与不吸烟的健康个体相比,吸烟个体的口腔微生物群不同。

IF 1.9 4区 医学 Q2 SUBSTANCE ABUSE
Ruth Adekunle, Jordan Monteith, Zhuang Wan, Joshua P Smith, Enrique Espinosa, Lei Huang, Wei Jiang
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引用次数: 0

摘要

背景和目的:长期吸烟会导致口腔健康问题,如牙周炎和蛀牙,这可能是由吸烟改变口腔微生物群引起的。长期吸烟对口腔微生物群的影响尚不完全清楚。方法:采用微生物16S rRNA测序方法,对20名中国男性慢性吸烟者和23名非吸烟者的口腔唾液微生物组进行了横断面研究。使用非参数Mann-Whitney检验和回归模型对吸烟时间、年龄和牙龈炎信息进行收集和分析。结果:与对照组相比,吸烟者口腔微生物群增加最多和减少最多的分别是链球菌和奈瑟菌属。在调整了年龄、牙龈炎、吸烟时间和FDR后,吸烟者中只有Pectinatus属和austrptococcus species的丰度比对照组显著增加。讨论与结论:本研究表明,长期口服烟草与一些促炎微生物群的富集有关,如南方葡萄球菌。科学意义:我们的研究表明,保持良好的口腔卫生,使用可减少促炎微生物群的口腔益生菌,或治疗口腔疾病可能有助于预防烟草富集的共生病原体的发病机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Distinct oral microbiomes in individuals with tobacco smoking compared to nonsmoking healthy individuals.

Background and objectives: Chronic tobacco smoking contributes to oral health problems, such as periodontitis and tooth decay, which can result from smoking-altered oral microbiomes. The impact of chronic tobacco smoking on the oral microbiome remains not fully understood.

Methods: This was a cross-sectional study comparing the oral salivary microbiomes of 20 chronic tobacco smokers and 23 nonsmoking controls, all of whom were Chinese males, using microbial 16S rRNA sequencing. The duration of smoking, age, and information on gingivitis were collected and analyzed using the nonparametric Mann-Whitney test and a regression model.

Results: The most increased and decreased oral microbiomes in smokers versus controls were the genera Streptococcus and Neisseria, respectively. After adjusting for age, gingivitis, smoking duration, and FDR, only the abundance of the Pectinatus genus and Streptococcus australis species was significantly increased in smokers compared to controls.

Discussion and conclusions: This study reveals that long-term oral tobacco smoking is associated with the enrichment of some proinflammatory microbiomes, such as S. australis.

Scientific significance: Our study suggests that maintaining good oral hygiene, using oral probiotics that reduce proinflammatory microbiomes, or treating oral diseases may help prevent the pathogenesis of tobacco-enriched commensal pathobionts.

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来源期刊
CiteScore
5.00
自引率
0.00%
发文量
118
期刊介绍: The American Journal on Addictions is the official journal of the American Academy of Addiction Psychiatry. The Academy encourages research on the etiology, prevention, identification, and treatment of substance abuse; thus, the journal provides a forum for the dissemination of information in the extensive field of addiction. Each issue of this publication covers a wide variety of topics ranging from codependence to genetics, epidemiology to dual diagnostics, etiology to neuroscience, and much more. Features of the journal, all written by experts in the field, include special overview articles, clinical or basic research papers, clinical updates, and book reviews within the area of addictions.
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