American Journal on Addictions最新文献

{"title":"The mediating role of impulsivity in the relationship between childhood maltreatment and depression in methamphetamine patients.","authors":"Saad Ullah, Yang Tian, Jia-Jing Chen, Arsalan Haider, Abdur Rab Tariq Kiyani, Han Chen, Ren Huang, Dong-Mei Wang, Xiang-Yang Zhang","doi":"10.1111/ajad.70102","DOIUrl":"10.1111/ajad.70102","url":null,"abstract":"<p><strong>Background and objectives: </strong>Childhood maltreatment (CM) significantly increases the risk of depression in patients with methamphetamine use disorder (MAUD). However, the underlying psychological mechanism remains unclear. The purpose of this study was to explore whether impulsivity mediates the relationship between CM and depression in patients with MAUD.</p><p><strong>Methods: </strong>We recruited 577 Chinese male inpatients with MAUD. CM, depression, and impulsivity were assessed using standardized questionnaires.</p><p><strong>Results: </strong>A total of 321 of 577 (55.63%) patients with MAUD had experienced at least one form of CM. Maltreated patients exhibited elevated impulsivity and severe depression compared to nonmaltreated patients (both p < .001). CM, impulsivity, and depression were significantly interrelated (all p < .01). In addition, impulsivity partially mediated the CM-depression link in patients with MAUD (β = .015, 95% CI [0.007, 0.026]).</p><p><strong>Discussion and conclusions: </strong>Our findings indicate that CM has a long-term effect on depression, and impulsivity is an essential contributor to depressive symptoms in patients with MAUD who have experienced CM. Future research should investigate these associations using multimodal approaches and assess focused interventions that may reduce impulsivity and mitigate the psychological impact of adverse childhood experiences (ACEs) in patients with MAUD.</p><p><strong>Scientific significance: </strong>We identified impulsivity as a key mechanism in the CM-depression link, offering a novel intervention target. Our findings advance the understanding of the psychological mechanisms in addiction psychiatry and suggest that interventions targeting impulsivity may help mitigate depression in this population.</p>","PeriodicalId":7762,"journal":{"name":"American Journal on Addictions","volume":" ","pages":"370-378"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145407895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Readability, linguistic complexity, and stigma in ChatGPT responses to opioid use disorder FAQs: A comparative analysis.","authors":"Vitor M Campos, Daniel L Heringer, Gabriel P A Costa, Henrique N P Oliva, Akhil Anand","doi":"10.1111/ajad.70101","DOIUrl":"10.1111/ajad.70101","url":null,"abstract":"<p><strong>Background and objectives: </strong>AI chatbots are increasingly used in patient education. For opioid use disorder (OUD), content must be readable and non-stigmatizing. We compared ChatGPT responses with U.S. health organization FAQs on readability, complexity, and stigma.</p><p><strong>Methods: </strong>We analyzed 50 OUD FAQs paired with ChatGPT GPT-4o responses. Outcomes included word and sentence counts, lexical density, and six readability indices. Paired differences were tested with t tests or Wilcoxon signed-rank tests.</p><p><strong>Results: </strong>ChatGPT responses were longer than FAQs, with a mean word count of 253.7 vs. 76.6 (difference 177; 95% CI, 151-203) and sentence count of 18.2 vs. 9.0 (difference 9.2; 95% CI, 7.6-10.9). Lexical density was higher by 6.5 percentage points (95% CI, 4.0-9.0), with more characters (0.55; 95% CI, 0.40-0.70) and syllables per word (0.19; IQR, 0.14-0.24). Readability grade levels were consistently higher: Coleman-Liau +3.43, Gunning Fog +3.47, SMOG + 2.96, Flesch-Kincaid +3.61, Automated Readability Index +4.33, and Flesch Reading Ease -20.4 (all p < .05). Stigmatizing term frequency was similar, 0.98 vs. 0.28 per answer (95% CI, -1.3 to +3.3).</p><p><strong>Discussion: </strong>ChatGPT responses were longer and more complex than FAQs, although the frequency of stigmatizing language was similar.</p><p><strong>Conclusions: </strong>ChatGPT produced more comprehensive but less readable content than FAQs, revealing a gap with health literacy standards. While stigmatizing terms were uncommon unless simplified, length and complexity may hinder use.</p><p><strong>Scientific significance: </strong>Findings quantify readability and stigma trade-offs in AI-generated OUD education and emphasize the need for plain language prompting and human review.