Glomerulopressin in end-stage renal disease. Effect of hemodialysis.

Abstract

Plasma and hemofiltrate activities and hemodialysis (HD) clearance of glomerulopressin (GP) were measured in eight end-stage renal disease (ESRD) patients. Four normal volunteers served as controls. Plasma GP was elevated significantly in the ESRD group and fell with HD. Significant amounts of GP were found in the hemofiltrate. Single passage through the dialyzer resulted in a 24.7% fall in plasma GP activity. Dialyzer clearance of GP averaged 144 ml/min (75.4% of urea clearance). In conclusion, plasma GP was elevated in ESRD and readily removed by HD.