Developmental regulation of circulating insulin-like growth factor-binding proteins in normal pregnancies and in pre-eclampsia

Moira S. Lewitt , Fergus P. Scott , Nicole M. Clarke , Robert C. Baxter
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引用次数: 37

Abstract

The insulin-like growth factors (IGFs) and their binding properties (IGFBPs) are believed to play important roles in the growth and development of the human fetus. They have been implicated in the pathophysiology of pre-eclampsia. In this study we have characterized the developmental regulation, in normal and pre-eclamptic pregnancies, of IGFs and IGFBPs in maternal serum, neonatal serum and amniotic fluid. In neonatal cord serum IGFBP-1, -2 and -6 decreased with increasing gestational age. In contrast, the ternary complex and its components, IGF-I, IGFBP-3 and ALS increased with gestation. We show that while ALS is an important limiting factor for ternary complex formation in the fetal circulation, there is a fraction of IGFBP-3 which is unable to form this complex. IGFs and IGFBPs in the maternal and fetal circulation were similar in normal and pre-eclamptic pregnancies.

循环胰岛素样生长因子结合蛋白在正常妊娠和子痫前期的发育调节
胰岛素样生长因子(IGFs)及其结合特性(igfbp)被认为在人类胎儿的生长发育中起着重要作用。它们与先兆子痫的病理生理有关。在本研究中,我们描述了正常妊娠和子痫前期妊娠中母体血清、新生儿血清和羊水中igf和igfbp的发育调节。新生儿脐带血清IGFBP-1、-2和-6随胎龄增加而降低。相反,三元复合物及其组分IGF-I、IGFBP-3和ALS随妊娠增加。我们发现,虽然ALS是胎儿循环中三元复合物形成的重要限制因素,但有一小部分IGFBP-3不能形成这种复合物。在正常妊娠和子痫前期,母体和胎儿循环中的igf和igfbp相似。
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