American Journal on Addictions最新文献_第6页

Interactive effects of ARRB2 and CHRNA5 genetic polymorphisms on cognitive function in Chinese male methamphetamine use disorder patients. ARRB2和CHRNA5基因多态性对中国男性甲基苯丙胺使用障碍患者认知功能的交互影响

IF 2.5 4区医学

American Journal on Addictions Pub Date : 2024-11-15 DOI: 10.1111/ajad.13666

Linjun Jiang, Dongmei Wang, Yang Tian, Jiajing Chen, Mengqian Qu, Han Chen, Ren Huang, Lianglun Jia, Fabing Fu, Shanshan Tang, Xiaotao Wang, Xiang-Yang Zhang

{"title":"Interactive effects of ARRB2 and CHRNA5 genetic polymorphisms on cognitive function in Chinese male methamphetamine use disorder patients.","authors":"Linjun Jiang, Dongmei Wang, Yang Tian, Jiajing Chen, Mengqian Qu, Han Chen, Ren Huang, Lianglun Jia, Fabing Fu, Shanshan Tang, Xiaotao Wang, Xiang-Yang Zhang","doi":"10.1111/ajad.13666","DOIUrl":"https://doi.org/10.1111/ajad.13666","url":null,"abstract":"Background and objectives: Both β-arrestin2 and nicotinic acetylcholine receptor (nAChR) have been implicated in cognitive processes, particularly in relation to psychiatric disorders, including addiction. Previous studies have suggested that nAChR may be regulated by β-arrestin2. However, no study has investigated the interaction of β-arrestin2 and nAChR on cognition. We aimed to examine the main and interactive effects of their respective encoding genes, ARRB2 and CHRNA5, on cognitive function in MUD patients.Methods: We recruited 559 patients with methamphetamine use disorder (MUD) and 459 healthy controls, assessed their cognitive functioning using the Chinese version of the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), and genotyped ARRB2 rs1045280 and CHRNA5 rs3829787 polymorphisms in MUD patients.Results: Compared to healthy controls, MUD patients scored significantly lower on all RBANS indexes. Neither ARRB2 rs1045280 nor CHRNA5 rs3829787 had main effects on cognitive function in MUD patients, but there were significant interactive effects between the two single nucleotide polymorphisms (SNPs) on multiple RBANS indexes, including immediate memory, visuospatial/constructional, delayed memory, and total score. In detail, among carriers of CHRNA5 rs3829787 T allele, ARRB2 rs1045280 TT carriers had higher RBANS scores than the C allele carriers, whereas among carriers of CHRNA5 rs3829787 CC genotype, ARRB2 rs1045280 TT carriers performed worse in RBANS.Conclusions and scientific significance: Our study identified for the first time an interactive effect between ARRB2 and CHRNA5 on cognitive function in MUD patients, which would enlarge our knowledge of genetic interaction on cognitive function.","PeriodicalId":7762,"journal":{"name":"American Journal on Addictions","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Profiles of polysubstance use among people reporting past 12-month sleep-motivated nonmedical use of prescription tranquilizers/sedatives. 报告过去 12 个月因睡眠而非医疗使用处方镇定剂/镇静剂的人群使用多种物质的概况。

IF 2.5 4区医学

American Journal on Addictions Pub Date : 2024-11-11 DOI: 10.1111/ajad.13665

Alyssa M Falise, Parvathy Prasanna Surendran, Carolin C Hoeflich, Catherine W Striley, Liva LaMontagne, Catalina Lopez-Quintero

{"title":"Profiles of polysubstance use among people reporting past 12-month sleep-motivated nonmedical use of prescription tranquilizers/sedatives.","authors":"Alyssa M Falise, Parvathy Prasanna Surendran, Carolin C Hoeflich, Catherine W Striley, Liva LaMontagne, Catalina Lopez-Quintero","doi":"10.1111/ajad.13665","DOIUrl":"https://doi.org/10.1111/ajad.13665","url":null,"abstract":"Background and objectives: Nonmedical use of prescription tranquilizers/sedatives (NMUPTS) is associated with a 15-times increased likelihood of polysubstance use (PSU). This is correlated with an increased risk for use disorders and death, therefore, to inform prevention efforts, we identified PSU profiles among adults reporting sleep-related NMUPTS.Methods: National Survey on Drug Use and Health 2015-2019 participants with past 12-month sleep-related NMUPTS and use of an additional drug(s) (n = 2603) were studied. Latent class analyses identified unique latent profiles, and multivariable logistic regressions identified covariates associated with each profile.Results: Alcohol (90.4%), tobacco (61.5%), and marijuana (55.5%) were most commonly reported, with an average of 3.6 additional substances. Two latent PSU profiles were identified: marijuana/alcohol/tobacco (MAT) (68.3%) and MAT + cocaine/hallucinogens/prescription drugs (MAT + CHPR) (31.7%). In comparison to those likely in the MAT profile, those likely in the MAT + CHPR profile had lower odds of being older than 18-25 years (26-34: adjusted odds ratio [AOR]: 0.5, 95% confidence interval [CI]: 0.3, 0.6; 35-49: AOR: 0.2, 95% CI: 0.1, 0.2; 50+: AOR: 0.1, 95% CI: 0.0, 0.1), female (AOR: 0.4, 95% CI: 0.3, 0.6), non-Hispanic Black (AOR: 0.5, 95% CI: 0.4, 0.8) or Hispanic in comparison to non-Hispanic White (AOR: 0.5, 95% CI: 0.4, 0.8), and to not have past 12-month insurance coverage (AOR: 1.7, 95% CI: 1.3, 2.3).Conclusions and scientific significance: Two PSU profiles were identified among people with NMUPTS, with noted variations in sociodemographic characteristics. In comparison to previous studies, sleep-related NMUPTS was associated with higher rates of stimulant use, suggesting stimulant use and sleep-related NMUPTS may be related.","PeriodicalId":7762,"journal":{"name":"American Journal on Addictions","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to "The prevalence and treatment utilization of substance use disorders among Muslims in the United States: A national epidemiological survey". 对 "美国穆斯林中药物使用失调症的流行和治疗利用情况 "的更正：全国流行病学调查"。

