American Journal on Addictions最新文献_第2页

Factors associated with receipt of second injection of naltrexone for opioid use disorder: Secondary analysis of 5 clinical trials. 阿片类药物使用障碍患者再次注射纳曲酮的相关因素：5项临床试验的二次分析

IF 2.5 4区医学

American Journal on Addictions Pub Date : 2025-06-08 DOI: 10.1111/ajad.70055

Matisyahu Shulman, Mei-Chen Hu, Maria A Sullivan, Miranda Greiner, Kaitlyn Ohrtman, Onumara Opara, Edward V Nunes, Adam Bisaga

{"title":"Factors associated with receipt of second injection of naltrexone for opioid use disorder: Secondary analysis of 5 clinical trials.","authors":"Matisyahu Shulman, Mei-Chen Hu, Maria A Sullivan, Miranda Greiner, Kaitlyn Ohrtman, Onumara Opara, Edward V Nunes, Adam Bisaga","doi":"10.1111/ajad.70055","DOIUrl":"https://doi.org/10.1111/ajad.70055","url":null,"abstract":"Background and objectives: Extended-release injectable naltrexone (XR-naltrexone) is an effective relapse prevention treatment of patients with opioid use disorder (OUD), but retention remains a problem. Previous trials have either only calculated the association of one or two predictors or used claims-based datasets with only limited data to identify these characteristics. This analysis tested multiple baseline and clinical predictors for association with early retention on XR-naltrexone using combined data from five consecutive studies enrolling patients with active opioid use.Methods: Bivariate associations between patients' demographic and clinical characteristics at baseline and during the weeks after the first XR-naltrexone injection, and receipt of a second injection were calculated (n = 200). Significant factors were included in a multivariable logistic regression model.Results: 148/200 participants (74%) received the second injection. Lower Hamilton-Depression Scale (HAM-D) scores after the first injection were significantly associated with receiving a second injection in univariate and multivariable analysis. The following factors were significantly associated with receipt of the second injection in the univariate but not in the multivariable model: longest period of abstinence 1-11 months, use of cocaine in the 7 days before enrollment, use of alcohol or cocaine in the week after first injection, lower severity of cravings for opioids after first injection, lower self-report withdrawal scores after the first injection.Conclusions and scientific significance: Depressive symptoms after first XR-naltrexone injection are associated with nonreceipt of a second injection. Clinicians should educate patients about this risk and monitor for possible depression symptoms after the first injection.","PeriodicalId":7762,"journal":{"name":"American Journal on Addictions","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144245946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Examining family member characteristics by treatment status of the relative with substance use problems. 通过药物使用问题亲属的治疗状况检查家庭成员特征。

IF 2.5 4区医学

American Journal on Addictions Pub Date : 2025-06-06 DOI: 10.1111/ajad.70054

Raquel Radaeli de Figueiredo van der Molen, Ronaldo Laranjeira, Martha Canfield, Claudio Jerônimo da Silva, Júlia Soeiro E Silva, Helena Takeyama Sakiyama, Douglas José Resende Lima, Maria de Fátima Rato Padin

{"title":"Examining family member characteristics by treatment status of the relative with substance use problems.","authors":"Raquel Radaeli de Figueiredo van der Molen, Ronaldo Laranjeira, Martha Canfield, Claudio Jerônimo da Silva, Júlia Soeiro E Silva, Helena Takeyama Sakiyama, Douglas José Resende Lima, Maria de Fátima Rato Padin","doi":"10.1111/ajad.70054","DOIUrl":"https://doi.org/10.1111/ajad.70054","url":null,"abstract":"Background and objectives: Family involvement is increasingly recognised as important to the treatment and recovery of individuals with substance use disorders. While affected family members (AFMs) can play a critical role in enhancing treatment engagement and improving outcomes, there is limited understanding of their characteristics and how these relate to whether their relative with substance use problems (RSU) is receiving treatment. This study examines factors associated with the treatment status of RSU, based on reports from and characteristics of AFMs who sought support through a public family programme.Methods: Records of 4471 AFMs who sought support from a family support programme in Brazil were analysed.Results: For 81.9% of AFMs, the RSU was not in treatment at the time of entry. AFMs with RSUs in treatment were more likely to be older, male, cohabiting with the RSU, and reported fewer negative symptoms, better understanding of addiction, and less conflict over substance use. RSUs in treatment were more likely to be female, educated, and have dual alcohol and drug use problems.Discussion and conclusions: Findings highlight factors linked to treatment status and offer directions for future research on substance use treatment and family dynamics.Scientific significance: By analysing a large sample of AFMs, this study offers empirical support for the role of family context and interpersonal dynamics in treatment access. These insights highlight the importance of integrating family-based approaches into substance use intervention strategies.","PeriodicalId":7762,"journal":{"name":"American Journal on Addictions","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144232916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of xylazine toxicity, overdose, dependence, and withdrawal: A systematic review. 二嗪毒性、过量、依赖和戒断的管理：系统回顾。

