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Eksperimental'naia onkologiia最新文献

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[The rate of macrophage inclusion in the elimination of tumor cells when administered to syngeneic animals]. [给药于同基因动物时，巨噬细胞在消除肿瘤细胞中的包涵率]。
Eksperimental'naia onkologiia Pub Date : 1990-01-01
V A Lavrovskiĭ, A S Ustinov
{"title":"[The rate of macrophage inclusion in the elimination of tumor cells when administered to syngeneic animals].","authors":"V A Lavrovskiĭ,&nbsp;A S Ustinov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A degree of destruction of tumour cells after their inoculation to a syngenic recipient correlates positively with sensitivity to the lytic effect of macrophages. A clear-cut participation of macrophages in elimination of tumours cells can be detected 8 h after their inoculation.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 5","pages":"35-6"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13378347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The effect of the bone marrow fibroblasts from patients with malignant diseases of the blood system on the colony-forming capacity of granulomonocytic precursor cells]. [血液系统恶性疾病患者骨髓成纤维细胞对肉芽单胞前体细胞集落形成能力的影响]。
Eksperimental'naia onkologiia Pub Date : 1990-01-01
V A Almazova, A Iu Zaritskiĭ, E R Machiulaĭtens, M V Blagosklonnyĭ, T D Zorina, V N Glibin
{"title":"[The effect of the bone marrow fibroblasts from patients with malignant diseases of the blood system on the colony-forming capacity of granulomonocytic precursor cells].","authors":"V A Almazova,&nbsp;A Iu Zaritskiĭ,&nbsp;E R Machiulaĭtens,&nbsp;M V Blagosklonnyĭ,&nbsp;T D Zorina,&nbsp;V N Glibin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The inhibiting activity of bone marrow fibroblasts and their ability to sustain survival of granulocytic cell precursors have been studied in patients with chronic myelocytic leukemia, chronic lymphoproliferative disorders, acute leukemia, myelodysplastic syndrome. Fibroblast conditioned medium inhibits proliferation of granulomonocytic precursors stimulated by leucocyte feeder layer or leucocyte conditioned medium. The effect depends both on the presence of monocytes and the specificity of the disease. The inhibitory effect is related with long-ranged factors. Bone marrow fibroblasts are able to sustain survival of hemopoietic precursors via humoral and cell-cell mechanisms. The regulatory role of bone marrow fibroblasts in hemopoietic disorders is discussed.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 5","pages":"49-52"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13378351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Cytogenetic characteristics of H3 oxide induced myeloid leukemia in Wistar rats]. [H3氧化物诱导Wistar大鼠髓系白血病的细胞遗传学特征]。
Eksperimental'naia onkologiia Pub Date : 1990-01-01
N G Nikolaevskaia, K N Muksinova, L D Murzina, V S Revina
{"title":"[Cytogenetic characteristics of H3 oxide induced myeloid leukemia in Wistar rats].","authors":"N G Nikolaevskaia,&nbsp;K N Muksinova,&nbsp;L D Murzina,&nbsp;V S Revina","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Frequency and spectrum of chromosomal aberrations were studied in hemopoietic cells of Wistar rats myeloid leukaemia induced by the prolonged exposure to tritium oxide. Differences in quantitative and structural damages of chromosomes were revealed by the cytogenetic assessment of eighteen rats with acute myeloid leukaemia (AML) and six rats with chronic myeloid leukaemia (CML). The most characteristic chromosomal aberrations for AML appeared to be rearrangements in chromosomes 1-3. In CML translocations by one of chromosomes 15-20 coupled with defects in the groups of chromosomes 5-10 seemed to be nonrandom.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 3","pages":"19-21"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13494164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Cytolytic activity of macrophages and T-lymphocytes in regard to tumor cells in the presence of normal tissue cells]. [正常组织细胞存在时巨噬细胞和t淋巴细胞对肿瘤细胞的细胞溶解活性]。
Eksperimental'naia onkologiia Pub Date : 1990-01-01
V A Lavrovskiĭ, E P Dobrunova
{"title":"[Cytolytic activity of macrophages and T-lymphocytes in regard to tumor cells in the presence of normal tissue cells].","authors":"V A Lavrovskiĭ,&nbsp;E P Dobrunova","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 4","pages":"77-8"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13526443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The ultrastructure and histochemical characteristics of the cells of malignant fibrous histiocytoma in rats]. [大鼠恶性纤维组织细胞瘤细胞的超微结构及组织化学特征]。
Eksperimental'naia onkologiia Pub Date : 1990-01-01
K M Pozharisskiĭ, A Iu Nikitin
{"title":"[The ultrastructure and histochemical characteristics of the cells of malignant fibrous histiocytoma in rats].","authors":"K M Pozharisskiĭ,&nbsp;A Iu Nikitin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Samples of tissue from malignant fibrous histiocytoma of rats induced by subcutaneous injection of paraffin pill-enclosed DMBA were studied for localization of acid phosphatase and non-specific esterases (15 samples) and cell ultrastructure (10). Tumours showed cellular heterogeneity consisting of 5 types of cells: histiocyte-like, fibroblast-like, giant multinuclear xanthomatous and undifferentiated. Acid phosphatase and non-specific esterases were found both in histiocyte-like and fibroblast-like cells which means that those enzymes are not the specific markers of tumors arising from monocytic-macrophagal system. Histochemical and ultrastructural features of experimental malignant fibrous histiocytoma were similar to those of its human analogue.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 5","pages":"25-9"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13325460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The secretion of type-E prostaglandins and the sensitivity to hydrogen peroxide of Syrian hamster clone cells transformed by the Rous sarcoma virus]. [劳斯肉瘤病毒转化的叙利亚仓鼠克隆细胞的e型前列腺素分泌和对过氧化氢的敏感性]。
