Alcohol Research : Current Reviews最新文献_第10页

Social and Cultural Contexts of Alcohol Use: Influences in a Social-Ecological Framework. 酒精使用的社会和文化背景:社会-生态框架的影响。

IF 9.4 1区医学

Alcohol Research : Current Reviews Pub Date : 2016-01-01

May Sudhinaraset, Christina Wigglesworth, David T Takeuchi

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Religious Affiliation and Spiritual Practices: An Examination of the Role of Spirituality in Alcohol Use and Alcohol Use Disorder. 宗教信仰和精神实践:精神在酒精使用和酒精使用障碍中的作用的检验。

IF 9.4 1区医学

Alcohol Research : Current Reviews Pub Date : 2016-01-01

Katie Witkiewitz, Elizabeth McCallion, Megan Kirouac

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Nature and Treatment of Comorbid Alcohol Problems and Post Traumatic Stress Disorder Among American Military Personnel and Veterans. 美国军人和退伍军人共病酒精问题和创伤后应激障碍的性质和治疗。

IF 9.4 1区医学

Alcohol Research : Current Reviews Pub Date : 2016-01-01

John P Allen, Eric F Crawford, Harold Kudler

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Drinking Over the Lifespan: Focus on Older Adults. 一生中饮酒:关注老年人。

IF 9.4 1区医学

Alcohol Research : Current Reviews Pub Date : 2016-01-01

Kristen L Barry, Frederic C Blow

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Advances in Medications and Tailoring Treatment for Alcohol Use Disorder. 酒精使用障碍的药物治疗和针对性治疗进展

IF 9.4 1区医学

Alcohol Research : Current Reviews Pub Date : 2015-01-01

Chamindi Seneviratne, Bankole A Johnson

{"title":"Advances in Medications and Tailoring Treatment for Alcohol Use Disorder.","authors":"Chamindi Seneviratne, Bankole A Johnson","doi":"","DOIUrl":"","url":null,"abstract":"Alcohol use disorder (AUD) is a chronic heritable brain disorder with a variable clinical presentation. This variability, or heterogeneity, in clinical presentation suggests complex interactions between environmental and biological factors, resulting in several underlying pathophysiological mechanisms in the development and progression of AUD. Classifying AUD into subgroups of common clinical or pathological characteristics would ease the complexity of teasing apart underlying molecular mechanisms. Genetic association analyses have revealed several polymorphisms-small differences in DNA-that increase a person's vulnerability to develop AUD and other alcohol-related intermediate characteristics, such as severity of drinking, age of AUD onset, or measures of craving. They also have identified polymorphisms associated with reduced drinking. Researchers have begun utilizing these genetic polymorphisms to identify alcoholics who might respond best to various treatments, thereby enhancing the effectiveness of currently tested medications for treating AUD. This review compares the efficacy of medications tested for treatment of AUD with and without incorporating genetics. It then discusses advances in pre-clinical genetic and genomic studies that potentially could be adapted to clinical trials to improve treatment efficacy. Although a pharmacogenetic approach is promising, it is relatively new and will need to overcome many challenges, including inadequate scientific knowledge and social and logistic constraints, to be utilized in clinical practice. ","PeriodicalId":7736,"journal":{"name":"Alcohol Research : Current Reviews","volume":"37 1","pages":"15-28"},"PeriodicalIF":9.4,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33976989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Advances in Human Neuroconnectivity Research: Applications for Understanding Familial History Risk for Alcoholism. 人类神经连通性研究进展:用于了解酗酒家族史风险的应用。

IF 9.4 1区医学

Alcohol Research : Current Reviews Pub Date : 2015-01-01

Anita Cservenka, Gabriela Alarcón, Scott A Jones, Bonnie J Nagel

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Advances in Diagnosis and Treatment of Fetal Alcohol Spectrum Disorders: From Animal Models to Human Studies. 胎儿酒精谱系障碍的诊断和治疗进展:从动物模型到人类研究

