Anaesthesiology intensive therapy最新文献_第5页

New therapeutic agents for type 2 diabetes: anaesthetic considerations. A narrative review. 新的2型糖尿病治疗药物：麻醉的考虑。叙述性评论

IF 1.7

Anaesthesiology intensive therapy Pub Date : 2025-09-17 DOI: 10.5114/ait/208895

Oliwia Doroba, Leszek Czupryniak, Filippo Sanfilippo, Paweł Andruszkiewicz, Mateusz Zawadka

{"title":"New therapeutic agents for type 2 diabetes: anaesthetic considerations. A narrative review.","authors":"Oliwia Doroba, Leszek Czupryniak, Filippo Sanfilippo, Paweł Andruszkiewicz, Mateusz Zawadka","doi":"10.5114/ait/208895","DOIUrl":"10.5114/ait/208895","url":null,"abstract":"An increasing number of patients treated with novel antidiabetic drugs, including glucagon-like-peptide-1 receptor agonists (GLP-1RA), dual glucose-dependent insulinotropic polypeptide receptor agonists and sodium-glucose cotransporter-2 (SGLT2) inhibitors, are presenting in the perioperative period. GLP-1RAs are known to delay gastric emptying, although current data remain preliminary and somewhat conflicting. SGLT2 inhibitors may be associated with euglycemic ketoacidosis in the perioperative period. To assess residual gastric content, gastric ultrasound may serve as a valuable tool in stratifying aspiration risk. Various recommendations are available for the perioperative management of patients on GLP-1RAs or SGLT2 inhibitors. These are based largely on expert opinion and multi-society consensus. This review aims to summarise the key perioperative considerations related to these drug classes and to familiarise practitioners with their pharmacological profiles. We highlight their potential adverse effects and present current recommendations from professional organisations to support safe and effective perioperative management.","PeriodicalId":7750,"journal":{"name":"Anaesthesiology intensive therapy","volume":"57 1","pages":"231-238"},"PeriodicalIF":1.7,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12793977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of antidepressants in neuropathic pain management: a retrospective, multicenter cross-sectional analysis. 抗抑郁药在神经性疼痛管理中的有效性：一项回顾性、多中心横断面分析。

IF 1.7

Anaesthesiology intensive therapy Pub Date : 2025-09-15 DOI: 10.5114/ait/208941

Marcin Kołacz, Dariusz Kosson, Radosław Rzepliński, Kinga Olczyk-Miiller, Piotr Mieszczański, Ewa Puchalska-Kowalczyk, Grzegorz Cichowlas

{"title":"Effectiveness of antidepressants in neuropathic pain management: a retrospective, multicenter cross-sectional analysis.","authors":"Marcin Kołacz, Dariusz Kosson, Radosław Rzepliński, Kinga Olczyk-Miiller, Piotr Mieszczański, Ewa Puchalska-Kowalczyk, Grzegorz Cichowlas","doi":"10.5114/ait/208941","DOIUrl":"10.5114/ait/208941","url":null,"abstract":"Introduction: Neuropathic pain (NP) arises as a direct consequence of a lesion or disease affecting the somatosensory nervous system. Antidepressants (ADs) are recommended for the pharmacological treatment of NP. However, current guidelines do not specify how long ADs may be effective in NP treatment if the patient is benefiting from the therapy.Material and methods: This was a retrospective cross-sectional study aiming to analyze the effectiveness of ADs in the treatment of NP by assessing the relationship between AD usage, the length of AD treatment and the intensity of pain in this group patients. Based on their pain intensity and length of treatment, the patients were divided into: three groups (NRS 0-3, NRS 4-6 and NRS ≥ 7), and six groups (< 1 month, 1-3 months, 3-6 months, 6-12 months, 1-2 years, 2-5 years, and > 5 years), respectively.Results: The study was conducted on a database from 421 patients, 231 (54.86%) of whom took antidepressants. We found that AD treatment significantly reduces the likelihood of being in the NRS 7-10 group compared to the NRS 0-3 group (OR = 0.611, 95% CI: 0.37-1.0, P = 0.05), and this reduction was observed up to 24 months of treatment (OR = 0.41, 95% CI: 0.22-0.75, P < 0.004).Conclusions: Considering the limitations of the study, the use of ADs in NP therapy may have a significant impact on reducing the occurrence of severe pain up to 24 months of therapy and should be included in pharmacotherapy in this group of patients.","PeriodicalId":7750,"journal":{"name":"Anaesthesiology intensive therapy","volume":"57 1","pages":"226-230"},"PeriodicalIF":1.7,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12793979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145073985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrasound-assisted peripheral venous cannulation in patients undergoing elective surgery under general anaesthesia: prospective randomized trial. 超声辅助外周静脉插管在全麻下择期手术患者中的应用：前瞻性随机试验。

