Arteriosclerosis (Dallas, Tex.)最新文献_第3页

Analysis of indium-111 platelet kinetics and imaging in patients with aortic grafts and abdominal aortic aneurysms. 主动脉移植及腹主动脉瘤患者铟111血小板动力学及影像学分析。

Arteriosclerosis (Dallas, Tex.) Pub Date : 1990-11-01 DOI: 10.1161/01.atv.10.6.1037

S R Hanson, H F Kotzé, H Pieters, A D Heyns

{"title":"Analysis of indium-111 platelet kinetics and imaging in patients with aortic grafts and abdominal aortic aneurysms.","authors":"S R Hanson, H F Kotzé, H Pieters, A D Heyns","doi":"10.1161/01.atv.10.6.1037","DOIUrl":"https://doi.org/10.1161/01.atv.10.6.1037","url":null,"abstract":"To quantitatively characterize processes of platelet thrombus formation in vivo, the kinetics and incorporation into thrombus of autologous In-111-labeled platelets were compared in six patients with aortic aneurysms and in seven patients with prosthetic aortic grafts. Although platelet survival was comparably shortened in both patient groups (mean, 5.8 days), the maximum radioactivity (percentage of whole body radioactivity) as determined by gamma camera imaging was higher in the aneurysms than in the grafts (3.3% +/- 1.6% vs. 1.6% +/- 1.1%, p = 0.05). Maximum In-111 uptake was also attained more quickly in the aneurysm patients (2.3 +/- 0.8 days vs. 3.5 +/- 1.3 days; p = 0.07). The experimental platelet kinetic and imaging data were subsequently evaluated by compartmental analysis to estimate both normal and disease-related components of platelet destruction. This analysis indicated that deposited platelet radioactivity had a longer residence time on grafts (2.9 +/- 1.7 days vs. 1.4 +/- 0.9 days, p = 0.07) but accumulated at a faster rate in aneurysms (5.0% +/- 3.4% per day vs. 1.4% +/- 0.9% per day, p = 0.02). As determined by imaging, only a proportion of increased platelet destruction was specifically due to the aneurysms (55% +/- 38%) or grafts (17% +/- 11%, p = 0.03). This result indicates additional components of platelet destruction unrelated to graft and aneurysm thrombus formation which, in some graft patients, may reflect a greater severity of vascular disease or other mechanisms causing a preferential shortening of platelet survival. Thus, the analytical approach described may be a useful one for discriminating components of in vivo platelet utilization including platelet removal due to normal hemostatic and senescent mechanisms, localized thrombus formation, and more generalized vascular disease.","PeriodicalId":77492,"journal":{"name":"Arteriosclerosis (Dallas, Tex.)","volume":"10 6","pages":"1037-44"},"PeriodicalIF":0.0,"publicationDate":"1990-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1161/01.atv.10.6.1037","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13396600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Intimal lesion formation in rat carotid arteries after endothelial denudation in absence of medial injury. 无内侧损伤的大鼠颈动脉内皮剥脱后内膜病变的形成。

Arteriosclerosis (Dallas, Tex.) Pub Date : 1990-11-01 DOI: 10.1161/01.atv.10.6.1082

J Fingerle, Y P Au, A W Clowes, M A Reidy

{"title":"Intimal lesion formation in rat carotid arteries after endothelial denudation in absence of medial injury.","authors":"J Fingerle, Y P Au, A W Clowes, M A Reidy","doi":"10.1161/01.atv.10.6.1082","DOIUrl":"https://doi.org/10.1161/01.atv.10.6.1082","url":null,"abstract":"Injury of an artery by passage of a balloon catheter causes both endothelial denudation and medial damage and produces a marked smooth muscle cell (SMC) proliferative response. In this study, the endothelium from rat carotid arteries was removed by use of a rotating loop of 5/0 monofilament suture (gentle denudation technique), which did not cause any detectable damage to the underlying medial cells but did cause platelet adherence. Expression of platelet-derived growth factor (PDGF) A-chain and PDGF receptor mRNA was comparable to that seen in ballooned carotids, but the medial SMC proliferative response to gentle denudation was markedly reduced when compared to that observed after balloon denudation (1.4% vs. 13.6%). Intimal lesions were only observed in those zones that remained denuded for more than 7 days. These results demonstrate that a denuding injury with no medial trauma is sufficient to induce intimal lesions and that the significantly higher proliferation seen in ballooned vessels might reflect a response of the medial cells to trauma that occurred during denudation.","PeriodicalId":77492,"journal":{"name":"Arteriosclerosis (Dallas, Tex.)","volume":"10 6","pages":"1082-7"},"PeriodicalIF":0.0,"publicationDate":"1990-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1161/01.atv.10.6.1082","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13327296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 219

