Progress in growth factor research最新文献_第8页

Growth factors in Parkinson's disease 帕金森病的生长因子

Progress in growth factor research Pub Date : 1994-01-01 DOI: 10.1016/0955-2235(94)90018-3

Klaus Unsicker

{"title":"Growth factors in Parkinson's disease","authors":"Klaus Unsicker","doi":"10.1016/0955-2235(94)90018-3","DOIUrl":"10.1016/0955-2235(94)90018-3","url":null,"abstract":"<div><p>The etiology of Parkinson's disease, one of the most frequent neurodegenerative disorders in human, is unknown. New hopes concerning satisfactory therapies include transplants of autologous adrenal medullary chromaffin tissue, fetal mesencephalic dopaminergic neurons, and local application of growth factors with a neurotrophic capacity. A large body of evidence supports the notion that neurons require trophic support not only during a limited period of ontogenesis, but during their whole lifespan. Relevant molecules promote survival, transmitter synthesis and other differentiated properties, and become crucially important when a neuron is metabolically or toxically impaired. Several molecules, most of which occur in the striatum and the substantia nigra, have been identified that protect lesioned dopaminergic nigrostriatal neurons in culture or in animal models of Parkinson's disease. These include members of the neurotrophin, fibroblast growth factor, and insulin-like growth factor families as well as epidermal growth factor/transforming growth factor alpha, interleukins and ciliary neurotrophic factor. Whether their effects are merely pharmacological, or reflect a physiological role in the nigrostriatal system, is unclear as yet. This article reviews experiments that document the trophic effects of these factors on dopaminergic neurons and discusses their possible physiological and therapeutic relevance.</p></div>","PeriodicalId":77335,"journal":{"name":"Progress in growth factor research","volume":"5 1","pages":"Pages 73-87"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0955-2235(94)90018-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19189222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 57

The human and mouse fibroblast growth factor 6 (FGF6) genes and their products: Possible implication in muscle development 人和小鼠成纤维细胞生长因子6 (FGF6)基因及其产物:可能与肌肉发育有关

Progress in growth factor research Pub Date : 1994-01-01 DOI: 10.1016/0955-2235(94)90014-0

François Coulier, Sandrine Pizette, Vincent Ollendorff , Odile deLapeyrière, Daniel Birnbaum

引用次数: 25

Control of nitric oxide synthase expression by transforming growth factor-β: Implications for homeostasis 通过转化生长因子-β控制一氧化氮合酶的表达:对体内平衡的影响

Progress in growth factor research Pub Date : 1994-01-01 DOI: 10.1016/0955-2235(94)00004-5

Yoram Vodovotz , Christian Bogdan

引用次数: 82

The role of neurotrophins during successive stages of sensory neuron development 神经营养因子在感觉神经元发育的连续阶段中的作用

Progress in growth factor research Pub Date : 1994-01-01 DOI: 10.1016/0955-2235(94)90010-8

Alun M. Davies

{"title":"The role of neurotrophins during successive stages of sensory neuron development","authors":"Alun M. Davies","doi":"10.1016/0955-2235(94)90010-8","DOIUrl":"10.1016/0955-2235(94)90010-8","url":null,"abstract":"<div><p>Neurotrophins comprise a family of basic homodimeric proteins. The isolation of the first two neurotrophins, nerve growth factor and brain-derived neurotrophic factor, was based on the ability of these proteins to promote the survival of embryonic neurons. However, the identification of additional neurotrophins by homology screening together with recent work on these proteins has shown that neurotrophins do more than just regulate neuronal survival. Neurotrophins influence the proliferation and differentiation of neuron progenitor cells and regulate the expression of several differentiated traits of neurons throughout life. Moreover, the influence of neurotrophins on survival is more complex than originally thought; some neurons switch their survival requirements from one set of neurotrophins to another during development and several neurotrophins may be involved in regulating the survival of a population of neurons at any one time. Most of what is known of the developmental physiology of neurotrophins has come from studying neurons of the peripheral nervous system. Quite apart from the accessibility of these neurons and their progenitor cell populations, investigation of the actions of neurotrophins on several well-characterised populations of sensory neurons has permitted the age-related changes in the effects of neurotrophins to be interpreted in the appropriate developmental context. In this review I provide a chronological account of the action of neurotrophins in neuronal development with special reference to sensory neurons.</p></div>","PeriodicalId":77335,"journal":{"name":"Progress in growth factor research","volume":"5 3","pages":"Pages 263-289"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0955-2235(94)90010-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18888798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 42

