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Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt fur Sera und Impfstoffe) zu Frankfurt a.M最新文献

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Physico-chemical characterization of candidate reference materials. 候选标准物质的物理化学特性。
Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt fur Sera und Impfstoffe) zu Frankfurt a.M Pub Date : 2006-01-01
Fatima Ferreira, Michael Wallner, Gabriele Gadermaier, Anja Erler, Gerhard Fritz, Otto Glatter, Martin Himly, Peter Briza, Ronald van Ree
{"title":"Physico-chemical characterization of candidate reference materials.","authors":"Fatima Ferreira, Michael Wallner, Gabriele Gadermaier, Anja Erler, Gerhard Fritz, Otto Glatter, Martin Himly, Peter Briza, Ronald van Ree","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77490,"journal":{"name":"Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt fur Sera und Impfstoffe) zu Frankfurt a.M","volume":" 95","pages":"75-82; discussion 82-3, 100-4"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26233180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Summary of the response to the questionnaire marketing authorization of allergen products in Europe sent to national regulatory agencies. 对发给各国监管机构的欧洲过敏原产品上市许可调查问卷的回复摘要。
Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt fur Sera und Impfstoffe) zu Frankfurt a.M Pub Date : 2006-01-01
Gerald Reese
{"title":"Summary of the response to the questionnaire marketing authorization of allergen products in Europe sent to national regulatory agencies.","authors":"Gerald Reese","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77490,"journal":{"name":"Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt fur Sera und Impfstoffe) zu Frankfurt a.M","volume":" 95","pages":"43-4; discussion 44"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26233280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prospects for CpG based immunotherapy in asthma and allergy. 基于CpG的哮喘和过敏免疫治疗前景。
Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt fur Sera und Impfstoffe) zu Frankfurt a.M Pub Date : 2006-01-01
David H Broide
{"title":"Prospects for CpG based immunotherapy in asthma and allergy.","authors":"David H Broide","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Although administration of protein allergens to subjects with allergic rhinitis and asthma is effective in modulating the immune response and reducing symptoms, alternative strategies to minimize the allergenicity of protein immunotherapy while improving the effectiveness are currently being investigated in animal models of asthma and in human subjects with allergic rhinitis. CpG DNA, and CpG DNA conjugated to a protein allergen have shown promise in animal models of asthma and have entered phase I/II clinical trials. Further, clinical trials are needed to determine whether any of these CpG DNA based therapies are safe and effective to use in subjects with allergic rhinitis and asthma.</p>","PeriodicalId":77490,"journal":{"name":"Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt fur Sera und Impfstoffe) zu Frankfurt a.M","volume":" 95","pages":"217-20; discussion 220-2"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26631269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Allergome: a unifying platform. Allergome:一个统一的平台。
Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt fur Sera und Impfstoffe) zu Frankfurt a.M Pub Date : 2006-01-01
Adriano Mari, Enrico Scala
{"title":"Allergome: a unifying platform.","authors":"Adriano Mari,&nbsp;Enrico Scala","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The approaches used in both basic research and clinical work in allergology must be reconsidered in the light of information technology. Internet resources are further amplified by the parallel development of other new tools, such as molecular biology and nanotechnology. Information technology, molecular biology and nanotechnology are tightly related entities that fully express their power once applied to biomedical fields. Bioinformatics applied to allergological research simplifies the approach to the increasing wealth of knowledge.</p>","PeriodicalId":77490,"journal":{"name":"Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt fur Sera und Impfstoffe) zu Frankfurt a.M","volume":" 95","pages":"29-39; discussion 39-40"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26233278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quality and clinical efficacy of allergen mixtures. 过敏原混合物的质量及临床疗效。
Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt fur Sera und Impfstoffe) zu Frankfurt a.M Pub Date : 2006-01-01
Hans-Jørgen Malling
{"title":"Quality and clinical efficacy of allergen mixtures.","authors":"Hans-Jørgen Malling","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77490,"journal":{"name":"Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt fur Sera und Impfstoffe) zu Frankfurt a.M","volume":" 95","pages":"253-7; discussion 257"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26631728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The CREATE project: future perspectives. CREATE项目:未来展望。
Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt fur Sera und Impfstoffe) zu Frankfurt a.M Pub Date : 2006-01-01
Ronald van Ree
