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Eksperimental'naia onkologiia最新文献

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[Effects of cortiphen and cyclophosphamide in uterine sarcoma induced primarily by 1,2-dimethylhydrazine and estradiol dipropionate in CBA mice]. [可的芬和环磷酰胺对1,2-二甲基肼和雌二醇诱发的CBA小鼠子宫肉瘤的影响]。
Eksperimental'naia onkologiia Pub Date : 1990-01-01
I B Merkulova, N A Vvedenskaia, V I Kiselev
{"title":"[Effects of cortiphen and cyclophosphamide in uterine sarcoma induced primarily by 1,2-dimethylhydrazine and estradiol dipropionate in CBA mice].","authors":"I B Merkulova,&nbsp;N A Vvedenskaia,&nbsp;V I Kiselev","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cortiphen and cyclophosphamide were studied for their effect on the mixed uterus sarcoma induced primarily by 1,2-dimethylhydrazine and oestradiol-dipropionate in CBA mice and its transplants. Their inhibitory action on the growth of these tumours is established.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 1","pages":"68-70"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13448131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Effects of cortiphen on human tumor strains transplanted into athymic mice and rats]. [可的芬对人肿瘤株移植胸腺小鼠和大鼠的影响]。
Eksperimental'naia onkologiia Pub Date : 1990-01-01
I K Bukharova, E S Revazova, L V Moroz
{"title":"[Effects of cortiphen on human tumor strains transplanted into athymic mice and rats].","authors":"I K Bukharova,&nbsp;E S Revazova,&nbsp;L V Moroz","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The antitumour activity of cortiphen synthesized at the All-Union Cancer Research Centre of the USSR Academy of Medical Sciences was studied on human tumour strains transplanted into nude mice and rats. Cortiphen was found to possess an expressed activity to kidney cancer, cancer of corpus uteri, chorionepithelioma, fibrosarcoma. Two strains of colon adenocarcinoma out of three have displayed an expressed sensitivity to cortiphen, while melanoma and Jewing sarcoma strains proved to be weakly sensitive to the preparation.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 1","pages":"66-8"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13448280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The effect of the combined use of cryosurgery and hyperthermia on an experimental tumor process]. [冷冻和热疗联合应用对实验性肿瘤过程的影响]。
Eksperimental'naia onkologiia Pub Date : 1990-01-01
A P Kuz'menko, I N Todor, V S Mosienko
{"title":"[The effect of the combined use of cryosurgery and hyperthermia on an experimental tumor process].","authors":"A P Kuz'menko,&nbsp;I N Todor,&nbsp;V S Mosienko","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The antitumour efficacy of a single cryosurgery use in combination with hyperthermia was studied in 165 mice with the Lewis carcinoma, sarcoma 180 and 169 rats with Guérin's carcinoma and sarcoma 45. A considerable decrease in the recurrence frequency was observed irrespective of the histological type of the primary tumour. The haemostasis-associated expressed hypoxia has been established to arise in tumour tissues after cryodestruction. A day after the cryodestruction a shift to alkaline pH in the tumour tissue has been observed along with hypoxia. The above conditions possibly specify the high antitumour efficacy of a combined use of the cryosurgery and hyperthermia.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 2","pages":"60-1"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13468191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The capacity of glucocorticoid receptors for activation as a possible criterion of the hormonal sensitivity of human tumors]. [糖皮质激素受体的激活能力，作为人类肿瘤激素敏感性的可能标准]。
Eksperimental'naia onkologiia Pub Date : 1990-01-01
E S Gershteĭn, K D Smirnova, L S Bassalyk
