Alcohol Research : Current Reviews最新文献_第9页

Measuring the burden--current and future research trends: results from the NIAAA Expert Panel on Alcohol and Chronic Disease Epidemiology. 衡量负担——当前和未来的研究趋势:来自NIAAA酒精和慢性病流行病学专家小组的结果。

IF 9.4 1区医学

Alcohol Research : Current Reviews Pub Date : 2013-01-01

Rosalind A Breslow, Kenneth J Mukamal

引用次数: 0

Overview: stress and alcohol use disorders revisited. 概述:重新审视压力和酒精使用障碍。

IF 9.4 1区医学

Alcohol Research : Current Reviews Pub Date : 2012-01-01

Robert M Anthenelli

引用次数: 0

How does stress lead to risk of alcohol relapse? 压力是如何导致酒精复发的?

IF 9.4 1区医学

Alcohol Research : Current Reviews Pub Date : 2012-01-01

Rajita Sinha

引用次数: 0

Identifying gene networks underlying the neurobiology of ethanol and alcoholism. 识别乙醇和酒精中毒的神经生物学基础基因网络。

IF 9.4 1区医学

Alcohol Research : Current Reviews Pub Date : 2012-01-01

Aaron R Wolen, Michael F Miles

{"title":"Identifying gene networks underlying the neurobiology of ethanol and alcoholism.","authors":"Aaron R Wolen, Michael F Miles","doi":"","DOIUrl":"","url":null,"abstract":"For complex disorders such as alcoholism, identifying the genes linked to these diseases and their specific roles is difficult. Traditional genetic approaches, such as genetic association studies (including genome-wide association studies) and analyses of quantitative trait loci (QTLs) in both humans and laboratory animals already have helped identify some candidate genes. However, because of technical obstacles, such as the small impact of any individual gene, these approaches only have limited effectiveness in identifying specific genes that contribute to complex diseases. The emerging field of systems biology, which allows for analyses of entire gene networks, may help researchers better elucidate the genetic basis of alcoholism, both in humans and in animal models. Such networks can be identified using approaches such as high-throughput molecular profiling (e.g., through microarray-based gene expression analyses) or strategies referred to as genetical genomics, such as the mapping of expression QTLs (eQTLs). Characterization of gene networks can shed light on the biological pathways underlying complex traits and provide the functional context for identifying those genes that contribute to disease development.","PeriodicalId":7736,"journal":{"name":"Alcohol Research : Current Reviews","volume":"34 3","pages":"306-17"},"PeriodicalIF":9.4,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31031220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epigenetics-beyond the genome in alcoholism. 表观遗传学——酗酒的基因组之外。

IF 9.4 1区医学

Alcohol Research : Current Reviews Pub Date : 2012-01-01

Bela G Starkman, Amul J Sakharkar, Subhash C Pandey

{"title":"Epigenetics-beyond the genome in alcoholism.","authors":"Bela G Starkman, Amul J Sakharkar, Subhash C Pandey","doi":"","DOIUrl":"","url":null,"abstract":"Genetic and environmental factors play a role in the development of alcoholism. Whole-genome expression profiling has highlighted the importance of several genes that may contribute to alcohol abuse disorders. In addition, more recent findings have added yet another layer of complexity to the overall molecular mechanisms involved in a predisposition to alcoholism and addiction by demonstrating that processes related to genetic factors that do not manifest as DNA sequence changes (i.e., epigenetic processes) play a role. Both acute and chronic ethanol exposure can alter gene expression levels in specific neuronal circuits that govern the behavioral consequences related to tolerance and dependence. The unremitting cycle of alcohol consumption often includes satiation and self-medication with alcohol, followed by excruciating withdrawal symptoms and the resultant relapse, which reflects both the positive and negative affective states of alcohol addiction. Recent studies have indicated that behavioral changes induced by acute and chronic ethanol exposure may involve chromatin remodeling resulting from covalent histone modifications and DNA methylation in the neuronal circuits involving a brain region called the amygdala. These findings have helped identify enzymes involved in epigenetic mechanisms, such as the histone deacetylase, histone acetyltransferase, and DNA methyltransferase enzymes, as novel therapeutic targets for the development of future pharmacotherapies for the treatment of alcoholism.","PeriodicalId":7736,"journal":{"name":"Alcohol Research : Current Reviews","volume":"34 3","pages":"293-305"},"PeriodicalIF":9.4,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31031219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Discovering genes involved in alcohol dependence and other alcohol responses: role of animal models. 发现与酒精依赖和其他酒精反应有关的基因:动物模型的作用。

