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A simple and practical method for assessing the adequacy of hemodialysis. 一种简单实用的血液透析充分性评估方法。
ASAIO transactions Pub Date : 1991-07-01
R Soundararajan, P Soundararajan
{"title":"A simple and practical method for assessing the adequacy of hemodialysis.","authors":"R Soundararajan,&nbsp;P Soundararajan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The authors plotted the values of the postdialysis/predialysis blood urea nitrogen ratio, R, of 104 functionally anephric maintenance hemodialysis patients against the Kt/V values that had been derived from a single-pool, variable-volume, urea kinetic modeling method. When the R value was less than or equal to 0.4, the Kt/V value was consistently greater than or equal to 1.0. Maintaining an R value below 0.4 would ensure that Kt/V would never be less than 1.0. When a Kt/V value of greater than 1 is desired, an R value of less than 0.4 should be the goal.</p>","PeriodicalId":77493,"journal":{"name":"ASAIO transactions","volume":"37 3","pages":"M393-4"},"PeriodicalIF":0.0,"publicationDate":"1991-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12914062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A model of right ventricular failure after global myocardial ischemia and mechanical left ventricular support. 全心心肌缺血和机械左心室支持后右心室衰竭模型。
ASAIO transactions Pub Date : 1991-07-01
T A Shuman, R S Palazzo, R B Jaquiss, B D Harper, B Barzilai, J L Cox, N T Kouchoukos, T H Wareing
{"title":"A model of right ventricular failure after global myocardial ischemia and mechanical left ventricular support.","authors":"T A Shuman,&nbsp;R S Palazzo,&nbsp;R B Jaquiss,&nbsp;B D Harper,&nbsp;B Barzilai,&nbsp;J L Cox,&nbsp;N T Kouchoukos,&nbsp;T H Wareing","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Postcardiotomy right ventricular (RV) failure after institution of mechanical left ventricular (LV) support is poorly understood. Using a canine model supported by cardiopulmonary bypass (CPB), the animals underwent 30 min of aortic clamping or no ischemia and were weaned to an LV assist device (LVAD). Echocardiographic measurements of LV and RV cavity size off support allowed calculation of percentage change in cavity area (fractional shortening). There were no differences at baseline. After 2 hrs on LVAD, there were significant differences between ischemic and control groups in both LV (38 +/- 12 vs. 61 +/- 6) and RV (15 +/- 3 vs. 55 +/- 12). The ischemic RV also had significantly decreased function compared with the LV (38 +/- 12 vs. 15 +/- 3). The control group demonstrated no differences in ventricular function. The authors concluded that global ischemia diminishes LV and RV function, and this effect is accentuated in the RV after LVAD support. In controls, RV function is not affected by LVAD support, but after ischemia, LVAD support alone often will be inadequate.</p>","PeriodicalId":77493,"journal":{"name":"ASAIO transactions","volume":"37 3","pages":"M212-3"},"PeriodicalIF":0.0,"publicationDate":"1991-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12914258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electric power induction through an isolated intestinal pouch. 电力感应通过一个孤立的肠袋。
ASAIO transactions Pub Date : 1991-07-01
D B Melvin, D M Brooks, R J Taliano
{"title":"Electric power induction through an isolated intestinal pouch.","authors":"D B Melvin,&nbsp;D M Brooks,&nbsp;R J Taliano","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A new transintegumental power transformer uses the walls of an isolated intestinal pouch to separate primary and secondary coils. It may surpass transcutaneous devices in heat dissipation potential and in comfort. It was acutely tested in 13 dogs. Corrections in geometry and insulation were suggested by the nine initial trials. In the remaining four animals, up to 14.1 W were delivered, incrementing over 90 to 395 min. Three pouch and two remote thermistors recorded temperature (T) at 10 min intervals. Thirty sets of data were taken at 4 W or less (Group A), 31 at 4-8 W (Group B), and 16 at more than 8 W (Group C). T elevations above reference drift were 0.096 + 0.062 degrees C, 0.468 + 0.234 degrees C, and 0.876 + 0.156 degrees C for groups A, B, and C, respectively. These were significant by t-tests (p less than 0.001 for Group A vs. B; p less than 0.05 for Group B vs. C). The concept appears to be feasible, and longer term implantation trials seem justified.