Progress in growth factor research最新文献_第6页

Comparison studies of IGFBP-5 binding to osteoblasts and osteoblast-derived extracellular matrix IGFBP-5与成骨细胞和成骨细胞来源的细胞外基质结合的比较研究

Progress in growth factor research Pub Date : 1995-01-01 DOI: 10.1016/0955-2235(95)00008-9

Dennis L. Andress

{"title":"Comparison studies of IGFBP-5 binding to osteoblasts and osteoblast-derived extracellular matrix","authors":"Dennis L. Andress","doi":"10.1016/0955-2235(95)00008-9","DOIUrl":"10.1016/0955-2235(95)00008-9","url":null,"abstract":"<div>Recent studies have identified a specific membrane protein in osteoblast-like cells which binds intact and carboxy-truncated IGFBP-5 with high affinity. The purpose of the present study was to evaluate the IGFBP-5 binding properties of osteoblast-derived extracellular matrix (ECM), with special interest in determining whether ECM proteoglycans were necessary for IGFBP-5 binding. Neonatal mouse osteoblasts and the ECM of these cells both bound intact [125I]IGFBP-5 and [125I]IGFB_-51–169, though the ECM bound both forms with lower affinity when compared to their cellular binding. Treatment of the ECM with heparinase or chondroitinase, to remove glycosaminoglycan (GAG) side-chains of proteoglycans, resulted in 20–34% enhanced binding of intact [125I]IGFBP-5 and a 92–100% enhancement of [125I]IGFBP-51–169 binding. Similar enzymatic treatment of osteoblast monolayers had no effect on the binding of either form of [125I]IGFBP-5. These results indicate that GAGs within ECM secreted by neonatal mouse osteoblasts do not mediate the binding of IGFBP-5. This study also shows that intact and carboxy-truncated IGFBP-5 preferentially bind to the osteoblast surface, but that removal of GAGs from osteoblast-derived ECM can increase IGFBP-5 localization to this pericellular space, particularly the carboxy-truncated form of IGFBP-5.</div>","PeriodicalId":77335,"journal":{"name":"Progress in growth factor research","volume":"6 2","pages":"Pages 337-344"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0955-2235(95)00008-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19785984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

The role of growth factors in preimplantation development 生长因子在植入前发育中的作用

Progress in growth factor research Pub Date : 1995-01-01 DOI: 10.1016/0955-2235(95)00001-1

Peter L. Kaye , Mark B. Harveyt

{"title":"The role of growth factors in preimplantation development","authors":"Peter L. Kaye , Mark B. Harveyt","doi":"10.1016/0955-2235(95)00001-1","DOIUrl":"10.1016/0955-2235(95)00001-1","url":null,"abstract":"<div>It has become clear that the mammalian embryo participates in a complex dialogue with the maternal physiology. The language of the dialogue is growth factor signalling. The embryo expresses receptors for insulin, IGFs, GH, EGF and cytokines including LIF, and CSFs; whilst ligands are secreted by the supporting tissues of the oviduct and uterus, and in some cases, the embryo itself. In the preimplantation period when the embryo is travelling to the uterus and passing through its first differentiation, these ligands affect embryonic physiology, apparently in ways that optimise developmental potential and synchronise embryonic and maternal physiologies. It is not yet clear in most cases whether this is by autocrine, paracrine or endocrine mode. In the crucial peri-implantation phase the embryo is preparing to invade the maternal system for which extensive uterine remodelling is necessary. A model is proposed in which a cascade of growth factor activities, orchestrated by the ovarian steroid patterns, choreographs the biochemical players (ECM proteinases and their inhibitors) which initiate this activity.</div>","PeriodicalId":77335,"journal":{"name":"Progress in growth factor research","volume":"6 1","pages":"Pages 1-24"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0955-2235(95)00001-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19688771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 61

Developmental regulation of circulating insulin-like growth factor-binding proteins in normal pregnancies and in pre-eclampsia 循环胰岛素样生长因子结合蛋白在正常妊娠和子痫前期的发育调节

Progress in growth factor research Pub Date : 1995-01-01 DOI: 10.1016/0955-2235(95)00030-5