</p>","PeriodicalId":7762,"journal":{"name":"American Journal on Addictions","volume":" ","pages":"362-369"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145443777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brief Report: Is once daily enough? Assessing the impact of timing of methadone dose on pain sensitivity via quantitative sensory testing in persons with opioid use disorder.","authors":"Gabriel P A Costa, Christina Riggione, Julia Meyerovich, Declan T Barry, Joao P De Aquino","doi":"10.1111/ajad.70162","DOIUrl":"10.1111/ajad.70162","url":null,"abstract":"<p><strong>Background and objectives: </strong>Once-daily methadone dosing for opioid use disorder (OUD) may leave periods of inadequate analgesia. We tested whether experimental pain sensitivity differs across the inter-dose interval.</p><p><strong>Methods: </strong>Twenty-five adults (52% female, 43.12 years old) with OUD receiving stable once-daily methadone completed thermal quantitative sensory testing at early post-dose and pre-dose.</p><p><strong>Results: </strong>Heat pain threshold (MD -3.75°C; g = -0.78; p < .001) and tolerance (MD -0.92°C; g = -0.49; p = .018) were lower at pre-dose. Temporal summation and conditioned pain modulation did not differ.</p><p><strong>Discussion and conclusions: </strong>Pain sensitivity increased pre-dose, consistent with a hyperalgesic window.</p><p><strong>Scientific significance: </strong>Preliminary experimental evidence that once-daily methadone may contribute to cyclical hyperalgesia in persons with OUD.</p>","PeriodicalId":7762,"journal":{"name":"American Journal on Addictions","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13132031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147760088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with readmission to residential treatment among clients transitioned from detoxification services in Alberta, Canada.","authors":"Abreham Mekonnen","doi":"10.1111/ajad.70159","DOIUrl":"https://doi.org/10.1111/ajad.70159","url":null,"abstract":"<p><strong>Background and objectives: </strong>Readmission to residential treatment increases healthcare costs, strains publicly funded systems, and may not adequately meet clients' needs. This study examined rates and predictors of readmission to residential treatment among clients transitioned from detoxification services.</p><p><strong>Method: </strong>Data from 4915 clients admitted between April 2015 and March 2022, encompassing 10,463 treatment admissions, were analyzed. Logistic regression was used to compare readmitted with nonreadmitted clients, focusing on sociodemographic characteristics, primary substance of concern, and program-related variables.</p><p><strong>Results: </strong>Overall, 41.6% (n = 2046) of clients were readmitted, with a mean of 3.7 admissions, indicating that a small subgroup accounted for a disproportionate use of limited treatment capacity. Higher odds of treatment readmission were associated with opiate or alcohol use, unstable employment or marital status, detox noncompletion or repeated cycling between completion and noncompletion, transition delays exceeding 14 days, polysubstance use, urban-rural mobility, and use of multiple detox facilities. Lower odds of treatment readmission were observed in individuals using cocaine, those admitted to integrated facilities offering both detox and residential care, and clients with less frequent detox utilization.</p><p><strong>Conclusion and scientific significance: </strong>Readmission to residential treatment is common and linked to both individual vulnerabilities and system-level factors. Strengthening protocols for alcohol and opioid use, enhancing coordination between detox and residential treatment, and targeting high-risk groups may reduce readmission. Interventions addressing non-completion of detox and delayed transitions could further reduce treatment readmission. This study uniquely examines readmission in relation to prior detoxification programs and clients' characteristics within a continuum-of-care framework.