{"title":"Postmenopausal hormone replacement therapy and insulin metabolism: effects of route of administration and implications for heart disease and diabetes risk.","authors":"I F Godsland, J C Stevenson","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77500,"journal":{"name":"British journal of clinical practice. Supplement","volume":"86 ","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"1996-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19956694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pamidronate in the treatment of osteolytic bone lesions in multiple myeloma patients--the American experience.","authors":"J Berenson","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77500,"journal":{"name":"British journal of clinical practice. Supplement","volume":"87 ","pages":"5-7; discussion 13-4"},"PeriodicalIF":0.0,"publicationDate":"1996-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19956702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Zoledronate in the treatment of Paget's disease.","authors":"E Siris","doi":"10.1080/09503159608412567","DOIUrl":"https://doi.org/10.1080/09503159608412567","url":null,"abstract":"Abstract This paper summarises the findings of a research study involving a group of care managers in a northern town, where multi-disciplinary guidelines, based on the care management framework, have been introduced for staff to follow when the abuse of older people is suspected or confirmed. The paper explores how care managers are addressing issues of identification, assessment and intervention in cases of suspected or confirmed abuse of older people; and to what extent issues of age, race gender and ability/disability influence decision making. The advantages and disadvantages of the care management model as applied to abuse of older people are discussed; and focus is given to the disjunction between guidelines, which recommend a standard response, and individual practice, which was found to differ widely in emphasis. Finally, it points to how future preventive strategies can be developed.","PeriodicalId":77500,"journal":{"name":"British journal of clinical practice. Supplement","volume":"87 ","pages":"19-20; discussion 22"},"PeriodicalIF":0.0,"publicationDate":"1996-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/09503159608412567","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19956706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The GH/IGF-I axis in puberty.","authors":"S Loche, M R Casini, A Faedda","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Puberty, either spontaneous, precocious or pharmacologically induced has profound effects on the physiology of the GH/IGF-I axis. Both spontaneous and stimulated GH secretion increase with puberty. The increase in spontaneous GH secretion is the result of increased GH pulse amplitude rather than frequency, and is probably an oestrogen-dependent effect. Parallel to the increase in GH secretion at puberty, circulating IGF-I and IGF binding protein-3 also increase. The pubertal increase in IGF-I correlates with stages of puberty as well as sex steroid levels. Circulating immunoreactive GHRH also increases with puberty, while circulating GH-binding protein levels are not affected by sexual maturation. Several data suggest an important role for the GH/IGF-I axis in the pubertal growth spurt. More recent data, however, have provided evidence of an important role for gonadal hormones in promoting adolescent growth independent of GH.</p>","PeriodicalId":77500,"journal":{"name":"British journal of clinical practice. Supplement","volume":"85 ","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"1996-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19955332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Can recombinant human growth hormone (rhGH) improve the adequacy of dialysis (KT/V)?","authors":"M Fischbach","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Dialysis adequacy as estimated by urea kinetics could lead to false interpretations, especially if the dialysed patient has a high growth velocity and a stimulated protein anabolic state as is expected during rhGH treatment. Assumptions made from comparison of the UKM parameters such as PCRn, KT/V and TACurea, which all derive from the same urea appearance, are particularly risky. Dialysis adequacy appreciation during rhGH treatment needs, at least, knowledge of urea kinetic and dietary intake, and these should not be calculated from the same parameters.</p>","PeriodicalId":77500,"journal":{"name":"British journal of clinical practice. Supplement","volume":"85 ","pages":"52-3"},"PeriodicalIF":0.0,"publicationDate":"1996-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19957758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P Cochat, E Bérard, J L André, P Berlier, C Buttet
{"title":"Is the response to rhGH in haemodialysis patients less effective than in patients with chronic renal failure? Société de Néphrologie Pédiatrique.","authors":"P Cochat, E Bérard, J L André, P Berlier, C Buttet","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A total of 82 prepubertal children with chronic renal insufficiency and with (HD, n = 28) or without (CRI, n = 54) haemodialysis were treated with rhGH, 1 i.u./kg/week. The absolute response (cm/year) was better in CRI children, but the growth velocity gain was similar in the two groups. In addition, the decrease in growth velocity during the second year on rhGH was more marked in CRI patients.</p>","PeriodicalId":77500,"journal":{"name":"British journal of clinical practice. Supplement","volume":"85 ","pages":"21-2"},"PeriodicalIF":0.0,"publicationDate":"1996-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19955339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}