{"title":"Aetiology of the relationship between callous-unemotional traits and conduct problems in childhood.","authors":"Essi Viding, Paul J Frick, Robert Plomin","doi":"10.1192/bjp.190.5.s33","DOIUrl":"10.1192/bjp.190.5.s33","url":null,"abstract":"<p><strong>Background: </strong>A callous and unemotional disposition is an indicator of early-onset antisocial behaviour.</p><p><strong>Aims: </strong>To investigate the extent to which genetic influences contribute to the overlap between callous-unemotional traits and conduct problems in a large population sample of 7-year-old twins.</p><p><strong>Method: </strong>Teachers provided ratings of callous-unemotional traits and conduct problems for 3434 twin pairs from the Twins Early Development Study. Model-fitting analyses were performed across the continuum of scores and at the extremes.</p><p><strong>Results: </strong>The phenotypic relationship was primarily genetically mediated, both across the continuum and at the extremes and was substantial.</p><p><strong>Conclusions: </strong>At 7 years of age, genetic influences on callous-unemotional traits overlap substantially with genetic influences on conduct problems. This combination should guide selection criteria in future molecular genetic studies.</p>","PeriodicalId":77411,"journal":{"name":"The British journal of psychiatry. Supplement","volume":"49 ","pages":"s33-8"},"PeriodicalIF":0.0,"publicationDate":"2007-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26697623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Conor Duggan, Lauren Mason, Penny Banerjee, John Milton
{"title":"Value of standard personality assessments in informing clinical decision - making in a medium secure unit.","authors":"Conor Duggan, Lauren Mason, Penny Banerjee, John Milton","doi":"10.1192/bjp.190.5.s15","DOIUrl":"https://doi.org/10.1192/bjp.190.5.s15","url":null,"abstract":"<p><strong>Background: </strong>Assessing those with personality disorder for treatment in secure settings is known to be unsatisfactory.</p><p><strong>Aim: </strong>To examine the utility of a standardised assessment of offenders with personality disorder referred for treatment in secure care in a naturalistic study.</p><p><strong>Method: </strong>A consecutive series of 89 men were assessed with a battery of four recommended instruments measuring personality and risk. Decisions on whether or not to admit were based on a multidisciplinary discussion informed by these assessments.</p><p><strong>Results: </strong>Of the 89 comprehensively assessed referrals, 60 (67%) were offered admission. High scores on the Psychopathy Checklist-Revised (especially on Factor 1) was the only measure that was associated with rejection. Of 44 patients discharged, 29 (66%) failed to complete treatment; none of the pre-admission assessments distinguished ;completers' from ;non-completers'. Although skills were acquired on the unit, follow-up of 24 men in the community showed that this had only a marginal effect on re-offending rate (58%).</p><p><strong>Conclusions: </strong>Current recommended assessment methods appear unsatisfactory in identifying those who either (a) complete treatment or (b) benefit from treatment. Our results throw doubt on their value.</p>","PeriodicalId":77411,"journal":{"name":"The British journal of psychiatry. Supplement","volume":"49 ","pages":"s15-9"},"PeriodicalIF":0.0,"publicationDate":"2007-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1192/bjp.190.5.s15","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26697705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Collecting service use data for economic evaluation in DSPD populations: development of the Secure Facilities Service Use Schedule.","authors":"Barbara Barrett, Sarah Byford","doi":"10.1192/bjp.190.5.s75","DOIUrl":"https://doi.org/10.1192/bjp.190.5.s75","url":null,"abstract":"<p><strong>Background: </strong>Economic evaluation of the Dangerous and Severe Personality Disorder Programme is essential to ensure value for money. The collection of individual-level service use information is crucial to any such evaluation, but the best way to collect these data in secure facilities is unclear.</p><p><strong>Aims: </strong>To develop a method for the collection of individual-level service use information for prisoners/patients in secure facilities.