Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism最新文献

{"title":"Adolescence. Alcohol sensitivity, tolerance, and intake.","authors":"Linda Patia Spear,&nbsp;Elena I Varlinskaya","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Research conducted in laboratory animals has shown adolescents to be less sensitive to numerous ethanol effects that may serve as cues to limit intake, including effects evident during intoxication (e.g., ethanol-induced motor impairment, anxiolysis, social impairment, and sedation), as well as during the post-intoxication period (e.g., \"hangover\"-associated anxiogenesis). Conversely, adolescents are more sensitive than adults to a few ethanol effects, including ethanol-induced social facilitation and impairments in hippocampal long-term-potentiation. These age-specific ethanol sensitivities are not simply related to developmental differences in ethanol pharmacokinetics. Instead, they appear related in part to an ontogenetic decline in expression of within session (acute) tolerance and to differential rates of development of neural systems underlying different actions of ethanol. Relatively high levels of ethanol intake often seen in adolescent rodents and their human counterparts may be related not only to an attenuated sensitivity of adolescents to negative cues that normally serve to limit drinking, but also their greater sensitivity to both the facilitation of social behavior by ethanol and the stimulation of ethanol intake by social experiences. Although data are sparse, studies in laboratory animals hint that under some circumstances chronic adolescent exposure to ethanol may influence ongoing neural maturation and later neural, cognitive, and behavioral functioning, including later sensitivity to and propensity to use ethanol. Recommendations for further research are discussed.</p>","PeriodicalId":77344,"journal":{"name":"Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism","volume":"17 ","pages":"143-59"},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25022915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Initiation and course of alcohol consumption among adolescents and young adults.","authors":"Jennifer L Maggs,&nbsp;John E Schulenberg","doi":"10.1007/0-306-48626-1_2","DOIUrl":"https://doi.org/10.1007/0-306-48626-1_2","url":null,"abstract":"<p><p>This chapter takes a normative developmental perspective on the etiology of alcohol use, focusing on the initiation and course of alcohol use (rather than alcohol use disorders) during adolescence and early adulthood. We review evidence regarding the sequelae and meaning of the age of initiation of alcohol use, consider variable- and pattern-centered approaches to modeling trajectories describing the course of alcohol use across adolescence and young adulthood, and offer developmental conceptualizations of risk and protective factors for alcohol use and related problems.</p>","PeriodicalId":77344,"journal":{"name":"Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism","volume":"17 ","pages":"29-47"},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/0-306-48626-1_2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25022910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The human adolescent brain and alcohol use disorders.","authors":"Susan F Tapert,&nbsp;Alecia D Schweinsburg","doi":"10.1007/0-306-48626-1_9","DOIUrl":"https://doi.org/10.1007/0-306-48626-1_9","url":null,"abstract":"","PeriodicalId":77344,"journal":{"name":"Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism","volume":"17 ","pages":"177-97"},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/0-306-48626-1_9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25024052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol and psychiatric comorbidity.","authors":"Jack R Cornelius,&nbsp;Oscar Bukstein,&nbsp;Ihsan Salloum,&nbsp;Duncan Clark","doi":"10.1007/0-306-47939-7_24","DOIUrl":"https://doi.org/10.1007/0-306-47939-7_24","url":null,"abstract":"<p><p>Comorbid psychiatric disorders and drug use disorders (DUDs) are common among alcoholics (Regier, Farmer, Rae, Locke, Keith, Judd, & Goodwin, 1990; Kessler, McGonagle, Zhao, Nelson, Hughes, Eshleman, Wittchen, & Kendler, 1994). These comorbid disorders often predict a shorter time to relapse of alcoholism (Greenfield, Weiss, Muenz, Vagge, Kelly, Bello, & Michael, 1998). However, despite the prevalence and the adverse effects of this comorbidity, few controlled treatment studies have been conducted involving this dual diagnosis population (Litten & Allen, 1999). To date, most of these few studies of alcoholics with comorbid disorders have been restricted to studies of alcoholics with either comorbid major depression or comorbid anxiety disorders (Litten & Allen, 1995). The results of these trials suggest efficacy for SSRI antidepressants and tricyclic antidepressants for treating alcoholics with comorbid major depression and suggest efficacy for buspirone for treating alcoholics with comorbid anxiety disorders (Mason, Kocsis, Ritvo, & Cutler, 1996; Cornelius, Salloum, Ehler, Jarrett, Cornelius, Perel, Thase, & Black, 1997; Kranzler, Burleson, Del Boca, Babor, Korner, Brown, & Bohn, 1994). However, controlled treatment studies involving alcoholics with other comorbid disorders are almost totally lacking. Consequently, to date, no empirically proven treatment exists for most of these comorbid disorders.</p>","PeriodicalId":77344,"journal":{"name":"Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism","volume":"16 ","pages":"361-74"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/0-306-47939-7_24","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22290433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spirituality, treatment, and recovery.","authors":"William R Miller","doi":"10.1007/0-306-47939-7_26","DOIUrl":"https://doi.org/10.1007/0-306-47939-7_26","url":null,"abstract":"","PeriodicalId":77344,"journal":{"name":"Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism","volume":"16 ","pages":"391-404"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/0-306-47939-7_26","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22290435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of alcoholic patients: advances and future challenges.","authors":"John P Allen","doi":"10.1007/0-306-47939-7_3","DOIUrl":"https://doi.org/10.1007/0-306-47939-7_3","url":null,"abstract":"<p><p>Noteworthy advances have been made in methods of assessing patients suffering alcohol problems. More than one hundred measures are now available to assist clinicians and researchers in screening for such problems, diagnosing them, and developing treatment plans individualized according to relevant patient characteristics. This chapter reviews progress in assessment supporting each of these activities and suggests directions for future research. It concludes by identifying a series of research issues that cut across multiple domains of alcohol assessment.