发布求助
文献互助 智能选刊 最新文献

Thyroidology最新文献

筛选
英文 中文
Surgical strategy for papillary carcinoma of the thyroid in an iodine rich area: decision on the operation table. 富碘地区甲状腺乳头状癌的手术策略:手术台上的决定。
Thyroidology Pub Date : 1993-12-01
T Harada, M Katagiri, K Shimaoka, K Yoshikawa, K Ohta, T Kiyono
{"title":"Surgical strategy for papillary carcinoma of the thyroid in an iodine rich area: decision on the operation table.","authors":"T Harada,&nbsp;M Katagiri,&nbsp;K Shimaoka,&nbsp;K Yoshikawa,&nbsp;K Ohta,&nbsp;T Kiyono","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In iodine rich areas the incidence of papillary carcinoma of the thyroid is extremely high but its prognosis is favorable. When papillary carcinoma is confined to one lobe, our standard surgical procedure has been total lobectomy with isthmusectomy rather than total thyroidectomy. Our followup study of 185 such patients reveals considerable difference in the outcome between the 85 patients with gross thyroid capsular invasion and the 100 patients without, regardless of the presence of cervical lymph node metastasis. In the latter group, the tumor could be completely resected in all patients; although 4 cases had recurrence and required reoperation, 3 patients are alive and well and one died of other disease. In contrast, 20 patients in the former group had incomplete resection of the tumor, 4 patients developed recurrence and needed to be reoperated and 7 patients eventually died of thyroid cancer. One hundred thirty three patients (71.9%) underwent modified neck dissection at the time of surgery to find lymph node metastasis in 37 of 59 cases (62.7%) without gross thyroid capsular invasion and 64 of 74 cases (86.5%) with such invasion. The difference is statistically significant (P < 0.05). From these results we conclude that for papillary thyroid cancer in iodine rich areas total lobectomy with isthmusectomy is the treatment of choice when gross thyroid capsular invasion is not recognized on the operation table. However, when gross thyroid capsular invasion is recognized, total or near total thyroidectomy has to be performed.</p>","PeriodicalId":77445,"journal":{"name":"Thyroidology","volume":"5 3","pages":"87-92"},"PeriodicalIF":0.0,"publicationDate":"1993-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18531457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Direct effect of protirelin (TRH) on PB[123I] in autonomous thyroid adenoma. 原肾上腺素(TRH)对自发性甲状腺腺瘤中PB[123I]的直接影响。
Thyroidology Pub Date : 1993-12-01
E Kallee, U Müh, R Wahl
{"title":"Direct effect of protirelin (TRH) on PB[123I] in autonomous thyroid adenoma.","authors":"E Kallee,&nbsp;U Müh,&nbsp;R Wahl","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In a retrospective study of 27 cases of iodine deficiency and/or latent primary hypothyroidism and in 16 cases of thyroid adenoma with hyperthyreosis the routine radioiodine uptake test was combined with a protirelin (TRH) test. After TRH infusion, [PB*I] and TSH increased significantly in all of these 27 patients who served as controls for the hyperthyroid patients. At the same time, the conversion rate Q rose in 14 of the control patients, but it dropped in 13 cases, thus indicating a TSH-induced discharge from the thyroid of radioiodine containing substances that were not bound to serum proteins. In nine of the 16 patients with autonomous adenoma, PB[*I] rose slightly, but Q did not increase significantly. In seven of the 16 adenoma patients, both PB[*I] and Q even dropped slightly in the absence of measurable serum TSH, thus indicating a negative direct effect of TRH on thyroid hormone metabolism.</p>","PeriodicalId":77445,"journal":{"name":"Thyroidology","volume":"5 3","pages":"81-5"},"PeriodicalIF":0.0,"publicationDate":"1993-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18531456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Principals of limited or radical surgery for differentiated thyroid cancer. 分化型甲状腺癌有限或根治性手术的原则。
Thyroidology Pub Date : 1993-12-01
H D Roeher, D Simon, J Witte, P E Goretzki