</p>","PeriodicalId":77493,"journal":{"name":"ASAIO transactions","volume":"37 3","pages":"M203-4"},"PeriodicalIF":0.0,"publicationDate":"1991-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12914333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Blood purification for postoperative liver failure with special reference to chronic hepatic support for those awaiting liver transplantation. 术后肝功能衰竭的血液净化，特别涉及等待肝移植的慢性肝脏支持。
ASAIO transactions Pub Date : 1991-07-01
S Omokawa, Y Asanuma, S Yoshida, Y Kato, K Koyama, T Sakurada, T Abe, S Miyagata
{"title":"Blood purification for postoperative liver failure with special reference to chronic hepatic support for those awaiting liver transplantation.","authors":"S Omokawa,&nbsp;Y Asanuma,&nbsp;S Yoshida,&nbsp;Y Kato,&nbsp;K Koyama,&nbsp;T Sakurada,&nbsp;T Abe,&nbsp;S Miyagata","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Blood purification, mainly plasma exchange (PE), was carried out for 13 cases of acute, and two cases of chronic postoperative liver failure. Four of thirteen acute cases (31%) survived. Although only one of eight with chronic liver disease survived, three of five without chronic liver disease survived. In most of those who lived, other organ failure occurred less often; total bilirubin and blood ammonia were less than 15 mg/dl and 200 micrograms/dl, respectively, before PE: and total bilirubin, blood ammonia, and branched chain amino acid/aromatic amino acid (BCAA/AAA) ratios recovered after five or fewer sessions of PE. Two chronic cases, treated for 1 and 4 years, respectively, were good candidates for liver or multiple organ transplantation. Although both died, PE was effective in reducing jaundice and in improving consciousness and general condition. Plasma exchange should be introduced early after assessing the changes in total bilirubin, blood ammonia, and coma grade in patients with acute postoperative liver failure. Plasma exchange could be useful as a chronic hepatic support system for those awaiting liver transplantation.</p>","PeriodicalId":77493,"journal":{"name":"ASAIO transactions","volume":"37 3","pages":"M330-2"},"PeriodicalIF":0.0,"publicationDate":"1991-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12914338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A hybrid artificial liver system. Function of cultured monolayer pig hepatocytes in plasma from hepatic failure patients. 混合人工肝系统。培养单层猪肝细胞在肝功能衰竭患者血浆中的功能。
ASAIO transactions Pub Date : 1991-07-01
J Uchino, H Matsue, M Takahashi, Y Nakajima, M Matsushita, T Hamada, E Hashimura
{"title":"A hybrid artificial liver system. Function of cultured monolayer pig hepatocytes in plasma from hepatic failure patients.","authors":"J Uchino,&nbsp;H Matsue,&nbsp;M Takahashi,&nbsp;Y Nakajima,&nbsp;M Matsushita,&nbsp;T Hamada,&nbsp;E Hashimura","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>To produce a new hybrid artificial liver system, cultured pig hepatocytes were used in this study. Hepatocytes from normal healthy pigs were cultured in multiwell dishes. From the third day of cultivation, hepatocytes were divided into three groups according to the media used (Group 1, L-15; Group 2, normal human plasma; Group 3, plasma from hepatic failure [HF] patients). Measurements of cellular function of the cultured pig hepatocytes included metabolic activity (gluconeogenesis and ureogenesis), DNA content, and amino acid changes in the plasma. The ability to provide gluconeogenesis and ureogenesis by the cultured hepatocytes in HF plasma was maintained for 3 days, equal to that observed in Groups 1 and 2. DNA content was no different in the three groups. Elevated amino acid levels in the HF plasma, Phe, Met, Lys, and Gly, were significantly reduced by the cultured hepatocytes. The results indicate that the use of primary cultured pig hepatocytes is a step toward a hybrid artificial liver system, and a promising candidate as a bioreactor.</p>","PeriodicalId":77493,"journal":{"name":"ASAIO transactions","volume":"37 3","pages":"M337-8"},"PeriodicalIF":0.0,"publicationDate":"1991-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12914342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimization of pacing parameters for conditioned latissimus dorsi muscle in cardiomyoplasty. 心肌成形术条件背阔肌起搏参数的优化。