Are calcium ion antagonists effective anti-atherogenic agents? 钙离子拮抗剂是有效的抗动脉粥样硬化剂吗?

Arteriosclerosis (Dallas, Tex.) Pub Date : 1990-11-01 DOI: 10.1161/01.atv.10.6.961

M Overturf

引用次数: 8

Calcium antagonists as anti-atherosclerotic agents. 钙拮抗剂作为抗动脉粥样硬化剂。

Arteriosclerosis (Dallas, Tex.) Pub Date : 1990-11-01 DOI: 10.1161/01.atv.10.6.963

P D Henry

引用次数: 30

Relationship of endogenous sex steroid hormones to lipids and apoproteins in postmenopausal women. 绝经后妇女内源性性类固醇激素与脂质和载脂蛋白的关系。

Arteriosclerosis (Dallas, Tex.) Pub Date : 1990-11-01 DOI: 10.1016/0378-5122(91)90216-D

L. Kuller, J. Gutai, E. Meilahn, K. Matthews, P. Plantinga

引用次数: 86

Nucleotide profiles in normal minipig arterial tissue. 正常迷你猪动脉组织的核苷酸谱。

Arteriosclerosis (Dallas, Tex.) Pub Date : 1990-09-01 DOI: 10.1161/01.atv.10.5.745

J M Pap, D F Hammer, D L Fry, R E Kelley, R A Altschuld

{"title":"Nucleotide profiles in normal minipig arterial tissue.","authors":"J M Pap, D F Hammer, D L Fry, R E Kelley, R A Altschuld","doi":"10.1161/01.atv.10.5.745","DOIUrl":"https://doi.org/10.1161/01.atv.10.5.745","url":null,"abstract":"The purpose of this study was to characterize the nucleotide profiles of a normal porcine elastic and muscular artery. Tissue samples (50 to 150 mg) were excised from the descending thoracic aorta and from the femoral artery of 14 normocholesterolemic, anesthetized minipigs. In three animals, transmural myocardial samples were also obtained. Nucleotide and nucleoside concentrations were analyzed by using a recently developed ion-pairing, reverse-phase, high-performance liquid chromatographic method. The arterial samples contained relatively low concentrations of adenosine triphosphate, approximately one-eighth that of the myocardial counterpart. Relative to the femoral artery, the aortic samples had significantly lower adenylate energy charges and higher levels of adenosine diphosphate, adenosine monophosphate, adenosine, and inosine. These baseline aortic levels did not change after in vitro exposure to 95% oxygen. The different energy states observed in the two arteries may reflect functional or metabolic differences in their medial smooth muscle cell populations. Alternatively, the lower energy state observed in the thicker walled aorta may be a manifestation of inadequate medial oxygen delivery that persists despite oxygen enrichment in vitro. We conclude that arterial energy states exhibit regional variation. This information will serve as a point of departure for the investigation of the role energy states may play in the atherosclerotic process.","PeriodicalId":77492,"journal":{"name":"Arteriosclerosis (Dallas, Tex.)","volume":"10 5","pages":"745-50"},"PeriodicalIF":0.0,"publicationDate":"1990-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1161/01.atv.10.5.745","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13552510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

9th National Conference on Thrombosis and Hemostasis. Dallas, Texas, November 1990. Abstracts. 第九届全国血栓与止血学术会议。达拉斯，德州，1990年11月。摘要。

Arteriosclerosis (Dallas, Tex.) Pub Date : 1990-09-01

引用次数: 0

Is it time to measure apolipoprotein B? 是时候测量载脂蛋白B了吗?