{"title":"Principals of limited or radical surgery for differentiated thyroid cancer.","authors":"H D Roeher,&nbsp;D Simon,&nbsp;J Witte,&nbsp;P E Goretzki","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Since the late sixties standard total thyroidectomy with or without selective radical neck dissection depending on the extent of the disease has become the routine surgical procedure for differentiated thyroid carcinoma (DTC;-papillary, follicular). This strategy has contributed remarkably to the increase of cure rates for various reasons. Only recently, in the last decade, has limited radicality with only unilateral lobectomy (= hemithyroidectomy) with or without partial contralateral resection been advocated as being sufficient for selected early tumor stages. We have analyzed a series of 252 patients, 174 (69%) being papillary and 78 (31%) follicular. Primary operation was done in 117 patients (46%) while 135 patients (54%) underwent reoperative surgery at this institution for either completion of radicality or because of loco-regional recurrence. From our evaluation we draw the conclusion that limited radicality (unilateral operation or subtotal) is justified only in pT-1-tumors in younger age (< 45 yrs) in order to avoid recurrence and unnecessary reoperation. On the other hand generous indication for reoperation is justified with the overall chance of almost 60% cure rate. All adjuvant treatment, mainly radioiodine should be applied thereafter.</p>","PeriodicalId":77445,"journal":{"name":"Thyroidology","volume":"5 3","pages":"93-6"},"PeriodicalIF":0.0,"publicationDate":"1993-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18531458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
L-thyroxine malabsorption due to the injection of herbal remedies. l -甲状腺素因注射中草药引起吸收不良。
Thyroidology Pub Date : 1993-12-01
O Geatti, A Barkan, D Turrin, P G Orsolon, B Shapiro
{"title":"L-thyroxine malabsorption due to the injection of herbal remedies.","authors":"O Geatti,&nbsp;A Barkan,&nbsp;D Turrin,&nbsp;P G Orsolon,&nbsp;B Shapiro","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Two patients are described in whom the absorption of l-thyroxine was impaired by non-prescription herbal and nutritional remedies. The absorption of thyroid hormones is discussed and an approach to the problem of patients who appear to be unresponsive to the usual doses of thyroid hormones is suggested.</p>","PeriodicalId":77445,"journal":{"name":"Thyroidology","volume":"5 3","pages":"97-102"},"PeriodicalIF":0.0,"publicationDate":"1993-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18532478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An update on management of differentiated thyroid carcinoma. 分化型甲状腺癌治疗的最新进展。
Thyroidology Pub Date : 1993-08-01
I J Chopra
{"title":"An update on management of differentiated thyroid carcinoma.","authors":"I J Chopra","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>While some may still favor lobectomy, most experts recommend total thyroidectomy for DTC followed by radioablation of thyroid remnant with 131I. After such a treatment, serum Tg level serves as a useful marker of metastases of DTC. Radioiodine (131I) is a reasonable good treatment for small (mg in weight) deposits of metastases. However, large lesions, and those in the lungs and bones, do not respond well to clinically \"safe\" doses of 131I. Some experts suggest that employment of radiation dose based approach to 131I may improve the outcome of treatment of DTC. Agents that enhance the sensitivity of the tissues to radiation effects of 131I should be helpful and research needs to be encouraged in that area.</p>","PeriodicalId":77445,"journal":{"name":"Thyroidology","volume":"5 2","pages":"57-60"},"PeriodicalIF":0.0,"publicationDate":"1993-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18530814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The medical treatment of non-toxic goiter: several questions remain. 无毒甲状腺肿的医学治疗:几个问题仍然存在。
Thyroidology Pub Date : 1993-08-01
D A Koutras