Moira S. Lewitt , Fergus P. Scott , Nicole M. Clarke , Robert C. Baxter

引用次数: 37

Multiple liver-enriched trans-acting factors interact with the glucocorticoid- (GRU) and cAMP-(CRU) responsive units within the h-IGFBP-1 promoter 多种富含肝脏的反式作用因子与h-IGFBP-1启动子内的糖皮质激素-(GRU)和cAMP-(CRU)应答单元相互作用

Progress in growth factor research Pub Date : 1995-01-01 DOI: 10.1016/0955-2235(95)00039-9

Eric Neau , Daniel Chambéry , Ghislaine Schweizer-Groyer , Françoise Cadepond , Nicole Jibard , André Groyer

{"title":"Multiple liver-enriched trans-acting factors interact with the glucocorticoid- (GRU) and cAMP-(CRU) responsive units within the h-IGFBP-1 promoter","authors":"Eric Neau , Daniel Chambéry , Ghislaine Schweizer-Groyer , Françoise Cadepond , Nicole Jibard , André Groyer","doi":"10.1016/0955-2235(95)00039-9","DOIUrl":"10.1016/0955-2235(95)00039-9","url":null,"abstract":"<div>In response to hormonal control, serum concentrations of insulin-growth factor-binding protein-1 (IGFBP-1) may vary as much as 10-fold, owing to strict control of its gene's expression in hepatocytes. IGFBP-1 gene transcription is increased by gluco-corticoids and cAMP and inhibited by insulin. The effect of insulin is dominant since it suppresses constitutive and both glucocorticoid- and cAMP-stimulated transcription. Close examination of the human (h) IGFBP-1 promoter sequences showed that the glucocorticoid (GRE, nt −88 to −102) and cAMP (CRE, nt −259 to −264) response elements are 5′-flanked by an A/T-rich imperfect palindrome (nt −102 to −117 and −265 to −285, respectively). These A/T-rich motifs are putative cis-elements for liver-enriched trans-acting factors.Competition experiments in electrophoretic mobility shift assay were carried out using rat liver nuclear extracts and a set of synthetic oligonucleotides designed from hIGFBP-1 Glucorticoid and cAMP Response Units (GRU and CRU), the rat transthyretin HNF3 cis-element and the ‘D-site’ of the mouse albumin promoter.The nucleotide motifs located between nt −108 and −121 of the GRU, interacted with the HNF3 family of rans-acting factors (α,β,γ), whereas those encompassing nt −181 to −104 bound DBP and/or nuclear proteins sharing similar sequence specificity (i.e. from the C/EBP family of bZIP proteins). We have also shown that the hIGFBP-1-GRE binds glucocorticoid receptor homodimers.In the case of the CRU, the cis-elements located between nt −249 and −285 bound DBP and/or nuclear proteins sharing similar sequence specificities. In addition, the nucleotide stretch lying between nt −256 and −275 was able to interact with the HNF3 family of trans-acting factors.</div>","PeriodicalId":77335,"journal":{"name":"Progress in growth factor research","volume":"6 2","pages":"Pages 103-117"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0955-2235(95)00039-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19786806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Expression, effects, and fate of IGFBP-5 are different in normal and malignant osteoblastic cells IGFBP-5在正常和恶性成骨细胞中的表达、作用和命运不同

Progress in growth factor research Pub Date : 1995-01-01 DOI: 10.1016/0955-2235(95)00037-2

