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Expression of growth factor-toxin fusion proteins. 生长因子-毒素融合蛋白的表达。
Targeted diagnosis and therapy Pub Date : 1992-01-01
G M Edwards, D Defeo-Jones, S M Stirdivant, D C Heimbrook, A Oliff
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引用次数: 0
Generation of chimeric toxins. 产生嵌合毒素。
Targeted diagnosis and therapy Pub Date : 1992-01-01
D FitzGerald, V K Chaudhary, R J Kreitman, C B Siegall, I Pastan
{"title":"Generation of chimeric toxins.","authors":"D FitzGerald, V K Chaudhary, R J Kreitman, C B Siegall, I Pastan","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77632,"journal":{"name":"Targeted diagnosis and therapy","volume":"7 ","pages":"447-62"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12799984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In vivo studies with chimeric toxins. Interleukin-2 fusion toxins as immunosuppressive agents. 嵌合毒素的体内研究。白细胞介素-2融合毒素作为免疫抑制剂。
Targeted diagnosis and therapy Pub Date : 1992-01-01 DOI: 10.1201/9781003066651-19
M. Shapiro, R. Kirkman, V. Kelley, P. Bacha, J. Nichols, T. Strom
{"title":"In vivo studies with chimeric toxins. Interleukin-2 fusion toxins as immunosuppressive agents.","authors":"M. Shapiro, R. Kirkman, V. Kelley, P. Bacha, J. Nichols, T. Strom","doi":"10.1201/9781003066651-19","DOIUrl":"https://doi.org/10.1201/9781003066651-19","url":null,"abstract":"","PeriodicalId":77632,"journal":{"name":"Targeted diagnosis and therapy","volume":"7 1","pages":"383-93"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65951774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular cloning of ricin. 蓖麻毒素的分子克隆。
Targeted diagnosis and therapy Pub Date : 1992-01-01 DOI: 10.1201/9781003066651-5
L. Roberts, J. Tregear, J. Lord
{"title":"Molecular cloning of ricin.","authors":"L. Roberts, J. Tregear, J. Lord","doi":"10.1201/9781003066651-5","DOIUrl":"https://doi.org/10.1201/9781003066651-5","url":null,"abstract":"A variety of strategies have been used to obtain cDNA and genomic clones encoding ricin. Since their isolation these sequences have been manipulated to allow expression of A chain (19) and A chain mutants (15,20,34), B chain (14,21-23) and proricin (24). Utilizing structural information (35), precise changes have been introduced into both A and B chains with the aim of probing catalytic and sugar-binding residues, respectively. In the longer term, such manipulations, coupled with successful expression and purification schemes, will allow the delineation of functional residues and domains, ensuring that ricin remains the prototype plant toxin with which to study cellular intoxication and ribosome inactivation and to utilize in pharmaceutical product development.","PeriodicalId":77632,"journal":{"name":"Targeted diagnosis and therapy","volume":"7 1","pages":"81-97"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65952262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Monoclonal antibody B72.3 immunoscintigraphy in the follow-up of patients with colorectal cancer. 单克隆抗体B72.3免疫显像在结直肠癌患者随访中的应用。
Targeted diagnosis and therapy Pub Date : 1992-01-01
S Lastoria, M Salvatore
{"title":"Monoclonal antibody B72.3 immunoscintigraphy in the follow-up of patients with colorectal cancer.","authors":"S Lastoria, M Salvatore","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77632,"journal":{"name":"Targeted diagnosis and therapy","volume":"6 ","pages":"57-71"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12743616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression of plant-derived ribosome-inactivating proteins in heterologous systems. 植物源性核糖体失活蛋白在异源系统中的表达。
Targeted diagnosis and therapy Pub Date : 1992-01-01
M Piatak, N Habuka
{"title":"Expression of plant-derived ribosome-inactivating proteins in heterologous systems.","authors":"M Piatak, N Habuka","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77632,"journal":{"name":"Targeted diagnosis and therapy","volume":"7 ","pages":"99-131"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12799216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The structure of diphtheria toxin as a guide to rational design. 以白喉毒素结构为指导，进行合理设计。
Targeted diagnosis and therapy Pub Date : 1992-01-01
P J Nicholls, R J Youle
{"title":"The structure of diphtheria toxin as a guide to rational design.","authors":"P J Nicholls, R J Youle","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77632,"journal":{"name":"Targeted diagnosis and therapy","volume":"7 ","pages":"339-63"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12799976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protein engineering of diphtheria toxin. Development of receptor-specific cytotoxic agents for the treatment of human disease. 白喉毒素蛋白工程。用于治疗人类疾病的受体特异性细胞毒性药物的开发。
Targeted diagnosis and therapy Pub Date : 1992-01-01
J R Murphy, F G Lakkis, J C vanderSpek, P Anderson, T B Strom
{"title":"Protein engineering of diphtheria toxin. Development of receptor-specific cytotoxic agents for the treatment of human disease.","authors":"J R Murphy, F G Lakkis, J C vanderSpek, P Anderson, T B Strom","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77632,"journal":{"name":"Targeted diagnosis and therapy","volume":"7 ","pages":"365-82"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12799977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression of plant-derived ribosome-inactivating proteins in heterologous systems. 植物源性核糖体失活蛋白在异源系统中的表达。
Targeted diagnosis and therapy Pub Date : 1992-01-01 DOI: 10.1201/9781003066651-6
M. Piatak, N. Habuka
{"title":"Expression of plant-derived ribosome-inactivating proteins in heterologous systems.","authors":"M. Piatak, N. Habuka","doi":"10.1201/9781003066651-6","DOIUrl":"https://doi.org/10.1201/9781003066651-6","url":null,"abstract":"","PeriodicalId":77632,"journal":{"name":"Targeted diagnosis and therapy","volume":"7 1","pages":"99-131"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65952271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Diphtheria toxin cloning and expression in Corynebacterium diphtheriae. 白喉棒状杆菌白喉毒素的克隆与表达。
Targeted diagnosis and therapy Pub Date : 1992-01-01 DOI: 10.1201/9781003066651-15
L. Greenfield
{"title":"Diphtheria toxin cloning and expression in Corynebacterium diphtheriae.","authors":"L. Greenfield","doi":"10.1201/9781003066651-15","DOIUrl":"https://doi.org/10.1201/9781003066651-15","url":null,"abstract":"","PeriodicalId":77632,"journal":{"name":"Targeted diagnosis and therapy","volume":"7 1","pages":"273-305"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65951635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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