Involvement of JAK-family tyrosine kinases in hematopoietin receptor signal transduction jak家族酪氨酸激酶参与造血素受体信号转导

Progress in growth factor research Pub Date : 1994-01-01 DOI: 10.1016/0955-2235(94)90005-1

Robert A. Kirken , Hallgeir Rui , O.M.Zack Howard , William L. Farrar

引用次数: 12

Mitogenic factors of corpora lutea 黄体的有丝分裂因子

Progress in growth factor research Pub Date : 1994-01-01 DOI: 10.1016/0955-2235(94)90003-5

Lawrence P. Reynolds , Anna T. Grazul-Bilska , S.Derek Killilea , Dale A. Redmer

{"title":"Mitogenic factors of corpora lutea","authors":"Lawrence P. Reynolds , Anna T. Grazul-Bilska , S.Derek Killilea , Dale A. Redmer","doi":"10.1016/0955-2235(94)90003-5","DOIUrl":"10.1016/0955-2235(94)90003-5","url":null,"abstract":"<div><p>The mammalian corpus luteum (CL), which plays a central role in the reproductive process because of its production of hormones such as progesterone, appears to be an exceptionally dynamic organ. Its rate of growth and development are extremely rapid and, even when the CL is functionally mature, its rate of cell turnover remains relatively high. Associated with this high rate of cell turnover, the mature CL receives the greatest blood supply per unit tissue of any organ, and also exhibits a relatively high metabolic rate. Although numerous growth factors have been identified in luteal tissue, their role in growth and differentiation of this dynamic organ remains unclear. Recently, while attempting to identify mitogenic factors of ovine and bovine CL, we have found that they produce several mitogens during the estrous cycle as well as pregnancy. The majority of these luteal-derived mitogenic factors are heparin-binding, and although some may represent previously identified factors, several appear to be novel heparin-binding growth factors. Isolation and purification of mitogenic factors produced by the CL will enable us to determine their roles in luteal growth, development and differentiated function, which will contribute to our understanding not only of the regulation of fertility but also of tissue growth and development in general.</p></div>","PeriodicalId":77335,"journal":{"name":"Progress in growth factor research","volume":"5 2","pages":"Pages 159-175"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0955-2235(94)90003-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18916800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 118

Evolution of the transforming growth factor-beta superfamily 转化生长因子- β超家族的进化

Progress in growth factor research Pub Date : 1994-01-01 DOI: 10.1016/0955-2235(94)90020-5

David W. Burt, Andrew S. Law

引用次数: 126

Bibliographic update: Nerve growth factor 书目更新:神经生长因子

Progress in growth factor research Pub Date : 1994-01-01 DOI: 10.1016/0955-2235(94)90021-3

引用次数: 0

Cytokine receptors and signal transduction 细胞因子受体与信号转导

Progress in growth factor research Pub Date : 1994-01-01 DOI: 10.1016/0955-2235(94)90015-9

Alice L.-F. Mui, Atsushi Miyajima

{"title":"Cytokine receptors and signal transduction","authors":"Alice L.-F. Mui, Atsushi Miyajima","doi":"10.1016/0955-2235(94)90015-9","DOIUrl":"10.1016/0955-2235(94)90015-9","url":null,"abstract":"<div><p>Cytokines are important regulators of hemopoiesis which exert their actions by binding to specific, high affinity, cell surface receptors. In the past several years, molecular cloning of these receptors has revealed a new superfamily referred to as the hemopoietic growth factor receptors. Members of this family are defined by a 200 amino acid conserved domain; however, it has become increasingly apparent that another characteristic of these receptors is the shared usage of a common signalling subunit among subgroups in this family. The shared signalling component explains the functional redundancy of many cytokines; however, the mechanism by which these receptors transduce a signal across the membrane is not yet clear. Studies into cytokine action have shown that many of the events that occur in response to ligand stimulation are similar to those observed for the better characterized intrinsic tyrosine kinase receptors. Thus, although the cytokine receptors do not possess intrinsic tyrosine kinase activity, these observations have led to a model of cytokine signal transduction adapted from the signalling mechanisms described for the tyrosine kinase receptors.</p></div>","PeriodicalId":77335,"journal":{"name":"Progress in growth factor research","volume":"5 1","pages":"Pages 15-35"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0955-2235(94)90015-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19189893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Regulation of phospholipase C isozymes 磷脂酶C同工酶的调控

Progress in growth factor research Pub Date : 1992-01-01 DOI: 10.1016/0955-2235(92)90025-D

Gwenith Jones, Graham Carpenter

引用次数: 14