Ch. Schmid, I. Schläpfer, M.A. Gosteli-Peter, E.R. Froesch, J. Zapf

{"title":"Expression, effects, and fate of IGFBP-5 are different in normal and malignant osteoblastic cells","authors":"Ch. Schmid, I. Schläpfer, M.A. Gosteli-Peter, E.R. Froesch, J. Zapf","doi":"10.1016/0955-2235(95)00037-2","DOIUrl":"10.1016/0955-2235(95)00037-2","url":null,"abstract":"<div>Normal osteoblasts from newborn rat calvaria and human osteosarcoma (Saos-2) cells express IGFBP-5 mRNA. IGF I increases IGFBP-5 mRNA levels in both cell types, whereas retinoic acid stimulates IGFBP-5 mRNA expression in calvaria but suppresses it in Saos-2 cells. IGFBP-5 mRNA expression is stimulated in normal bone cells by parathyroid hormone. 30 nM IGFBP-5 stimulates 3H-thymidine incorporation in calvaria (which produce IGF I contributing to basal proliferation in serum-free medium) but not in Saos-2 cells which produce little IGF I and IGF II. Among the 5 rhIGFBPs tested (IGFBP-2 to -6), only IGFBP-5 stimulates DNA synthesis in calvaria cells, and only IGFBP-6 in Saos-2 cells.RhIGFBP-5 displays a short half-life (∼30 min) in serum-free medium of calvaria cells and a long half-life (∼15 h) in the medium of Saos-2 cells. Fragments of 20 and 14 kDa accumulate in the media of both cell types. Intact (31 kDa) IGFBP-5 is associated and remains with the extracellular matrix of mature calvaria osteoblasts but not of Saos-2 cells.Among the IGFBPs produced IGFBP-5 is unique with regard to its marked affinity to matrix of normal bone cells, its short half-life when released, and its stimulatory effects on DNA synthesis.</div>","PeriodicalId":77335,"journal":{"name":"Progress in growth factor research","volume":"6 2","pages":"Pages 167-173"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0955-2235(95)00037-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19786812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Bibliographic update: Hepatocyte growth factor 书目更新:肝细胞生长因子

Progress in growth factor research Pub Date : 1994-01-01 DOI: 10.1016/0955-2235(94)90026-4

引用次数: 0

Growth factors in CNS repair and regeneration 生长因子在中枢神经系统修复和再生中的作用

Progress in growth factor research Pub Date : 1994-01-01 DOI: 10.1016/0955-2235(94)00008-9

Ann Logan , James J Oliver , Martin Berry

引用次数: 60

Regulatory issues in clinical applications of cytokines and growth factors 细胞因子和生长因子临床应用中的监管问题

Progress in growth factor research Pub Date : 1994-01-01 DOI: 10.1016/0955-2235(94)90006-X

Karen D. Weiss, Jay P. Siegel, Theresa L. Gerrard

引用次数: 3

Growth factors in mouse primordial germ cell migration and proliferation 生长因子对小鼠原始生殖细胞迁移和增殖的影响

Progress in growth factor research Pub Date : 1994-01-01 DOI: 10.1016/0955-2235(94)90001-9

Massimo De Felici, Maurizio Pesce

{"title":"Growth factors in mouse primordial germ cell migration and proliferation","authors":"Massimo De Felici, Maurizio Pesce","doi":"10.1016/0955-2235(94)90001-9","DOIUrl":"10.1016/0955-2235(94)90001-9","url":null,"abstract":"<div>Information obtained mainly from in vitro culture studies and genetic analysis of mouse mutants White spotting and Steel indicate a pivotal role of growth factors in the development of mouse primordial germ cells (PGCs). While stem cell factor (SCF) and TGFβ1 seem to have a role in PGC migration (as an adhesion factor and a chemoattractant, respectively), the former is certainly required for PGC survival in vitro and probably in vivo as well. Recent findings suggest that the mechanism by which SCF supports PGC survival is by preventing PGC apoptosis. A similar action appears to be exerted by leukemia inhibitory factor (LIF), a further growth factor influencing PGC growth in culture.PGC proliferation seems to be mainly induced by cAMP dependent mechanisms, but futther investigations are needed to clarify the interrelationships among the different molecular pathways activated by SCF, LIF, cAMP and other putative PGC growth factors (i.e. bFGF). Stimulation of long-term proliferation of PGCs, leading to derivation of ES-like cells (embryonal germ cells) obtained by using a combination of growth factors (bFGF, SCF and LIF), opens new intriguing perspectives for such studies and transgenic technology.</div>","PeriodicalId":77335,"journal":{"name":"Progress in growth factor research","volume":"5 2","pages":"Pages 135-143"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0955-2235(94)90001-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18916798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 51

Are fibroblast growth factors regulators of myogenesis in vivo? 成纤维细胞生长因子是体内肌生成的调节因子吗?

Progress in growth factor research Pub Date : 1994-01-01 DOI: 10.1016/0955-2235(94)90002-7

Bradley B. Olwin, Kevin Hannon, Arthur J. Kudla

引用次数: 47