</p><p><strong>Methods: </strong>Services provided within secure facilities were identified through examination of facility and policy literature, and discussions with managerial and clinical staff. Appropriate methods of measuring the quantities of services used were then explored and a new research tool capable of capturing all relevant services was developed and pilot tested.</p><p><strong>Results: </strong>The Secure Facilities Service Use Schedule (SF-SUS) records service use information from records and is capable of capturing data on the use of all individual-level services provided within a secure facility plus external services commonly accessed by occupants. Discussion The SF-SUS is able to collect meaningful individual-level service use information for the economic evaluation of services provided within secure facilities.</p>","PeriodicalId":77411,"journal":{"name":"The British journal of psychiatry. Supplement","volume":"49 ","pages":"s75-8"},"PeriodicalIF":0.0,"publicationDate":"2007-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1192/bjp.190.5.s75","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26697628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An agitation of contrary opinions.","authors":"Peter T Yrer","doi":"10.1192/bjp.190.5.s1","DOIUrl":"https://doi.org/10.1192/bjp.190.5.s1","url":null,"abstract":"<p><p>Those people who are dangerous often have personality disorders. Should these individuals be dealt with by criminal justice or mental health services? England (note not Scotland) has taken the mental health route with the Dangerous and Severe Personality Disorder Programme. Is this bold move wise or foolish? To answer this question we have both evidence and opinion - neither is conclusive.</p>","PeriodicalId":77411,"journal":{"name":"The British journal of psychiatry. Supplement","volume":"49 ","pages":"s1-2"},"PeriodicalIF":0.0,"publicationDate":"2007-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1192/bjp.190.5.s1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26697703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Early detection and intervention in psychosis: an ethical paradigm shift.","authors":"Thomas H McGlashan","doi":"10.1192/bjp.187.48.s113","DOIUrl":"https://doi.org/10.1192/bjp.187.48.s113","url":null,"abstract":"<p><p>This paper will first posit the rationale for intervention before onset, then outline the current usual practice of treating schizophrenia and the determinants of that practice. Recent developments that permit or demand a change in this practice will then be elaborated. The article concludes with an elaboration of the currently known risks and benefits of early intervention research. The ethics of early intervention are undergoing a paradigm shift, a shift that supports early intervention research as being necessary to bring empirical balance to territory that is currently overpopulated with zealous opinions.</p>","PeriodicalId":77411,"journal":{"name":"The British journal of psychiatry. Supplement","volume":"48 ","pages":"s113-5"},"PeriodicalIF":0.0,"publicationDate":"2005-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1192/bjp.187.48.s113","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25220894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andreas Bechdolf, Stephan Ruhrmann, Michael Wagner, Kai Uwe Kühn, Birgit Janssen, Ronald Bottlender, Anke Wieneke, Frauke Schulze-Lutter, Wolfgang Maier, Joachim Klosterkötter
{"title":"Interventions in the initial prodromal states of psychosis in Germany: concept and recruitment.","authors":"Andreas Bechdolf, Stephan Ruhrmann, Michael Wagner, Kai Uwe Kühn, Birgit Janssen, Ronald Bottlender, Anke Wieneke, Frauke Schulze-Lutter, Wolfgang Maier, Joachim Klosterkötter","doi":"10.1192/bjp.187.48.s45","DOIUrl":"https://doi.org/10.1192/bjp.187.48.s45","url":null,"abstract":"<p><strong>Background: </strong>The Early Detection and Intervention Programme of the German Research Network on Schizophrenia (GRNS) investigates the initial prodromal phase of psychosis in a multidimensional approach. Two intervention strategies are being studied by two large-scale multicentre projects.</p><p><strong>Aims: </strong>To present the concept of the intervention studies, and to provide an interim report of the recruitment procedure.</p><p><strong>Method: </strong>Comprehensive cognitive-behavioural therapy has been developed for patients in the \"early initial prodromal state\". For patients in the \"late initial prodromal state\" the atypical neuroleptic amisulpride is explored. Both interventions are evaluated in randomised controlled trials using clinical management as the control condition.