmar, I. Idvall","doi":"10.1111/J.1699-0463.1984.TB04383.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1984.TB04383.X","url":null,"abstract":"A correlative histological and cytological study of 28 cases of solitary neurilemoma is presented. The typical histological mixture of Antoni type A and B tissue correlated well with the cytological findings. In the smears, the Antoni type A tissue was represented by tissue fragments with a fibrillar ground substance and slender, spindle-shaped cells forming obvious Verocay bodies in 24 cases, and the Antoni type B tissue by loose, microcystic fragments with single, elongated nuclei sometimes looking like fish-hooks and with indistinct, slender, cytoplasmic processes. The ancient neurilemomas, a variant of the ordinary neurilemomas, in this series were characterised both histologically and cytologically by nuclear hyperchromasia and polymorphism, which it is important to be aware of in order to avoid an erroneous diagnosis of sarcoma or probable sarcoma. The differential diagnosis is discussed and it is concluded that diagnosis of neurilemoma by fine-needle aspiration biopsy is possible, particularly when Verocay bodies and/or a fibrillar ground substance are present in the smears. It is stressed that fine-needle aspiration biopsy is an important aid to pre-operative diagnosis of neurilemoma, and thus to planning of the operative treatment.","PeriodicalId":77652,"journal":{"name":"Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology","volume":"1 1","pages":"91-101"},"PeriodicalIF":0.0,"publicationDate":"2009-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84723345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 51

Fibroma of tendon sheath. A light and electron-microscopic study of 6 cases. 腱鞘纤维瘤。6例病例的光电子显微镜观察。

Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology Pub Date : 2009-08-17 DOI: 10.1111/J.1699-0463.1984.TB04421.X

L. Lundgren, L. Kindblom

{"title":"Fibroma of tendon sheath. A light and electron-microscopic study of 6 cases.","authors":"L. Lundgren, L. Kindblom","doi":"10.1111/J.1699-0463.1984.TB04421.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1984.TB04421.X","url":null,"abstract":"The clinical picture, the light and electron microscopic appearance, and the histochemical findings are described in six cases of fibroma of tendon sheath. The ages at onset for the four men and two women range between 16 and 54 years. The lesions were well circumscribed, rounded or oval, and had a diameter of about 1 cm. Light-microscopically the lesions consisted of a dense fibrocollagenous tissue with a variable degree of collagenization and cellularity, the peripheral zone often being most cellular and containing slit-like vascular spaces. Electron-microscopically two main cell types were identified: myofibroblasts and fibroblasts, the former dominating in cellular areas, the latter dominating in collagenized areas. The histochemical analysis indicated the presence of sulphated glucosaminoglycans within the collagenous matrix. Immunoperoxidase staining for factor VIII RAG-related antigen gave prominence to the endothelium of capillary-like blood vessels. The differential diagnosis against giant cell tumor of tendon sheath is discussed. The observations indicate that fibroma of tendon sheath is a distinct entity of probable reactive, non-neoplastic nature.","PeriodicalId":77652,"journal":{"name":"Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology","volume":"23 1","pages":"401-9"},"PeriodicalIF":0.0,"publicationDate":"2009-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78779177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

The elimination of i. v.-injected tumor cells. Studies with 125IUDR labelled cells in 4 syngeneic murine tumor systems. 消除静脉注射的肿瘤细胞。125IUDR标记细胞在4种同基因小鼠肿瘤系统中的研究。

Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology Pub Date : 2009-08-17 DOI: 10.1111/J.1699-0463.1984.TB04373.X

W. Ryd, B. Hagmar

引用次数: 4

Prognosis for soft-tissue sarcoma in the locomotor system. A retrospective population-based follow-up study of 237 patients. 运动系统软组织肉瘤的预后。237例患者的回顾性人群随访研究。

Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology Pub Date : 2009-08-17 DOI: 10.1111/J.1699-0463.1984.TB04417.X