IF 2.5 4区医学

American Journal on Addictions Pub Date : 2025-06-06 DOI: 10.1111/ajad.70051

Philipa Owusu-Antwi, Priya Atodaria, Edmund Appiah-Kubi, Zainab Shah, Elpidio Marlon Garcia

{"title":"Management of xylazine toxicity, overdose, dependence, and withdrawal: A systematic review.","authors":"Philipa Owusu-Antwi, Priya Atodaria, Edmund Appiah-Kubi, Zainab Shah, Elpidio Marlon Garcia","doi":"10.1111/ajad.70051","DOIUrl":"https://doi.org/10.1111/ajad.70051","url":null,"abstract":"Background and objectives: Xylazine, an alpha-2-adrenergic agonist, has been increasingly implicated in substance use and overdose crises. However, little is known about its effects on humans. With the growing public health crisis surrounding xylazine, it has become important to recognize and promptly manage symptoms of xylazine toxicity, withdrawal, and overdose. We conducted a systematic review to consolidate the existing literature on the topics, aiming to identify gaps and propose evidence-based actions for managing patients.Methods: Published literature from 1957 to 2024 was searched to identify studies focusing on the management of xylazine intoxication, withdrawal, overdose, and dependence in humans. PRISMA guidelines and JBI critical appraisal tools were used to ensure the methodological quality of the included studies and reduce bias in study selection. Thirty-four studies were included in this review.Results: Xylazine misuse was common among men aged 19-45 years and was more likely to be used with other substances than alone. The doses ranged from 40 to 4300 mg, with no established toxic dosing. Supportive care included treatment with naloxone, alpha-2 agonists, and GABAergic medications. There is no antidote or evidence-based treatment recommendations.Discussion and conclusions: This systematic review consolidated the outcomes and proposed guidelines from xylazine management trials. It can serve as a reference for providers to promptly manage xylazine toxicity, withdrawal, and overdose symptoms to improve patient outcomes.Scientific significance: Although there is currently no standardized treatment or antidote, this review will aid ongoing research to address these gaps in xylazine management.","PeriodicalId":7762,"journal":{"name":"American Journal on Addictions","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144232917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and correlates of tobacco and cannabis co-use among late middle-aged (50-64 years) and older adults (65+ years) in the United States using pooled national survey data. 美国中老年（50-64岁）和老年人（65岁以上）中烟草和大麻共同使用的患病率及其相关因素

IF 2.5 4区医学

American Journal on Addictions Pub Date : 2025-06-06 DOI: 10.1111/ajad.70053

Margaret C Fahey, Sarah Gutkind, Bethea A Kleykamp, Erin A McClure, Benjamin Han, Pia M Mauro

