{"title":"转化生长因子- β超家族的进化","authors":"David W. Burt, Andrew S. Law","doi":"10.1016/0955-2235(94)90020-5","DOIUrl":null,"url":null,"abstract":"<div><p>Transforming growth factor β1 (TGF-β1) is the prototype of an increasingly complex superfamily of growth and differentiation factors. To date, a total of 74 TGF-β-like sequences have been published, probably representing 23 distinct genes. These sequences were obtained from mammalian, avian, amphibian and insect species, thus emphasising the ancient nature of the TGF-β superfamily peptides. This article summarises current hypotheses concerning the evolutionary history of this protein superfamily, based on the molecular phylogeny of the published sequences. Comparison of the deduced amino acid sequences leads to the definition of five main groups within the superfamily (TGF-β, Bone Morphogenetic Proteins [BMP], Anti-Müllerian Hormone [AMH], Inhibin α [INHα] and GDF-9) and six subgroups within the BMPs (60A, Decapentaplegic [ddp], Vg1, BMP-3, Inhibin β [<span><math><mtext>INHβ</mtext><msub><mi></mi><mn><mtext>A</mtext><mtext>B</mtext></mn></msub></math></span>] and nodal). This classification predicts possible phylogenetic and functional relationships among these proteins.</p></div>","PeriodicalId":77335,"journal":{"name":"Progress in growth factor research","volume":"5 1","pages":"Pages 99-107, 109-118"},"PeriodicalIF":0.0000,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0955-2235(94)90020-5","citationCount":"126","resultStr":"{\"title\":\"Evolution of the transforming growth factor-beta superfamily\",\"authors\":\"David W. Burt, Andrew S. Law\",\"doi\":\"10.1016/0955-2235(94)90020-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Transforming growth factor β1 (TGF-β1) is the prototype of an increasingly complex superfamily of growth and differentiation factors. To date, a total of 74 TGF-β-like sequences have been published, probably representing 23 distinct genes. These sequences were obtained from mammalian, avian, amphibian and insect species, thus emphasising the ancient nature of the TGF-β superfamily peptides. This article summarises current hypotheses concerning the evolutionary history of this protein superfamily, based on the molecular phylogeny of the published sequences. Comparison of the deduced amino acid sequences leads to the definition of five main groups within the superfamily (TGF-β, Bone Morphogenetic Proteins [BMP], Anti-Müllerian Hormone [AMH], Inhibin α [INHα] and GDF-9) and six subgroups within the BMPs (60A, Decapentaplegic [ddp], Vg1, BMP-3, Inhibin β [<span><math><mtext>INHβ</mtext><msub><mi></mi><mn><mtext>A</mtext><mtext>B</mtext></mn></msub></math></span>] and nodal). This classification predicts possible phylogenetic and functional relationships among these proteins.</p></div>\",\"PeriodicalId\":77335,\"journal\":{\"name\":\"Progress in growth factor research\",\"volume\":\"5 1\",\"pages\":\"Pages 99-107, 109-118\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1994-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0955-2235(94)90020-5\",\"citationCount\":\"126\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Progress in growth factor research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0955223594900205\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in growth factor research","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0955223594900205","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Evolution of the transforming growth factor-beta superfamily
Transforming growth factor β1 (TGF-β1) is the prototype of an increasingly complex superfamily of growth and differentiation factors. To date, a total of 74 TGF-β-like sequences have been published, probably representing 23 distinct genes. These sequences were obtained from mammalian, avian, amphibian and insect species, thus emphasising the ancient nature of the TGF-β superfamily peptides. This article summarises current hypotheses concerning the evolutionary history of this protein superfamily, based on the molecular phylogeny of the published sequences. Comparison of the deduced amino acid sequences leads to the definition of five main groups within the superfamily (TGF-β, Bone Morphogenetic Proteins [BMP], Anti-Müllerian Hormone [AMH], Inhibin α [INHα] and GDF-9) and six subgroups within the BMPs (60A, Decapentaplegic [ddp], Vg1, BMP-3, Inhibin β [] and nodal). This classification predicts possible phylogenetic and functional relationships among these proteins.
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