</p><p><strong>Results: </strong>Between January 2001 and March 2003, 1212 individuals seeking help for mental health problems were screened for putative prodromal symptoms at four university centres. More than 388 individuals fulfilled criteria for both interventions and 188 (48.5%) gave informed consent to participate in the trials.</p><p><strong>Conclusions: </strong>The screening procedure appears to be feasible and trial participation seems to be acceptable to a relevant proportion of people at increased risk of developing psychosis.</p>","PeriodicalId":77411,"journal":{"name":"The British journal of psychiatry. Supplement","volume":"48 ","pages":"s45-8"},"PeriodicalIF":0.0,"publicationDate":"2005-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1192/bjp.187.48.s45","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25222009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical characteristics of first-admitted patients with ICD-10 schizotypal disorder.","authors":"Peter Handest, Josef Parnas","doi":"10.1192/bjp.187.48.s49","DOIUrl":"https://doi.org/10.1192/bjp.187.48.s49","url":null,"abstract":"<p><strong>Background: </strong>The clinical picture of schizotypal disorders is rarely comprehensively described.</p><p><strong>Aims: </strong>To describe psychopathological profiles of patients with ICD-10 schizotypal disorder.</p><p><strong>Method: </strong>A total of 151 first-admitted patients (with affective and somatic disorders excluded) were given a comprehensive psychopathological evaluation, including the Bonn Scale for the Assessment of Basic Symptoms. Patients with schizotypal disorder (n=50) were compared with those with psychosis (n=51) and those outside the schizophrenia spectrum (other diagnoses, n=50) on a number of psychopathological scales.</p><p><strong>Results: </strong>Patients with schizotypal disorder scored intermediately between patients with psychosis and other diagnoses on scales related to positive and negative symptoms, disorders of emotional contact and formal thought disorder, but had the same scores as patients with schizophrenia for subtle aberrations of subjective experience. Schizotypal criteria were not normally distributed with an excess of patients between 2 and 6 criteria. Family history of schizophrenia was equally elevated among those with schizotypal disorder and those with psychosis.</p><p><strong>Conclusions: </strong>ICD-10 schizotypy represents a milder, less psychotic, variant of schizophrenia but there is no clear-cut division between the two disorders.</p>","PeriodicalId":77411,"journal":{"name":"The British journal of psychiatry. Supplement","volume":"48 ","pages":"s49-54"},"PeriodicalIF":0.0,"publicationDate":"2005-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1192/bjp.187.48.s49","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25222010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lisa J Phillips, Patrick D McGorry, Alison R Yung, Thomas H McGlashan, Barbara Cornblatt, Joachim Klosterkötter
{"title":"Prepsychotic phase of schizophrenia and related disorders: recent progress and future opportunities.","authors":"Lisa J Phillips, Patrick D McGorry, Alison R Yung, Thomas H McGlashan, Barbara Cornblatt, Joachim Klosterkötter","doi":"10.1192/bjp.187.48.s33","DOIUrl":"https://doi.org/10.1192/bjp.187.48.s33","url":null,"abstract":"<p><strong>Background: </strong>Clinical and research focus has recently shifted from established psychotic disorders to first-episode psychosis and the prepsychotic phase of illness.</p><p><strong>Aims: </strong>To describe the principles, progress and dilemmas associated with the prospective detection, engagement and treatment of young people at risk of developing a psychotic disorder.</p><p><strong>Method: </strong>Strategies to identify young people at heightened risk of a psychotic disorder are described. Preventive interventions and results of their evaluation are provided.</p><p><strong>Results: </strong>Well-validated criteria for identifying young people at heightened risk of psychosis have been developed, evidence of the efficacy of various psychological and pharmacological interventions in preventing progression has accumulated and progress towards the identification of clinical and neurobiological predictors of transition to acute psychosis has been made.