{"title":"Prevalence and correlates of tobacco and cannabis co-use among late middle-aged (50-64 years) and older adults (65+ years) in the United States using pooled national survey data.","authors":"Margaret C Fahey, Sarah Gutkind, Bethea A Kleykamp, Erin A McClure, Benjamin Han, Pia M Mauro","doi":"10.1111/ajad.70053","DOIUrl":"https://doi.org/10.1111/ajad.70053","url":null,"abstract":"Background: Adults in later life (ages 50+) are disproportionately impacted by tobacco morbidity and mortality. While tobacco prevalence has stagnated, cannabis use prevalence is rising at higher rates for older (vs. younger) age groups.Objective: To update the literature and better characterize co-use in older age using nationally representative data.Methods: National Survey on Drug Use and Health 2015-2019 data were used to assess the prevalence of past-month tobacco-only, cannabis-only, and tobacco and cannabis co-use among adults 50+ years (N = 43,963) in late middle-age (50-64) and older adulthood (65+ years). Multinomial logistic regressions explored sociodemographic/health characteristics associated with past-month co-use and cannabis-only use (vs. tobacco-only). We characterized past-year healthcare visits by use patterns.Results: One in five adults 50+ years reported past-month tobacco and/or cannabis use. Past-month co-use was higher in middle-age (3.5%) than older age (0.8%). Co-use was more likely among individuals reporting fair/poor health (vs. excellent/very good) (adjusted risk ratio [aRRR] = 1.27, 95% confidence interval [CI] = 1.01, 1.60), and with past-year mental illness (aRRR = 1.67, 95% CI = 1.39, 2.01). Cannabis-only use (vs. tobacco-only) was more likely among those with mental illness, yet less likely among those with good or fair/poor health than excellent/very good health. Most (90.2%) had any past-year healthcare contact, with all visit types overrepresented by tobacco-only use.Conclusion and scientific significance: Older U.S. adults with poorer physical and mental health were more likely to report past-month co-use than tobacco-only. These data uniquely describe the prevalence and characteristics of adults 50+ years in the U.S. who co-use tobacco and cannabis use.","PeriodicalId":7762,"journal":{"name":"American Journal on Addictions","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144232918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthetic cannabinoid use and the acquired preparedness model. 合成大麻素的使用和获得性准备模型。

IF 2.5 4区医学

American Journal on Addictions Pub Date : 2025-05-20 DOI: 10.1111/ajad.70049

Tyler Pia, Andrea H Weinberger

{"title":"Synthetic cannabinoid use and the acquired preparedness model.","authors":"Tyler Pia, Andrea H Weinberger","doi":"10.1111/ajad.70049","DOIUrl":"https://doi.org/10.1111/ajad.70049","url":null,"abstract":"Background and objectives: Synthetic cannabinoids (SCs) cause adverse physiological and psychological effects. There is little information about current SC use in the general United States (U.S.) population (i.e., nonclinical samples). The current study investigated the frequency and characteristics of SC use in a nonclinical U.S. sample and investigated potential motivations for use via the Acquired Preparedness Model (APM) of addiction (i.e., impulsivity, positive outcome expectancies (POEs)).Methods: In this cross-sectional study, adults who endorsed past-year SC use (n = 232) completed an online survey. Descriptive statistics were performed to examine characteristics of the sample. Mediation analyses were performed to examine the relationship between facets of impulsivity (Sensation Seeking, Positive Urgency, Negative Urgency, Total Impulsivity) and frequency of SC use with POEs as a mediating variable.Results: The mean age of the sample was 41 years old (SD = 13.36) and 62.9% identified as male. The mean frequency of past-year SC use was 83 days (SD = 93.1). Greater Sensation Seeking was the only facet of impulsivity significantly associated with a higher frequency of SC use. POEs were not significantly associated with the frequency of SC use and did not mediate the relationship between impulsivity and frequency of SC use.Discussion and conclusions: U.S. adults with past-year SC use reported using SC to manage stress, anxiety, and pain. Greater Sensation Seeking was associated with greater frequency of past-year SC use.Scientific significance: The present study is novel for its examination of SC in a nonclinical, adult sample and the use of the APM to examine motivations for SC use.","PeriodicalId":7762,"journal":{"name":"American Journal on Addictions","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of primary care team-based learning sessions for opioid use disorder. 基于初级保健团队的阿片类药物使用障碍学习课程评估

IF 2.5 4区医学

American Journal on Addictions Pub Date : 2025-05-20 DOI: 10.1111/ajad.70050

Cory B Lutgen, Elisabeth Callen, Elise Robertson, Tarin Clay, Gabriela Gaona, Kathryn Cates-Wessel, Yalda Jabbarpour, Melissa K Filippi