{"title":"The medical treatment of non-toxic goiter: several questions remain.","authors":"D A Koutras","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In this review it is concluded that thyroxine (T4), triiodothyronine (T3) and iodine (KI), singly or in combination, are all effective in reducing the goiter size, but there is insufficient evidence to prove which is the best (possibly the combination of T4 + KI?). Higher doses are more effective than smaller, but also lead to more side-effects. Thus, the optimal dose has yet to be found. The suppression of the pituitary thyroid axis plays a major role in the treatment of non-toxic goiter, but it is not definite that this is the only mechanism responsible for the beneficial effect of the agents mentioned. In view of the lack of better evidence, it is simply suggested that non-toxic goiters in young persons should be initially treated aggressively with 200 micrograms of T4/day or more for some months. If the goiter shrinks then the dose should be gradually decreased. If the goiter persists, it is futile to continue with large doses for more than 6-12 months. One may continue with smaller doses, maintaining the serum TSH in the low-normal range. The treatment of benign thyroid nodules with thyroxine is controversial. Probably thyroxine is beneficial in about a third of the cases. For both non-toxic goiters and nodules, autonomy should be excluded before starting thyroxine treatment, and old age, cardiac disease and a poor general condition are contraindications.</p>","PeriodicalId":77445,"journal":{"name":"Thyroidology","volume":"5 2","pages":"49-55"},"PeriodicalIF":0.0,"publicationDate":"1993-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18530813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of thyrotropin in triiodothyronine generation in hypothyroidism. 促甲状腺素在甲状腺功能减退中三碘甲状腺原氨酸生成中的作用。
Thyroidology Pub Date : 1993-08-01
M U Kabadi
{"title":"Role of thyrotropin in triiodothyronine generation in hypothyroidism.","authors":"M U Kabadi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Most of the circulating T3 is generated by monodeiodination of T4 in extrathyroidal tissue with only minor contribution by the thyroid gland. Since T3 is the main active thyroid hormone and TSH is the major modulator of its synthesis and release by the thyroid gland, TSH may also play a significant role in synthesis and release of T3 by the peripheral tissues as documented in recent in vitro animal studies. However, the data regarding its influence on T4 metabolism in humans is lacking. Hypothyroidism may provide an appropriate environment for assessing the influence of TSH in synthesis and release of T3 by the extrathyroidal tissues, since circulating T3 is almost totally derived via peripheral conversion of T4, and serum TSH varies from subnormal levels in central hypothyroidism to a wide range of supernormal concentration in the primary variety. This study determined the relationship between serum TSH concentration and T3 and T4 ratio, a reliable index of conversion of T4 into T3 in peripheral tissues, in 75 subjects with hypothyroidism including both the primary and the central types. Serum T3 was significantly higher (p < 0.001) in primary hypothyroidism (1.48 +/- 0.13 mM/l) in comparison with the central type (0.71 +/- 0.09 mM/l) despite almost equally low serum T4 concentration in both groups. In primary hypothyroidism, T3:T4 ratio (0.026 +/- 0.0012) was significantly higher (p < 0.01) than normal (0.017 +/- 0.0010) along with supernormal TSH (71 +/- 6.4 mU/L) concentration prior to initiation of LT4 replacement therapy and normalized (0.015 +/- 0.0008) on achieving euthyroid state with correction of serum TSH level (3.8 +/- 0.3 mU/L).(ABSTRACT TRUNCATED AT 250 WORDS)</p>","PeriodicalId":77445,"journal":{"name":"Thyroidology","volume":"5 2","pages":"41-7"},"PeriodicalIF":0.0,"publicationDate":"1993-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18530812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
L-thyroxine overdose: a case of marked, severe, prolonged, excess ingestion and review of the literature. l -甲状腺素过量:一个明显的，严重的，长期的，过量摄入的病例和文献回顾。
Thyroidology Pub Date : 1993-08-01
B Shapiro, M D Gross, O Geatti