IF 1.7

Anaesthesiology intensive therapy Pub Date : 2025-08-28 DOI: 10.5114/ait/208286

Michal Kalina, Barbora Stadlerová, David Astapenko, Marcela Bílská, Vladimír Černý, Roman Škulec

{"title":"Ultrasound-assisted peripheral venous cannulation in patients undergoing elective surgery under general anaesthesia: prospective randomized trial.","authors":"Michal Kalina, Barbora Stadlerová, David Astapenko, Marcela Bílská, Vladimír Černý, Roman Škulec","doi":"10.5114/ait/208286","DOIUrl":"10.5114/ait/208286","url":null,"abstract":"Introduction: Peripheral venous catheter (PVC) insertion is a common intervention, conventionally performed using visualization and palpation techniques. It has been reported that the first attempt success rate can be as low as 51%. Ultrasound guidance improves the overall success rate and the success rate of the first attempt. Therefore, we performed a randomized, prospective, clinical trial to compare two different techniques of PVC insertion in the setting of an operating theatre with a focus on the first attempt success rate.Material and methods: This clinical trial allocated patients scheduled for elective surgery in general anaesthesia to undergo PVC cannulation with ultrasound guidance (Group A) or to undergo PVC cannulation without the use of ultrasound (Group B).Results: A total of 613 adult patients were enrolled. The success of the first cannulation attempt was significantly higher in Group A compared to Group B (Group A: 90.6%, Group B: 84.5%, P = 0.039). The overall success rate in both groups was 100%. The time needed to perform PVC cannulation was significantly lower in Group B than Group A (Group A: 406 ± 200 s, Group B: 301 ± 215 s, P < 0.001).Conclusions: We found that ultrasound-guided PVC cannulation was associated with a higher first-attempt success rate than the conventional technique.","PeriodicalId":7750,"journal":{"name":"Anaesthesiology intensive therapy","volume":"57 1","pages":"219-225"},"PeriodicalIF":1.7,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12793995/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144939166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regional anesthesia as an alternative to general anesthesia for managing polytrauma surgically. 区域麻醉作为全身麻醉的一种替代方法用于外科治疗多发创伤。

IF 1.7

Anaesthesiology intensive therapy Pub Date : 2025-08-27 DOI: 10.5114/ait/208285

Francesca Gargano, Marco Fiore, Eleni McCaffery, Giuseppe Pascarella, Alessandro Ruggiero, Sabrina Migliorelli, Massimiliano Carassiti

引用次数: 0

Is general anesthesia neuroinjury-free and safe for gynecological patients' cognition? A comparison of two typical anesthesia schemes based on propofol and sevoflurane. 全麻对妇科患者的认知无神经损伤、安全吗？基于异丙酚和七氟醚的两种典型麻醉方案的比较。

