Matrix (Stuttgart, Germany). Supplement最新文献_第9页

Extraction of type IV collagenase/gelatinase from plasma membranes of human pancreatic cancer cells. 人胰腺癌细胞质膜中IV型胶原酶/明胶酶的提取。

Matrix (Stuttgart, Germany). Supplement Pub Date : 1992-01-01

S Zucker, U M Moll, R M Lysik, E I DiMassimo, J W Schwedes, L A Liotta

引用次数: 0

The production of collagenase and an inhibitor of collagenase by rat mammary carcinoma cells. 大鼠乳腺癌细胞产生胶原酶及胶原酶抑制剂的研究。

Matrix (Stuttgart, Germany). Supplement Pub Date : 1992-01-01

J M Whitelock, R L O'Grady

引用次数: 0

Unique features of the tissue collagenase cleavage site in interstitial collagens. 组织胶原酶在间质性胶原中切割部位的独特特征。

Matrix (Stuttgart, Germany). Supplement Pub Date : 1992-01-01

G B Fields, H E Van Wart

引用次数: 0

Limited proteolysis of types I, II and III collagens at hyper-reactive sites by Clostridium histolyticum collagenase. 溶组织梭菌胶原酶在高活性位点对I型、II型和III型胶原蛋白的有限水解。

Matrix (Stuttgart, Germany). Supplement Pub Date : 1992-01-01

M F French, A Bhown, H E Van Wart

引用次数: 0

Pz-peptidase is not a matrix metalloproteinase. pz -肽酶不是基质金属蛋白酶。

Matrix (Stuttgart, Germany). Supplement Pub Date : 1992-01-01

A J Barrett, U Tisljar

引用次数: 0

Dissociation of tissue inhibitor of metalloproteinases (TIMP) from enzyme complexes yields fully active inhibitor. 金属蛋白酶组织抑制剂(TIMP)从酶复合物中解离产生完全活性抑制剂。

Matrix (Stuttgart, Germany). Supplement Pub Date : 1992-01-01

G Murphy

引用次数: 0

Secreted inhibitors of metalloproteinases (IMPs) that are distinct from TIMP. 与TIMP不同的金属蛋白酶(IMPs)分泌抑制剂。

Matrix (Stuttgart, Germany). Supplement Pub Date : 1992-01-01

M J Banda, E W Howard, G S Herron, G Apodaca

{"title":"Secreted inhibitors of metalloproteinases (IMPs) that are distinct from TIMP.","authors":"M J Banda, E W Howard, G S Herron, G Apodaca","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The tissue inhibitor of metalloproteinases (TIMP, M(r) 30,000) is secreted by many cell and tissue types and has been shown to inhibit most secreted mammalian metalloproteinases. In matrix and tissue invasion assays, the inactivation or removal of TIMP enhances invasiveness. However, many of the cells that secrete TIMP also secrete other metalloproteinase inhibitors. By analysis of medium conditioned by various endothelial, mesenchymal, and neural cells on SDS-.substrate-polyacrylamide-inhibitor gels (reverse zymograms), we have detected at least three other distinct inhibitors of metalloproteinases (IMPs). Some or all of these IMPs have been detected in secretions of mouse, rabbit, sheep, and human cells and are all smaller in apparent molecular size than TIMP (IMP-1, M(r) 26,000; IMP-2, M(r) 21,000; IMP-3, M(r) 18,000). These IMPs are not proteolytic degradation products of TIMP nor do they represent nonglycosylated TIMP. The IMPs do not cross-react in the native or denatured state with any of several anti-TIMP antibodies. The IMPs appear to be regulated independently of each other and of TIMP. In vitro, the complex consisting of one of the IMPs, or TIMP, and a metalloproteinase can be dissociated into functional inhibitor and metalloproteinase. Whether this characteristic is significant in vivo is not known. IMP-2 has been purified from several sources and shares sequence homology with TIMP, suggesting that the IMPs and TIMP may constitute a gene family. The most significant characteristic of IMP-2 is that it appears to preferentially inhibit, on a mole:mole basis, the M(r) 68,000 gelatinase rather than collagenase or stromelysin.(ABSTRACT TRUNCATED AT 250 WORDS)</p>","PeriodicalId":77254,"journal":{"name":"Matrix (Stuttgart, Germany). Supplement","volume":"1 ","pages":"294-8"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12649210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structure of the human 70 K type IV collagenase gene and assignment of the gene to the q21 region of chromosome 16. 人类70k型胶原酶基因的结构及其在16号染色体q21区的定位。

Matrix (Stuttgart, Germany). Supplement Pub Date : 1992-01-01

P Huhtala, L Chow, T Shows, K Tryggvason

引用次数: 0

Mr 95,000 metalloproteinase produced by rat mammary epithelial cells. mr95000金属蛋白酶由大鼠乳腺上皮细胞产生。

Matrix (Stuttgart, Germany). Supplement Pub Date : 1992-01-01

J G Lyons, B Birkedal-Hansen, W G Moore, G Harber, H Birkedal-Hansen

引用次数: 0

Identification of two arginine residues involved in the binding of substrate to neutral endopeptidase 24-11. 鉴定参与底物与中性内肽酶24-11结合的两个精氨酸残基。

Matrix (Stuttgart, Germany). Supplement Pub Date : 1992-01-01

H Le Moual, A Beaumont, B P Roques, P Crine, G Boileau

引用次数: 0