{"title":"Effect of growth hormone treatment on pubertal growth in a boy with cystinosis and growth failure after renal transplantation.","authors":"D Haffner, E Wühl, R Nissel, F Schaefer, O Mehls","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Recombinant human growth hormone (rhGH) has proven effective in improving growth in short prepubertal children with chronic renal failure (CRF) before and after renal transplantation. However, its effect in pubertal patients is still doubtful. We report the case of a boy with nephropathic cystinosis and persistent growth failure despite successful renal transplantation who was treated with rhGH (30 i.u./m2 body surface area/week sc) from early puberty up to final height.</p>","PeriodicalId":77500,"journal":{"name":"British journal of clinical practice. Supplement","volume":"85 ","pages":"7-9"},"PeriodicalIF":0.0,"publicationDate":"1996-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19955334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"rhGH use in children with CRI and undergoing dialysis post-transplant in Japan: a multicentre study. MultiCenter Study Group Japan.","authors":"H Kawaguchi, K Ito","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We evaluated the effect of rhGH at both 0.5 and 1.0 i.u./kg/week, on the growth of 83 CRI (pre- and dialysis) and 23 transplanted children after one year. Growth velocity (GV) was significantly increased in predialysis children on a dose of 0.5 i.u. (p < 0.001), from 3.8cm/year at baseline to 7.8cm/year at six months and 7.3cm/year at one year. On a dose of 1.0 i.u., GV was increased from 4.5cm/year at baseline to 10.3cm/year at six months and 8.7cm/year at one year (p < 0.01). When the increment in GV was compared a significant difference was noted between 0.5 i.u. and 0.1 i.u. at both six and 12 months (p < 0.01). GV was also significantly increased in dialysed children treated with 0.5 i.u., from 3.5cm/year to 5.6cm/year at six months (p < 0.01) and 5.4cm/year at one year (p < 0.01). On a dose of 1.0 i.u., the increase was from 3.4 to 8.4cm/year at six months (p < 0.001) and 8.3cm/year at one year (p < 0.01). There was a significant difference in GV between the 0.5 and 1.0 i.u. groups at both six and 12 months (p < 0.01). In transplanted children, GV was significantly improved over one year of GH treatment from 5.0 to 7.7cm/year at 0.5 i.u. (p < 0.05) and from 3.7 to 6.3cm/year at 1.0 i.u. (p < 0.05); however, there was no statistical difference between the groups. Seven out of 23 children showed evidence of deterioration of graft function during rhGH treatment. This was due to acute rejection (AR) in every case. AR was noted in two of 10 children (20%) in the 0.5 i.u. group and five of 13 children (38%) in the 1.0 i.u. group. Our results demonstrate that rhGH effectively stimulates GV, not only in CRI, but also in dialysed children. Attention should, however, be paid to deterioration of renal function.</p>","PeriodicalId":77500,"journal":{"name":"British journal of clinical practice. Supplement","volume":"85 ","pages":"26-31"},"PeriodicalIF":0.0,"publicationDate":"1996-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19955341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The role of recombinant human growth hormone (rhGH) in pubertal patients.","authors":"L Rees","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Growth response to rhGH decreases with increasing age. Transplanted adolescents, however, respond to rhGH in a comparable way to that of younger children. Caution should be used in transplanted children who, in our experience, grow as well as younger children. Whether or not the use of rhGH improves final height if used during puberty remains unknown.</p>","PeriodicalId":77500,"journal":{"name":"British journal of clinical practice. Supplement","volume":"85 ","pages":"14-7"},"PeriodicalIF":0.0,"publicationDate":"1996-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19955337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A C Hokken-Koelega, R C de Jong, R A Donckerwolcke, J W Groothoff, E D Wolff
{"title":"Use of recombinant human growth hormone (rhGH) in pubertal patients with CRI/dialysis/post-transplant: Dutch data. Dutch Study Group on Growth in Children with Chronic Renal Disease.","authors":"A C Hokken-Koelega, R C de Jong, R A Donckerwolcke, J W Groothoff, E D Wolff","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In the intermediate term, recombinant human growth hormone (rhGH) therapy in a dose of 28-30 i.u./m2/week accelerates growth significantly in most pubertal patients with growth retardation secondary to chronic renal insufficiency (CRI), dialysis and after renal transplantation (RTx), without evidence of adverse effects or acceleration of bone maturation. Therefore, rhGH therapy may well improve the final height of these patients.</p>","PeriodicalId":77500,"journal":{"name":"British journal of clinical practice. Supplement","volume":"85 ","pages":"5-6"},"PeriodicalIF":0.0,"publicationDate":"1996-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19955333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Is rhGH anabolic in patients undergoing peritoneal dialysis?","authors":"C J Stefanidis","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effect of rhGH treatment on protein metabolism was studied in nine prepubertal patients on CAPD. An improvement in nitrogen balance as evidenced by a falling of blood urea nitrogen and urea nitrogen appearance with a constant protein intake was noticed. The significant increase in serum creatinine and creatinine excretion with a constant weekly creatinine clearance and the increase in mid-arm muscle circumference were all indications of an improvement in lean body mass. In addition, there was an improvement in the pattern of plasma amino acids and an increase in serum albumin, possibly as a result of the improvement of protein metabolism.