IF 1.7

Anaesthesiology intensive therapy Pub Date : 2025-08-21 DOI: 10.5114/ait/208017

Włodzimierz Płotek, Artur Bekała, Jadwiga Łuczak-Wawrzyniak, Katarzyna Dudzińska-Rapczewska, Małgorzata Gasińska-Błotniak, Marcin Cybulski, Agnieszka Kubik-Komar, Elżbieta Kubera, Maciej Wilczak, Wojciech Dąbrowski

{"title":"Is general anesthesia neuroinjury-free and safe for gynecological patients' cognition? A comparison of two typical anesthesia schemes based on propofol and sevoflurane.","authors":"Włodzimierz Płotek, Artur Bekała, Jadwiga Łuczak-Wawrzyniak, Katarzyna Dudzińska-Rapczewska, Małgorzata Gasińska-Błotniak, Marcin Cybulski, Agnieszka Kubik-Komar, Elżbieta Kubera, Maciej Wilczak, Wojciech Dąbrowski","doi":"10.5114/ait/208017","DOIUrl":"10.5114/ait/208017","url":null,"abstract":"Introduction: The aim of the study was to evaluate the neurocognitive safety of two schemes of general anesthesia based on propofol or sevoflurane applied to patients undergoing laparoscopic gynecological operations, with a special focus on the patients' age, American Society of Anesthesiologists (ASA) physical status/risk category I, II, or III, and levels of neuromarkers.Material and methods: The Montreal Cognitive Assessment (MoCA) was chosen for cognitive assessment. The potential neuroinjury after anesthesia and operation was assessed with a set of neuromarkers: glial fibrillary acidic protein (GFAP), neurofilament light chain (NFL), tau protein (tau), and ubiquitin C-terminal hydrolase L1 (UCH-L1). The study was conducted on a group of women with no prior neurological or psychiatric diseases.Results: A total of 61 patients (mean age 40.57 years) were included in the study (29 patients under propofol-based anesthesia [PBA], 32 patients under sevoflurane-based anesthesia [SBA]). The groups were demographically comparable. The patients in both groups exhibited a postoperative increase in the MoCA regardless of the type of anesthesia. The NFL and UCH-L1 levels increased significantly in both groups. The GFAP levels were significantly higher in the SBA group. Neither the age nor the increase in the neuromarkers influenced the patients' cognition.Conclusions: The types of anesthesia applied in the laparoscopic gynecological operations resulted in a cognitively safe outcome despite detectable alterations in the neuromarkers.","PeriodicalId":7750,"journal":{"name":"Anaesthesiology intensive therapy","volume":"57 1","pages":"205-214"},"PeriodicalIF":1.7,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12793981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144939025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

iPACK block with adductor canal block vs. lumbar erector spinae plane block (L-ESPB) in total knee arthroplasty: a randomized, double-blinded, controlled trial. 全膝关节置换术中iPACK阻滞联合内收管阻滞vs腰椎竖肌脊柱平面阻滞（L-ESPB）：一项随机、双盲、对照试验。

IF 1.7

Anaesthesiology intensive therapy Pub Date : 2025-08-21 DOI: 10.5114/ait/208016

Tomasz Reysner, Katarzyna Wieczorowska-Tobis, Grzegorz Kowalski, Lukasz Lapaj, Przemyslaw Daroszewski, Małgorzata Reysner