ASAIO transactions Pub Date : 1991-07-01
C R Davies, R M Novoa, G B Jacobs, H Irié, J F Chen, D M Cosgrove
{"title":"Optimization of pacing parameters for conditioned latissimus dorsi muscle in cardiomyoplasty.","authors":"C R Davies,&nbsp;R M Novoa,&nbsp;G B Jacobs,&nbsp;H Irié,&nbsp;J F Chen,&nbsp;D M Cosgrove","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Synchronous paced contractions of latissimus dorsi muscle pedicle (LDM) around the heart improve ventricular function in dynamic cardiomyoplasty. To optimize assistance and prolong pacemaker battery life, the LDM should be stimulated with the lowest energy pacing parameters (PP) that will produce maximal muscle contraction. Muscle fractional shortening (FS) and duration of contraction (CT) were studied in conditioned, fatigue-resistant LDM of six goats. Fractional shortening and CT were determined at increasing amplitude, (A, 1-6v); pulse width, (PW, 60-450 musec); and frequency, (F, 5-130 Hz). Maximal rate of contraction was determined by pacing at higher rates. Maximal FS plateaued after V, 2.4 +/- .6v; PW, 125 +/- 47 musec; and F, 36 +/- 9 Hz. Mean CT for all PP was significantly longer (p less than or equal to 0.001) than the burst length (185 msec). Increasing F resulted in CT, which peaked at 460 +/- 59 msec. Increasing rate of contraction demonstrated that over 87 beats per minute the muscle fails to achieve complete relaxation, and, therefore, maximal FS.</p>","PeriodicalId":77493,"journal":{"name":"ASAIO transactions","volume":"37 3","pages":"M163-4"},"PeriodicalIF":0.0,"publicationDate":"1991-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12914535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hemostatic evaluation of Sarns/3M-VAD implantation in calves. 小腿Sarns/3M-VAD植入止血效果评价。
ASAIO transactions Pub Date : 1991-07-01
D L Amrani, C Christensen, L Hauerwas, M Rieder, M W Mosesson, D Schmidt, R Flemma, G A Prophet, W Pierce
{"title":"Hemostatic evaluation of Sarns/3M-VAD implantation in calves.","authors":"D L Amrani,&nbsp;C Christensen,&nbsp;L Hauerwas,&nbsp;M Rieder,&nbsp;M W Mosesson,&nbsp;D Schmidt,&nbsp;R Flemma,&nbsp;G A Prophet,&nbsp;W Pierce","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The authors evaluated the potential for thrombotic complications arising from implantation of a ventricular assist device (Sarns/3M-VAD) in four calves. Coagulation screening tests (prothrombin time [PT], partial thromboplastin time [PTT], thrombin time [TT]), fibrinogen levels, and antithrombin III functional activity were found to be of little value as predictors of the degree of activation of the hemostatic system. However, platelet counts, adenosine diphosphate (ADP)- and collagen-induced platelet aggregation, and thromboxane (TXB2) levels were good indicators of changes in platelet reactivity. Platelet counts (initial value 6 x 10(5) rose, and were associated with increased rate and extent of ADP- and collagen-induced platelet aggregation, which remained elevated during the entire 25 day postimplantation period. The first 5 days postimplantation revealed a typical acute inflammatory response, with increased platelet levels, but with TXB2 levels significantly decreased during this period. A monoclonal antibody based bovine D-dimer assay and Western blot studies indicated a small but significant increase in circulating bovine D-dimer, indicating localized fibrin formation and its dissolution.</p>","PeriodicalId":77493,"journal":{"name":"ASAIO transactions","volume":"37 3","pages":"M308-10"},"PeriodicalIF":0.0,"publicationDate":"1991-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12914548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glomerulopressin in end-stage renal disease. Effect of hemodialysis. 肾小球加压素在终末期肾病中的作用。血液透析的效果。
ASAIO transactions Pub Date : 1991-07-01
X J Zhou, N D Vaziri, C J Kaupke