IF 9.4 1区医学

Alcohol Research : Current Reviews Pub Date : 2015-01-01

Nathen J Murawski, Eileen M Moore, Jennifer D Thomas, Edward P Riley

{"title":"Advances in Diagnosis and Treatment of Fetal Alcohol Spectrum Disorders: From Animal Models to Human Studies.","authors":"Nathen J Murawski, Eileen M Moore, Jennifer D Thomas, Edward P Riley","doi":"","DOIUrl":"","url":null,"abstract":"Prenatal alcohol exposure can cause a number of physical, behavioral, cognitive, and neural impairments, collectively known as fetal alcohol spectrum disorders (FASD). This article examines basic research that has been or could be translated into practical applications for the diagnosis or treatment of FASD. Diagnosing FASD continues to be a challenge, but advances are being made at both basic science and clinical levels. These include identification of biomarkers, recognition of subtle facial characteristics of exposure, and examination of the relation between face, brain, and behavior. Basic research also is pointing toward potential new interventions for FASD involving pharmacotherapies, nutritional therapies, and exercise interventions. Although researchers have assessed the majority of these treatments in animal models of FASD, a limited number of recent clinical studies exist. An assessment of this literature suggests that targeted interventions can improve some impairments resulting from developmental alcohol exposure. However, combining interventions may prove more efficacious. Ultimately, advances in basic and clinical sciences may translate to clinical care, improving both diagnosis and treatment. ","PeriodicalId":7736,"journal":{"name":"Alcohol Research : Current Reviews","volume":"37 1","pages":"97-108"},"PeriodicalIF":9.4,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33976992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in Electrophysiological Research. 电生理研究进展。

IF 9.4 1区医学

Alcohol Research : Current Reviews Pub Date : 2015-01-01

Chella Kamarajan, Bernice Porjesz

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Translating Alcohol Research: Opportunities and Challenges. 翻译酒精研究:机遇与挑战。

IF 9.4 1区医学

Alcohol Research : Current Reviews Pub Date : 2015-01-01

Angela M Batman, Michael F Miles

{"title":"Translating Alcohol Research: Opportunities and Challenges.","authors":"Angela M Batman, Michael F Miles","doi":"","DOIUrl":"","url":null,"abstract":"Alcohol use disorder (AUD) and its sequelae impose a major burden on the public health of the United States, and adequate long-term control of this disorder has not been achieved. Molecular and behavioral basic science research findings are providing the groundwork for understanding the mechanisms underlying AUD and have identified multiple candidate targets for ongoing clinical trials. However, the translation of basic research or clinical findings into improved therapeutic approaches for AUD must become more efficient. Translational research is a multistage process of stream-lining the movement of basic biomedical research findings into clinical research and then to the clinical target populations. This process demands efficient bidirectional communication across basic, applied, and clinical science as well as with clinical practitioners. Ongoing work suggests rapid progress is being made with an evolving translational framework within the alcohol research field. This is helped by multiple interdisciplinary collaborative research structures that have been developed to advance translational work on AUD. Moreover, the integration of systems biology approaches with collaborative clinical studies may yield novel insights for future translational success. Finally, appreciation of genetic variation in pharmacological or behavioral treatment responses and optimal communication from bench to bedside and back may strengthen the success of translational research applications to AUD. ","PeriodicalId":7736,"journal":{"name":"Alcohol Research : Current Reviews","volume":"37 1","pages":"7-14"},"PeriodicalIF":9.4,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33976987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Utilization of Magnetic Resonance Imaging in Research Involving Animal Models of Fetal Alcohol Spectrum Disorders. 磁共振成像在胎儿酒精谱系障碍动物模型研究中的应用。

IF 9.4 1区医学

Alcohol Research : Current Reviews Pub Date : 2015-01-01

Xiaojie Wang, Christopher D Kroenke

{"title":"Utilization of Magnetic Resonance Imaging in Research Involving Animal Models of Fetal Alcohol Spectrum Disorders.","authors":"Xiaojie Wang, Christopher D Kroenke","doi":"","DOIUrl":"","url":null,"abstract":"It is well recognized that fetal alcohol exposure can profoundly damage the developing brain. The term fetal alcohol spectrum disorder (FASD) describes the range of deficits that result from prenatal alcohol exposure. Over the past two decades, researchers have used magnetic resonance imaging (MRI) as a noninvasive technique to characterize anatomical, physiological, and metabolic changes in the human brain that are part of FASD. As using animal models can circumvent many of the complications inherent to human studies, researchers have established and explored a number of models involving a range of species. Using MRI-based modalities, the FASD animal models have demonstrated decreased brain volume and abnormal brain shape, disrupted cellular morphology differentiation, altered neurochemistry, and blood perfusion. These animal studies have facilitated characterization of the direct effects of ethanol; in many cases identifying specific sequelae related to the timing and dose of exposure. Further, as a result of the ability to perform traditional (such as histological) analyses on animal brains following neuroimaging experiments, this work leads to improvements in the accuracy of our interpretations of neuroimaging findings in human studies. ","PeriodicalId":7736,"journal":{"name":"Alcohol Research : Current Reviews","volume":"37 1","pages":"39-51"},"PeriodicalIF":9.4,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33976990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0