American Journal on Addictions最新文献

Absorption of naloxone in patients prescribed buprenorphine-naloxone.

IF 2.5 4区医学

American Journal on Addictions Pub Date : 2025-02-02 DOI: 10.1111/ajad.13674

Ian Michel, Domenic Ochal, Aniket Paharia, Paul Jannetto, Scott Breitinger, Tyler Oesterle

{"title":"Absorption of naloxone in patients prescribed buprenorphine-naloxone.","authors":"Ian Michel, Domenic Ochal, Aniket Paharia, Paul Jannetto, Scott Breitinger, Tyler Oesterle","doi":"10.1111/ajad.13674","DOIUrl":"https://doi.org/10.1111/ajad.13674","url":null,"abstract":"Background and objectives: When administered as prescribed, the naloxone component of buprenorphine-naloxone combination medications is putatively considered inert due to reduced naloxone bioavailability via transmucosal. However, there is a growing body of evidence to the contrary. The aim of our study is to determine the extent of naloxone absorption in a large cohort of patients receiving sublingual buprenorphine-naloxone.Methods: Using the Mayo Clinic Unified Data Platform, 425 patients prescribed sublingual buprenorphine/naloxone who received a controlled substance monitoring panel (CSMP) between January 1, 2022, and January 1, 2023 were identified and included. The CSMP is an immunoassay panel that confirms positive results quantitatively with gas chromatography mass spectrometry or liquid chromatography tandem mass spectrometry. This panel provides urinary detection for buprenorphine (cutoff: 5 ng/mL), naloxone (25 ng/mL), as well as their respective metabolites norbuprenorphine (5 ng/mL), norbuprenorphine-glucuronide (20 ng/mL), and naloxone-glucuronide (100 ng/mL).Results: Of our 425 patients, 76% had norbuprenorphine (n = 323), and 77% had norbuprenorphine-glucuronide (n = 327) in their toxicology tests, respectively. Naloxone-glucuronide was detected in 91% (n = 294) of the specimens with norbuprenorphine and 88.7% (n = 290) of the specimens with norbuprenorphine-glucuronide.Conclusion and scientific significance: To our knowledge, this is the largest study to date demonstrating the presence of naloxone metabolites in patients taking combined buprenorphine-naloxone medications. The results of this study refute the notion that naloxone absorption is negligible when administered in sublingual preparations. Further research on how this absorption impacts medication usage, dosing, adherence, and side effects is necessary.","PeriodicalId":7762,"journal":{"name":"American Journal on Addictions","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143073465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does cyber dating abuse victimization predict next-day alcohol and cannabis use among college students? 网络约会虐待受害者是否预示着大学生第二天会使用酒精和大麻？

IF 2.5 4区医学

American Journal on Addictions Pub Date : 2025-01-07 DOI: 10.1111/ajad.13672

Meagan J Brem, T J Shaw, Allison Tobar-Santamaria

{"title":"Does cyber dating abuse victimization predict next-day alcohol and cannabis use among college students?","authors":"Meagan J Brem, T J Shaw, Allison Tobar-Santamaria","doi":"10.1111/ajad.13672","DOIUrl":"https://doi.org/10.1111/ajad.13672","url":null,"abstract":"Background and objectives: Cyber dating abuse (CDA) is prevalent on college campuses, with 43% of college students experiencing CDA each year. Yet, the potential impacts of CDA victimization on college students' health outcomes remain poorly understood. Informed by the self-medication hypothesis and longitudinal data linking dating abuse to substance use outcomes, the present study tested the hypothesis that CDA victimization positively associates with college students' next-day alcohol use (number of drinks consumed, odds of any drinking) and odds of cannabis use (yes/no). We also explored whether CDA's association with next-day substance use varied as a function of gender.Methods: Daily data on alcohol use, cannabis use, and CDA victimization were collected across 60 consecutive days from 236 undergraduates who were in dating relationships (73.73% cisgender women).Results: Multilevel modeling revealed gender differences. Among men, CDA victimization predicted next-day cannabis use (aOR = 7.34, p < .001), but negatively related to the number of drinks consumed the following day (B = -2.63, p < .001). Among women, CDA victimization did not relate to next-day cannabis or alcohol use. Regardless of gender, CDA victimization was unrelated to the odds of any drinking.Discussion and conclusions: College men are more likely to use cannabis the day after experiencing CDA victimization relative to other days. Targeting CDA and related aftermath may benefit college-based substance use intervention.Scientific significance: This is the first study to identify that cannabis use occurs subsequent to CDA victimization, which can inform college-based CDA and cannabis use prevention programming.","PeriodicalId":7762,"journal":{"name":"American Journal on Addictions","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ORN Consultant Recruitment - Join A National Public Health Alliance

IF 2.5 4区医学

American Journal on Addictions Pub Date : 2024-12-27 DOI: 10.1111/ajad.13671