{"title":"iPACK block with adductor canal block vs. lumbar erector spinae plane block (L-ESPB) in total knee arthroplasty: a randomized, double-blinded, controlled trial.","authors":"Tomasz Reysner, Katarzyna Wieczorowska-Tobis, Grzegorz Kowalski, Lukasz Lapaj, Przemyslaw Daroszewski, Małgorzata Reysner","doi":"10.5114/ait/208016","DOIUrl":"10.5114/ait/208016","url":null,"abstract":"Introduction: Total knee arthroplasty (TKA) is associated with severe pain. We examined whether an ultrasound-guided, single-injection L2 erector spinae plane block could improve analgesia compared to an ultrasound-guided iPACK (infiltration between the popliteal artery and capsule of the knee) block with adductor canal block (ACB) in patients undergoing TKA under spinal anesthesia.Material and methods: Ninety patients aged 65-89 years of both sexes (ASA I-III) scheduled for TKA were randomly allocated to receive iPACK block (ropivacaine 0.2%, 20 mL) with ACB (ropivacaine 0.2%, 10 mL), lumbar erector spinae plane block (L-ESPB) (ropivacaine 0.2%, 20 mL on each side), or to the control group. The primary outcome was total opioid consumption. The secondary outcomes included pain scores, time to first rescue opioid analgesia, quadriceps muscle strength, neutrophil-to-lymphocyte ratio (NLR), and platelet- to-lymphocyte ratio (PLR).Results: The total opioid consumption in 48 h was significantly lower in the iPACK+ACB group (mean ± SD) (3.0 ± 3.3) compared to L-ESPB (6.8 ± 3.8, P = 0.0442) and the control group (18.2 ± 4.0, P < 0.001). The time to first rescue opioid analgesia was longer in the iPACK+ACB (12.0 ± 1.9) compared to the L-ESPB (9.2 ± 1.9, P < 0.001) group and the control group (4.3 ± 1.1, P < 0.001). The pain scores, NLR, and PLR levels were significantly lower in the iPACK+ACB and L-ESPB groups than at all time points in the control group.Conclusions: The iPACK+ACB is more effective than L-ESPB in pain management following TKA. iPACK+ACB and the L-ESPB lowered total opioid consumption and prolonged time to first opioid analgesia. NLR and PLR levels did not differ between the groups.","PeriodicalId":7750,"journal":{"name":"Anaesthesiology intensive therapy","volume":"57 1","pages":"195-204"},"PeriodicalIF":1.7,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12793982/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144939007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advocating for universal access to epidural analgesia for women during childbirth: a scientific review Polish National Social Campaign "Hear the voice of pain". 倡导妇女在分娩时普遍获得硬膜外镇痛：一项科学审查波兰全国社会运动“倾听疼痛的声音”。

IF 1.7

Anaesthesiology intensive therapy Pub Date : 2025-07-29 DOI: 10.5114/ait/207671

Dorota Karkowska, Michał Modro, Tomasz Adam Karkowski

引用次数: 0

The obesity paradox in murine sepsis models: a systematic review and meta-analysis. 小鼠败血症模型中的肥胖悖论：一项系统综述和荟萃分析。

IF 1.7

Anaesthesiology intensive therapy Pub Date : 2025-07-25 DOI: 10.5114/ait/207612

Weronika Wasyluk, Marcin Czop, Martyna Wasyluk, Joanna Janisz-Hezron, Agnieszka Zwolak

{"title":"The obesity paradox in murine sepsis models: a systematic review and meta-analysis.","authors":"Weronika Wasyluk, Marcin Czop, Martyna Wasyluk, Joanna Janisz-Hezron, Agnieszka Zwolak","doi":"10.5114/ait/207612","DOIUrl":"10.5114/ait/207612","url":null,"abstract":"The obesity paradox, suggesting improved survival in obese individuals compared to those with normal weight, remains debated, particularly in sepsis. While it has been explored in clinical and experimental settings, conclusive evidence is lacking. This study systematically reviews and meta-analyses the relationship between obesity and survival in murine sepsis models. This systematic review and meta-analysis following PRISMA guidelines included studies from PubMed/Medline (up to January 31, 2025) comparing sepsis survival in obese and non-obese mice. All eligible murine studies were systema-tically reviewed, whereas only those employing diet induced obesity (DIO) and cecal ligation and puncture (CLP) were pooled in the meta-analysis and meta-regression. Twenty-one studies (38 survival experiments) met the criteria: CLP (n = 14), intraperitoneal lipopolysaccharide (n = 7), and other bacterial inoculation models (n = 17). Across all models, obesity increased survival in 10, decreased it in 9, and had no effect in 19 experiments. Quantitative synthesis of 10 CLP-DIO experiments (159 obese vs. 149 lean mice) showed no overall mortality difference (P = 0.391). Meta-regression explained 86% of heterogeneity: later highfat diet (HFD) initiation and longer feeding reduced mortality, whereas older age at sepsis induction increased mortality (all P < 0.001). Across the studies, obesity exerted mixed effects; pooled analysis of CLP DIO experiments showed no survival benefit. Variability among studies was associated with time related factors: age at HFD initiation, feeding duration, and age at sepsis induction, highlighting the need to investigate these relationships and to develop a time point standardized CLP DIO sepsis model.","PeriodicalId":7750,"journal":{"name":"Anaesthesiology intensive therapy","volume":"57 1","pages":"182-194"},"PeriodicalIF":1.7,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144740957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anabolic androgenic steroids and illicit drugs as potential modulating factors in malignant hyperthermia: a case series. 合成代谢雄激素类固醇和非法药物作为恶性热疗的潜在调节因素：一个病例系列。