{"title":"Glomerulopressin in end-stage renal disease. Effect of hemodialysis.","authors":"X J Zhou,&nbsp;N D Vaziri,&nbsp;C J Kaupke","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Plasma and hemofiltrate activities and hemodialysis (HD) clearance of glomerulopressin (GP) were measured in eight end-stage renal disease (ESRD) patients. Four normal volunteers served as controls. Plasma GP was elevated significantly in the ESRD group and fell with HD. Significant amounts of GP were found in the hemofiltrate. Single passage through the dialyzer resulted in a 24.7% fall in plasma GP activity. Dialyzer clearance of GP averaged 144 ml/min (75.4% of urea clearance). In conclusion, plasma GP was elevated in ESRD and readily removed by HD.</p>","PeriodicalId":77493,"journal":{"name":"ASAIO transactions","volume":"37 3","pages":"M235-6"},"PeriodicalIF":0.0,"publicationDate":"1991-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12914786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prolongation of cardiac xenograft function after reduction of natural antibodies using double filtration plasmapheresis. 双滤过血浆置换法减少天然抗体后心脏异种移植物功能的延长。
ASAIO transactions Pub Date : 1991-07-01
H Suga, H Ishida, M Kimikawa, Y Hayasaka, S Teraoka, T Agishi, K Ota
{"title":"Prolongation of cardiac xenograft function after reduction of natural antibodies using double filtration plasmapheresis.","authors":"H Suga,&nbsp;H Ishida,&nbsp;M Kimikawa,&nbsp;Y Hayasaka,&nbsp;S Teraoka,&nbsp;T Agishi,&nbsp;K Ota","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A double filtration plasmapheresis (DFPP) technique was applied to selectively remove the natural antibodies in discordant xenotransplantation. A swine heart was heterotopically transplanted in a canine neck after two DFPP procedures during which 200 to 500 ml of plasma were replaced with the same amount of Hartman's solution containing 7% human albumin. Mean removal rate of IgC and IgM by DFPP ranged from 74.2 +/- 0.5 to 95.9 +/- 2.8%. The anti-swine lymphocytotoxic reaction of canine serum was decreased after DFPP but still remained in low titers. Mean graft survival time in the group treated by DFPP in which 1000 ml of plasma was totally replaced was prolonged to 107 +/- 47 min, while it was 9 +/- 5 min in the group without any treatment (p less than 0.01). Deposits of canine IgM and C3 on the vascular endothelium of the graft were observed on immunofluorescence, while there were no deposits of IgG. In conclusion, DFPP effectively removed the natural antibodies, resulting in prolongation of xenograft survival time. Immunofluorescence study suggested that natural IgM antibodies played an important role in this xeno-hyperacute rejection.</p>","PeriodicalId":77493,"journal":{"name":"ASAIO transactions","volume":"37 3","pages":"M433-4"},"PeriodicalIF":0.0,"publicationDate":"1991-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12915136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combined LDL apheresis and hemodialysis in a patient with end-stage renal disease and accelerated coronary atherosclerosis. LDL单采联合血液透析治疗终末期肾病合并冠状动脉粥样硬化加速患者1例。
ASAIO transactions Pub Date : 1991-07-01
P Grützmacher, C Vallbracht, E Scheuermann, P Kurz, W Schoeppe
{"title":"Combined LDL apheresis and hemodialysis in a patient with end-stage renal disease and accelerated coronary atherosclerosis.","authors":"P Grützmacher,&nbsp;C Vallbracht,&nbsp;E Scheuermann,&nbsp;P Kurz,&nbsp;W Schoeppe","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The first long-term experience with lipid apheresis in a hemodialysis patient with refractory combined hyperlipidemia and coronary heart disease is described. Simultaneous treatment was performed once a week using two separate machines connected by parallel flow. Correction of hyperlipidemia was achieved, accompanied by inhibition of progressive coronary heart disease, enabling kidney transplantation.</p>","PeriodicalId":77493,"journal":{"name":"ASAIO transactions","volume":"37 3","pages":"M435-6"},"PeriodicalIF":0.0,"publicationDate":"1991-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12915137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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