IF 2.5 4区医学

American Journal on Addictions Pub Date : 2024-10-29 DOI: 10.1111/ajad.13664

引用次数: 0

Call for Review Papers 2024 征集 2024 年综述论文

IF 2.5 4区医学

American Journal on Addictions Pub Date : 2024-10-24 DOI: 10.1111/ajad.13657

引用次数: 0

Addiction Psychiatry Advanced Psychotherapy Curriculum January Session - Transference Focused Psychotherapy 成瘾精神病学高级心理治疗课程一月份课程--移情心理治疗

IF 2.5 4区医学

American Journal on Addictions Pub Date : 2024-10-24 DOI: 10.1111/ajad.13663

引用次数: 0

Patient-provider interactions about cannabis for therapeutic purposes vary as a function of provider type: A pilot study. 患者与提供者之间关于用于治疗目的的大麻的互动因提供者类型而异：一项试点研究。

IF 2.5 4区医学

American Journal on Addictions Pub Date : 2024-10-24 DOI: 10.1111/ajad.13656

Jivan Achar, Alan J Budney, Cara A Struble

{"title":"Patient-provider interactions about cannabis for therapeutic purposes vary as a function of provider type: A pilot study.","authors":"Jivan Achar, Alan J Budney, Cara A Struble","doi":"10.1111/ajad.13656","DOIUrl":"10.1111/ajad.13656","url":null,"abstract":"Background and objectives: Limited evidence guides the efficacy and safety of cannabis for therapeutic purposes (CTP). Healthcare providers lack requisite knowledge to advise and support patients. This study aimed to describe and compare several aspects of initial CTP interactions across different provider types.Methods: Adult cannabis consumers (N = 507) from the United States completed an anonymous online survey about their initial CTP interaction with their healthcare provider. Providers were categorized into four groups (Mental Health [MH], Family Medicine [FM], Medical Clinics [MC], and Other Specialty [OS]). Analyses compared several aspects of the interaction (e.g., risk mitigation, recommendations, satisfaction/confidence) across groups.Results: Less than half of the sample reported discussion of cannabis risks (44.0%) or follow-ups at subsequent visits (46.7%). Recommendations (where to obtain, consumption method, dose, frequency, and authorization) were uncommon (9.7%-25.2%). While the MH group reported the highest rates of risk mitigation behaviors, regression models adjusted for sociodemographic and cannabis characteristics were largely nonsignificant. For recommendations, the MC group was more likely than the MH group to report receiving all recommendations (p < .05). Younger age and greater cannabis-related problems increased likelihood of risk mitigation and recommendations.Discussion and conclusions: CTP interactions focused on risk but generally lacked comprehensive recommendations that could potentially promote safe use. Data from provider perspectives could support the need for CTP guidelines and develop training for healthcare providers to promote safe CTP practices.Scientific significance: For the first time, this study explored several aspects of CTP interactions and compared experiences across a variety of providers.","PeriodicalId":7762,"journal":{"name":"American Journal on Addictions","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142493088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Call for Special Issue Papers 2024 征集 2024 年特刊论文

IF 2.5 4区医学

American Journal on Addictions Pub Date : 2024-10-24 DOI: 10.1111/ajad.13658

引用次数: 0

AAAP Podcast Episode 10: A Discussion On Cybersecurity With Norma Krayem AAAP 播客第 10 集：与 Norma Krayem 讨论网络安全问题

IF 2.5 4区医学

American Journal on Addictions Pub Date : 2024-10-24 DOI: 10.1111/ajad.13660

引用次数: 0

Become A AAAP Member! 成为 AAAP 会员！

IF 2.5 4区医学

American Journal on Addictions Pub Date : 2024-10-24 DOI: 10.1111/ajad.13662