</p><p><strong>Conclusions: </strong>The detection, monitoring and treatment of young people in the prepsychotic phase is a growth area in psychiatry. The ethical considerations about treatment options, treatment of minors and provision of information about risk status must be treated with sensitivity if the potential benefit to many young people and their families is to be realised.</p>","PeriodicalId":77411,"journal":{"name":"The British journal of psychiatry. Supplement","volume":"48 ","pages":"s33-44"},"PeriodicalIF":0.0,"publicationDate":"2005-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1192/bjp.187.48.s33","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25220900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pia Jeppesen, Lone Petersen, Anne Thorup, Maj-Britt Abel, Johan Oehlenschlaeger, Torben Ø Christensen, Gertrud Krarup, Ralf Hemmingsen, Per Jørgensen, Merete Nordentoft
{"title":"Integrated treatment of first-episode psychosis: effect of treatment on family burden: OPUS trial.","authors":"Pia Jeppesen, Lone Petersen, Anne Thorup, Maj-Britt Abel, Johan Oehlenschlaeger, Torben Ø Christensen, Gertrud Krarup, Ralf Hemmingsen, Per Jørgensen, Merete Nordentoft","doi":"10.1192/bjp.187.48.s85","DOIUrl":"https://doi.org/10.1192/bjp.187.48.s85","url":null,"abstract":"<p><strong>Background: </strong>The families of patients with first-episode psychosis often play a major role in care and often experience lack of support.</p><p><strong>Aims: </strong>To determine the effect of integrated treatment v. standard treatment on subjective burden of illness, expressed emotion (EE), knowledge of illness and satisfaction with treatment in key relatives of patients with a first episode of schizophrenia-spectrum disorder.</p><p><strong>Method: </strong>Patients with ICD-10 schizophrenia-spectrum disorders (first episode) were randomly assigned to integrated treatment or to standard treatment. Integrated treatment consisted of assertive community treatment, psychoeducational multi-family groups and social skills training. Key relatives were assessed with the Social Behaviour Assessment Schedule (SBAS, burden of illness), the 5-min speech sample (EE), and a multiple choice questionnaire at entry and after 1 year.</p><p><strong>Results: </strong>Relatives in integrated treatment felt less burdened and were significantly more satisfied with treatment than relatives in standard treatment. There were no significant effects of intervention groups on knowledge of illness and EE.</p><p><strong>Conclusions: </strong>The integrated treatment reduced family burden of illness and improved satisfaction with treatment.</p>","PeriodicalId":77411,"journal":{"name":"The British journal of psychiatry. Supplement","volume":"48 ","pages":"s85-90"},"PeriodicalIF":0.0,"publicationDate":"2005-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1192/bjp.187.48.s85","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25221895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Implementing cognitive-behavioural therapy for first-episode psychosis.","authors":"Jean Addington, John Gleeson","doi":"10.1192/bjp.187.48.s72","DOIUrl":"https://doi.org/10.1192/bjp.187.48.s72","url":null,"abstract":"<p><p>Significant symptomatic improvement after a first episode of psychosis is not matched by a similar improvement in functional outcome. Thus, increased attention has been given to psychological intervention, in particular cognitive cognitive-behavioural therapy (CBT), with the hope of enhancing functional recovery. Outcome trials of CBT for schizophrenia are few, in particular for the first episode, and have been occasionally criticised for their lack of significance compared with supportive therapies. We describe a modular CBT approach for those with a first episode of psychosis that addresses adaptation as well as both functional and symptomatic outcome and one that parallels the theoretical shift in CBT that has occurred in the last decade. Guidelines for integrating CBT into an early psychosis service are presented.</p>","PeriodicalId":77411,"journal":{"name":"The British journal of psychiatry. Supplement","volume":"48 ","pages":"s72-6"},"PeriodicalIF":0.0,"publicationDate":"2005-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1192/bjp.187.48.s72","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25222014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}