</p>","PeriodicalId":7762,"journal":{"name":"American Journal on Addictions","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147721647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthcare professionals' perceptions of participation in one state physician health program.","authors":"Cristiana N P Araujo, Sidney Fire, Anna D'Ambrosio, Heather Thomas, Tish Conwell, Alexandria Polles, Lisa J Merlo","doi":"10.1111/ajad.70160","DOIUrl":"https://doi.org/10.1111/ajad.70160","url":null,"abstract":"<p><strong>Background and objectives: </strong>Participation in physician health programs (PHPs) is associated with positive outcomes for healthcare professionals (HCPs) with potentially-impairing conditions, but more information is needed about PHP completer experiences. The present study explored program completers' perceptions of their involvement with one state PHP.</p><p><strong>Methods: </strong>A PHP staff member with no monitoring role conducted exit interviews via telephone with all individuals who completed the program between January 2019 and September 2023 (n = 666). Deidentified interview responses were examined using quantitative descriptive analysis and thematic analysis.</p><p><strong>Results: </strong>The HCPs who completed PHP participation were generally satisfied with the program. Three major themes emerged: (1) PHP offers valuable support; (2) Helpful components of the PHP; and (3) Challenges encountered during PHP monitoring. The HCPs generally expressed appreciation for the PHP, with many describing a bittersweet journey. Components of the program identified as helpful included peer support, availability and expertise of case managers, accountability, advocacy and support offered by the program, and mental healthcare. Key challenges faced by program completers included the financial burden, feeling overwhelmed by program requirements, and perceived stigma and negative treatment related to their PHP involvement.</p><p><strong>Discussion and conclusions: </strong>Many PHP completers perceive PHP support as critical to improving their recovery outcomes. Additional resources may be needed to relieve the perceived financial burden of PHP participation, mitigate disruption to daily life/responsibilities, and reduce emotional distress following referral to PHP.</p><p><strong>Scientific significance: </strong>This is a large qualitative study of the perspectives and experiences of PHP completers.</p>","PeriodicalId":7762,"journal":{"name":"American Journal on Addictions","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147721597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential mortality among US veterans: Social determinants of health, substance use disorder, and substance use treatment.","authors":"Kashfi Pandit, Aerin deRussy, John Blosnich, Gala True, Ann E Montgomery","doi":"10.1111/ajad.70158","DOIUrl":"10.1111/ajad.70158","url":null,"abstract":"<p><strong>Background and objectives: </strong>Veterans face disproportionate suicide and mortality risks driven by intersecting social determinants of health (SDH), including housing instability, unemployment, and justice involvement, and co-occurring substance use disorders (SUD). This study examined how these intersecting factors influence mortality and whether SUD treatment mitigated mortality risks among US veterans.</p><p><strong>Methods: </strong>Using national Veterans Health Administration data (2014-2019), we identified 215,944 veterans with SUD and an indicator of one of three adverse SDH: housing instability, justice involvement, or unemployment. We tracked suicide and all-cause mortality for 1 year following SDH exposure. We used discrete-time survival models to assess associations between month-specific SUD treatment and mortality outcomes, controlling for demographic, clinical (i.e., mental health conditions, suicidal behavior), and contextual covariates.</p><p><strong>Results: </strong>Nearly half of veterans (48%) received SUD treatment. Those who received treatment had lower all-cause mortality (2.1% vs. 4.3%; p < .001) but no significant difference in suicide mortality (0.14% vs. 0.15%; p = .75). [Correction added on 22 April 2026, after first online publication: The preceding sentence has been revised in this version.] SUD treatment was associated with a 24% (aOR = 1.24; 95% CI: 1.16-1.34) reduction in all-cause mortality, though its interaction with each adverse SDH was not statistically significant. Suicide deaths remained concentrated among White veterans, those aged 18-34, with no service connection, and with time-varying suicidal ideation or attempts (p < .001).</p><p><strong>Discussion and conclusions: </strong>Engagement in SUD treatment reduces all-cause mortality among veterans facing compounded social adversity but does not independently mitigate suicide deaths.</p><p><strong>Scientific significance: </strong>Integrated approaches that embed suicide prevention within addiction and SDH-focused care are essential to address the multifactorial drivers of veterans' suicidal mortality.