{"title":"L-thyroxine overdose: a case of marked, severe, prolonged, excess ingestion and review of the literature.","authors":"B Shapiro,&nbsp;M D Gross,&nbsp;O Geatti","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A case of a man with thyroid cancer who ingested between 0.9 and 3.3 mg l-thyroxine per day for over 10 years (the highest dose for 3 years) is reported. This had been prescribed for suppression of TSH for a well differentiated thyroid cancer. He was essentially asymptomatic and suffered no apparent ill effects from this prolonged and markedly excessive dosage of l-thyroxine. The literature lists a wide range of ill effects from both chronic and acute thyroid hormone overdosage but also records many examples of tolerance to excessive levels of exogenous thyroid hormone. The various circumstances leading to thyroid hormone overdose and potential ill-effects are reviewed.</p>","PeriodicalId":77445,"journal":{"name":"Thyroidology","volume":"5 2","pages":"61-6"},"PeriodicalIF":0.0,"publicationDate":"1993-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18530815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Iodine induced splitting of peptide bonds in human thyroglobulin. 碘诱导人甲状腺球蛋白肽键分裂。
Thyroidology Pub Date : 1993-08-01
A Gardas, H Domek
{"title":"Iodine induced splitting of peptide bonds in human thyroglobulin.","authors":"A Gardas,&nbsp;H Domek","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Human thyroglobulin pretreated with iodine (1mM) at alkaline pH is split to small molecular weight fragments after reduction with dithiothreitol. Iodine pretreatment alone did not induce any changes in the thyroglobulin molecular weight.</p>","PeriodicalId":77445,"journal":{"name":"Thyroidology","volume":"5 2","pages":"67-9"},"PeriodicalIF":0.0,"publicationDate":"1993-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18530816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Measurement of serum thyrotropin levels using sensitive immunoradiometricassays in patients with chronic renal failure: alterations suggesting an intact pituitary thyroid axis. 使用敏感免疫放射测定法测量慢性肾衰竭患者血清促甲状腺素水平:提示垂体-甲状腺轴完整的改变
Thyroidology Pub Date : 1993-08-01
L J Joseph, K B Desai, H J Mehta, M N Mehta, A F Almeida, V N Acharya, A M Samuel
{"title":"Measurement of serum thyrotropin levels using sensitive immunoradiometricassays in patients with chronic renal failure: alterations suggesting an intact pituitary thyroid axis.","authors":"L J Joseph,&nbsp;K B Desai,&nbsp;H J Mehta,&nbsp;M N Mehta,&nbsp;A F Almeida,&nbsp;V N Acharya,&nbsp;A M Samuel","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Serum thyroid stimulating hormone (TSH) levels were measured in 127 patients with varying grade of chronic renal failure (CRF). Sensitive immunoradiometricassays (IRMA) were used so that small changes in TSH levels if any, could be appreciated, and to see if such alterations exhibit some relationship with those in thyroid hormone levels. Mean serum TSH levels in the patient group of 2.33 microU/ml (0.07-7.3) was significantly higher in comparison to 1.73 microU/ml (0.25-4.6) in normal subjects (p < 0.001). However, they were not significantly different when measured by radioimmunoassay (RIA) as compared to normals. Serum triiodothyronine (T3), thyroxine (T4) and free triiodothyronine (FT3) levels of 72 +/- 32 ng/dl, 7.4 +/- 2.6 micrograms/dl and 2.9 +/- 0.9 pg/ml were significantly lower than in normal subjects, whereas serum free thyroxine (FT4) showed a slight though not significant elevation. When patients were divided in three subgroups according to the degree of renal insufficiency, TSH levels showed a gradual rise with corresponding depression in their T3, FT3 and T4 levels. In 19 patients who were on hemodialysis (HD) and subsequently received successful renal transplantation, most of the thyroid function parameters returned towards the normals with TSH undergoing significant depression from their pretransplant levels as well as from normal levels. The results indicated that a slight but significant elevation in TSH levels could be revealed by sensitive IRMA in patients with CRF. Rising TSH levels with increasing renal insufficiency and its inverse relationship with T3 and T4 levels suggest maintenance of pituitary thyroid axis.(ABSTRACT TRUNCATED AT 250 WORDS)</p>","PeriodicalId":77445,"journal":{"name":"Thyroidology","volume":"5 2","pages":"35-9"},"PeriodicalIF":0.0,"publicationDate":"1993-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18530811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信