{"title":"Assessment of primary care team-based learning sessions for opioid use disorder.","authors":"Cory B Lutgen, Elisabeth Callen, Elise Robertson, Tarin Clay, Gabriela Gaona, Kathryn Cates-Wessel, Yalda Jabbarpour, Melissa K Filippi","doi":"10.1111/ajad.70050","DOIUrl":"https://doi.org/10.1111/ajad.70050","url":null,"abstract":"Background and objectives: Often patients with opioid use disorder (OUD) do not receive needed treatment; in part, this is due to the lack of available clinicians who treat OUD. To address the workforce gap, this study assessed OUD-related training for physicians and healthcare team members using the Project Extension for Community Healthcare Outcomes® (Project ECHO) model in a primary care, team-based setting.Methods: Twelve 1-h virtual Project ECHO sessions were held from April 2023 through March 2024. Twenty practices and 130 participants participated. Baseline and endpoint surveys, and brief post-session surveys were collected. Descriptive statistics, non-parametric tests, and Likert scales were used for survey questions. Analyses were performed at the group and individual level, and by role over time, using Mann-Whitney U tests, Wilcoxon Signed Rank tests, and Quade's ANCOVA, respectively. Sensitivity analyses were also completed.Results: Participants self-reported confidence and knowledge significantly increased at the individual, group, and role level. The greatest increases were seen on the topics of treating patients with fentanyl or co-occurring hepatitis C, office-based treatments, and behavioral health/counseling.Discussion and conclusions: Primary care team-based educational models have the potential to increase confidence and knowledge among participants, which may contribute to bridging care gaps for patients with OUD.Scientific significance: To our knowledge, this is one of the first studies to use Project ECHO across clinical teams. This study demonstrates that accessible team-based learning can strengthen self-reported confidence and knowledge and potentially contribute to increased role recognition, and strengthen the approach to opioid use disorder patient care.","PeriodicalId":7762,"journal":{"name":"American Journal on Addictions","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of persistent cannabis use on depression, psychosis, and suicidality following cannabis-induced psychosis: A longitudinal study. 持续使用大麻对抑郁症、精神病和自杀的影响：一项纵向研究。

IF 2.5 4区医学

American Journal on Addictions Pub Date : 2025-05-14 DOI: 10.1111/ajad.70048

Valerio Ricci, Domenico De Berardis, Giovanni Martinotti, Giuseppe Maina

{"title":"Effects of persistent cannabis use on depression, psychosis, and suicidality following cannabis-induced psychosis: A longitudinal study.","authors":"Valerio Ricci, Domenico De Berardis, Giovanni Martinotti, Giuseppe Maina","doi":"10.1111/ajad.70048","DOIUrl":"https://doi.org/10.1111/ajad.70048","url":null,"abstract":"Background and objectives: Cannabis use is associated with psychotic disorder onset and exacerbation. This study examines how continued cannabis use affects depressive symptoms, psychotic symptoms, and suicidal behaviors following cannabis-induced first-episode psychosis (FEP).Methods: Sixty-five participants (aged 16-50 years) with FEP were recruited from psychiatric inpatient facilities in northern Italy. Participants were categorized into two groups: non-cannabis users (NCU) and cannabis users (CU), based on substance use during the 9-month follow-up. Twenty-one participants (32.3%) were lost to follow-up, with a final sample of 44 subjects (NCU = 22, CU = 22). Assessments were conducted at baseline, 3 months, and 9 months using PANSS, CDSS, SSI, and GAF scales).Results: CU exhibited persistently higher depression (CDSS) and suicidality (SSI) scores than NCU throughout follow-up, with significant differences at both 3 months (CDSS: p = .000006; SSI: p < .001) and 9 months (CDSS: p = .0000001; SSI: p < .001). Positive psychotic symptoms improved in both groups, though CU showed slower recovery and higher relapse rates (59.9% vs. 18.8%). PANSS positive subscale scores remained significantly higher in CU at 3 months (p = .001) and 9 months (p < .0002). GAF scores improved significantly only in NCU (p = .024 at 9 months).Discussion and conclusions: Continued cannabis use adversely affects depressive and psychotic symptoms and suicidality in FEP patients, while cannabis cessation is associated with improved clinical outcomes.Scientific significance: This study tracks depressive symptoms, suicidality, and psychotic manifestations in cannabis-induced FEP, demonstrating that continued use is associated with treatment-resistant depressive symptoms even when psychotic symptoms improve, highlighting the need for integrated clinical approaches.","PeriodicalId":7762,"journal":{"name":"American Journal on Addictions","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment patterns and healthcare resource use among veterans initiating medication for incident moderate-to-severe alcohol use disorder. 中重度酒精使用障碍退伍军人的治疗模式和医疗资源使用