Arteriosclerosis (Dallas, Tex.) Pub Date : 1990-09-01 DOI: 10.1161/01.atv.10.5.665

A D Sniderman, J Silberberg

引用次数: 46

Noninvasive ultrasound evaluation of pressure gradients in aortic root of homozygotes for familial hypercholesterolemia. 家族性高胆固醇血症纯合子主动脉根部压力梯度的无创超声评价。

Arteriosclerosis (Dallas, Tex.) Pub Date : 1990-09-01 DOI: 10.1161/01.atv.10.5.710

F Faccenda, P Rubba, A Gnasso, P Pauciullo, A Postiglione, C Cortese, M Mancini

{"title":"Noninvasive ultrasound evaluation of pressure gradients in aortic root of homozygotes for familial hypercholesterolemia.","authors":"F Faccenda, P Rubba, A Gnasso, P Pauciullo, A Postiglione, C Cortese, M Mancini","doi":"10.1161/01.atv.10.5.710","DOIUrl":"https://doi.org/10.1161/01.atv.10.5.710","url":null,"abstract":"The aim of this study was to measure noninvasively by Doppler ultrasound the blood flow velocity at the level of the aortic root in patients with homozygous familial hypercholesterolemia (FH) to detect abnormal pressure gradients. Seven patients with homozygous FH and seven healthy controls matched for age and sex were included in the study. Continuous-wave Doppler (2 MHz) was used to measure the highest detectable velocity from the aortic root; the probe was positioned in the suprasternal notch. When an abnormal velocity was detected, the corresponding pressure drop was calculated from the formula: Delta P = 4Vmax2. Each FH patient had an abnormal aortic velocity consistent with a pressure gradient across the valvular area. All the controls had normal aortic velocities (p less than 0.01). The measurement of the pressure drop across the aortic valvular area in FH patients gives an estimate of the lesions produced by cholesterol deposition in a crucial area of the cardiovascular system near the origin of coronary arteries. The noninvasivity of this method makes it an excellent method for obtaining parameters for follow-up and clinical trials.","PeriodicalId":77492,"journal":{"name":"Arteriosclerosis (Dallas, Tex.)","volume":"10 5","pages":"710-3"},"PeriodicalIF":0.0,"publicationDate":"1990-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1161/01.atv.10.5.710","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13359008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Fibrinogen receptors do not undergo spontaneous redistribution on surface-activated platelets. 纤维蛋白原受体不能在表面活化的血小板上进行自发的再分配。

Arteriosclerosis (Dallas, Tex.) Pub Date : 1990-09-01 DOI: 10.1161/01.atv.10.5.738

J G White, G Escolar

{"title":"Fibrinogen receptors do not undergo spontaneous redistribution on surface-activated platelets.","authors":"J G White, G Escolar","doi":"10.1161/01.atv.10.5.738","DOIUrl":"https://doi.org/10.1161/01.atv.10.5.738","url":null,"abstract":"Studies with fibrinogen coupled to colloidal fibrinogen-gold (Fgn/Au) have suggested that fibrinogen receptors glycoprotein IIb-IIIa (GPIIb-IIIa) on human platelets may undergo spontaneous reorganization and centralization during surface activation. The present study has examined that hypothesis. Platelets were allowed to spread on grids for 20 minutes, just as in previous studies, but they were fixed before, rather than after, exposure to Fgn/Au or latex spherules. A monoclonal antibody to GPIIb-IIIa was also employed. Control experiments demonstrated that Fgn/Au and latex move toward the central zones and into channels of the open canalicular system on surface-activated platelets treated in the usual manner. However, when surface-activated platelets were fixed after spreading and before exposure to ligand, Fgn/Au particles and latex sperules were evenly dispersed over the entire cell membrane. Immunogold staining of GPIIb-IIIa also revealed edge-to-edge localization of the GPIIb-IIIa receptors on surface-activated cells. The findings are consistent with the concept that fibrinogen receptors do not undergo spontaneous reorganization on surface-activated platelets.","PeriodicalId":77492,"journal":{"name":"Arteriosclerosis (Dallas, Tex.)","volume":"10 5","pages":"738-44"},"PeriodicalIF":0.0,"publicationDate":"1990-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1161/01.atv.10.5.738","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12862707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22