{"title":"The CREATE project: future perspectives.","authors":"Ronald van Ree","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77490,"journal":{"name":"Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt fur Sera und Impfstoffe) zu Frankfurt a.M","volume":" 95","pages":"98-9; discussion 100-4"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26233183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The importance of minor allergens in allergen standardization. 次要过敏原在过敏原标准化中的重要性。
Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt fur Sera und Impfstoffe) zu Frankfurt a.M Pub Date : 2006-01-01
Domingo Barber, Florentino Polo, Manuel Lombardero, Mayte Villalba, Rosalía Rodríguez
{"title":"The importance of minor allergens in allergen standardization.","authors":"Domingo Barber,&nbsp;Florentino Polo,&nbsp;Manuel Lombardero,&nbsp;Mayte Villalba,&nbsp;Rosalía Rodríguez","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77490,"journal":{"name":"Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt fur Sera und Impfstoffe) zu Frankfurt a.M","volume":" 95","pages":"128-34; discussion 134, 155"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26233186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Test procedures for allergoids and hypoallergenic recombinant allergens: immunological characterization. 类过敏原和低致敏性重组过敏原的试验程序:免疫学特性。
Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt fur Sera und Impfstoffe) zu Frankfurt a.M Pub Date : 2006-01-01
Helmut Fiebig, Helga Kahlert, Andreas Nandy, Martin Wald, Roland Suck, Bernhard Weber
{"title":"Test procedures for allergoids and hypoallergenic recombinant allergens: immunological characterization.","authors":"Helmut Fiebig,&nbsp;Helga Kahlert,&nbsp;Andreas Nandy,&nbsp;Martin Wald,&nbsp;Roland Suck,&nbsp;Bernhard Weber","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77490,"journal":{"name":"Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt fur Sera und Impfstoffe) zu Frankfurt a.M","volume":" 95","pages":"135-46; discussion147-8, 155"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26233187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Usefulness of pollen chamber in the evaluation of clinical trials with allergen products. 花粉室在过敏原产品临床试验评价中的作用。
Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt fur Sera und Impfstoffe) zu Frankfurt a.M Pub Date : 2006-01-01
Norbert Krug
{"title":"Usefulness of pollen chamber in the evaluation of clinical trials with allergen products.","authors":"Norbert Krug","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77490,"journal":{"name":"Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt fur Sera und Impfstoffe) zu Frankfurt a.M","volume":" 95","pages":"167-70; discussion 170-1"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26233190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Computational resources: a regulatory need, a tool for research. 计算资源:监管需要，研究工具。
Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt fur Sera und Impfstoffe) zu Frankfurt a.M Pub Date : 2006-01-01
Renato Truffer, Michael B Stadler, Monique Vogel, Adriano Mari, Beda M Stadler
{"title":"Computational resources: a regulatory need, a tool for research.","authors":"Renato Truffer,&nbsp;Michael B Stadler,&nbsp;Monique Vogel,&nbsp;Adriano Mari,&nbsp;Beda M Stadler","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>We have recently reported a new method based on protein motifs to predict allergenicity by protein sequence. By using the more complete allergen database Allergome (www.allergome.org), as the basis for the motif identification process, we obtained a new set of allergenic motifs. We studied whether an allergenic motif may be used instead of a full length allergen for predicting allergenicity.</p><p><strong>Methods: </strong>Sequence accession numbers of allergens were received from A. Mari of the Allergome Project. The sequences were downloaded and integrated in the allergen database, which was used to produce new motifs applicable for allergenicity prediction. The motif containing allergenic tropomyosins of different non vertebrate species was chosen. A consensus sequence of the tropomyosin motif was synthesized and expressed in Escherichia coli (E. coli). The purified peptide was analyzed for specificity with enzyme linked-immunosorbent assay (ELISA).</p><p><strong>Results: </strong>Based on the Allergome dataset, we calculated 69 motifs containing 912 sequences. Prediction performance of this new set of allergenic motifs is increased compared to the original 52 motifs. The IgE immunological reactivity of the recombinant tropomyosin motif was comparable to that obtained with a full length recombinant shrimp tropomyosin (rPen a 1) tested in the ImmunoCAP system.</p><p><strong>Discussion: </strong>The use of the motif-based allergenicity prediction method is more accurate than the guidelines proposed by FAO/WHO, however continuous updates of the motif dataset are necessary to guarantee a high prediction performance of this method. The experiments performed with the tropomyosin motif showed that peptides based on the consensus sequence of motifs may represent the allergenic epitope, which can be used in future diagnostic or therapeutic approaches.</p>","PeriodicalId":77490,"journal":{"name":"Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt fur Sera und Impfstoffe) zu Frankfurt a.M","volume":" 95","pages":"11-5, discussion 15-6"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26233274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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