</p>","PeriodicalId":7762,"journal":{"name":"American Journal on Addictions","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147607780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brief Report: Opioid-related disorders increase patient-directed discharge in admissions for hemorrhagic or ischemic stroke.","authors":"Rohan M Shah, Shiv Patel, Brent Schnipke, Brandon Hamm","doi":"10.1111/ajad.70157","DOIUrl":"https://doi.org/10.1111/ajad.70157","url":null,"abstract":"<p><strong>Background and objectives: </strong>Opioid use has been linked to increased stroke incidence and severity; however, data on effects during acute stroke hospitalization are limited.</p><p><strong>Methods: </strong>We used the 2016-2020 National Inpatient Sample to evaluate the effects of opioid disorders on patient-directed discharge (PDD) and length of stay (LOS) in 3,101,545 patients.</p><p><strong>Results: </strong>On multivariate analysis, opioid disorders were independently associated with discharge AMA (aOR: 2.29; 95% CI: 1.98-2.65) and longer LOS (β: 1.5, SE: 0.138; p < .001).</p><p><strong>Discussion and conclusions: </strong>Opioid disorders may predispose PDD and prolonged hospital courses in stroke admissions.</p><p><strong>Scientific significance: </strong>Opioid disorders may warrant targeted inpatient management and health system planning in stroke.</p>","PeriodicalId":7762,"journal":{"name":"American Journal on Addictions","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147572148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cannabis cessation and neurocognitive recovery: Patterns, predictors, and clinical implications-a systematic review.","authors":"Valerio Ricci, Thomas Fraccalini, Giovanni Martinotti, Giuseppe Maina","doi":"10.1111/ajad.70156","DOIUrl":"https://doi.org/10.1111/ajad.70156","url":null,"abstract":"<p><strong>Background and objectives: </strong>Cannabis use disorder affects millions globally, with growing interest in neurocognitive recovery following cessation. The reversibility of cannabis-induced neuroadaptations remains critical for clinicians, given increasing cannabis potency and early initiation. This systematic review examines neurocognitive recovery patterns and biomarker changes following cannabis cessation, focusing on clinical implications and factors influencing recovery trajectories.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted using PubMed, EMBASE, PsycINFO, and Cochrane databases (2000-2025). Studies examining neurocognitive recovery following cannabis cessation were included, with abstinence periods ranging from acute (≥72 h) to extended (months to years). Primary outcomes included neuroimaging changes, cognitive performance, and biomarker recovery patterns. Study quality was assessed using Newcastle-Ottawa Scale and Cochrane Risk of Bias tools. Narrative synthesis was employed due to heterogeneity.</p><p><strong>Results: </strong>Twenty-six studies met the inclusion criteria. Neuroimaging demonstrated CB1 receptor normalization within 4 weeks and cognitive improvements within the first week of cessation. Recovery patterns varied by age of onset and use intensity. Adolescent-onset users showed less complete recovery than adult-onset users; heavy users required extended recovery periods. Cognitive deficits in attention and executive function persisted beyond acute cessation.</p><p><strong>Discussion and conclusions: </strong>Cannabis cessation produces substantial neurocognitive recovery, particularly within the first year. However, recovery requires extended clinical support, age-stratified approaches, and systematic cognitive monitoring. Current evidence challenges assumptions about permanent cannabis-related brain damage while highlighting vulnerabilities in adolescent populations.</p><p><strong>Scientific significance: </strong>These findings provide evidence-based guidance for treatment duration, realistic expectation-setting, and individualized prognosis determination in cannabis use disorder recovery.