</p>","PeriodicalId":77344,"journal":{"name":"Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism","volume":"16 ","pages":"13-24"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/0-306-47939-7_3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22291778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomarkers as aids to identification of relapse in alcoholic patients.","authors":"John P Allen,&nbsp;Raymond Anton","doi":"10.1007/0-306-47939-7_4","DOIUrl":"https://doi.org/10.1007/0-306-47939-7_4","url":null,"abstract":"<p><p>Since return to drinking is common in patients recovering from alcoholism, recognition of relapse should be an important component of treatment. Recurrent assessment with biochemical measures can provide clinicians with useful information on the drinking status of their patients. This chapter addresses issues surrounding the importance of early detection of relapse, describes biochemical markers that may assist in this, reviews relevant scientific investigations, and offers recommendations to researchers and clinicians.</p>","PeriodicalId":77344,"journal":{"name":"Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism","volume":"16 ","pages":"25-38"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/0-306-47939-7_4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22291779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brief interventions and the treatment of alcohol use disorders: current evidence.","authors":"M. Fleming","doi":"10.1007/0-306-47939-7_25","DOIUrl":"https://doi.org/10.1007/0-306-47939-7_25","url":null,"abstract":"","PeriodicalId":77344,"journal":{"name":"Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism","volume":"50 1","pages":"375-90"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51347319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in the use of naltrexone: an integration of preclinical and clinical findings.","authors":"Stephanie S O'Malley,&nbsp;Janice C Froehlich","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Both preclinical and clinical studies are critical in the development of effective pharmacotherapeutic approaches for treating alcoholism. Nowhere has this been more evident than in the development of naltrexone for treating alcohol relapse. As studies continue on the use of naltrexone for modifying alcohol intake, promising avenues for continued work on maximizing the efficacy of naltrexone for treating alcohol abuse and alcoholism are emerging. Recent research suggests that naltrexone can influence key components of alcohol dependence, including loss of control over the decision to drink and the amount of alcohol consumed. Although not uniformly positive, the majority of clinical trials supports the hypothesis that naltrexone can reduce the urge to drink, increase the number of days abstinent, and minimize the risk of relapse to heavy drinking. Human laboratory and preclinical paradigms that have investigated how naltrexone alters patterns of drinking suggest that naltrexone treatment results in earlier cessation of drinking within a session. In addition, preclinical data suggest that the amount of alcohol consumed declines during subsequent sessions in the presence of naltrexone. Based on this analysis, future clinical trials should consider using analytic approaches that evaluate patterns of drinking (e.g., multiple event analysis) rather than single events (e.g., survival analysis). Furthermore, behavioral interventions and instructions can also be developed to take advantage of this effect. Additional preclinical and clinical work is warranted to identify dosing strategies that ensure adequate drug levels while reducing the possibility of developing tolerance to naltrexone. Finally, studies designed to identify the characteristics of drinking populations that are responsive to naltrexone and studies investigating the potential advantage of combining naltrexone with agents that alter a number of neurotransmitter systems are exciting new avenues of research. Ultimately, these lines for research promise to provide critical information that can be used to maximize the efficacy of naltrexone for treating alcoholism.</p>","PeriodicalId":77344,"journal":{"name":"Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism","volume":"16 ","pages":"217-45"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22291758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Animal models of motivation for drinking in rodents with a focus on opioid receptor neuropharmacology.","authors":"George F Koob,&nbsp;Amanda J Roberts,&nbsp;Brigitte L Kieffer,&nbsp;Charles J Heyser,&nbsp;Simon N Katner,&nbsp;Roberto Ciccocioppo,&nbsp;Friedbert Weiss","doi":"10.1007/0-306-47939-7_19","DOIUrl":"https://doi.org/10.1007/0-306-47939-7_19","url":null,"abstract":"<p><p>Ethanol, like other drugs of abuse, has motivating properties that can be developed as animal models of self-administration. A major strength of the operant approach where an animal must work to obtain ethanol is that it reduces confounds due to palatability and controls for nonspecific malaise-inducing effects. In the domain of opioid peptide systems, limited access paradigms have good predictive validity. In addition, animal models of excessive drinking-either environmentally or genetically induced-also appear sensitive to blockade or inactivation of opioid peptide receptors. Ethanol availability can be predicted by cues associated with positive reinforcement, and these models are sensitive to the administration of opioid antagonists. Perhaps most exciting are the recent results suggesting that the key element in opioid peptide systems that is important for the positive reinforcing effects of ethanol is the mu-opioid receptor. How exactly ethanol modulates mu-receptor function will be a major challenge of future research. Nevertheless, the apparently critical role of the mu receptor in ethanol reinforcement refocuses the neuropharmacology of ethanol reinforcement in the opioid peptide domain and opens a novel avenue for exploring medications for treating alcoholism.</p>","PeriodicalId":77344,"journal":{"name":"Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism","volume":"16 ","pages":"263-81"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/0-306-47939-7_19","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22291760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}