{"title":"[The capacity of glucocorticoid receptors for activation as a possible criterion of the hormonal sensitivity of human tumors].","authors":"E S Gershteĭn,&nbsp;K D Smirnova,&nbsp;L S Bassalyk","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>For the functional activity evaluation of glucocorticoid receptors (GR) a specific method for their activated form determination was developed on the experimental model of the rat liver. The method is based on the interaction of GR with DNA-cellulose. It has been shown that 26-41% of the total rat liver GR are able of undergoing activation and being bound to DNA-cellulose. Activated GR were studied in 88 renal tumours and in 37 melanomas. 20% of renal tumours and 33% of melanomas contain GR which are not able to undergo activation. The number of activated GR in most cases is much lower than the total GR number. There is no direct correlation between the concentrations of total and activated GR, as well as between the total GR content and the percent of activated forms in the whole receptor pool. It appears that the study of activated GR may give more reliable information about the hormone sensitivity of tumours than the determination of the total receptor content.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 2","pages":"33-5"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13469722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Effects of intracellular Na+/K+ ratio on histone gene expression in ascitic cells of leukemia P-388 and Ehrlich cancer]. [细胞内Na+/K+比值对白血病P-388和埃利希癌腹水细胞组蛋白基因表达的影响]。
Eksperimental'naia onkologiia Pub Date : 1990-01-01
N V Smirnova, E V Kolosov, S D Kaz'min
{"title":"[Effects of intracellular Na+/K+ ratio on histone gene expression in ascitic cells of leukemia P-388 and Ehrlich cancer].","authors":"N V Smirnova,&nbsp;E V Kolosov,&nbsp;S D Kaz'min","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The intracellular Na+/K+ ratio was studied for its effect on histone genes expression in Ehrlich carcinoma and leukemia P-388 ascites cells. After equilibration with certain Na+/K+ ratio buffers at 0-4 degrees C the cells were treated during 1 h at 37 degrees C with ouabain added to the corresponding medium. Then total RNAs were extracted and analyzed by the reaction of blot-hybridization with histone genes cluster in plasmid p604. The maximal level of histone genes expression in leukemia P-388 cells was observed under conditions when intracellular Na+/K+ ratio corresponded to those at S-phase of the mitotic cycle. In Ehrlich carcinoma ascites cells the expression of histone genes was not dependent on the Na+/K+ ratio. A conclusion is drawn that the intracellular ratio of monovalent cations is one of the possible mechanisms which regulates the gene expression during the mitotic cycle.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 3","pages":"34-7"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13494755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Effects of indices of the test-system "age--normal antibodies--leukocytes--lymphocytes" on immunological parameters under the action of cancer risk factors]. [肿瘤危险因素作用下“年龄-正常抗体-白细胞-淋巴细胞”检测系统指标对免疫参数的影响]。
Eksperimental'naia onkologiia Pub Date : 1990-01-01
E V Montsevichiute-Eringene, B A Kaminskene, V E Milashene, D A Kharatseius
{"title":"[Effects of indices of the test-system \"age--normal antibodies--leukocytes--lymphocytes\" on immunological parameters under the action of cancer risk factors].","authors":"E V Montsevichiute-Eringene,&nbsp;B A Kaminskene,&nbsp;V E Milashene,&nbsp;D A Kharatseius","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>It is established that application of the test-system \"age-normal antibodies-leucocytes-lymphocytes\" permits refusing in certain cases from the generally-accepted laboratory immunological tests and prognosticate their values depending on the test-system indices when using the regression models. The great incongruity of the predicted and real values of the concrete immunological index may be the manifestation of the risk factors associated with the oncological and other diseases.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 3","pages":"40-4"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13494756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Role of intracellular pH in the development of resistance of leukemic cells to antineoplastic drugs]. [细胞内pH值在白血病细胞对抗肿瘤药物产生耐药性中的作用]。
Eksperimental'naia onkologiia Pub Date : 1990-01-01
O L Shestova, T A Ogloblina, L L Litinskaia
