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Immunolocalization of metalloproteinases and TIMP in normal and pathological tissues. 金属蛋白酶和TIMP在正常和病理组织中的免疫定位。
Matrix (Stuttgart, Germany). Supplement Pub Date : 1992-01-01
J J Reynolds, R M Hembry
{"title":"Immunolocalization of metalloproteinases and TIMP in normal and pathological tissues.","authors":"J J Reynolds,&nbsp;R M Hembry","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Molecular and biochemical studies have made substantial contributions to the understanding of metalloproteinases (MPs) and their natural inhibitor TIMP (tissue inhibitor of metalloproteinases) but knowledge of their specific roles in tissue breakdown in vivo is still meagre. A major problem is that there are few techniques available that can detect small amounts of these entities at the sites of resorption. One approach to this problem is to prepare specific polyclonal antisera for use in immunolocalization studies on cells and tissues ex vivo. Another is to develop model systems of rapid matrix destruction. Examples of these techniques are presented and discussed in relation to other studies. In many situations unique patterns of synthesis have been observed, consistent with specific roles for the individual MPs and biochemical data. Active collagenase can be localized to extracellular components in tissues where rapid destruction is taking place. Thus both approaches are proving invaluable in defining the roles of MPs and TIMP in normal and pathological situations.</p>","PeriodicalId":77254,"journal":{"name":"Matrix (Stuttgart, Germany). Supplement","volume":"1 ","pages":"375-82"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12649747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inhibition of ovulation in the perfused rat ovary by a synthetic collagenase inhibitor. 合成胶原酶抑制剂对灌注大鼠卵巢排卵的抑制作用。
Matrix (Stuttgart, Germany). Supplement Pub Date : 1992-01-01
T A Butler, C Zhu, R A Mueller, G C Fuller, W J Lemaire, J F Woessner
{"title":"Inhibition of ovulation in the perfused rat ovary by a synthetic collagenase inhibitor.","authors":"T A Butler,&nbsp;C Zhu,&nbsp;R A Mueller,&nbsp;G C Fuller,&nbsp;W J Lemaire,&nbsp;J F Woessner","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77254,"journal":{"name":"Matrix (Stuttgart, Germany). Supplement","volume":"1 ","pages":"400-1"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12649755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characteristics of human salivary collagenase and its relationship to periodontal diseases. 人唾液胶原酶的特征及其与牙周病的关系。
Matrix (Stuttgart, Germany). Supplement Pub Date : 1992-01-01
T Sorsa, V J Uitto, K Suomalainen
{"title":"Characteristics of human salivary collagenase and its relationship to periodontal diseases.","authors":"T Sorsa,&nbsp;V J Uitto,&nbsp;K Suomalainen","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77254,"journal":{"name":"Matrix (Stuttgart, Germany). Supplement","volume":"1 ","pages":"406-7"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12649758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-coordinate regulation of metalloproteinase gene expression in cornea. 角膜金属蛋白酶基因表达的非协调调控。
Matrix (Stuttgart, Germany). Supplement Pub Date : 1992-01-01
M E Fini, M T Girard
{"title":"Non-coordinate regulation of metalloproteinase gene expression in cornea.","authors":"M E Fini,&nbsp;M T Girard","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77254,"journal":{"name":"Matrix (Stuttgart, Germany). Supplement","volume":"1 ","pages":"203-4"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12650039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of specific calmodulin and protein kinase C inhibitors on the interleukin 1 induced collagenase production in human uterine cervical fibroblasts. 特异性钙调素和蛋白激酶C抑制剂对白细胞介素1诱导的人子宫颈成纤维细胞胶原酶生成的影响。
Matrix (Stuttgart, Germany). Supplement Pub Date : 1992-01-01
A Ito, Y Ojima, L C Chen, H Nagase, Y Mori
{"title":"Influence of specific calmodulin and protein kinase C inhibitors on the interleukin 1 induced collagenase production in human uterine cervical fibroblasts.","authors":"A Ito,&nbsp;Y Ojima,&nbsp;L C Chen,&nbsp;H Nagase,&nbsp;Y Mori","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77254,"journal":{"name":"Matrix (Stuttgart, Germany). Supplement","volume":"1 ","pages":"205-6"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12650040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fibronectin fragments, but not intact fibronectin, signalling through the fibronectin receptor induce metalloproteinase gene expression in fibroblasts. 纤维连接蛋白片段，但不是完整的纤维连接蛋白，通过纤维连接蛋白受体信号传导诱导成纤维细胞金属蛋白酶基因表达。
Matrix (Stuttgart, Germany). Supplement Pub Date : 1992-01-01
P M Tremble, C H Damsky, Z Werb
{"title":"Fibronectin fragments, but not intact fibronectin, signalling through the fibronectin receptor induce metalloproteinase gene expression in fibroblasts.","authors":"P M Tremble,&nbsp;C H Damsky,&nbsp;Z Werb","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77254,"journal":{"name":"Matrix (Stuttgart, Germany). Supplement","volume":"1 ","pages":"212-4"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12650043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structural basis for the action of thermolysin. 热溶素作用的结构基础。