Eksperimental'naia onkologiia Pub Date : 1990-01-01
E A Kashleva, V A Matveeva, E N Uvarova, T E Kliuchareva
{"title":"[The secretion of type-E prostaglandins and the sensitivity to hydrogen peroxide of Syrian hamster clone cells transformed by the Rous sarcoma virus].","authors":"E A Kashleva,&nbsp;V A Matveeva,&nbsp;E N Uvarova,&nbsp;T E Kliuchareva","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Seven clonal sublines of the strain of syrian hamster embryo cells transformed in vitro by the Rous sarcoma virus were obtained. All clones possessed both high resistance to damage by hydrogen peroxide and a capacity to release E-type prostaglandins in response to contact with NK-cells in vitro. The clones did not differ from each other and from the parent population in respect to these qualitative properties. Possible relation between these two properties and their role in resistance of transformed cells to cytotoxic activity of macrophages, neutrophils and NK-cells and thus to their ability to survive in vivo are discussed.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 5","pages":"32-4"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13325462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Surface membrane antigens and receptors of the Reed-Sternberg and Hodgkin's cells in lymphogranulomatosis]. [淋巴肉芽肿病中Reed-Sternberg和Hodgkin细胞的表面膜抗原和受体]。
Eksperimental'naia onkologiia Pub Date : 1990-01-01
D F Gluzman
{"title":"[Surface membrane antigens and receptors of the Reed-Sternberg and Hodgkin's cells in lymphogranulomatosis].","authors":"D F Gluzman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The results obtained provide evidence concerning the nature of the Hodgkin and Reed-Sternberg cells. The data based on application of new methods developed during last years such as different enzymo- and immunocytochemical techniques, monoclonal antibody and lectin application and molecular studies of gene rearrangement are presented.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 3","pages":"3-9"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13342738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Expert systems in oncology: concepts, problems, perspectives]. [肿瘤学专家系统:概念、问题、观点]。
Eksperimental'naia onkologiia Pub Date : 1990-01-01
O M Kshivets
{"title":"[Expert systems in oncology: concepts, problems, perspectives].","authors":"O M Kshivets","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The architecture and fields of application of the expert systems in oncology are described. These systems allow systematization, developing and realizing the approximate knowledge, heuristics and algorithms of the expert-oncologists by the computer systems for solution of optimization problems of diagnosis and treatment of cancer patients. Principles of the functioning of expert systems are considered through the examples of solutions of concrete problems in oncology. Intellectual possibilities of the man-machine interaction under clinical conditions are discussed. The vistas of technological development of expert systems in oncology are evaluated.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 4","pages":"9-16"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13351950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Characteristics of genotoxic and carcinogenic action of metals]. [金属的遗传毒性和致癌作用特点]。
Eksperimental'naia onkologiia Pub Date : 1990-01-01
T P Maksimchuk, G A Babenko
{"title":"[Characteristics of genotoxic and carcinogenic action of metals].","authors":"T P Maksimchuk,&nbsp;G A Babenko","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The data on carcinogenic activity of certain metals and their compounds to humans and experimental animals are reviewed. Cellular uptake and intracellular distribution of metal compounds, metal-induced genotoxicity in different short-term tests are described. Specific lesions of DNA produced by carcinogenic metals, the influence of metal ions on the cell growth, DNA replication and DNA repair involved in mutagenesis and oncogenesis are under discussion. Mechanisms of metal carcinogenesis are studied to a less extent as compared with organic carcinogenesis.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 4","pages":"3-9"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13352059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Lymphocyte proliferation and differentiation in chronic lympholeukemia]. 慢性淋巴白血病的淋巴细胞增殖和分化。
Eksperimental'naia onkologiia Pub Date : 1990-01-01
I N Kogarko
{"title":"[Lymphocyte proliferation and differentiation in chronic lympholeukemia].","authors":"I N Kogarko","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Proliferative activity and differentiation levels of lymphocytes of lymph nodes and peripheral blood of practically healthy people and patients with chronic lymphocytic leukemia have been studied using the present physicochemical methods (autoradiography with labelled DNA and RNA precursors, microspectrocytometry, NMR spectroscopy, kinetic formaldehyde method, etc.). The following points have been stated: stage character of changes in normal and leukemic cells, differences in synthesis of nucleic acids in different periods of the cell cycle in norm and under chronic lymphocytic leukemia, proliferation peculiarities of lymphocytes in lymph nodes and in blood, presence of DNA defects in the process development, changes in lipids of lymphocytes and blood plasma at early stages of the disease and in the process of its development.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 5","pages":"43-9"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13378350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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