IF 9.4 1区医学

Alcohol Research : Current Reviews Pub Date : 2012-01-01

Kari J Buck, Lauren C Milner, Deaunne L Denmark, Seth G N Grant, Laura B Kozell

{"title":"Discovering genes involved in alcohol dependence and other alcohol responses: role of animal models.","authors":"Kari J Buck, Lauren C Milner, Deaunne L Denmark, Seth G N Grant, Laura B Kozell","doi":"","DOIUrl":"","url":null,"abstract":"The genetic determinants of alcoholism still are largely unknown, hindering effective treatment and prevention. Systematic approaches to gene discovery are critical if novel genes and mechanisms involved in alcohol dependence are to be identified. Although no animal model can duplicate all aspects of alcoholism in humans, robust animal models for specific alcohol-related traits, including physiological alcohol dependence and associated withdrawal, have been invaluable resources. Using a variety of genetic animal models, the identification of regions of chromosomal DNA that contain a gene or genes which affect a complex phenotype (i.e., quantitative trait loci [QTLs]) has allowed unbiased searches for candidate genes. Several QTLs with large effects on alcohol withdrawal severity in mice have been detected, and fine mapping of these QTLs has placed them in small intervals on mouse chromosomes 1 and 4 (which correspond to certain regions on human chromosomes 1 and 9). Subsequent work led to the identification of underlying quantitative trait genes (QTGs) (e.g., Mpdz) and high-quality QTG candidates (e.g., Kcnj9 and genes involved in mitochondrial respiration and oxidative stress) and their plausible mechanisms of action. Human association studies provide supporting evidence that these QTLs and QTGs may be directly relevant to alcohol risk factors in clinical populations.","PeriodicalId":7736,"journal":{"name":"Alcohol Research : Current Reviews","volume":"34 3","pages":"367-74"},"PeriodicalIF":9.4,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31033959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resilience to meet the challenge of addiction: psychobiology and clinical considerations. 应对成瘾挑战的复原力:心理生物学和临床考虑。

IF 9.4 1区医学

Alcohol Research : Current Reviews Pub Date : 2012-01-01

Tanja N Alim, William B Lawson, Adriana Feder, Brian M Iacoviello, Shireen Saxena, Christopher R Bailey, Allison M Greene, Alexander Neumeister

{"title":"Resilience to meet the challenge of addiction: psychobiology and clinical considerations.","authors":"Tanja N Alim, William B Lawson, Adriana Feder, Brian M Iacoviello, Shireen Saxena, Christopher R Bailey, Allison M Greene, Alexander Neumeister","doi":"","DOIUrl":"","url":null,"abstract":"Acute and chronic stress-related mechanisms play an important role in the development of addiction and its chronic, relapsing nature. Multisystem adaptations in brain, body, behavioral, and social function may contribute to a dysregulated physiological state that is maintained beyond the homeostatic range. In addition, chronic abuse of substances leads to an altered set point across multiple systems. Resilience can be defined as the absence of psychopathology despite exposure to high stress and reflects a person's ability to cope successfully in the face of adversity, demonstrating adaptive psychological and physiological stress responses. The study of resilience can be approached by examining interindividual stress responsibility at multiple phenotypic levels, ranging from psychological differences in the way people cope with stress to differences in neurochemical or neural circuitry function. The ultimate goal of such research is the development of strategies and interventions to enhance resilience and coping in the face of stress and prevent the onset of addiction problems or relapse.","PeriodicalId":7736,"journal":{"name":"Alcohol Research : Current Reviews","volume":"34 4","pages":"506-15"},"PeriodicalIF":9.4,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31356558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stress, epigenetics, and alcoholism. 压力，表观遗传和酗酒

IF 9.4 1区医学

Alcohol Research : Current Reviews Pub Date : 2012-01-01

Sachin Moonat, Subhash C Pandey

{"title":"Stress, epigenetics, and alcoholism.","authors":"Sachin Moonat, Subhash C Pandey","doi":"","DOIUrl":"","url":null,"abstract":"Acute and chronic stressors have been associated with alterations in mood and increased anxiety that may eventually result in the development of stress-related psychiatric disorders. Stress and associated disorders, including anxiety, are key factors in the development of alcoholism because alcohol consumption can temporarily reduce the drinker's dysphoria. One molecule that may help mediate the relationship between stress and alcohol consumption is brain-derived neurotrophic factor (BDNF), a protein that regulates the structure and function of the sites where two nerve cells interact and exchange nerve signals (i.e., synapses) and which is involved in numerous physiological processes. Aberrant regulation of BDNF signaling and alterations in synapse activity (i.e., synaptic plasticity) have been associated with the pathophysiology of stress-related disorders and alcoholism. Mechanisms that contribute to the regulation of genetic information without modification of the DNA sequence (i.e., epigenetic mechanisms) may play a role in the complex control of BDNF signaling and synaptic plasticity-for example, by modifying the structure of the DNA-protein complexes (i.e., chromatin) that make up the chromosomes and thereby modulating the expression of certain genes. Studies regarding the epigenetic control of BDNF signaling and synaptic plasticity provide a promising direction to understand the mechanisms mediating the interaction between stress and alcoholism.","PeriodicalId":7736,"journal":{"name":"Alcohol Research : Current Reviews","volume":"34 4","pages":"495-505"},"PeriodicalIF":9.4,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31356556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genes contributing to the development of alcoholism: an overview. 导致酗酒的基因:综述。

IF 9.4 1区医学

Alcohol Research : Current Reviews Pub Date : 2012-01-01

Howard J Edenberg

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Alcohol Dependence and Genes Encoding α2 and γ1 GABAA Receptor Subunits: Insights from Humans and Mice. 酒精依赖和编码α2和γ1 GABAA受体亚基的基因:来自人和小鼠的见解

IF 9.4 1区医学

Alcohol Research : Current Reviews Pub Date : 2012-01-01

Cecilia M Borghese, R Adron Harris

引用次数: 0