Matrix (Stuttgart, Germany). Supplement Pub Date : 1992-01-01
D E Tronrud, S L Roderick, B W Matthews
{"title":"Structural basis for the action of thermolysin.","authors":"D E Tronrud,&nbsp;S L Roderick,&nbsp;B W Matthews","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>High resolution X-ray crystallography has been used to determine the modes of binding to thermolysin of a series of different inhibitors including dipeptides, mercaptans, hydroxamates, N-carboxymethyl peptides and phosphonamidates. The interactions displayed by such inhibitors illustrate interactions that are presumed to occur between the enzyme and its substrates during catalysis. The crystallographic analysis, together with model building, suggest a detailed stereochemical mechanism of action for thermolysin and, by analogy, other zinc proteases such as carboxypeptidase A and the angiotensin converting enzyme. Analysis of a series of phosphonamidates, which are presumed to be transition-state analogues, has shown that chemically similar inhibitors can adopt dissimilar modes of binding. These different configurations provide a rationalization for large differences in the kinetics of binding that are observed for these inhibitors. Experiments with thermolysin as a test case suggest that knowledge of the three-dimensional structure of an enzyme or receptor will greatly facilitate the rational design of drugs directed at such targets.</p>","PeriodicalId":77254,"journal":{"name":"Matrix (Stuttgart, Germany). Supplement","volume":"1 ","pages":"107-11"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12650827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Achromobacter collagenase on fibronectin: activation of FN-gelatinase and FN-laminase. 无色杆菌胶原酶对纤维连接蛋白的影响:fn -明胶酶和fn -层合酶的激活。
Matrix (Stuttgart, Germany). Supplement Pub Date : 1992-01-01
J M Imhoff, X Blondeau, T Planchenault, I Emod, V Keil-Dlouha
{"title":"Effect of Achromobacter collagenase on fibronectin: activation of FN-gelatinase and FN-laminase.","authors":"J M Imhoff,&nbsp;X Blondeau,&nbsp;T Planchenault,&nbsp;I Emod,&nbsp;V Keil-Dlouha","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77254,"journal":{"name":"Matrix (Stuttgart, Germany). Supplement","volume":"1 ","pages":"138-40"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12650832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and regulation of keratinocyte collagenase. 角质细胞胶原酶的合成与调控。
Matrix (Stuttgart, Germany). Supplement Pub Date : 1992-01-01
M J Petersen, D T Woodley, G P Stricklin, E J O'Keefe
{"title":"Synthesis and regulation of keratinocyte collagenase.","authors":"M J Petersen,&nbsp;D T Woodley,&nbsp;G P Stricklin,&nbsp;E J O'Keefe","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We have recently demonstrated that human keratinocytes synthesize and secrete procollagenase and tissue inhibitor of metalloproteinases (TIMP) in culture. We have examined the response of keratinocyte collagenase production to the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), interleukin-1, extracellular matrix proteins and phagocytosis. Collagenase production in keratinocytes was markedly stimulated by TPA and paralleled the morphologic changes induced by the phorbol ester. Synthesis of collagenase increased six- to 34-fold with TPA, whereas the level of TIMP rose only three-fold. Interleukin-1 did not stimulate collagenase production by the keratinocytes, in contrast to its effect on cultured fibroblasts. When keratinocytes were plated on type I or type IV collagen, they synthesized increased amounts of collagenase compared with cells cultured on laminin or in the absence of matrix. TIMP synthesis was not increased by collagen. Finally, phagocytosis of latex beads did not augment collagenase production by the keratinocytes.</p>","PeriodicalId":77254,"journal":{"name":"Matrix (Stuttgart, Germany). Supplement","volume":"1 ","pages":"192-7"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12650837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preparation of peptidyl hydroxamic acid derivatives which inhibit interstitial collagenases. 抑制间质胶原酶的肽基羟肟酸衍生物的制备。
Matrix (Stuttgart, Germany). Supplement Pub Date : 1992-01-01
Y Nagai, S Hattori, S Odake, T Okayama, M Obata, T Morikawa
{"title":"Preparation of peptidyl hydroxamic acid derivatives which inhibit interstitial collagenases.","authors":"Y Nagai,&nbsp;S Hattori,&nbsp;S Odake,&nbsp;T Okayama,&nbsp;M Obata,&nbsp;T Morikawa","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77254,"journal":{"name":"Matrix (Stuttgart, Germany). Supplement","volume":"1 ","pages":"313"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12649170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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