IF 2.5 4区医学

American Journal on Addictions Pub Date : 2025-05-12 DOI: 10.1111/ajad.70036

Regina Grebla, Teresa L Kauf, Angela Lax, Erin E Cook, Yilu Lin, Jieruo Liu, Shuqian Liu, Amy K O'Sullivan, Lizheng Shi, Sherry Shi, Maria A Sullivan, Elyse Swallow, Katie Witkiewitz, Karen Drexler

{"title":"Treatment patterns and healthcare resource use among veterans initiating medication for incident moderate-to-severe alcohol use disorder.","authors":"Regina Grebla, Teresa L Kauf, Angela Lax, Erin E Cook, Yilu Lin, Jieruo Liu, Shuqian Liu, Amy K O'Sullivan, Lizheng Shi, Sherry Shi, Maria A Sullivan, Elyse Swallow, Katie Witkiewitz, Karen Drexler","doi":"10.1111/ajad.70036","DOIUrl":"https://doi.org/10.1111/ajad.70036","url":null,"abstract":"Background and objectives: Several medications for alcohol use disorder (MAUDs) are recommended to treat alcohol use disorder (AUD) in the Veterans Affairs (VA) guidelines. This study descriptively characterized treatment patterns and healthcare resource utilization (HCRU) among VA patients with AUD treated with VA-recommended MAUDs.Methods: Veterans Health Administration data (VHA; 08/01/2013-11/30/2019) were used to identify 31,384 adults aged ≥18 years with AUD who initiated disulfiram (n = 2115), acamprosate (n = 3756), oral naltrexone (n = 25,082), or extended-release naltrexone (XR-NTX; n = 431) following AUD diagnosis. Study measures, stratified by medication received, included treatment adherence (proportion of days covered), discontinuation, and HCRU over 1 year.Results: Mean time to treatment discontinuation was high for all MAUDs but longest for XR-NTX (92 vs. 55-59 days; all p < .001). Relative to the year preceding AUD diagnosis, treatment with MAUDs was associated with fewer hospitalizations (XR-NTX: 0.48 vs. 0.42; oral naltrexone: 0.58 vs. 0.47; acamprosate: 0.67 vs. 0.60; disulfiram: 0.63 vs. 0.57) and more outpatient visits per patient (XR-NTX: 20.0 vs. 36.0; oral naltrexone: 19.0 vs. 30.0; acamprosate: 19.0 vs. 31.0; disulfiram: 17.0 vs. 29.0).Conclusion: Among veterans with AUD, this descriptive analysis found that MAUD use was associated with reduced hospitalizations, and XR-NTX was associated with a longer treatment duration versus oral MAUDs.Scientific significance: This real-world study is among the first to describe clinical characteristics, treatment patterns, and HCRU in VHA patients who initiated MAUDs when all MAUDs were included in the VHA formulary.","PeriodicalId":7762,"journal":{"name":"American Journal on Addictions","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association between cannabis use and suicidal intensity in psychiatric inpatients. 精神科住院病人大麻使用与自杀强度之间的关系。

IF 2.5 4区医学

American Journal on Addictions Pub Date : 2025-05-10 DOI: 10.1111/ajad.70047

Adeolu Funso Oladunjoye, Alan Swann, Thomas R Kosten, Michelle Patriquin, Tim Bigdeli, Peter Barr, Anna V Wilkinson, Mark J Harding, David A Nielsen, David P Graham