</p>","PeriodicalId":77500,"journal":{"name":"British journal of clinical practice. Supplement","volume":"85 ","pages":"44-6"},"PeriodicalIF":0.0,"publicationDate":"1996-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19957756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Use of recombinant human growth hormone (rhGH) in pubertal patients with renal disease.","authors":"H Maxwell","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Growth during puberty in renal failure and following renal transplantation is often poor. Treatment with rhGH improved height SDS in 13 pubertal children with renal disease.</p>","PeriodicalId":77500,"journal":{"name":"British journal of clinical practice. Supplement","volume":"85 ","pages":"10-1"},"PeriodicalIF":0.0,"publicationDate":"1996-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19955335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C J Stefanidis, A Papathanassiou, K Michelis, X Theodoridis, F Papachristou, J Sotiriou
{"title":"Diabetes mellitus after therapy with recombinant human growth hormone (rhGH).","authors":"C J Stefanidis, A Papathanassiou, K Michelis, X Theodoridis, F Papachristou, J Sotiriou","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>An eight-year-old boy developed diabetes mellitus (DM) after kidney transplantation. This boy had previously been treated with recombinant human growth hormone (rhGH) for short stature due to chronic renal failure. An impaired glucose tolerance was documented after one year of rhGH treatment. An oral glucose tolerance test returned to normal six months after the discontinuation of rhGH. The boy was treated again with rhGH for seven months until his transplantation. A high fever with an enlargement of the parotid gland was noted and signs of acute rejection appeared two weeks post-transplantation. Two months after transplantation, overt DM had developed, and he was treated with insulin. The insulin dose was progressively decreased and was discontinued eight months after transplantation.</p>","PeriodicalId":77500,"journal":{"name":"British journal of clinical practice. Supplement","volume":"85 ","pages":"66-7"},"PeriodicalIF":0.0,"publicationDate":"1996-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19955840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Recombinant human growth hormone (rhGH) is effective in pubertal patients.","authors":"A C Hokken-Koelega","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Recombinant human growth hormone (rhGH) therapy in a dose of 28-30 i.u./m2/week results in a significant and sustained improvement of height in most pubertal patients with growth retardation secondary to chronic renal insufficiency (CRI), dialysis or after renal transplantation (RTx). Long-term data indicate that rhGH therapy leads to a significant improvement in the final height of growth-retarded pubertal patients after renal transplantation.</p>","PeriodicalId":77500,"journal":{"name":"British journal of clinical practice. Supplement","volume":"85 ","pages":"12-3"},"PeriodicalIF":0.0,"publicationDate":"1996-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19955336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Is the impact of recombinant human growth hormone (rhGH) on the plasma lipid profile beneficial or harmful?","authors":"U Querfeld","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Growth hormone (GH) can modulate the metabolism of lipoproteins by affecting both their secretion and uptake by the liver and their catabolism by lipolytic enzymes in plasma. Clinical studies in adults indicate that patients with GH deficiency have atherogenic lipoprotein profiles that are ameliorated by GH administration. However, in children with GH deficiency or chronic renal insufficiency (CRI), just modest changes in total plasma lipids and lipoprotein profiles have been observed. In contrast, GH administration results in a significant increase in lipoprotein(a) (Lp(a)) levels that does not seem to be mediated by IGF-I but rather by the direct effect of GH on the hepatic secretion of Lp(a). In patients with CRF, Lp(a) is frequently elevated and GH administration may lead to a further increase in plasma levels necessitating monitoring of this highly atherogenic particle during rhGH treatment.</p>","PeriodicalId":77500,"journal":{"name":"British journal of clinical practice. Supplement","volume":"85 ","pages":"54-5"},"PeriodicalIF":0.0,"publicationDate":"1996-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19957759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Recombinant human growth hormone (rhGH) treatment of infants and young children with chronic renal failure.","authors":"H Maxwell","doi":"10.1080/09503159608415353","DOIUrl":"https://doi.org/10.1080/09503159608415353","url":null,"abstract":"<p><p>Infants with chronic renal failure often grow badly despite medical management. rhGH treatment results in good catch-up growth and should be used in infants who do not respond to conservative management.</p>","PeriodicalId":77500,"journal":{"name":"British journal of clinical practice. Supplement","volume":"85 ","pages":"64-5"},"PeriodicalIF":0.0,"publicationDate":"1996-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/09503159608415353","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19957763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}