</p>","PeriodicalId":7762,"journal":{"name":"American Journal on Addictions","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147502812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving access to direct acting antivirals via a multimodal integrated care program in an addiction medicine clinic.","authors":"Arya Zandvakili, Joseph Rattenni, James Burton, Lakshmi Guduguntla, Marcus Osman, Sayeh Sabbagh, Stephan Arndt, Ben Miskle, Quanhathai Kaewpoowat, Michael Ohl, Andrea Weber, Alison Lynch","doi":"10.1111/ajad.70155","DOIUrl":"https://doi.org/10.1111/ajad.70155","url":null,"abstract":"<p><strong>Background and objectives: </strong>Injection drug use is a driver of hepatitis C virus (HCV) transmission, thus integrating HCV care into addiction care is likely necessary for HCV elimination. Here we describe how we integrated HCV care into our addiction medicine (AM) clinic and evaluate its effect on HCV treatment.</p><p><strong>Methods: </strong>Integrated care involves HCV screening and treatment with either DAA prescription directly in AM clinic or via telemedicine with an infectious diseases (ID) specialist. Using retrospective chart review, we assessed if the program affected rates of direct-acting antivirals (DAA) initiation, DAA completion, and sustained virological response (SVR).</p><p><strong>Results: </strong>Among 72 treatment naïve patients, the rate of DAA initiation increased after integrated care (HR 2.21, 95% CI 1.05-4.66), but rates of DAA completion or SVR did not significantly increase. Integrated care was associated with more DAA prescriptions (0.6 vs. 0 prescriptions per month, p = .004) and decreased referrals to hepatology (0.2 vs. 1 referrals per month, p = .001). Compared to referring patients to hepatology, prescribing DAAs in AM clinic was associated with higher rates of DAA initiation (HR 42.46; 95% CI: 15.25-118.24) and completion (HR 8.33; 95% CI: 2.76-25.16).</p><p><strong>Discussion and conclusions: </strong>An integrated care program that involved both in-person and telemedicine options improve access to DAA therapy. Enhancing interprofessional collaboration and expanding telemedicine services offers a practical model for strengthening HCV care delivery.</p><p><strong>Scientific significance: </strong>This study demonstrates a practical approach to integrating HCV care into addiction treatment through development of inter-professional collaboration between healthcare specialties.</p>","PeriodicalId":7762,"journal":{"name":"American Journal on Addictions","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147442273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing tobacco use in the context of opioid use disorder: A systematic review of smoking cessation interventions.","authors":"Suprit Parida, Victoria Ameral, Noah Wolkowicz, Megan M Kelly, Jessica A Patterson, Mehmet Sofuoglu, R Ross MacLean","doi":"10.1111/ajad.70154","DOIUrl":"https://doi.org/10.1111/ajad.70154","url":null,"abstract":"<p><strong>Background and objectives: </strong>Rates of tobacco use disorder (TUD) are high among individuals with opioid use disorder (OUD), who consistently show lower response rates to evidence-based treatment approaches for TUD relative to the general population. This systematic review aims to provide a comprehensive and updated examination of the current evidence regarding TUD treatments for individuals with OUD. We first summarize potential mechanisms driving TUD and treatment nonresponse among those with OUD, given the likely roles of overlapping reward and withdrawal processes in co-occurrence and treatment challenges. We then provide an updated review of the relevant literature on treating TUD among those with OUD.</p><p><strong>Methods: </strong>Our review identified a total of 25 studies, with 9 examining pharmacological treatments, 5 examining behavioral treatments, and 11 examining a combination treatment approach.</p><p><strong>Results: </strong>Consistent with previous research, pharmacological treatments were generally ineffective for smoking cessation among those with OUD. No studies reported continuous abstinence at 6 months post-quit date. Contingency management interventions showed some promise but smoking largely resumed after incentives were removed.</p><p><strong>Discussion and conclusions: </strong>Overall, findings demonstrate limited progress in identifying durable, effective smoking cessation interventions for individuals with OUD.</p><p><strong>Scientific significance: </strong>Traditional cessation treatment approaches fail to address smoking in individuals with OUD. Novel pharmacological and behavioral strategies that can be implemented into existing medications for OUD clinical care are necessary.</p>","PeriodicalId":7762,"journal":{"name":"American Journal on Addictions","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147343747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}