{"title":"The association between cannabis use and suicidal intensity in psychiatric inpatients.","authors":"Adeolu Funso Oladunjoye, Alan Swann, Thomas R Kosten, Michelle Patriquin, Tim Bigdeli, Peter Barr, Anna V Wilkinson, Mark J Harding, David A Nielsen, David P Graham","doi":"10.1111/ajad.70047","DOIUrl":"https://doi.org/10.1111/ajad.70047","url":null,"abstract":"Background: Over the past 15 years, most states have legalized the medical use of cannabis. Since then, daily use nearly tripled while the number of adults dying by suicide increased by 31%. Key studies found a greater suicidal intensity associated with cannabis use (CU) in adolescents. Adult associations have been understudied. The purpose of this study was to evaluate associations between CU and suicidal ideation intensity (SII) in adults.Methods: We examined 530 psychiatric inpatients ages 18 and above using the Columbia-Suicide Severity Rating Scale and the Alcohol, Smoking and Substance Involvement Screening Test for CU. We conducted a path analysis model of moderating and mediating factors, including psychiatric comorbidity, emotional regulation, psychological flexibility, and polygenic risk scores for externalization, CU, and suicide.Results: Sixteen percent of the participants had no suicidality, 34.3% reported suicidal ideation, and 49.6% reported a prior suicide attempt. CU was found to be associated with lower risk of SII for females (p = .026) but not for males (p = .525), and increased CU was associated with greater risk of SII with lower psychological flexibility in males (p = .049) but not females (p = .628).Conclusions: CU was associated with increased SII among psychiatric inpatients, with sex-specific patterns and potential mediation by psychological flexibility. Further studies exploring specific amounts, duration of use, and time frames of CU during adolescence and adulthood may provide insights into its associated risks, especially as legalization expands.Scientific significance: Patterns of past and current CU may increase understanding of mechanisms predicting increased SII in adult male psychiatric inpatients.","PeriodicalId":7762,"journal":{"name":"American Journal on Addictions","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review of the complex intersection between religion, spirituality, and harm reduction. 回顾宗教、灵性和减少伤害之间的复杂交集。

IF 2.5 4区医学

American Journal on Addictions Pub Date : 2025-05-10 DOI: 10.1111/ajad.70046

Jessica Van Denend, Jeremy Weleff, Kelly Park, Oriana Mayorga, M Gabriela Garcia-Vassallo

{"title":"A review of the complex intersection between religion, spirituality, and harm reduction.","authors":"Jessica Van Denend, Jeremy Weleff, Kelly Park, Oriana Mayorga, M Gabriela Garcia-Vassallo","doi":"10.1111/ajad.70046","DOIUrl":"https://doi.org/10.1111/ajad.70046","url":null,"abstract":"Background and objectives: Within substance use research, religion and spirituality (r/s) have been understudied in relation to harm reduction approaches. We perform a literature review to characterize various intersections between r/s and harm reduction.Methods: We searched major databases, Google Scholar, and other sources for academic articles and gray literature on the intersection between r/s and harm reduction. We describe areas of overlap and tension as well as analyze the results using three tiers of proximity to lived/living experience.Results: Of the 457 papers identified, 169 met final inclusion. Of these, 100 papers contained discussion of alignment between religious or spiritual values and harm reduction values, 39 discussed strategic uses of religious or spiritual resources, 22 discussed harm reduction practices in relation to substances with religious/spiritual relevance, such as psychedelics, and 8 discussed religious/spiritual support for harm reduction workers. Eighteen noted that content was coproduced with persons with lived/living experience, 75 of them noted content was informed by relationship with persons with lived/living experience, and in 76 no such engagement was mentioned.Discussion and conclusions: The relevance of r/s is not limited to abstinence-based models and has significance in the harm reduction literature.Scientific significance: This is the first systematic study of the complex intersection between r/s and harm reduction. The results point to opportunities to further understand r/s as both barrier to and resource for harm reduction efforts, as well as how proximity to those with lived/living experience may influence alignment with harm reduction values.","PeriodicalId":7762,"journal":{"name":"American Journal on Addictions","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0