A. Rydholm, N. Berg, B. Gullberg, B. Persson, K. Thorngren

{"title":"Prognosis for soft-tissue sarcoma in the locomotor system. A retrospective population-based follow-up study of 237 patients.","authors":"A. Rydholm, N. Berg, B. Gullberg, B. Persson, K. Thorngren","doi":"10.1111/J.1699-0463.1984.TB04417.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1984.TB04417.X","url":null,"abstract":"To identify variables of prognostic importance for soft-tissue sarcoma in the locomotor system, we performed a retrospective follow-up study on a consecutive, unselected, population-based series of 237 patients mainly treated by surgery, 1964-1978. Patients with metastasis at the time of diagnosis were not included. All histologic material was re-evaluated and histologic malignancy-grading (four-grade scale) performed without knowledge of the clinical course. The surgical procedures were classified as marginal and broad excisions. Patient follow-up ranged between 3- and 18 years. Multivariate analysis of the data by Coxs proportional hazard regression techniques disclosed seven negative prognostic variables of primary significance; high malignancy-grade (IV and III), pain at rest, male sex, increasing age and tumor size, a marginal excision and an extracompartmental tumor site, in order of decreasing relative risk (5.9-1.9) as regards survival. A secondary variable, that of local recurrence, was then included in the model and was found to have a stronger influence on survival than any of the other variables. Patients with local recurrence had a mortality risk which was 8.3 times that of patients without local recurrence. A risk curve based on the prognostic variables having primary significance was constructed. By this risk curve, patients with very good or very bad prognosis could be identified. The results are important when evaluating the efficiency of different therapies in non-randomized trials. In such studies the prognostic variables could be used to identify patients having comparable prognoses. In addition, patients found to have a good prognosis could be excluded from trials with adjuvant therapy.","PeriodicalId":77652,"journal":{"name":"Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology","volume":"26 1","pages":"375-86"},"PeriodicalIF":0.0,"publicationDate":"2009-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84102827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 58

D-penicillamine-induced angiopathy in rats. The effect of high dose D-penicillamine treatment on aortic permeability to albumin and on the ultrastructure of the vessel. d -青霉胺致大鼠血管病变。大剂量d -青霉胺治疗对主动脉对白蛋白通透性及血管超微结构的影响。

Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology Pub Date : 2009-08-15 DOI: 10.1111/J.1699-0463.1983.TB02772.X

B. A. Jensen, J. Chemnitz, B. C. Christensen, P. Junker, I. Lorenzen

{"title":"D-penicillamine-induced angiopathy in rats. The effect of high dose D-penicillamine treatment on aortic permeability to albumin and on the ultrastructure of the vessel.","authors":"B. A. Jensen, J. Chemnitz, B. C. Christensen, P. Junker, I. Lorenzen","doi":"10.1111/J.1699-0463.1983.TB02772.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1983.TB02772.X","url":null,"abstract":"Male Sprague-Dawley rats were treated with D-penicillamine (D-pen) 500 mg/kg/day for 10 or 42 days. Pair fed rats served as controls. Changes in aortic morphology were examined by light- and transmission-electron microscopy (TEM). In addition, the endothelial permeability and the penetration through the aortic wall of albumin were studied 10 minutes, 24 and 48 hours after i. v. injection of human serum 131I-albumin (131I-HSA). TEM revealed extensive elastolysis in the arterial wall of D-pen-treated rats, consistent with an inhibitory effect on crosslink formation. In experimental animals excess deposition of collagen and glycoaminoglycans was observed in the subendothelial and medial layer of the aortic wall, together with prominent basal membrane substance around aortic smooth muscle cells. The aorta/serum-ratio and the radioactive build-up 24 and 48 hours after injection of 131I-HSA was reduced in animals treated with D-pen for 42 days, indicating an impeded transmural transport of tracer which may be caused by a steric exclusion effect of abundant hyaluronate. The endothelial ultrastructure was unaffected by D-pen, and no differences in aortic 131I-HSA radioactivity or aorta/serum-ratio were recorded between experimental and control groups 10 minutes after tracer injection, indicating that the permeability of the endothelial barrier to albumin remained unaffected by D-pen treatment. These observations support the hypothesis that treatment with high doses of D-pen may induce a fibroproliferative response in rat aorta, possibly by an inhibitory effect on the cross-linking of collagen and elastin.","PeriodicalId":77652,"journal":{"name":"Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology","volume":"37 1","pages":"403-11"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90873731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Cystosarcoma phyllodes. A review of 19 cases with emphasis on the occurrence of associated breast carcinoma. Cystosarcoma叶状柄。回顾19例合并性乳腺癌的发生。

Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology Pub Date : 2009-08-15 DOI: 10.1111/J.1699-0463.1986.TB02961.X

L. Christensen, M. Nielsen, P. Madsen

引用次数: 11

Campylobacter enterocolitis. An important differential diagnosis in ulcerative colitis. 弯曲杆菌小肠结肠炎。溃疡性结肠炎的重要鉴别诊断。

Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology Pub Date : 2009-08-15 DOI: 10.1111/J.1699-0463.1983.TB02723.X

A. Vesterby, U. Baandrup, N. O. Jacobsen, K. Albertsen

引用次数: 4