IF 1.7

Anaesthesiology intensive therapy Pub Date : 2025-07-23 DOI: 10.5114/ait/207611

Mary Dos Santos Silva, Luciane Micheletti, Rafael Souza, Brandow Souza, Pamela Andrade, Mariz Vainzof, Helga Silva

引用次数: 0

Advancements in neuromonitoring for predicting cerebral vasospasm in aneurysmal subarachnoid hemorrhage using near-infrared spectroscopy: an observational study and review of the literature. 近红外光谱预测动脉瘤性蛛网膜下腔出血脑血管痉挛的神经监测进展：一项观察性研究和文献综述。

IF 1.7

Anaesthesiology intensive therapy Pub Date : 2025-07-10 DOI: 10.5114/ait/202002

Augusto Leone, Till Brombach, Julie Etingold, Philipp Manall, Francesco Carbone, Antonio Colamaria, Uwe Spetzger

{"title":"Advancements in neuromonitoring for predicting cerebral vasospasm in aneurysmal subarachnoid hemorrhage using near-infrared spectroscopy: an observational study and review of the literature.","authors":"Augusto Leone, Till Brombach, Julie Etingold, Philipp Manall, Francesco Carbone, Antonio Colamaria, Uwe Spetzger","doi":"10.5114/ait/202002","DOIUrl":"10.5114/ait/202002","url":null,"abstract":"Introduction: Aneurysmal subarachnoid hemorrhage (aSAH), a severe form of hemorrhagic stroke, poses significant diagnostic and management challenges, particularly in predicting and managing cerebral vasospasm and delayed cerebral ischemia. This study explores the predictive value of near-infrared spectroscopy (NIRS) in high-grade aSAH patients.Material and methods: This observational study included 16 high-grade aSAH patients treated at a single institution from June 2020 to November 2023. Neuromonitoring incorporated daily transcranial Doppler and continuous NIRS, alongside routine computed tomography perfusion. The primary endpoint was the occurrence of major cerebral vasospasms detected by digital subtraction angiography preceded by a decrease in regional oxygen saturation as indicated by NIRS.Results: Among the participants, vasospasms were most prevalent in the internal carotid artery (56.3%), followed by the middle cerebral artery (50%). NIRS detected alterations in 43.8% of the cohort, with 25% occurring before vasospasm onset. A correlation between early NIRS alterations and specific vasospasm locations was identified.Conclusions: Conclusions: While NIRS shows potential for continuous, non-invasive monitoring of cerebral oxygenation, its utility in predicting vasospasms is limited. The findings underscore the importance of integrating NIRS with other neuromonitoring modalities to enhance predictive accuracy and patient management in aSAH. Large-scale studies are necessary to establish protocols and intervention thresholds.","PeriodicalId":7750,"journal":{"name":"Anaesthesiology intensive therapy","volume":"57 1","pages":"157-164"},"PeriodicalIF":1.7,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0