{"title":"[Role of intracellular pH in the development of resistance of leukemic cells to antineoplastic drugs].","authors":"O L Shestova,&nbsp;T A Ogloblina,&nbsp;L L Litinskaia","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Intracellular pH (pHi) of mouse lymphoid leukemia P388 cells was measured at the wavelength of 518 and 570 nm of fluorescein: pHi of rubomycin-sensitive P388 cells was higher than pHi of the cells resistant to this antitumour antibiotic (6.98 +/- 0.04 and 6.63 +/- 0.03, respectively, P less than 0.001). The role of pHi is established during induction of the resistance of tumour cells to the antitumour drugs.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 3","pages":"61-2"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13494762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Use of monoclonal antibodies and lectins in the study of subpopulations of lymphoid cells in normal state and in leukemia]. [单克隆抗体和凝集素在正常和白血病淋巴样细胞亚群研究中的应用]。
Eksperimental'naia onkologiia Pub Date : 1990-01-01
V A Nadgornaia, D M Skliarenko, D F Gluzman, E V Kaz'mina
{"title":"[Use of monoclonal antibodies and lectins in the study of subpopulations of lymphoid cells in normal state and in leukemia].","authors":"V A Nadgornaia,&nbsp;D M Skliarenko,&nbsp;D F Gluzman,&nbsp;E V Kaz'mina","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The heterogeneity of cell populations with peanut agglutinin receptors in reactive tonsilar tissue has been stated. It contains B lymphocytes (HLA-DR+, CD 10+, IPO-10+ cells), part of T-cells (CD 4+), but no CD 8+ lymphocytes. PNA+ CD 10+ cells are the normal analogues of centrocytic non-Hodgkin's lymphomas.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 4","pages":"51-3"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13529174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Effects of recombinant interleukin-2 on several characteristics of functional activity of lymphocytes from the lymph nodes regional to tumor and mononuclear cells of peripheral blood in cancer patients]. [重组白细胞介素-2对肿瘤患者淋巴细胞及外周血单个核细胞功能活性的影响]。
Eksperimental'naia onkologiia Pub Date : 1990-01-01
R A Semenova-Kobzar', L Ia Kushko, L V Iakhimovich, V S Protsyk, B A Tolstopiatov, V F Konovalenko, N M Berezhnaia
{"title":"[Effects of recombinant interleukin-2 on several characteristics of functional activity of lymphocytes from the lymph nodes regional to tumor and mononuclear cells of peripheral blood in cancer patients].","authors":"R A Semenova-Kobzar',&nbsp;L Ia Kushko,&nbsp;L V Iakhimovich,&nbsp;V S Protsyk,&nbsp;B A Tolstopiatov,&nbsp;V F Konovalenko,&nbsp;N M Berezhnaia","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The level of endogenous production of IL-2 by lymphocytes of lymph nodes regional to tumour and by mononuclear cells of peripheral blood, proliferative response of these cell to recombinant IL-2, as well as a modifying influence of autologous serum and actively proliferating bioptats of autologous tumours on enumerated parameters have been studied in cancer patients (tumours of the head and neck and locomotor system). Regional IL-2-dependent immunotherapy of malignant tumors with obligatory preliminary testing for individual sensitivity of the tumor bioptat to the influence of the RIL-2 and RIL-2 activated lymphocytes is shown to be promising.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 4","pages":"53-7"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13529175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The proliferative kinetics and acid-soluble proteins of the nuclear chromatin in tumor cells with a modified polyamine level]. [肿瘤细胞中多胺修饰的核染色质的增殖动力学和酸溶蛋白]。
Eksperimental'naia onkologiia Pub Date : 1990-01-01
G Z Negreĭ, Iu V Ianish, M P Zavelevich, V A Shliakhovenko
{"title":"[The proliferative kinetics and acid-soluble proteins of the nuclear chromatin in tumor cells with a modified polyamine level].","authors":"G Z Negreĭ,&nbsp;Iu V Ianish,&nbsp;M P Zavelevich,&nbsp;V A Shliakhovenko","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The inhibition of polyamine synthesis by DFMO (2.7 x 10(-3) M) resulted in a decrease of proliferation rate of L and OH-1 cells. The patterns of acid-soluble nuclear proteins were studied by the SDS electrophoresis. The content of protein fraction with molecular weight 25 kD was shown to correlate with the rate of proliferation of cell cultures.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 5","pages":"65-7"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13377500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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